Metabolic Regulation of Kisspeptin

Castellano, Juan Manuel; Tena-Sempere, Manuel

doi:10.1007/978-1-4614-6199-9_17

Cited by 42Hypothalamic control of reproductive hormonesRegulation of Appetite and ObesityNeuropeptides and Animal Physiology

Metabolic Regulation of Kisspeptin

Castellano, Juan Manuel, Tena-Sempere, Manuel·2013·Advances in Experimental Medicine and Biology

DOI 10.1007/978-1-4614-6199-9_17

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Abstract

Body energy balance and metabolic signals are important modulators of puberty and reproductive function, so that perturbations of metabolism and energy reserves (ranging from persistent energy insufficiency to morbid obesity) are frequently linked to reproductive disorders. The mechanisms for the tight association between body metabolic state and reproduction are multifaceted, and likely involve numerous peripheral hormones and central transmitters. In recent years, a prominent role of kisspeptins in the central pathways responsible for conveying metabolic information into the brain centers responsible for reproductive control, and specifically GnRH neurons, has been proposed on the basis of a wealth of expression and functional data. In this chapter, we will summarize such evidence, with special attention to the potential (direct and/or indirect) interaction of leptin and kisspeptin pathways. In addition, other potential metabolic modulators of kisspeptin signaling, as well as some of the putative molecular mechanisms for the metabolic regulation of Kiss1 will be briefly reviewed. Conflictive data, including those questioning an essential role of Kiss1 neurons in mediating leptin effects on the reproductive axis, will be also discussed. All in all, we aim to provide an integral and balanced view of the physiological relevance and potential mechanisms for the metabolic control of the kisspeptin system, as important pathway for the integral regulation of energy balance, puberty onset, and fertility.

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When energy deficits occur through undernutrition or excessive energy expenditure, the KISS1 gene is downregulated, resulting in subsequent repression of the GnRH neurons and downregulation of the reproductive axis.
“Importantly, when energy deficits occur, through undernutrition or excessive energy expenditure, the KISS1 gene is downregulated resulting in subsequent repression of the GnRH neurons and downregulation of the reproductive axis [134,135].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [134]
For women, exercising in a fed state results in a greater total daily energy expenditure and increased fat oxidation, potentially improving body composition.
“whereas exercising in a fed state will result in a greater total daily energy expenditure and increased fat oxidation, potentially improving body composition [134,135]”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [134]

TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works
TOR, a central controller of cell growth.
Schmelzle, T., & Hall, M. (2000) · Cell · doi:10.1016/s0092-8674(00)00117-3 · Cited by 2,044 · see citing works
Identification of targets of leptin action in rat hypothalamus.
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,475 · see citing works
Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset
Frisch, R. E., & McArthur, J. W. (1974) · Science · doi:10.1126/science.185.4155.949 · Cited by 1,412 · see citing works
Hypothalamic mTOR Signaling Regulates Food Intake
Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278 · see citing works
Childhood obesity and adult morbidities
Biro, F. M., & Wien, M. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28701b · Cited by 1,098 · see citing works
Recombinant human leptin in women with hypothalamic amenorrhea
Welt, C. K., Chan, J. L., Bullen, J., Murphy, R., Smith, P., DePaoli, A. M., Karalis, A., & Mantzoros, C. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040388 · Cited by 908 · see citing works
Kisspeptin Signaling in the Brain
Oakley, A. E., Clifton, D. K., & Steiner, R. A. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0005 · Cited by 842 · see citing works
Height and weight at menarche and a hypothesis of critical body weights and adolescent events
Frisch, R. E., & Revelle, R. (1970) · Science · doi:10.1126/science.169.3943.397 · Cited by 721 · see citing works
KiSS‐1 Neurones Are Direct Targets for Leptin in the ob/ob Mouse
Smith, J. T., Acohido, B. V., Clifton, D. K., & Steiner, R. A. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01417.x · Cited by 559 · see citing works
Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition
Castellano, J. M., Navarro, V. M., Fernández-Fernández, R., Nogueiras, R., Tovar, S. A., Roa, J., Vazquez, M. J., Vigo, E., Casanueva, F. F., Aguilar, E., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0337 · Cited by 557 · see citing works
Self-citation
Leptin's Actions on the Reproductive Axis: Perspectives and Mechanisms
Cunningham, M. J., Clifton, D. K., & Steiner, R. A. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.2.216 · Cited by 531 · see citing works
The expanding TOR signaling network
Martin, D. E., & Hall, M. N. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.008 · Cited by 496 · see citing works
Central and Peripheral Administration of Kisspeptin‐10 Stimulates the Hypothalamic‐Pituitary‐Gonadal Axis
Thompson, E. L., Patterson, M., Murphy, K. G., Smith, K. L., Dhillo, W. S., Todd, J. F., Ghatei, M. A., & Bloom, S. R. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01240.x · Cited by 482 · see citing works
Body weight and food intake as initiating factors for puberty in the rat
Kennedy, G. C., & Mitra, J. (1963) · The Journal of Physiology · doi:10.1113/jphysiol.1963.sp007112 · Cited by 443 · see citing works
Childhood obesity and the timing of puberty
Ahmed, M. L., Ong, K. K., & Dunger, D. B. (2009) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.02.004 · Cited by 409 · see citing works
Targeting mammalian target of rapamycin (mTOR) for health and diseases
Tsang, C. K., Qi, H., Liu, L. F., & Zheng, X. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.12.008 · Cited by 403 · see citing works
Novel signals for the integration of energy balance and reproduction
Fernandez-Fernandez, R., Martini, A. C., Navarro, V. M., Castellano, J. M., Diéguez, C., Aguilar, E., Pinilla, L., & Tena‐Sempere, M. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.026 · Cited by 385 · see citing works
Self-citation
Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function
Quennell, J. H., Mulligan, A. C., Tups, A., Liu, X., Phipps, S. J., Kemp, C. J., Herbison, A. E., Grattan, D. R., & Anderson, G. M. (2009) · Endocrinology · doi:10.1210/en.2008-1693 · Cited by 385 · see citing works
Neuroendocrine Regulation and Actions of Leptin
Casanueva, F. F., & Diéguez, C. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0187 · Cited by 381 · see citing works
Hypothalamic pathways linking energy balance and reproduction
Hill, J. W., Elmquist, J. K., & Elias, C. F. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00670.2007 · Cited by 366 · see citing works
Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
Donato, J., Cravo, R. M., Frazão, R., Gautron, L., Scott, M. M., Lachey, J. L., de Castro, I. A., Margatho, L. O., Lee, S., Lee, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci45106 · Cited by 356 · see citing works
Characterization of Kiss1 neurons using transgenic mouse models
Cravo, R. M., Margatho, L. O., Osborne-Lawrence, S., Donato, J., Atkin, S., Bookout, A. L., Rovinsky, S., Frazão, R., Lee, C. E., Gautron, L., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.022 · Cited by 353 · see citing works
New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
Roa, J., Aguilar, E., Diéguez, C., Pinilla, L., & Tena‐Sempere, M. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.07.002 · Cited by 343 · see citing works
Self-citation
