Engineering precision nanoparticles for drug delivery

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

Nishita, M., Park, S.-Y., Nishio, T., Kamizaki, K., Wang, Z., Tamada, K., Takumi, T., Hashimoto, R., Otani, H., Pazour, G. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-016-0028-x · Cited by 15,947

Double-slit photoelectron interference in strong-field ionization of the neon dimer

Kunitski, M., Eicke, N., Huber, P., Köhler, J., Zeller, S., Voigtsberger, J., Schlott, N., Henrichs, K., Sann, H., Trinter, F., et al. (2019) · Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover) · doi:10.15488/5174 · Cited by 8,378

Double-slit photoelectron interference in strong-field ionization of the neon dimer

Kunitski, M., Eicke, N., Huber, P., Köhler, J., Zeller, S., Voigtsberger, J., Schlott, N., Henrichs, K., Sann, H., Trinter, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07882-8 · Cited by 8,162

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

Chapman, P. B., Hauschild, A., Robert, C., Haanen, J. B., Ascierto, P., Larkin, J., Dummer, R., Garbe, C., Testori, A., Maio, M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103782 · Cited by 7,720

Nano based drug delivery systems: recent developments and future prospects

Patra, J. K., Das, G., Fraceto, L. F., Campos, E. V. R., Rodríguez-Torres, M. D. P., Acosta‐Torres, L. S., Diaz-Torres, L. A., Grillo, R., Swamy, M. K., Sharma, S., et al. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0392-8 · Cited by 7,085

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002

Analysis of nanoparticle delivery to tumours

Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218

A New Initiative on Precision Medicine

Collins, F. S., & Varmus, H. (2015) · New England Journal of Medicine · doi:10.1056/nejmp1500523 · Cited by 5,202

LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Hacein-Bey-Abina, S., Von Kalle, C., Schmidt, M., McCormack, M. P., Wulffraat, N., Leboulch, P., Lim, A., Osborne, C. S., Pawliuk, R., Morillon, E., et al. (2003) · Science · doi:10.1126/science.1088547 · Cited by 3,587

Non-viral vectors for gene-based therapy

Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123

Knocking down barriers: advances in siRNA delivery

Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115

Cellular uptake of nanoparticles: Journey inside the cell

Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859

Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease

Cavazzana, M., Hacein‐Bey‐Abina, S., Basile, G. D. S., Gross, F., Yvon, E. S., Nusbaum, P., Selz, F., Hue, C., Dogniaux, S., Casanova, J., et al. (2000) · Science · doi:10.1126/science.288.5466.669 · Cited by 2,685

Delivery technologies for cancer immunotherapy

Riley, R., June, C. H., Langer, R., & Mitchell, M. J. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0006-z · Cited by 2,678

Advances and Challenges of Liposome Assisted Drug Delivery

Sercombe, L., Veerati, T., Moheimani, F., Wu, S. Y., Sood, A. K., & Hua, S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00286 · Cited by 2,672

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1958-5 · Cited by 2,586

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

Davis, M. E., Zuckerman, J. E., Choi, C. H. J., Seligson, D. B., Tolcher, A. W., Alabi, C. A., Yen, Y., Heidel, J. D., & Ribas, A. (2010) · Nature · doi:10.1038/nature08956 · Cited by 2,541

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

Cheng, Q., Wei, T., Farbiak, L., Johnson, L. T., Dilliard, S. A., & Siegwart, D. J. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0669-6 · Cited by 2,383

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

Tenzer, S., Docter, D., Kuharev, J., Musyanovych, A., Fetz, V., Hecht, R., Schlenk, F., Fischer, D., Kiouptsi, K., Reinhardt, C., et al. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.181 · Cited by 2,283

The Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction

Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016) · Nanomedicine · doi:10.2217/nnm.16.5 · Cited by 1,990

The Architecture of Cognitive Control in the Human Prefrontal Cortex

Koechlin, É., Ody, C., & Kouneiher, F. (2003) · Science · doi:10.1126/science.1088545 · Cited by 1,939

Rational design of cationic lipids for siRNA delivery

Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1602 · Cited by 1,822

Airway Mucus Function and Dysfunction

Fahy, J. V., & Dickey, B. F. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0910061 · Cited by 1,804

Nanoparticle biointerfacing by platelet membrane cloaking

Hu, C. J., Fang, R. H., Wang, K.-C., Luk, B. T., Thamphiwatana, S., Dehaini, D., Nguyen, P., Angsantikul, P., Wen, C. H., Kroll, A. V., et al. (2015) · Nature · doi:10.1038/nature15373 · Cited by 1,795

Nanoparticles in the clinic: an update

Anselmo, A. C., & Mitragotri, S. (2019) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10143 · Cited by 1,766

The entry of nanoparticles into solid tumours

Sindhwani, S., Syed, A. M., Ngai, J., Kingston, B. R., Maiorino, L., Rothschild, J., MacMillan, P., Zhang, Y., Rajesh, N. U., Hoang, T., et al. (2020) · Nature Materials · doi:10.1038/s41563-019-0566-2 · Cited by 1,732

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

Ensign, L. M., Cone, R. A., & Hanes, J. S. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.12.009 · Cited by 1,671

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609

Barrier properties of mucus

Cone, R. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.008 · Cited by 1,459

Molecular-channel driven actuator with considerations for multiple configurations and color switching

Mu, J., Wang, G., Yan, H., Li, H., Wang, X., Gao, E., Hou, C., Pham, A. T. C., Wu, L., Zhang, Q., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03032-2 · Cited by 1,458

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

Foroozandeh, P., & Aziz, A. A. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2728-6 · Cited by 1,438

Engineered nanoparticles interacting with cells: size matters

Shang, L., Nienhaus, K., & Nienhaus, G. U. (2014) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-12-5 · Cited by 1,358

Smart cancer nanomedicine

van der Meel, R., Sulheim, E., Shi, Y., Kiessling, F. M., Mulder, W. J. M., & Lammers, T. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0567-y · Cited by 1,279

