Cited by 246Hypothalamic control of reproductive hormonesRegulation of Appetite and ObesityNeuropeptides and Animal Physiology

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Metabolic regulation of kisspeptin — the link between energy balance and reproduction

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Navarro, Víctor M.·2020·Nature Reviews Endocrinology

DOI 10.1038/s41574-020-0363-7PMC PMC8852368

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Abstract

Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive function. These neurons are subjected to a plethora of regulatory factors that ultimately affect the release of kisspeptin, which modulates gonadotropin-releasing hormone (GnRH) release from GnRH neurons to control the reproductive axis. The presence of sufficient energy reserves is critical to achieve successful reproduction. Consequently, metabolic factors impose a very tight control over kisspeptin synthesis and release. This Review offers a synoptic overview of the different steps in which kisspeptin neurons are subjected to metabolic regulation, from early developmental stages to adulthood. We cover an ample array of known mechanisms that underlie the metabolic regulation of KISS1 expression and kisspeptin release. Furthermore, the novel role of kisspeptin neurons as active players within the neuronal circuits that govern energy balance is discussed, offering evidence of a bidirectional role of these neurons as a nexus between metabolism and reproduction.

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Authors: Navarro, V. M.
ORCID: Navarro, Víctor M.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2020-05-19
Volume: 16
Issue: 8
Pages: 407-420
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/s41574-020-0363-7
PMC: PMC8852368
OpenAlex: W3028029900
Cited by: 240
References: 203
Citations by year: 2026: 37 · 2025: 46 · 2024: 37 · 2023: 43 · 2022: 46 · 2021: 25 · 2020: 5
FWCI: 4.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD099084, R01HD090151, R21HD095383)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: kisspeptin, kisspeptin neurons, hypothalamus, energy balance, gonadotropin-releasing hormone, reproductive axis, neural circuits
MeSH terms: Animals, Dynorphins, Energy Metabolism, Female, Homeostasis, Humans, Hypothalamo-Hypophyseal System, Hypothalamus, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Neurons, Ovary, Puberty, Reproduction, Neurokinin B, Kisspeptins

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Metabolic regulation of kisspeptin — the link between energy balance and reproduction

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