Targeting the mTOR signaling network in cancer
Chiang, G. G., & Abraham, R. T. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.08.001 · Cited by 328 · see citing works
Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice
Quennell, J. H., Howell, C. S., Roa, J., Augustine, R. A., Grattan, D. R., & Anderson, G. M. (2011) · Endocrinology · doi:10.1210/en.2010-1100 · Cited by 291 · see citing works
Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells
Backholer, K., Smith, J. T., Rao, A. V. N., Pereira, A., Iqbal, J., Ogawa, S., Li, Q., & Clarke, I. J. (2010) · Endocrinology · doi:10.1210/en.2009-1190 · Cited by 289 · see citing works
Leptin is an effective treatment for hypothalamic amenorrhea
Chou, S. H., Chamberland, J. P., Liu, X., Matarese, G., Gao, C., Stefanakis, R., Brinkoetter, M. T., Gong, H., Arampatzi, K., & Mantzoros, C. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015674108 · Cited by 287 · see citing works
Regulation of Hypothalamic Expression of KiSS-1 and GPR54 Genes by Metabolic Factors: Analyses Using Mouse Models and a Cell Line
Luque, R. M., Kineman, R. D., & Tena‐Sempere, M. (2007) · Endocrinology · doi:10.1210/en.2007-0500 · Cited by 261 · see citing works
Self-citation
Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats
Castellano, J. M., Navarro, V. M., Fernández-Fernández, R., Roa, J., Vigo, E., Pineda, R., Diéguez, C., Aguilar, E., Pinilla, L., & Tena‐Sempere, M. (2006) · Diabetes · doi:10.2337/db05-1584 · Cited by 249 · see citing works
Self-citation
The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System
Roa, J., García-Galiano, D., Varela, L., Sanchez-Garrido, M. A., Pineda, R., Castellano, J. M., Ruíz-Pino, F., Romero, M., Aguilar, E., López, M., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0096 · Cited by 247 · see citing works
Self-citation
Kisspeptin Directly Excites Anorexigenic Proopiomelanocortin Neurons but Inhibits Orexigenic Neuropeptide Y Cells by an Indirect Synaptic Mechanism
Fu, L.-Y., & van den Pol, A. N. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2098-10.2010 · Cited by 243 · see citing works
Neuropeptide Y: a novel neuroendocrine peptide in the control of pituitary hormone secretion, and its relation to luteinizing hormone.
Sp, K., & Wr, C. (1992) · PubMed · Cited by 231 · see citing works
Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis.
Jayasena, C., Nijher, G., Chaudhri, O., Murphy, K., Ranger, A., Lim, A., Patel, D., Mehta, A., Todd, C., Ramachandran, R., et al. (2009) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2009-0406 · Cited by 211 · see citing works
Leptin in male reproduction: the testis paradigm
Tena‐Sempere, M., & Barreiro, M. L. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00008-4 · Cited by 208 · see citing works
Self-citation
Early Metabolic Programming of Puberty Onset: Impact of Changes in Postnatal Feeding and Rearing Conditions on the Timing of Puberty and Development of the Hypothalamic Kisspeptin System
Castellano, J. M., Overgaard, A., Sanchez-Garrido, M. A., Ruíz-Pino, F., Romero, M., García-Galiano, D., Aguilar, E., Pinilla, L., Diéguez, C., Mikkelsen, J. D., et al. (2011) · Endocrinology · doi:10.1210/en.2010-1415 · Cited by 206 · see citing works
Self-citation
The Creb1 coactivator Crtc1 is required for energy balance and fertility
Altarejos, J. Y., Goebel, N., Conkright, M. D., Inoue, H., Xie, J., Arias, C. M., Sawchenko, P. E., & Montminy, M. (2008) · Nature Medicine · doi:10.1038/nm.1866 · Cited by 200 · see citing works
Arcuate Kisspeptin/Neurokinin B/Dynorphin (KNDy) Neurons Mediate the Estrogen Suppression of Gonadotropin Secretion and Body Weight
Mittelman‐Smith, M. A., Williams, H., Krajewski, S. J., Lai, J. Y., Ciofi, P., McMullen, N. T., & Rance, N. E. (2012) · Endocrinology · doi:10.1210/en.2012-1045 · Cited by 189 · see citing works
NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy
Kalra, S. P., & Kalra, P. S. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.06.003 · Cited by 182 · see citing works
Molecular Mapping of the Neural Pathways Linking Leptin to the Neuroendocrine Reproductive Axis
Louis, G. W., Greenwald-Yarnell, M. L., Phillips, R., Coolen, L. M., Lehman, M. N., & Myers, M. G. (2011) · Endocrinology · doi:10.1210/en.2011-0096 · Cited by 178 · see citing works
Metabolic control of puberty onset: New players, new mechanisms
Roa, J., García-Galiano, D., Castellano, J. M., Gaytán, F., Pinilla, L., & Tena‐Sempere, M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.018 · Cited by 174 · see citing works
Self-citation
Kisspeptins: Bridging energy homeostasis and reproduction
Castellano, J. M., Overgaard, A., Mikkelsen, J. D., & Tena‐Sempere, M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.057 · Cited by 168 · see citing works
Self-citation
KiSS-1/kisspeptins and the metabolic control of reproduction: Physiologic roles and putative physiopathological implications
Castellano, J. M., Roa, J., Luque, R. M., Diéguez, C., Aguilar, E., Pinilla, L., & Tena‐Sempere, M. (2008) · Peptides · doi:10.1016/j.peptides.2008.06.007 · Cited by 166 · see citing works
