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Engineering precision nanoparticles for drug delivery
Open accessAbstract
In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers - systemic, microenvironmental and cellular - that are heterogeneous across patient populations and diseases. Overcoming this patient heterogeneity has also been accomplished through precision therapeutics, in which personalized interventions have enhanced therapeutic efficacy. However, nanoparticle development continues to focus on optimizing delivery platforms with a one-size-fits-all solution. As lipid-based, polymeric and inorganic nanoparticles are engineered in increasingly specified ways, they can begin to be optimized for drug delivery in a more personalized manner, entering the era of precision medicine. In this Review, we discuss advanced nanoparticle designs utilized in both non-personalized and precision applications that could be applied to improve precision therapies. We focus on advances in nanoparticle design that overcome heterogeneous barriers to delivery, arguing that intelligent nanoparticle design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.
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“The literature has shown that nanoparticles with a diameter greater than 200 nm pose a risk of activating the complement system. Particles with diameters of 50 and 200 nm can escape from the splenic space, enter the sinusoidal endothelial pores, and accumulate in large quantities at sites of liver fibrosis (29, 30).”
From Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation (2025) · cites this paper as [30]
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“To avoid these limitations, non‐positively charged vectors were also developed by conjugating nucleic acids into nanoparticles, which however requires complicated synthesis procedure, and the transfection efficiency is strongly affected by the size, shape, and surface environment of the nanoparticles.[ 16 ]”
From A General and Efficient Strategy for Gene Delivery Based on Tea Polyphenols Intercalation and Self‐Polymerization (2023) · cites this paper as [16]
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In the citing paper
“To avoid these limitations, non‐positively charged vectors were also developed by conjugating nucleic acids into nanoparticles, which however requires complicated synthesis procedure, and the transfection efficiency is strongly affected by the size, shape, and surface environment of the nanoparticles.[ 16 ]”
From A General and Efficient Strategy for Gene Delivery Based on Tea Polyphenols Intercalation and Self‐Polymerization (2023) · cites this paper as [16]
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“After modification or stimulation by corresponding factors, these smart nanoparticles efficiently aggregate at the target location and release their payloads, establishing a smart treatment mode.8–12”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [9]
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“Nanoparticles taken intravenously can circulate for extended period of time with reduced clearance rates from the renal system due to their ultra-small size and superior drug loading and encapsulation efficacy.11”
From Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment (2022) · cites this paper as [11]
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Items 201–316 of 316
Effect of Cell Sex on Uptake of Nanoparticles: The Overlooked Factor at the Nanobio Interface
Serpooshan, V., Sheibani, S., Pushparaj, P., Wojcik, M., Jang, A. Y., Santoso, M. R., Jang, J. H., Huang, H., Safavi‐Sohi, R., Haghjoo, N., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b06212 · Cited by 108
Zupančič, E., Curato, C., Paisana, M. C., Rodrigues, C. A. B., Porat, Z., Viana, A. S., Afonso, C. A. M., Pinto, J. F., Gaspar, R. S., Moreira, J. N., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.05.014 · Cited by 107
Silica Nanoparticle as a Lymph Node Targeting Platform for Vaccine Delivery
An, M., Li, M. C., Xi, J., & Liu, H. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b06024 · Cited by 106
Lee, S., Kim, Y., Cho, C., Kim, Y. T., Kim, S. M., Hur, S. Y., Kim, J., Kim, B., Kim, S. C., Ryu, H., et al. (2017) · Cancer Research and Treatment · doi:10.4143/crt.2016.376 · Cited by 100
Delivery of therapeutics with nanoparticles: what's new in cancer immunotherapy?