Targeting Tumor Microenvironment for Cancer Therapy

Roma-Rodrigues, C., Mendes, R., Baptista, P. V., & Fernandes, A. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040840 · Cited by 1,187

Liposomes and polymersomes: a comparative review towards cell mimicking

Rideau, E., Dimova, R., Schwille, P., Wurm, F. R., & Landfester, K. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00162f · Cited by 1,144

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

Hua, S., de Matos, M. B. C., Metselaar, J. M., & Storm, G. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00790 · Cited by 1,089

Mutual Insight on Ferroelectrics and Hybrid Halide Perovskites: A Platform for Future Multifunctional Energy Conversion

Pandey, R., Vats, G., Yun, J. S., Bowen, C., Ho-Baillie, A. W. Y., Seidel, J., Butler, K. T., & Seok, S. I. (2019) · Advanced Materials · doi:10.1002/adma.201807376 · Cited by 1,078

Multistage nanoparticle delivery system for deep penetration into tumor tissue

Wong, C., Stylianopoulos, T., Cui, J., Martin, J. D., Chauhan, V. P., Jiang, W., Popović, Z., Jain, R. K., Bawendi, M. G., & Fukumura, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018382108 · Cited by 1,076

Advances in Biomaterials for Drug Delivery

Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 890

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

Zhou, Q., Shao, S., Wang, J., Xu, C., Xiang, J., Piao, Y., Zhou, Z., Yu, Q., Tang, J., Liu, X., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0485-z · Cited by 831

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

Smith, T. T., Stephan, S. B., Moffett, H. F., McKnight, L. E., Ji, W., Reiman, D., Bonagofski, E., Wohlfahrt, M. E., Pillai, S. P. S., & Stephan, M. T. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.57 · Cited by 801

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

Menjoge, A. R., Kannan, R. M., & Tomalia, D. A. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.01.009 · Cited by 796

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

Wang, C., Ye, Y., Hochu, G. M., Sadeghifar, H., & Gu, Z. (2016) · Nano Letters · doi:10.1021/acs.nanolett.5b05030 · Cited by 794

Role of nanoparticle size, shape and surface chemistry in oral drug delivery

Banerjee, A., Qi, J., Gogoi, R., Wong, J., & Mitragotri, S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.051 · Cited by 777

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

Arias, L. S., Pessan, J. P., Vieira, A. P. M., de Lima, T. M. T., Delbem, A. C. B., & Monteiro, D. R. (2018) · Antibiotics · doi:10.3390/antibiotics7020046 · Cited by 749

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy

Li, H., Du, J., Du, X., Xu, C., Sun, C.-Y., Wang, H., Cao, Z.-T., Yang, X., Zhu, Y.-H., Nie, S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522080113 · Cited by 726

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

Miao, L., Li, L., Huang, Y., Delcassian, D., Chahal, J., Han, J., Shi, Y., Sadtler, K., Gao, W., Lin, J., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0247-3 · Cited by 723

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

Oberli, M. A., Reichmuth, A. M., Dorkin, J. R., Mitchell, M. J., Fenton, O. S., Jaklenec, A., Anderson, D. G., Langer, R., & Blankschtein, D. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b03329 · Cited by 719

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

Bertrand, N., Grenier, P., Mahmoudi, M., Lima, E. M., Appel, E. A., Dormont, F., Lim, J.-M., Karnik, R., Langer, R., & Farokhzad, O. C. (2017) · Nature Communications · doi:10.1038/s41467-017-00600-w · Cited by 708

The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery

Cheng, X., & Lee, R. J. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.01.022 · Cited by 703

Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy

Palmerston Mendes, L., Pan, J., & Torchilin, V. (2017) · Molecules · doi:10.3390/molecules22091401 · Cited by 701

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

Shae, D., Becker, K. W., Christov, P. P., Yun, D. S., Lytton‐Jean, A. K. R., Sevimli, S., Ascano, M., Kelley, M. C., Johnson, D. B., Balko, J. M., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-018-0342-5 · Cited by 694

Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors

Dai, Q., Wilhelm, S., Ding, D., Syed, A. M., Sindhwani, S., Zhang, Y., Chen, Y. Y., MacMillan, P., & Chan, W. C. W. (2018) · ACS Nano · doi:10.1021/acsnano.8b03900 · Cited by 672

Quantum Dots in Biomedical Applications

Wagner, A. M., Knipe, J. M., Orive, G., & Peppas, N. A. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.022 · Cited by 659

A Dense Poly(Ethylene Glycol) Coating Improves Penetration of Large Polymeric Nanoparticles Within Brain Tissue

Nance, E. A., Woodworth, G. F., Sailor, K. A., Shih, T.-Y., Xu, Q., Swaminathan, G., Xiang, D., Eberhart, C., & Hanes, J. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003594 · Cited by 649

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

Billingsley, M. M., Singh, N., Ravikumar, P., Zhang, R., June, C. H., & Mitchell, M. J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b04246 · Cited by 636

Drug Retention Rate and Predictive Factors of Drug Survival for Interleukin-1 Inhibitors in Systemic Juvenile Idiopathic Arthritis

Sota, J., Insalaco, A., Cimaz, R., Alessio, M., Cattalini, M., Gallizzi, R., Maggio, M. C., Lopalco, G., Torre, F. L., Fabiani, C., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01526 · Cited by 616

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Whitehead, K. A., Dorkin, J. R., Vegas, A. J., Chang, P. H., Veiseh, O., Matthews, J., Fenton, O. S., Zhang, Y., Olejnik, K. T., Yesilyurt, V., et al. (2014) · Nature Communications · doi:10.1038/ncomms5277 · Cited by 615

Delivery technologies for genome editing

Yin, H., Kauffman, K. J., & Anderson, D. G. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.280 · Cited by 597

Differential influences of environment and self-motion on place and grid cell firing

Chen, G., Lü, Y., King, J. A., Cacucci, F., & Burgess, N. (2019) · Nature Communications · doi:10.1038/s41467-019-08550-1 · Cited by 595