Self-citation
Ovarian Function and Obesity—Interrelationship, Impact on Women’s Reproductive Lifespan and Treatment Options
Rachoń, D., & Teede, H. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.026 · Cited by 161 · see citing works
Characterisation of Arcuate Nucleus Kisspeptin/Neurokinin B Neuronal Projections and Regulation during Lactation in the Rat
True, C. A., Kirigiti, M. A., Ciofi, P., Grove, K. L., & Smith, M. S. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02076.x · Cited by 159 · see citing works
Sex Steroids and the Control of the Kiss1 System: Developmental Roles and Major Regulatory Actions
García-Galiano, D., Pinilla, L., & Tena‐Sempere, M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02230.x · Cited by 153 · see citing works
Self-citation
Effects of Chronic Hyperghrelinemia on Puberty Onset and Pregnancy Outcome in the Rat
Fernández-Fernández, R., Navarro, V. M., Barreiro, M. L., Vigo, E., Tovar, S. A., Sirotkin, A. V., Casanueva, F. F., Aguilar, E., Diéguez, C., Pinilla, L., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1622 · Cited by 147 · see citing works
Self-citation
Guinea Pig Kisspeptin Neurons Are Depolarized by Leptin via Activation of TRPC Channels
Qiu, J., Fang, Y., Bosch, M. A., Rønnekleiv, O. K., & Kelly, M. J. (2011) · Endocrinology · doi:10.1210/en.2010-1285 · Cited by 146 · see citing works
Roles of ghrelin and leptin in the control of reproductive function
Tena-Sempere, M. (2007) · Neuroendocrinology · doi:10.1159/000108410 · Cited by 141 · see citing works
Self-citation
The Ventral Premammillary Nucleus Links Fasting-Induced Changes in Leptin Levels and Coordinated Luteinizing Hormone Secretion
Donato, J., Silva, R. J., Sita, L. V., Lee, S., Lee, C., Lacchini, S., Bittencourt, J. C., Franci, C. R., Canteras, N. S., & Elias, C. F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0405-09.2009 · Cited by 133 · see citing works
KiSS-1 and Reproduction: Focus on Its Role in the Metabolic Regulation of Fertility
Tena-Sempere, M. (2006) · Neuroendocrinology · doi:10.1159/000095549 · Cited by 132 · see citing works
Self-citation
Cdh1 Is Essential for Endometrial Differentiation, Gland Development, and Adult Function in the Mouse Uterus1
Reardon, S. N., King, M. L., MacLean, J. A., et al. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.112.098871 · Cited by 131 · see citing works
KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake
Brown, R. E., Imran, S. A., Ur, E., & Wilkinson, M. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.10.011 · Cited by 130 · see citing works
Regulation of Food Intake Through Hypothalamic Signaling Networks Involving mTOR
Woods, S. C., Seeley, R. J., & Cota, D. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155505 · Cited by 125 · see citing works
Effects of Single or Repeated Intravenous Administration of Kisspeptin upon Dynamic LH Secretion in Conscious Male Rats
Tovar, S. A., Vazquez, M. J., Navarro, V. M., Fernández-Fernández, R., Castellano, J. M., Vigo, E., Roa, J., Casanueva, F. F., Aguilar, E., Pinilla, L., et al. (2006) · Endocrinology · doi:10.1210/en.2005-1397 · Cited by 122 · see citing works
Self-citation
Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction
Wu, M., Dumalska, I., Morozova, E., van den Pol, A. N., & Alreja, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908200106 · Cited by 117 · see citing works
Alteration in Neonatal Nutrition Causes Perturbations in Hypothalamic Neural Circuits Controlling Reproductive Function
Caron, É., Ciofi, P., Prévot, V., & Bouret, S. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6074-11.2012 · Cited by 112 · see citing works
Hypothesis: Kisspeptin Mediates Male Hypogonadism in Obesity and Type 2 Diabetes
George, J. T., Millar, R. P., & Anderson, R. A. (2010) · Neuroendocrinology · doi:10.1159/000299767 · Cited by 110 · see citing works
Melanocortins May Stimulate Reproduction by Activating Orexin Neurons in the Dorsomedial Hypothalamus and Kisspeptin Neurons in the Preoptic Area of the Ewe
Backholer, K., Smith, J., & Clarke, I. J. (2009) · Endocrinology · doi:10.1210/en.2009-0604 · Cited by 109 · see citing works
Kisspeptin and the seasonal control of reproduction in hamsters
Simonneaux, V., Ansel-Bollepalli, L., Revel, F. G., Klosen, P., Pévet, P., & Mikkelsen, J. D. (2008) · Peptides · doi:10.1016/j.peptides.2008.06.006 · Cited by 106 · see citing works
Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice
Stengel, A., Wang, L., Goebel‐Stengel, M., & Taché, Y. (2011) · Neuroreport · doi:10.1097/wnr.0b013e32834558df · Cited by 104 · see citing works
Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states
Roa, J., Vigo, E., García-Galiano, D., Castellano, J. M., Navarro, V. M., Pineda, R., Diéguez, C., Aguilar, E., Pinilla, L., & Tena‐Sempere, M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90240.2008 · Cited by 104 · see citing works
Self-citation