Fontana, F., Liu, D., Hirvonen, J. J., & Santos, H. A. (2016) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1421 · Cited by 98
Zhang, L., Su, H., Wang, H., Li, Q., Li, X., Zhou, C., Xu, J., Chai, Y., Liang, X., Xiong, L., et al. (2019) · Theranostics · doi:10.7150/thno.30523 · Cited by 96
Zhang, Y., Shen, S., Zhao, G., Xu, C., Zhang, H., Luo, Y., Cao, Z., Shi, J. Y., Zhao, Z., Lian, Z., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119302 · Cited by 96
The application of nanotechnology in immune checkpoint blockade for cancer treatment
Deng, H., & Zhang, Z. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.09.026 · Cited by 95
Wang, Y., Luan, Z., Zhao, C., Bai, C., & Yang, K. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.105136 · Cited by 95
Brown, S. B., Wang, L. A., Jungels, R. R., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.10.003 · Cited by 93
Chavez-Santoscoy, A. V., Roychoudhury, R., Pohl, N. L. B., Wannemuehler, M. J., Narasimhan, B., & Ramer‐Tait, A. E. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.027 · Cited by 92
Małota, Z., Głowacki, J., Sadowski, W., et al. (2018) · BMC Cardiovascular Disorders · doi:10.1186/s12872-018-0865-6 · Cited by 91
Clegg, J. R., Irani, A. S., Ander, E. W., Ludolph, C. M., Venkataraman, A. K., Zhong, J. X., & Peppas, N. A. (2019) · Science Advances · doi:10.1126/sciadv.aax7946 · Cited by 91
Self-citationJose, S., Cinu, T. A., Sebastian, R., Shoja, M. H., Aleykutty, N., Durazzo, A., Lucarini, M., Santini, A., & Souto, E. B. (2019) · Polymers · doi:10.3390/polym11111905 · Cited by 91
Hathaway, H. J., Ajuebor, J., Stephens, L. J., Coffey, A., Potter, U., Sutton, J. M., & Jenkins, A. T. A. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.11.030 · Cited by 90
Dong, W., Ye, J., Zhou, J., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.10.002 · Cited by 90
Wang, J., Potocny, A. M., Rosenthal, J., & Day, E. S. (2019) · ACS Omega · doi:10.1021/acsomega.9b04150 · Cited by 89
Cao, F., Yan, M., Liu, Y., Liu, L., & Ma, G. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701439 · Cited by 88
McSweeney, M. D., Wessler, T., Price, L., Ciociola, E. C., Herity, L. B., Piscitelli, J. A., Zamboni, W. C., Forest, M. G., Cao, Y., & Lai, S. K. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.06.002 · Cited by 86
Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing
Maule, G., Casini, A., Montagna, C., Ramalho, A. S., De Boeck, K., Debyser, Z., Carlon, M. S., Petris, G., & Cereseto, A. (2019) · Nature Communications · doi:10.1038/s41467-019-11454-9 · Cited by 86
Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery
Papa, A., Korin, N., Kanapathipillai, M., Mammoto, A., Mammoto, T., Jiang, A. R., Mannix, R. J., Uzun, O., Johnson, C. P., Bhatta, D. B., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.003 · Cited by 85
Antigen-specific immunotherapies in rheumatic diseases
Pozsgay, J., Szekanecz, Z., & Sármay, G. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.107 · Cited by 85
Valcourt, D. M., Dang, M. N., Scully, M. A., & Day, E. S. (2020) · ACS Nano · doi:10.1021/acsnano.9b09263 · Cited by 85
Guo, F., Fu, Q., Zhou, K., Jin, C., Wu, W.-C., Ji, X., Yan, Q., Yang, Q., Wu, D., Li, A., et al. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00595-5 · Cited by 85
Organelle-specific targeting of polymersomes into the cell nucleus
Zelmer, C., Zweifel, L. P., Kapinos, L. E., Craciun, I., Güven, Z. P., Palivan, C. G., & Lim, R. Y. H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916395117 · Cited by 83