Emerging concepts in dendrimer‐based nanomedicine: from design principles to clinical applications

Kannan, R., Nance, E. A., Kannan, S., & Tomalia, D. A. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12280 · Cited by 561

Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration

Li, H.-J., Du, J.-Z., Liu, J., Du, X.-J., Shen, S., Zhu, Y.-H., Wang, X., Ye, X., Nie, S., & Wang, J. (2016) · ACS Nano · doi:10.1021/acsnano.6b02326 · Cited by 537

Win-Stay-Lose-Learn Promotes Cooperation in the Spatial Prisoner's Dilemma Game

Liu, Y., Chen, X., Li, Z., Wang, L., & Perc, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030689 · Cited by 531

Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

Zhang, F., Parayath, N. N., Ene, C., Stephan, S. B., Koehne, A. L., Coon, M. E., Holland, E. C., & Stephan, M. T. (2019) · Nature Communications · doi:10.1038/s41467-019-11911-5 · Cited by 527

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

Dong, Y., Love, K. T., Dorkin, J. R., Sirirungruang, S., Zhang, Y., Chen, D., Bogorad, R. L., Yin, H., Chen, Y., Vegas, A. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322937111 · Cited by 488

Analyte-Responsive Hydrogels: Intelligent Materials for Biosensing and Drug Delivery

Culver, H. R., Clegg, J. R., & Peppas, N. A. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00533 · Cited by 483

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

Chen, Q., Hu, Q., Dukhovlinova, E., Chen, G., Ahn, S., Wang, C., Ogunnaike, E. A., Ligler, F. S., Dotti, G., & Gu, Z. (2019) · Advanced Materials · doi:10.1002/adma.201900192 · Cited by 470

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

Lyon, R. P., Setter, J. R., Bovee, T. D., Doronina, S. O., Hunter, J. H., Anderson, M. E., Balasubramanian, C., Duniho, S. M., Leiske, C. I., Li, F., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2968 · Cited by 465

The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles

Xie, X., Liao, J., Shao, X., Li, Q., & Lin, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-04229-z · Cited by 461

T cell‐targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

Schmid, D., Park, C. G., Hartl, C. A., Subedi, N., Cartwright, A. N., Puerto, R. B., Zheng, Y., Maiarana, J., Freeman, G. J., Wucherpfennig, K. W., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01830-8 · Cited by 449

Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment

Li, R., He, Y., Zhang, S., Qin, J., & Wang, J. (2017) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2017.11.009 · Cited by 435

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial

Alton, E. W. F. W., Armstrong, D. K., Ashby, D., Bayfield, K. J., Bilton, D., Bloomfield, E. V., Boyd, A. C., Brand, J., Buchan, R., Calcedo, R., et al. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00245-3 · Cited by 428

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

Maugeri, M., Nawaz, M., Papadimitriou, A., Angerfors, A., Camponeschi, A., Na, M., Hölttä, M., Skantze, P., Johansson, S., Sundqvist, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12275-6 · Cited by 428

Engineered nanomedicines with enhanced tumor penetration

Ding, J., Chen, J., Gao, L., Jiang, Z., Zhang, Y., Li, M., Xiao, Q., Lee, S. S., & Chen, X. (2019) · Nano Today · doi:10.1016/j.nantod.2019.100800 · Cited by 426

Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes

Wang, X., Ishida, T., & Kiwada, H. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.02.010 · Cited by 421

On the role of helper lipids in lipid nanoparticle formulations of siRNA

Kulkarni, J. A., Witzigmann, D., Leung, J., Tam, Y. Y. C., & Cullis, P. R. (2019) · Nanoscale · doi:10.1039/c9nr09347h · Cited by 406

Role of Nanoparticle Mechanical Properties in Cancer Drug Delivery

Hui, Y., Yi, X., Hou, F., Wibowo, D., Zhang, F., Zhao, D., Gao, H., & Zhao, C. (2019) · ACS Nano · doi:10.1021/acsnano.9b03924 · Cited by 398

64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer

Lee, H., Shields, A. F., Siegel, B. A., Miller, K. D., Krop, I. E., Ma, C. X., LoRusso, P. M., Münster, P. N., Campbell, K., Gaddy, D. F., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3193 · Cited by 397

Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical trials

Caster, J. M., Patel, A. N., Zhang, T., & Wang, A. Z. (2016) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1416 · Cited by 389

Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery

Fang, Y., Xue, J., Gao, S., Lu, A., Yang, D., Jiang, H., He, Y., & Shi, K. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1388451 · Cited by 388

Exopolysaccharide Produced by Probiotic Strain Lactobacillus paraplantarum BGCG11 Reduces Inflammatory Hyperalgesia in Rats

Dinić, M., Pecikoza, U. B., Đokić, J., Stepanović-Petrović, R. M., Milenković, M., Stevanović, M. M., Filipović, N., Begović, J., Golić, N., & Lukić, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00001 · Cited by 387

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

Patel, A. K., Kaczmarek, J. C., Bose, S., Kauffman, K. J., Mir, F. F., Heartlein, M. W., DeRosa, F., Langer, R., & Anderson, D. G. (2019) · Advanced Materials · doi:10.1002/adma.201805116 · Cited by 383

Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population

Yang, Q., Jacobs, T. M., McCallen, J., Moore, D. T., Huckaby, J. T., Edelstein, J., & Lai, S. K. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b03437 · Cited by 382

Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials

Chen, W., Luo, G., & Zhang, X. (2018) · Advanced Materials · doi:10.1002/adma.201802725 · Cited by 382

pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics

Palanikumar, L., Al-Hosani, S., Kalmouni, M., Nguyen, V. P., Ali, L., Pasricha, R., Barrera, F. N., & Magzoub, M. M. (2020) · Communications Biology · doi:10.1038/s42003-020-0817-4 · Cited by 371

A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing

Chen, G., Abdeen, A. A., Wang, Y., Shahi, P. K., Robertson, S., Xie, R., Suzuki, M., Pattnaik, B. R., Saha, K., & Gong, S. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0539-2 · Cited by 361