Fasting Reduces KiSS‐1 Expression in the Anteroventral Periventricular Nucleus (AVPV): Effects of Fasting on the Expression of KiSS‐1 and Neuropeptide Y in the AVPV or Arcuate Nucleus of Female Rats
Κalamatianos, T., Grimshaw, S. E., Poorun, R., Hahn, J. D., & Coen, C. W. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01757.x · Cited by 101 · see citing works
Ghrelin as a pleotrophic modulator of gonadal function and reproduction
Tena‐Sempere, M. (2008) · Nature Clinical Practice Endocrinology &#38 Metabolism · doi:10.1038/ncpendmet1003 · Cited by 101 · see citing works
Self-citation
Effects of intrauterine undernutrition on hypothalamic Kiss1 expression and the timing of puberty in female rats
Iwasa, T., Matsuzaki, T., Murakami, M., FUJISAWA, S., Kinouchi, R., Gereltsetseg, G., Kuwahara, A., Yasui, T., & Irahara, M. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.183558 · Cited by 94 · see citing works
Leptin is not the Critical Signal for Kisspeptin or Luteinising Hormone Restoration During Exit from Negative Energy Balance
True, C. A., Kirigiti, M. A., Kievit, P., Grove, K. L., & Smith, M. S. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02144.x · Cited by 93 · see citing works
Alterations in Hypothalamic KiSS-1 System in Experimental Diabetes: Early Changes and Functional Consequences
Castellano, J. M., Navarro, V. M., Roa, J., Pineda, R., Sanchez-Garrido, M. A., García-Galiano, D., Vigo, E., Diéguez, C., Aguilar, E., Pinilla, L., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0849 · Cited by 93 · see citing works
Self-citation
Insulin and NPY pathways and the control of GnRH function and puberty onset
Pralong, F. P. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.037 · Cited by 78 · see citing works
Preweaning Over- and Underfeeding Alters Onset of Puberty in the Rat Without Affecting Kisspeptin1
Smith, J. T., & Spencer, S. J. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.111.097758 · Cited by 78 · see citing works
Sex Steroids and Leptin Regulate the “First Kiss” (KiSS 1/G-Protein-Coupled Receptor 54 System) in Human Gonadotropin-Releasing-Hormone-Secreting Neuroblasts
Morelli, A., Marini, M., Mancina, R., Luconi, M., Vignozzi, L., Fibbi, B., Filippi, S., Pezzatini, A., Forti, G., Vannelli, G. B., et al. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00782.x · Cited by 73 · see citing works
Obesity and Its Relationship to Infertility in Men and Women
de Mola, J. R. L. (2009) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2009.03.002 · Cited by 64 · see citing works
Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects
Castellano, J. M., Bentsen, A. H., Romero, M., Pineda, R., Ruíz-Pino, F., García-Galiano, D., Sanchez-Garrido, M. A., Pinilla, L., Mikkelsen, J. D., & Tena‐Sempere, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00081.2010 · Cited by 63 · see citing works
Self-citation
Neuroendocrine Regulation of Reproductive Cyclicity
Schwartz, N. B. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-707-9_8 · Cited by 56 · see citing works
Changes in Insulin, Glucose and Ketone Bodies, But Not Leptin or Body Fat Content Precede Restoration of Luteinising Hormone Secretion in Ewes
Szymanski, L. A., Schneider, J. E., Friedman, M. I., et al. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01551.x · Cited by 53 · see citing works
Fasting reduces the kiss1 mRNA levels in the caudal hypothalamus of gonadally intact adult female rats
Matsuzaki, T., Iwasa, T., Kinouchi, R., Yoshida, S., Murakami, M., Gereltsetseg, G., Yamamoto, S., Kuwahara, A., Yasui, T., & Irahara, M. (2011) · Endocrine Journal · doi:10.1507/endocrj.k11e-131 · Cited by 52 · see citing works
Suppression of basal spontaneous gonadotropin-releasing hormone neuronal activity during lactation: role of inhibitory effects of neuropeptide Y.
Xu, J., Kirigiti, M. A., Cowley, M. A., Grove, K. L., & Smith, M. (2009) · Endocrinology · doi:10.1210/en.2008-0962 · Cited by 51 · see citing works
Mouse fertility is not dependent on the CREB coactivator Crtc1
Breuillaud, L., Halfon, O., Magistretti, P. J., Pralong, F. P., & Cardinaux, J. (2009) · Nature Medicine · doi:10.1038/nm0909-989 · Cited by 42 · see citing works
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Wahab, F., Aziz, F., Irfan, S., Zaman, W.-U., & Shahab, M. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.09.001 · Cited by 40 · see citing works
Clinical aspects of male sex differentiation
Svensson, J., & Giwercman, Y. L. (2010) · CRC Press eBooks · doi:10.3109/9781841847474-26 · Cited by 35 · see citing works
Sensitivities of mRNA expression levels of Kiss1 and its receptor, Kiss1r, to nutritional status are changed during the developmental period in female rats
Iwasa, T., Matsuzaki, T., Murakami, M., Kinouchi, R., Gereltsetseg, G., Fujisawa, S., Kuwahara, A., Yasui, T., & Irahara, M. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0129 · Cited by 34 · see citing works
Will leptin become the treatment of choice for functional hypothalamic amenorrhea?
Welt, C. K. (2007) · Nature Clinical Practice Endocrinology &#38 Metabolism · doi:10.1038/ncpendmet0561 · Cited by 17 · see citing works