Nanoparticles for dendritic cell-based immunotherapy
Tran, T. H., Tran, T. T. P., Nguyen, H. T., Phung, C. D., Jeong, J., Stenzel, M. H., Jin, S. G., Yong, C. S., Truong, D. H., & Kim, J. O. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.03.029 · Cited by 81
Khor, S. Y., Vu, M. N., Pilkington, E. H., Johnston, A. P. R., Whittaker, M. R., Quinn, J. F., Truong, N. P., & Davis, T. P. (2018) · Small · doi:10.1002/smll.201801702 · Cited by 81
Sarfraz, M., Afzal, A., Yang, T., Gai, Y., Raza, S. M., Khan, M. W., Cheng, Y., Ma, X., & Xiang, G. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030151 · Cited by 81
Oliva, N., Solanes, M. C., Beckerman, M., Seliktar, S., Hayward, A. M., Stanley, J., Parry, N. M., Edelman, E. R., & Artzi, N. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa1616 · Cited by 79
Li, D., Zhuang, J., He, H., Jiang, S., Banerjee, A., Lü, Y., Wu, W., Mitragotri, S., Gan, L., & Qi, J. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b11821 · Cited by 79
Zhong, Q., Merkel, O. M., Reineke, J., & da Rocha, S. R. P. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00036 · Cited by 74
Nanoparticle Delivery of miR-708 Mimetic Impairs Breast Cancer Metastasis
Ramchandani, D., Lee, S. K., Yomtoubian, S., Han, M. S., Tung, C., & Mittal, V. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0702 · Cited by 74
Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles
Strand, M. S., Krasnick, B. A., Pan, H., Zhang, X., Bi, Y., Brooks, C., Wetzel, C., Sankpal, N., Fleming, T., Goedegebuure, S. P., et al. (2019) · Oncotarget · doi:10.18632/oncotarget.27109 · Cited by 74
Osteoclasts in the Inflammatory Arthritis: Implications for Pathologic Osteolysis
Jung, Y., Kang, Y. M., & Han, S. W. (2019) · Immune Network · doi:10.4110/in.2019.19.e2 · Cited by 73
Microfluidic-assisted polymer-protein assembly to fabricate homogeneous functionalnanoparticles
Zhang, L., Beatty, A., Lu, L. N., et al. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110768 · Cited by 73
Wu, S., Gu, L., Qin, J., Zhang, L., Sun, F., Liu, Z., Wang, Y., & Shi, D. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b16385 · Cited by 71
Vhora, I., Lalani, R., Bhatt, P., Patil, S., & Misra, A. R. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.04.006 · Cited by 70
Hauschild, A., Ascierto, P. A., Schadendorf, D., Grob, J., Ribas, A., Kiecker, F., Dutriaux, C., Демидов, Л. В., Lebbé, C., Rutkowski, P. L., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2019.10.033 · Cited by 70
Mesoporous silica nanorods for improved oral drug absorption
Zheng, N., Li, J., Xu, C., et al. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1362414 · Cited by 69
Horwitz, D. A., Bickerton, S., Koss, M. N., et al. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40773 · Cited by 69
Glucose and H2O2 Dual-Responsive Polymeric Micelles for the Self-Regulated Release of Insulin
Liu, X., Li, C., Lv, J., Huang, F., An, Y., Shi, L., & Ma, R. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b01185 · Cited by 68
Matrix Metalloproteinase-sensitive Multistage Nanogels Promote Drug Transport in 3D Tumor Model
Nagel, G., Sousa‐Herves, A., Wedepohl, S., & Calderón, M. (2019) · Theranostics · doi:10.7150/thno.34851 · Cited by 67
Papi, M., Palmieri, V., Digiacomo, L., Giulimondi, F., Palchetti, S., Ciasca, G., Perini, G., Caputo, D. D., Cartillone, M. C., Cascone, C., et al. (2019) · Nanoscale · doi:10.1039/c9nr01413f · Cited by 65