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

Leung, A. K. K., Tam, Y. Y. C., Chen, S., Hafez, I. M., & Cullis, P. R. (2015) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b02891 · Cited by 359

Hydrogels and Scaffolds for Immunomodulation

Singh, A. K., & Peppas, N. A. (2014) · Advanced Materials · doi:10.1002/adma.201402105 · Cited by 358

Platelet-like Nanoparticles: Mimicking Shape, Flexibility, and Surface Biology of Platelets To Target Vascular Injuries

Anselmo, A. C., Modery-Pawlowski, C. L., Menegatti, S., Kumar, S., Vogus, D. R., Tian, L. L., Chen, M., Squires, T. M., Gupta, A. S., & Mitragotri, S. (2014) · ACS Nano · doi:10.1021/nn503732m · Cited by 354

Nanotoxicity of Silver Nanoparticles to Red Blood Cells: Size Dependent Adsorption, Uptake, and Hemolytic Activity

Chen, L., Fang, L., Ling, J., Ding, C. Z., Kang, B., & Huang, C. Z. (2015) · Chemical Research in Toxicology · doi:10.1021/tx500479m · Cited by 349

Inflammation‐Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti‐PD1 Antibody

Wang, C., Sun, W., Wright, G., Wang, A. Z., & Gu, Z. (2016) · Advanced Materials · doi:10.1002/adma.201506312 · Cited by 346

Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein–Barr Virus (EBV)

Lawson, J. S., Salmons, B., & Glenn, W. K. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00001 · Cited by 340

Stimuli‐responsive nanotherapeutics for precision drug delivery and cancer therapy

Qiao, Y., Wan, J., Zhou, L., Ma, W., Yang, Y., Luo, W., Yu, Z., & Wang, H. (2019) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1527 · Cited by 332

Gold nanoparticle based photothermal therapy: Development and application for effective cancer treatment

Yang, W., Liang, H., Ma, S., Wang, D., & Huang, J. (2019) · Sustainable materials and technologies · doi:10.1016/j.susmat.2019.e00109 · Cited by 331

Breaking Down the Barriers to Precision Cancer Nanomedicine

von Roemeling, C., Jiang, W., Chan, C. K., Weissman, I. L., & Kim, B. Y. S. (2017) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.07.006 · Cited by 330

Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease

Fonseca‐Santos, B., Chorilli, M., & Gremião, M. P. D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s87148 · Cited by 320

Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types

Kou, L., Bhutia, Y. D., Yao, Q., He, Z., Sun, J., & Ganapathy, V. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00027 · Cited by 318

Shape and size-dependent immune response to antigen-carrying nanoparticles

Kumar, S., Anselmo, A. C., Banerjee, A., Zakrewsky, M., & Mitragotri, S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.069 · Cited by 311

Nanoparticles: Oral Delivery for Protein and Peptide Drugs

Cao, S., Xu, S., Wang, H., Ling, Y., Dong, J., Xia, R.-D., & Sun, X. (2019) · AAPS PharmSciTech · doi:10.1208/s12249-019-1325-z · Cited by 307

Immuno-Oncology: Emerging Targets and Combination Therapies

Marshall, H. T., & Djamgoz, M. B. A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00315 · Cited by 303

Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability

Lamson, N. G., Berger, A. M., Fein, K. C., & Whitehead, K. A. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0465-5 · Cited by 297

Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release

Ruan, S., Cao, X., Cun, X., Hu, G., Zhou, Y., Zhang, Y., Lu, L., He, Q., & Gao, H. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.05.006 · Cited by 291

Prediction of Drug-Drug Interactions with Bupropion and Its Metabolites as CYP2D6 Inhibitors Using a Physiologically-Based Pharmacokinetic Model

Xue, C., Zhang, X., & Cai, W. (2017) · Pharmaceutics · doi:10.3390/pharmaceutics10010001 · Cited by 291

Shear-stress sensitive lenticular vesicles for targeted drug delivery

Holme, M. N., Fedotenko, I., Abegg, D., Althaus, J., Babel, L., Favarger, F., Reiter, R., Tanasescu, R., Zaffalon, P.-L., Ziegler, A., et al. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.84 · Cited by 290

Tailoring nanoparticle designs to target cancer based on tumor pathophysiology

Sykes, E. A., Dai, Q., Sarsons, C. D., Chen, J., Rocheleau, J. V., Hwang, D. M., Zheng, G., Cramb, D. T., Rinker, K. D., & Chan, W. C. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521265113 · Cited by 287

Influence of particle size and shape on their margination and wall-adhesion: implications in drug delivery vehicle design across nano-to-micro scale

Cooley, M. B., Sarode, A., Hoore, M., Fedosov, D. A., Mitragotri, S., & Gupta, A. S. (2018) · Nanoscale · doi:10.1039/c8nr04042g · Cited by 285

Repeated Aerosolized AAV-CFTR for Treatment of Cystic Fibrosis: A Randomized Placebo-Controlled Phase 2B Trial

Moss, R. B., Milla, C. E., Colombo, J. L., Accurso, F. J., Zeitlin, P. L., Clancy, J. P., Spencer, L. T., Pilewski, J. M., Waltz, D. A., Dorkin, H. L., et al. (2007) · Human Gene Therapy · doi:10.1089/hum.2007.022 · Cited by 276

Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer

Ganson, N. J., Povsic, T. J., Sullenger, B. A., Alexander, J. H., Zelenkofske, S. L., Sailstad, J. M., Rusconi, C. P., & Hershfield, M. S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.034 · Cited by 275

Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis

Robinson, E., MacDonald, K. D., Slaughter, K., McKinney, M., Patel, S., Sun, C., & Sahay, G. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.014 · Cited by 272

Strategies to improve tumor penetration of nanomedicines through nanoparticle design

Zhang, Y., Lin, R., Li, H., He, W., Du, J., & Wang, J. (2018) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1519 · Cited by 270