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Morelli, A., Sarchielli, E., Comeglio, P., Filippi, S., Vignozzi, L., Marini, M., Rastrelli, G., Maneschi, E., Cellai, I., Persani, L., et al. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.017 · Cited by 107 · see citing works
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Sims, S. T., Kerksick, C. M., Smith-Ryan, A. E., Janse de Jonge, X. A. K., Hirsch, K. R., Arent, S. M., Hewlings, S. J., Kleiner, S. M., Bustillo, E., Tartar, J. L., et al. (2023) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2023.2204066 · Cited by 91 · see citing works
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The physiology of functional hypothalamic amenorrhea associated with energy deficiency in exercising women and in women with anorexia nervosa
Allaway, H. C. M., Southmayd, E. A., & De Souza, M. J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0053 · Cited by 89 · see citing works

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Διερεύνηση της πιθανής συσχέτισης των επιπέδων της λεπτίνης, της αδιπονεκτίνης και της kisspeptin με τα ωοθηκικά αποθέματα των γυναικών αναπαραγωγικής ηλικίας
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[Advances in the study of neuroendocrinological regulation of kisspeptin in fish reproduction].
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Authors: Castellano, J. M., & Tena-Sempere, M.
Affiliations: University of Córdoba (ES)
ORCID: Castellano, Juan Manuel
Venue: Advances in Experimental Medicine and Biology
Publisher: Springer New York
Published: 2013
Volume: 784
Pages: 363-383
ISSN: 0065-2598 (ISSN-L)
DOI: 10.1007/978-1-4614-6199-9_17
OpenAlex: W45641751
Cited by: 42
References: 81
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 2
FWCI: 23.06
Type: book chapter
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Advances in experimental medicine and biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: kisspeptin, Kiss1 neurons, leptin, GnRH neurons, puberty onset, energy balance, reproductive axis, obesity, fertility, hypothalamic-pituitary-gonadal axis
MeSH terms: Animals, Brain, Energy Metabolism, Fertility, Humans, Gonadotropin-Releasing Hormone, Neurons, Obesity, Morbid, Puberty, Reproduction, Signal Transduction, Leptin, Kisspeptins

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Metabolic Regulation of Kisspeptin

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