Manshian, B., Jiménez, J., Himmelreich, U., & Soenen, S. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.02.039 · Cited by 63
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
Wilson, R., Espinosa‐Díez, C., Kanner, N., Chatterjee, N., Ruhl, R. A., Hipfinger, C., Advani, S. J., Li, J., Khan, O. F., Franovic, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms13597 · Cited by 63
Riley, R., Dang, M. N., Billingsley, M. M., Abraham, B., Gundlach, L., & Day, E. S. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00681 · Cited by 63
Self-citationOral delivery of nanoparticles - let’s not forget about the protein corona
Berardi, A., & Bombelli, F. B. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1610384 · Cited by 63
Hong, S.-T., Lin, H., Wang, C.-S., Chang, C.-H., Lin, A. M.-Y., Yang, J. C., & Lo, Y. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0519-6 · Cited by 63
He, C., Yue, H., Xu, L., Liu, Y.-F., Song, Y., Tang, C., & Yin, C. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.12.005 · Cited by 62
Transport Barriers and Oncophysics in Cancer Treatment
Nizzero, S., Žiemys, A., & Mauro Ferrari, B. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.02.008 · Cited by 61
Wechsler, M. E., Ramirez, J. E. V., & Peppas, N. A. (2019) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.9b02196 · Cited by 61
Self-citationEngineered nanoparticles for systemic siRNA delivery to malignant brain tumours
Karlsson, J. E., Rui, Y., Kozielski, K., Placone, A. L., Choi, O., Tzeng, S. Y., Kim, J., Keyes, J. J., Bogorad, M. I., Gabrielson, K. L., et al. (2019) · Nanoscale · doi:10.1039/c9nr04795f · Cited by 60
Yang, X., Yu, Y., Huang, X., et al. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.10.092 · Cited by 59
Dölen, Y., Valente, M., Tagit, O., Jäger, E., van Dinther, E. A. W., van Riessen, N. K., Hrubý, M., Gileadi, U., Cerundolo, V., & Figdor, C. G. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1738813 · Cited by 59
Immunotherapy Through the Years
Eno, J. (2017) · Journal of the Advanced Practitioner in Oncology · doi:10.6004/jadpro.2017.8.7.8 · Cited by 58
Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine
Wei, L., Zhao, Y., Hu, X., & Tang, L. (2020) · ACS Central Science · doi:10.1021/acscentsci.9b01174 · Cited by 57
Wu, L., Rodríguez‐Rodríguez, C., Cun, D., Yang, M., Saatchi, K., & Häfeli, U. O. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.05.004 · Cited by 57
In Vivo Retargeting of Poly(beta aminoester) (OM‐PBAE) Nanoparticles is Influenced by Protein Corona
Fornaguera, C., Guerra‐Rebollo, M., Lázaro, M. Á., Cascante, A., Rubio, N., Blanco, J., & Borrós, S. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900849 · Cited by 56
Shape Effect of Nanoparticles on Tumor Penetration in Monolayers Versus Spheroids
Zhang, L., Wang, Y., Yang, D., Huang, W., Hao, P., Feng, S., Appelhans, D., Zhang, T., & Zan, X. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00107 · Cited by 55
New Four-Die Forging Devices (FDFD) Design Solutions and Open-Die Forging Technologies
Lazorkin, V. (2018) · Advances in Materials · doi:10.11648/j.am.20180701.11 · Cited by 53
Zhang, T., Song, Y., Xing, Y., et al. (2019) · Nanoscale · doi:10.1039/c9nr07190c · Cited by 53
Firdessa-Fite, R., & Creusot, R. J. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.10.015 · Cited by 53
Delivery of Nanoparticles across the Intestinal Epithelium via the Transferrin Transport Pathway