A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1–insensitive models of triple-negative breast cancer

Cheng, N., Watkins-Schulz, R., Junkins, R. D., David, C. N., Johnson, B. M., Montgomery, S. A., Peine, K. J., Darr, D. B., Yuan, H., McKinnon, K. P., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.120638 · Cited by 267

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

Wang, D., Wang, T., Yu, H., Feng, B., Zhou, L., Zhou, F., Hou, B., Zhang, H., Luo, M., & Li, Y. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau6584 · Cited by 265

Optimization and Design of Magnetic Ferrite Nanoparticles with Uniform Tumor Distribution for Highly Sensitive MRI/MPI Performance and Improved Magnetic Hyperthermia Therapy

Du, Y., Liu, X., Liang, Q. Y., Liang, X., & Tian, J. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00630 · Cited by 264

Improving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting

Murakami, M., Cabral, H., Matsumoto, Y., Wu, S., Kano, M. R., Yamori, T., Nishiyama, N., & Kataoka, K. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001385 · Cited by 263

Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer

Huang, K., Hsu, F., Qiu, J. T., Chern, G., Lee, Y.-A., Chang, C., Huang, Y., Sung, Y., Chiang, C.-C., Huang, R.-L., et al. (2020) · Science Advances · doi:10.1126/sciadv.aax5032 · Cited by 262

Lipid nanoparticles for delivery of messenger RNA to the back of the eye

Patel, S., Ryals, R. C., Weller, K. K., Pennesi, M. E., & Sahay, G. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.015 · Cited by 260

Subcutaneous drug delivery and the role of the lymphatics

McLennan, D. N., Porter, C. J. H., & Charman, S. A. (2005) · Drug Discovery Today: Technologies · doi:10.1016/j.ddtec.2005.05.006 · Cited by 259

An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases

Liu, Y., Crowe, W. N., Wang, L., Lu, Y., Petty, W. J., Habib, A. A., & Zhao, D. (2019) · Nature Communications · doi:10.1038/s41467-019-13094-5 · Cited by 258

The effect of pH on cell viability, cell migration, cell proliferation, wound closure, and wound reepithelialization: In vitro and in vivo study

Kruse, C., Singh, M., Targosinski, S., Sinha, I., Sørensen, J. A., Eriksson, E. K., & Nuutila, K. (2017) · Wound Repair and Regeneration · doi:10.1111/wrr.12526 · Cited by 252

Oral Delivery of Biologics for Precision Medicine

Durán‐Lobato, M., Niu, Z., & Alonso, M. J. (2019) · Advanced Materials · doi:10.1002/adma.201901935 · Cited by 252

Polymeric Nanoparticles for Nonviral Gene Therapy Extend Brain Tumor Survival in Vivo

Mangraviti, A., Tzeng, S. Y., Kozielski, K., Wang, Y., Jin, Y., Gullotti, D. M., Pedone, M., Buaron, N., Liu, A., Wilson, D. R., et al. (2015) · ACS Nano · doi:10.1021/nn504905q · Cited by 251

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

Sunshine, J. C., Perica, K., Schneck, J. P., & Green, J. J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.050 · Cited by 245

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

Chen, B., Su, Y.-C., Chang, C.-J., Burnouf, P., Chuang, K., Chen, C.-H., Cheng, T., Chen, Y.-T., Wu, J.-Y., & Roffler, S. R. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b03109 · Cited by 241

Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats

Zhang, C.-X., Cheng, Y., Liu, D., Liu, M., Cui, H., Zhang, B., Mei, Q., & Zhou, S. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0451-9 · Cited by 233

Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial‐Membrane‐Coated Nanoparticles

Patel, R. B., Ye, M., Carlson, P. M., Jaquish, A. A., Zangl, L. M., Ma, B., Wang, Y., Arthur, I. S., Xie, R., Brown, R. J., et al. (2019) · Advanced Materials · doi:10.1002/adma.201902626 · Cited by 233

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy

Wilson, D. R., Sen, R., Sunshine, J. C., Pardoll, D. M., Green, J. J., & Kim, Y. J. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.10.013 · Cited by 225

Rational Design of Cancer Nanomedicine for Simultaneous Stealth Surface and Enhanced Cellular Uptake

Jin, Q., Deng, Y., Chen, X., & Ji, J. (2019) · ACS Nano · doi:10.1021/acsnano.8b07746 · Cited by 220

Optimization of a degradable polymer–lipid nanoparticle for potent systemic delivery of mRNA to the lung endothelium and immune cells

Kaczmarek, J. C., Kauffman, K. J., Fenton, O. S., Sadtler, K., Patel, A. K., Heartlein, M. W., DeRosa, F., & Anderson, D. G. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b02917 · Cited by 218

High throughput toxicity screening and intracellular detection of nanomaterials

Collins, A. R., Annangi, B., Rubio, L., Marcos, R., Dorn, M., Merker, C., Estrela‐Lopis, I., Cimpan, M. R., Ibrahim, M. Y., Cimpan, E., et al. (2016) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1413 · Cited by 217

Cell membrane-coated nanosized active targeted drug delivery systems homing to tumor cells: A review

He, Z., Zhang, Y., & Feng, N. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110298 · Cited by 217

Polyethyleneimine/DNA polyplexes with reduction-sensitive hyaluronic acid derivatives shielding for targeted gene delivery

He, Y., Cheng, G., Li, X., Nie, Y., He, B., & Gu, Z. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.049 · Cited by 216

Engineering precision biomaterials for personalized medicine

Aguado, B. A., Grim, J. C., Rosales, A. M., Watson-Capps, J. J., & Anseth, K. S. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aam8645 · Cited by 216

Barriers to the free diffusion of proteins and lipids in the plasma membrane

Trimble, W. S., & Grinstein, S. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201410071 · Cited by 210

Evolution of Nanoparticle Protein Corona across the Blood–Brain Barrier

Cox, A., Andreozzi, P., Magro, R. D., Fiordaliso, F., Corbelli, A., Talamini, L., Chinello, C., Raimondo, F., Magni, F., Tringali, M., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b03500 · Cited by 210

Engineering patient-specific cancer immunotherapies

Scheetz, L., Park, K. S., Li, Q., Lowenstein, P. R., Castro, M. G., Schwendeman, A., & Moon, J. J. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0436-x · Cited by 208

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

Wibroe, P. P., Anselmo, A. C., Nilsson, P. H., Sarode, A., Gupta, V., Urbanics, R., Szebeni, J., Hunter, A. C., Mitragotri, S., Mollnes, T. E., et al. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.47 · Cited by 206

Nanoscale drug delivery systems and the blood–brain barrier

Khalin, I., Alyautdin, R., Ismail, N. M., Haron, M. H., & Kuznetsov, D. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s52236 · Cited by 204

Regulatory T cell-targeted hybrid nanoparticles combined with immuno-checkpoint blockage for cancer immunotherapy

Ou, W., Thapa, R. K., Jiang, L., Soe, Z. C., Gautam, M., Chang, J., Jeong, J., Ku, S., Choi, H., Yong, C. S., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.018 · Cited by 204

Correction: Corrigendum: The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins

Harsman, A., Oeljeklaus, S., Wenger, C., Huot, J. L., Warscheid, B., & Schneider, A. (2017) · Nature Communications · doi:10.1038/ncomms16123 · Cited by 201

Positron Emission Tomography-Guided Photodynamic Therapy with Biodegradable Mesoporous Silica Nanoparticles for Personalized Cancer Immunotherapy

Xu, C., Nam, J., Hong, H., Xu, Y., & Moon, J. J. (2019) · ACS Nano · doi:10.1021/acsnano.9b06691 · Cited by 200

Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

Povsic, T. J., Lawrence, M. G., Lincoff, A. M., Mehran, R., Rusconi, C. P., Zelenkofske, S. L., Huang, Z., Sailstad, J. M., Armstrong, P. W., Steg, P. G., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.04.058 · Cited by 198

Glucose-Responsive Nanoparticles for Rapid and Extended Self-Regulated Insulin Delivery

Volpatti, L. R., Matranga, M. A., Cortinas, A. B., Delcassian, D., Daniel, K. B., Langer, R., & Anderson, D. G. (2019) · ACS Nano · doi:10.1021/acsnano.9b06395 · Cited by 198

Soft Discoidal Polymeric Nanoconstructs Resist Macrophage Uptake and Enhance Vascular Targeting in Tumors

Key, J., Palange, A. L., Gentile, F., Aryal, S., Stigliano, C., Mascolo, D. D., Rosa, E. D., Cho, M., Lee, Y., Singh, J. V., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b04866 · Cited by 195

Direct isolation and characterization of circulating exosomes from biological samples using magnetic nanowires

Lim, J., Choi, M., Lee, H., Kim, Y.-H., Han, J., Lee, E. S., & Cho, Y. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0433-3 · Cited by 195

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier

Suk, J. S., Kim, A. J., Trehan, K., Schneider, C. S., Cebotaru, L., Woodward, O. M., Boylan, N. J., Boyle, M., Lai, S. K., Guggino, W. B., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.01.007 · Cited by 193

Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting

Ahmad, A., Khan, F., Mishra, R. K., & Khan, R. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00511 · Cited by 192

Cancer Cell Membrane‐Coated Nanoparticles for Personalized Therapy in Patient‐Derived Xenograft Models

Rao, L., Yu, G., Meng, Q., Bu, L., Tian, R., Lin, L., Deng, H., Yang, W., Zan, M., Ding, J., et al. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201905671 · Cited by 192

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

Halaby, M. J., Hezaveh, K., Lamorte, S., Ciudad, M. T., Kloetgen, A., MacLeod, B. L., Guo, M., Chakravarthy, A., Medina, T. D. S., Ugel, S., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aax8189 · Cited by 190

Targeting dendritic cells: a promising strategy to improve vaccine effectiveness

Macri, C., Dumont, C., Johnston, A. P. R., & Mintern, J. D. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.6 · Cited by 187

Rational designs of in vivo CRISPR-Cas delivery systems

Xu, C., Chen, G., Luo, Y., Zhang, Y., Zhao, G., Lu, Z.-D., Czarna, A., Gu, Z., & Wang, J. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.11.005 · Cited by 187

Lipid nanoparticles for intranasal administration: application to nose-to-brain delivery

Battaglia, L., Panciani, P., Muntoni, E., Capucchio, M., Biasibetti, E., Bonis, P. D., Mioletti, S., Fontanella, M., & Swaminathan, S. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1429401 · Cited by 185

Gold Nanoparticle Size and Shape Effects on Cellular Uptake and Intracellular Distribution of siRNA Nanoconstructs

Yue, J., Feliciano, T. J., Li, W., Lee, A., & Odom, T. W. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00252 · Cited by 182

Selective permeability of mucus barriers

Witten, J. J., Samad, T. S., & Ribbeck, K. (2018) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2018.03.010 · Cited by 176

In utero nanoparticle delivery for site-specific genome editing

Ricciardi, A. S., Bahal, R., Farrelly, J. S., Quijano, E., Bianchi, A. H., Luks, V. L., Putman, R., López‐Giráldez, F., Coşkun, S., Song, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04894-2 · Cited by 176

Targeted antigen delivery to dendritic cell via functionalized alginate nanoparticles for cancer immunotherapy

Zhang, C., Shi, G., Zhang, J., Song, H., Niu, J., Shi, S., Huang, P., Wang, Y., Wang, W., Li, C., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.020 · Cited by 172

Dendrimer Advances for the Central Nervous System Delivery of Therapeutics

Xu, L., Zhang, H., & Wu, Y. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400182z · Cited by 171

ApoE-modified solid lipid nanoparticles: A feasible strategy to cross the blood-brain barrier