Yong, J. M., Mantaj, J., Cheng, Y., & Vllasaliu, D. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11070298 · Cited by 52
Hosta‐Rigau, L., & Städler, B. (2013) · Molecular Pharmaceutics · doi:10.1021/mp4001298 · Cited by 49
T cell immunotherapy enhanced by designer biomaterials
Dunn, Z. S., Mac, J., & Wang, P. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119265 · Cited by 48
Translational nanoparticle engineering for cancer vaccines
Grippin, A., Sayour, E. J., & Mitchell, D. A. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1290036 · Cited by 47
Wadajkar, A. S., Dancy, J. G., Roberts, N. B., Connolly, N. P., Strickland, D. K., Winkles, J. A., Woodworth, G. F., & Kim, A. J. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.006 · Cited by 47
Zhang, S., Asghar, S., Yu, F., et al. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02272 · Cited by 47
Pang, L., Macauley, M. S., Arlian, B. M., Nycholat, C. M., & Paulson, J. C. (2017) · ChemBioChem · doi:10.1002/cbic.201600702 · Cited by 45
Redox-Responsive Polymeric Nanocomplex for Delivery of Cytotoxic Protein and Chemotherapeutics
Lim, W. Q., Phua, S. Z. F., & Zhao, Y. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b09605 · Cited by 45
Interplay of Nanoparticle Rigidity and Its Translocation Ability through Cell Membrane
Zhang, L., Chen, H., Xie, J., Becton, M., & Wang, X. (2019) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.9b07452 · Cited by 45
Li, R., Liang, J., He, Y., Qin, J., He, H., Lee, S., Pang, Z., & Wang, J. (2017) · Theranostics · doi:10.7150/thno.22072 · Cited by 44
Caldorera‐Moore, M. E., Ramirez, J. E. V., & Peppas, N. A. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1547732 · Cited by 43
Self-citationZan, Y., Dai, Z., Liang, L., et al. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1654040 · Cited by 43
Shi, H., Xu, M. J., Zhu, J., Yang, L., He, Z., Zhang, Y., Xu, Q., Niu, Y., & Liu, Y. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb02055a · Cited by 42
Stephen, Z. R., Chiarelli, P. A., Revia, R. A., Wang, K., Kievit, F. M., Dayringer, C., Jeon, M., Ellenbogen, R. G., & Zhang, M. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2998 · Cited by 41
Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent
Dzuricky, M. J., Xiong, S., Weber, P., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b02095 · Cited by 41
Acoustically responsive polydopamine nanodroplets: A novel theranostic agent
Mannaris, C., Yang, C., Carugo, D., et al. (2019) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2019.104782 · Cited by 39
Almeida, A. P. B., Damaceno, G. B. R., Carneiro, A. F., Bohr, A., Gonçalves, H. R., Valadares, M. C., Nascimento, T. L., & Lima, E. M. (2019) · Journal of Biomaterials Applications · doi:10.1177/0885328219863291 · Cited by 38
Foroozandeh, P., Aziz, A. A., & Mahmoudi, M. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b15533 · Cited by 38
The shape effect on polymer nanoparticle transport in a blood vessel
Uhl, C. G., Gao, Y., Zhou, S., et al. (2018) · RSC Advances · doi:10.1039/c8ra00033f · Cited by 37
Yan, Y. J., Dong, Y., Yue, S., Qiu, X., Sun, H., & Zhong, Z. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b17223 · Cited by 37
Yuan, P., Mao, X., Wu, X., Liew, S. S., Li, L., & Yao, S. Q. (2019) · Angewandte Chemie · doi:10.1002/ange.201901699 · Cited by 37
Engineering tolerance using biomaterials to target and control antigen presenting cells.
Tostanoski, L. H., Gosselin, E. A., & Jewell, C. M. (2016) · PubMed · Cited by 36
Zhang, Y., Meng, S., Ding, J., et al. (2018) · The Analyst · doi:10.1039/c8an01620h · Cited by 36
Gold Nanorods Coated with Apolipoprotein E Protein Corona for Drug Delivery
Yeo, E. L. L., Cheah, J. U.-J., Thong, P. S. P., Soo, K. C., & Kah, J. C. Y. (2019) · ACS Applied Nano Materials · doi:10.1021/acsanm.9b01196 · Cited by 36
The influence of nanoparticle shape on bilateral exocytosis from Caco-2 cells
Zhuang, J., Wang, D., Li, D., Yang, Y., Lü, Y., Wu, W., Wu, W., & Qi, J. (2018) · Chinese Chemical Letters · doi:10.1016/j.cclet.2018.10.012 · Cited by 35
Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy
Truex, N. L., Holden, R. L., Wang, B., Chen, P., Hanna, S., Hu, Z., Shetty, K. S., Olive, O., Neuberg, D. S., Hacohen, N., et al. (2020) · Scientific Reports · doi:10.1038/s41598-019-56943-5 · Cited by 35
The potential of nanoparticle vaccines as a treatment for cancer
Urbanavicius, D. B., Alvarez, T., Such, G. K., Johnston, A. P. R., & Mintern, J. D. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2017.12.022 · Cited by 34
Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging
Pant, K., Neuber, C., Zarschler, K., Wodtke, J., Meister, S., Haag, R., Pietzsch, J., & Stephan, H. (2019) · Small · doi:10.1002/smll.201905013 · Cited by 32
Xu, C., Gao, F., Wu, J., Niu, S., Li, F., Jin, L., Shi, Q., & Du, L. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s213518 · Cited by 31
Jarvis, M., Arnold, M. T., Ott, J., Krishnan, V., Pant, K., Prabhakarpandian, B., & Mitragotri, S. (2018) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10089 · Cited by 30
Concomitant SK current activation and sodium current inhibition cause J wave syndrome
Chen, M., Xu, D.-Z., Wu, A. Z.-Y., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.122329 · Cited by 30
BioTM Buzz (Volume 4, Issue 1)
Anselmo, A. C. (2018) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10125 · Cited by 30
Polymeric micelles for pH-responsive delivery of cisplatin
Shahin, M., Nikouei, N. S., & Lavasanifar, A. (2014) · Journal of drug targeting · doi:10.3109/1061186x.2014.921925 · Cited by 29
Tsubata, T. (2019) · Immune Network · doi:10.4110/in.2019.19.e1 · Cited by 27
Garapaty, A., & Champion, J. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217022 · Cited by 27
Biological Responses to Nanoscale Particles
(2019) · Nanoscience and technology · doi:10.1007/978-3-030-12461-8 · Cited by 27
Marloye, M., Lawler, S. E., & Berger, G. (2019) · Pharmaceutical Patent Analyst · doi:10.4155/ppa-2019-0013 · Cited by 25
Dong, Y., Lin, Y., Gao, X., Zhao, Y., Wan, Z., Wang, H., Wei, M., Chen, X., Qin, W., Yang, G., et al. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10127-3 · Cited by 25
Unmet Needs in Developing Nanoparticles for Precision Medicine
Schwartz, S. (2017) · Nanomedicine · doi:10.2217/nnm-2016-0390 · Cited by 24
Tatar, A.-S., Jurj, A. M., Tomuleasa, C., et al. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.110478 · Cited by 24
Jung, H.-H., Kim, S., Moon, J.-H., Jeong, S.-U., Jang, S., Park, C., & Lee, C. (2019) · Immune Network · doi:10.4110/in.2019.19.e19 · Cited by 23
Shaban, M., Hasanzadeh, M., & Solhi, E. (2019) · Analytical Methods · doi:10.1039/c9ay01988j · Cited by 21
Shahzad, K. A., Naeem, M., Zhang, L., Wan, X., Song, S., Pei, W., Zhao, C., Jin, X., & Shen, C. (2019) · Immunological Investigations · doi:10.1080/08820139.2019.1695134 · Cited by 21
Development of a nanoparticle that releases nucleic acids in response to a mitochondrial environment
Yamada, Y., Fukuda, Y., Sasaki, D., et al. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.02.009 · Cited by 20
Creber, C., Cooper, R., Plange‐Rhule, J., Bovet, P., Lambert, E. V., Forrester, T., Schoeller, D. A., Riesen, W., Korte, W. C., Cao, G., et al. (2018) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0737-5 · Cited by 19
Prenatal gene therapy offers the earliest possible cure