Magro, R. D., Ornaghi, F., Cambianica, I., Beretta, S., Re, F., Musicanti, C., Rigolio, R., Donzelli, E., Canta, A., Ballarini, E., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.01.039 · Cited by 168

Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions

da Silva‐Candal, A., Brown, T. D., Krishnan, V., López-Loureiro, I., Ávila-Gómez, P., Pusuluri, A., Pérez, A. C., Correa‐Paz, C., Hervella, P., Castillo, J., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.07.026 · Cited by 167

Correction: Corrigendum: PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer

Song, W., Tang, L., Xu, Y., Xu, J., Zhang, W., Xie, H., Wang, S., & Guan, X. (2017) · Scientific Reports · doi:10.1038/srep44346 · Cited by 165

Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo

Johnsen, K. B., Bak, M., Melander, F., Thomsen, M. S., Burkhart, A., Kempen, P. J., Andresen, T. L., & Moos, T. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.005 · Cited by 164

Fetal gene therapy for neurodegenerative disease of infants

Massaro, G., Mattar, C. N. Z., Wong, A. M. S., Sirka, E., Buckley, S. M. K., Herbert, B. R., Karlsson, S., Perocheau, D. P. B., Burke, D. G., Heales, S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0106-7 · Cited by 160

Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy

Qian, Y., Jin, H., Qiao, S., Dai, Y., Huang, C., Lu, L., Luo, Q., & Zhang, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.05.008 · Cited by 158

Mitochondria‐Targeting, Intracellular Delivery of Native Proteins Using Biodegradable Silica Nanoparticles

Yuan, P., Mao, X., Wu, X., Liew, S. S., Li, L., & Yao, S. Q. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201901699 · Cited by 157

Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery

Wagner, A. M., Gran, M. P., & Peppas, N. A. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.01.013 · Cited by 155

The particle in the spider's web: transport through biological hydrogels

Witten, J. J., & Ribbeck, K. (2017) · Nanoscale · doi:10.1039/c6nr09736g · Cited by 154

Predicting the influence of liposomal lipid composition on liposome size, zeta potential and liposome-induced dendritic cell maturation using a design of experiments approach

Soema, P. C., Willems, G.-J., Jiskoot, W., Amorij, J., & Kersten, G. F. A. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.06.026 · Cited by 153

Neoantigen Vaccine Delivery for Personalized Anticancer Immunotherapy

Guo, Y., Lei, K., & Tang, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01499 · Cited by 152

Biologically Inspired Design of Nanoparticle Artificial Antigen-Presenting Cells for Immunomodulation

Hickey, J. W., Vicente, F. P., Howard, G. P., Mao, H., & Schneck, J. P. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03734 · Cited by 151

Nanovaccines for cancer immunotherapy

Zhang, Y. X., Lin, S., Wang, X., & Zhu, G. (2019) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1559 · Cited by 146

The role of apolipoprotein- and vitronectin-enriched protein corona on lipid nanoparticles for in vivo targeted delivery and transfection of oligonucleotides in murine tumor models

Chen, D., Parayath, N. N., Ganesh, S., Wang, W., & Amiji, M. M. (2019) · Nanoscale · doi:10.1039/c9nr05788a · Cited by 139

Targeted delivery of antibiotics to the infected pulmonary tissues using ROS-responsive nanoparticles

Wang, Y., Yuan, Q., Feng, W., Pu, W., Ding, J., Zhang, H., Li, X., Yang, B., Dai, Q., Cheng, L., et al. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0537-4 · Cited by 138

Recent advances in co-delivery systems based on polymeric nanoparticle for cancer treatment

Afsharzadeh, M., Hashemi, M., Mokhtarzadeh, A., Abnous, K., & Ramezani, M. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1376675 · Cited by 137

Transferrin–Copper Nanocluster–Doxorubicin Nanoparticles as Targeted Theranostic Cancer Nanodrug

Goswami, U., Dutta, A., Raza, A., et al. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b15165 · Cited by 137

Epilepsy Disease and Nose-to-Brain Delivery of Polymeric Nanoparticles: An Overview

Musumeci, T., Bonaccorso, A., & Puglisi, G. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030118 · Cited by 137

Nano–Cell Interactions of Non-Cationic Bionanomaterials

Ho, L. W. C., Liu, Y., Han, R., Bai, Q., & Choi, C. H. J. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00103 · Cited by 137

Hydrogen-Bonded Tannic Acid-Based Anticancer Nanoparticle for Enhancement of Oral Chemotherapy

Le, Z., Chen, Y., Tian, H., Tian, H., Zhao, P., Yang, C., He, Z., Liu, L., Leong, K. W., Mao, H., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b18979 · Cited by 134

Mucosal Immunization with a pH-Responsive Nanoparticle Vaccine Induces Protective CD8 + Lung-Resident Memory T Cells

Knight, F. C., Gilchuk, P., Kumar, A., Becker, K. W., Sevimli, S., Jacobson, M. E., Suryadevara, N., Wang-Bishop, L., Boyd, K. L., Crowe, J. E., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b00326 · Cited by 133

Uniform Core–Shell Nanoparticles with Thiolated Hyaluronic Acid Coating to Enhance Oral Delivery of Insulin

Tian, H., He, Z., Sun, C., Yang, C., Zhao, P., Liu, L., Leong, K. W., Mao, H., Liu, Z., & Chen, Y. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800285 · Cited by 132

The impact of nanoparticle shape on cellular internalisation and transport: what do the different analysis methods tell us?

Wang, W., Gaus, K., Tilley, R. D., et al. (2019) · Materials Horizons · doi:10.1039/c9mh00664h · Cited by 132

Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells

Yi, Y., Kim, H. J., Zheng, M., Mi, P., Naito, M., Kim, B. S., Min, H. S., Hayashi, K., Perche, F., Toh, K., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.006 · Cited by 131

Self-assembled peptide–poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis

Guan, S., Munder, A., Hedtfeld, S., Braubach, P., Glage, S., Zhang, L., Lienenklaus, S., Schultze, A., Hasenpusch, G., Garrels, W., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-018-0358-x · Cited by 130

Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles

Tan, T., Hu, H., Wang, H., Li, J., Wang, Z., Wang, J., Wang, S., Zhang, Z., & Li, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-11235-4 · Cited by 130

A reanalysis of nanoparticle tumor delivery using classical pharmacokinetic metrics

Price, L. S. L., Stern, S. T., Deal, A. M., Kabanov, A. V., & Zamboni, W. C. (2020) · Science Advances · doi:10.1126/sciadv.aay9249 · Cited by 128

Enhanced anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles

Sousa, F., Dhaliwal, H. K., Gattacceca, F., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.07.033 · Cited by 127

Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing

Sarett, S. M., Werfel, T. A., Lee, L., Jackson, M. A., Kilchrist, K. V., Brantley‐Sieders, D. M., & Duvall, C. L. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621240114 · Cited by 126

Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease

Livraghi-Butrico, A., Grubb, B. R., Wilkinson, K. J., Volmer, A. S., Burns, K. A., Evans, C. M., O’Neal, W. K., & Boucher, R. C. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.63 · Cited by 124

Rational Design of PLGA Nanoparticle Vaccine Delivery Systems To Improve Immune Responses

Gu, P., Wusiman, A., Zhang, Y., Liu, Z., Bo, R., Hu, Y., Liu, J., & Wang, D. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00860 · Cited by 124

Drug Delivery Research for the Future: Expanding the Nano Horizons and Beyond

Mitragotri, S., Lammers, T., Bae, Y. H., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.01.011 · Cited by 123

Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials

Bruinsmann, F. A., Vaz, G. R., Alves, A. D. C. S., Aguirre, T. A. S., Pohlmann, A. R., Guterres, S. S., & Sonvico, F. (2019) · Molecules · doi:10.3390/molecules24234312 · Cited by 123

In Silico Study of Gold Nanoparticle Uptake into a Mammalian Cell: Interplay of Size, Shape, Surface Charge, and Aggregation

Lunnoo, T., Assawakhajornsak, J., & Puangmali, T. (2019) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.8b07616 · Cited by 122

Messenger RNA therapy for rare genetic metabolic diseases

Berraondo, P., Martini, P. G. V., Avila, M. A., & Fontanellas, A. (2019) · Gut · doi:10.1136/gutjnl-2019-318269 · Cited by 121

Active Cellular and Subcellular Targeting of Nanoparticles for Drug Delivery

Nag, O. K., & Delehanty, J. B. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11100543 · Cited by 121

Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach

Sedighi, M., Sieber, S., Rahimi, F., Shahbazi, M., Rezayan, A. H., Huwyler, J., & Witzigmann, D. (2018) · Drug Delivery and Translational Research · doi:10.1007/s13346-018-0587-4 · Cited by 118

Antigen Delivery to Macrophages Using Liposomal Nanoparticles Targeting Sialoadhesin/CD169

Chen, W. C., Kawasaki, N., Nycholat, C. M., Han, S., Pilotte, J., Crocker, P. R., & Paulson, J. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039039 · Cited by 117

Triggered nanoparticles as therapeutics

Kim, C. S., Duncan, B., Creran, B., & Rotello, V. M. (2013) · Nano Today · doi:10.1016/j.nantod.2013.07.004 · Cited by 113

In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance

Pearson, R. M., Casey, L. M., Hughes, K. R., Miller, S. D., & Shea, L. D. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.005 · Cited by 113

Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo

Li, K., Lu, L., Xue, C., Liu, J., He, Y., Zhou, J., Xia, Z., Dai, L., Luo, Z. Y., Mao, Y., et al. (2019) · Nanoscale · doi:10.1039/c9nr06505a · Cited by 113

Nanoparticle cancer vaccines: Design considerations and recent advances

Liu, J., Miao, L., Sui, J., Hao, Y., & Huang, G. (2019) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2019.10.006 · Cited by 113

Near infrared light-triggered nanoparticles using singlet oxygen photocleavage for drug delivery systems

Dariva, C. G., Coelho, J. F. J., & Serra, A. C. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.042 · Cited by 110

pH/Redox Dual-Responsive Polyplex with Effective Endosomal Escape for Codelivery of siRNA and Doxorubicin against Drug-Resistant Cancer Cells

Gao, Y., Li, J., Wang, Q., Hu, H., Zhao, X., Chen, D., & Qiao, M. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b02016 · Cited by 110

Lipid NanoparticlesFrom Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221

The blood–brain barrier: Structure, regulation and drug delivery

Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906

Smart nanoparticles for cancer therapy

Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073

Targeting drugs to tumours using cell membrane-coated nanoparticles

Fang, R. H., Gao, W., & Zhang, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00699-x · Cited by 980

Nanodelivery of nucleic acids

Mendes, B. B., Conniot, J., Avital, A., Yao, D., Jiang, X., Zhou, X., Sharf-Pauker, N., Xiao, Y., Adir, O., Liang, H., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00104-y · Cited by 719

The future of precision medicine: towards a more predictive personalized medicine

Elemento, O. (2020) · Emerging Topics in Life Sciences · doi:10.1042/etls20190197 · Cited by 67

Genomic medicine on the frontier of precision medicine

Hasanzad, M., Sarhangi, N., Naghavi, A., Ghavimehr, E., Khatami, F., Chimeh, S. E., Larijani, B. A., & Meybodi, H. R. A. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00880-6 · Cited by 20

Precision (personalized) medicine

Walton, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95274-3.00002-6 · Cited by 3

Detecting Personalized Determinants During Drug Treatment from Omics Big Data

Wang, L., Yu, X., Zhang, C., & Zeng, T. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612824666181106102111 · Cited by 10

TRANSFORMING HEALTHCARE WITH PRECISION MEDICINE: UNVEILING THE FUTURE OF PERSONALIZED TREATMENT

Moulik, A. K., Ratnam, R. S., Sriushaswini, B., et al. (2023) · doi:10.53555/jptcp.v30i17.2885