DeWeerdt, S. (2018) · Nature · doi:10.1038/d41586-018-07643-z · Cited by 19
SERS-based nanostrategy for rapid anemia diagnosis
Muhammad, P., Hanif, S., Yan, J., et al. (2019) · Nanoscale · doi:10.1039/c9nr09152a · Cited by 19
Novel screening test for celiac disease using peptide functionalised gold nanoparticles
Kaur, A., Shimoni, O., & Wallach, M. G. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i47.5379 · Cited by 17
Fabrication and Characterization of Tumor Nano-Lysate as a Preventative Vaccine for Breast Cancer
Dombroski, J. A., Jyotsana, N., Crews, D. W., et al. (2020) · Langmuir · doi:10.1021/acs.langmuir.0c00947 · Cited by 16
León-Janampa, N., Zimic, M., Shinkaruk, S., et al. (2020) · Nanotechnology · doi:10.1088/1361-6528/ab6ab1 · Cited by 15
The precision medicine approach to cancer therapy: part 1 — solid tumours
(2019) · Pharmaceutical journal/The pharmaceutical journal · doi:10.1211/pj.2019.20207119 · Cited by 12
Hocking, K. M., Evans, B. C., Komalavilas, P., et al. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2018.0169 · Cited by 11
Tanaka, R., Arai, K., Matsuno, J., Soejima, M., Lee, J. H., Takahashi, R., Sakurai, K., & Fujii, S. (2020) · Polymer Chemistry · doi:10.1039/d0py00610f · Cited by 10
pVAX1-A20 alleviates colitis in mice by promoting regulatory T cells
Hu, T., Hu, T., Ma, L., Zeng, X., Liu, J., Cheng, B., Yang, P., Qiu, S., Yang, G., Chen, D., et al. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.11.005 · Cited by 8
Research works printed but not linked: 2
- Pieter, S. & Mahmoudi, M. Drug Delivery Systems (World Scientific, 2017).
- Chacón-Lozsán, F., et al. Hemodynamic management of high blood pressure. Ther. Adv. Cardiol. 1, 73–79 (2017).
Cited by
Sorted by citations
Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221
The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073
Targeting drugs to tumours using cell membrane-coated nanoparticles
Fang, R. H., Gao, W., & Zhang, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00699-x · Cited by 980
Mendes, B. B., Conniot, J., Avital, A., Yao, D., Jiang, X., Zhou, X., Sharf-Pauker, N., Xiao, Y., Adir, O., Liang, H., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00104-y · Cited by 719
Metadata
- Authors
- Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R.
- Affiliations
- Abramson Cancer Center (US)
- University of Pennsylvania (US)
- The University of Texas at Austin (US)
- Corresponding author
- Mitchell, Michael J.
- Peppas, Nicholas A.
- ORCID
- Venue
- Nature Reviews Drug Discovery
- Published
- 2020-12-04
- Volume
- 20
- Issue
- 2
- Pages
- 101-124
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC7717100
- OpenAlex
- W3109746568
- Cited by
- 7,933
- References
- 316
- Citations by year
- 2026: 1402 · 2025: 1818 · 2024: 1723 · 2023: 1460 · 2022: 1082 · 2021: 441 · 2020: 2
- FWCI
- 49.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (DGE-184529 8, 1845298, 1033746)
- American Association for Cancer Research (18-80-44-MITC, 18-80-44)
- American Cancer Society (129784‐IRG‐16‐188‐38‐IRG)
- Pratt Foundation
- National Institutes of Health (DP2TR002776, / NIDDK R01, / NCI R01, 5r01eb000246-20, CA016520)
- National Cancer Institute (CA016520, R01CA241661, R37CA244911, P30CA016520)
- National Institute of Allergy and Infectious Diseases (T32AI007632)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK123049)
- National Institute of Biomedical Imaging and Bioengineering (R01EB022025, R01-EB000246)
- National Center for Advancing Translational Sciences
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- nanoparticles, drug delivery, precision medicine, personalized medicine, nanoparticle design, lipid nanoparticles, polymeric nanoparticles, inorganic nanoparticles, biological barriers, patient heterogeneity, targeted delivery
- MeSH terms
- Biomedical Engineering, Pharmaceutical Preparations, Humans, Drug Delivery Systems, Nanoparticles, Precision Medicine
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