The DOI matches its Crossref record; 296 of the 296 references it cites were found in a registry or an index.
The role of short-chain fatty acids in microbiota–gut–brain communication
Open accessAbstract
Short-chain fatty acids (SCFAs), the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract, are speculated to have a key role in microbiota-gut-brain crosstalk. However, the pathways through which SCFAs might influence psychological functioning, including affective and cognitive processes and their neural basis, have not been fully elucidated. Furthermore, research directly exploring the role of SCFAs as potential mediators of the effects of microbiota-targeted interventions on affective and cognitive functioning is sparse, especially in humans. This Review summarizes existing knowledge on the potential of SCFAs to directly or indirectly mediate microbiota-gut-brain interactions. The effects of SCFAs on cellular systems and their interaction with gut-brain signalling pathways including immune, endocrine, neural and humoral routes are described. The effects of microbiota-targeted interventions such as prebiotics, probiotics and diet on psychological functioning and the putative mediating role of SCFA signalling will also be discussed, as well as the relationship between SCFAs and psychobiological processes. Finally, future directions to facilitate direct investigation of the effect of SCFAs on psychological functioning are outlined.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The gut microbiota influences gut barrier and produce neurotransmitters, amino acids and microbial metabolites61.”
From Association between attention-deficit/hyperactivity disorders and intestinal disorders: A systematic review and Meta-analysis (2025) · cites this paper as [61]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“gut microbiota dysbiosis has been implicated in behavioral and neurologic pathologies, such as depression, Alzheimer's (AD) and Parkinson's (PD) diseases and autism spectrum disorder (ASD) (9, 21, 25–27).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [21]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“brain to gut signaling can directly affect the microbiota, either via immune system or gut functions such as motility, release of neurotransmitters and intestinal immune tone (12, 17, 21, 31).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [21]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“the gut microbiota can interact with the CNS via gut modulation or directly via metabolites and endotoxin translocation from the lumen to the circulation (9, 17, 21).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [21]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“altered SCFA production has been demonstrated in a variety of neuropathologies (19, 21, 33–35).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [21]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“these SCFAs regulate the expression levels of tryptophan 5-hydroxylase 1, the enzyme involved in synthesis of serotonin, and tyrosine hydroxylase, which is involved in a rate-limiting step in the biosynthesis of dopamine, noradrenaline and adrenaline; therefore, producing an effect on brain neurochemistry (21, 55, 56, 116, 117).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [21]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Microbial metabolites such as short chain fatty acids (SCFAs) exert beneficial effects on psychiatric disorders via the microbiota–gut–brain axis through humoral, hormonal, and immune pathways [12].”
From Effect of Supplementation with Probiotics in Patients with Schizophrenia: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials (2025) · cites this paper as [12]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“SCFAs exert their physiological activities by acting as endogenous ligands for G-protein-coupled receptors (GPCRs), and modulating gene expression by inhibiting histone deacetylases (HDACs).282”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [282]
The cited source says what the claim attributes to it.
In the citing paper
“SCFAs can modulate the levels of neurotransmitters and neurotrophic factors and regulate the expression of tryptophan 5-hydroxylase, the enzyme involved in the synthesis of serotonin, and tyrosine hydroxylase, the enzyme involved in the rate-limiting step in dopamine, noradrenaline, and adrenaline synthesis (18, 132, 164, 222).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [132]
The cited source says what the claim attributes to it.
In the citing paper
“Other pathways through which SCFAs can influence gutbrain communication and brain function include immune, endocrine, neuronal, vagal, and other humoral pathways (360).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [360]
The cited source says what the claim attributes to it.
In the citing paper
“growing evidence supports the idea that SCFAs also exert crucial physiological effects on several organs, including the brain (17, 20, 21).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [21]
The cited source says what the claim attributes to it.
In the citing paper
“Accumulating evidence suggests that SCFAs that cross into the CNS have neuroactive properties.”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [21]
The cited source says what the claim attributes to it.
In the citing paper
“It was described that SCFAs may modulate the levels of neurotransmitters and neurotrophic factors.”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [21]
In the citing paper
“SCFAs are endogenous ligands for a subset of GPCRs, including GPR43 and GPR41, which were subsequently renamed as free fatty acid receptor 2 (FFAR2) and FFAR3, respectively.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [282]
In the citing paper
“Another important GPCR activated by SCFA is GPR109A, also known as hydroxycarboxylic acid receptor 2 (HCAR2), which is activated by butyrate and β-D-hydroxy butyrate.282”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [282]
In the citing paper
“and intracellular SCFAs can influence gene expression via histone deacetylation (HDAC) inhibition (Dalile et al., 2019)”
From The modulatory effects of gut microbes and metabolites on blood-brain barrier integrity and brain function in sepsis-associated encephalopathy (2023) · cites this paper as Dalile et al., 2019
In the citing paper
“Moreover, SCFAs are endogenous ligands of orphan G protein-coupled receptors (GPCRs)”
From The modulatory effects of gut microbes and metabolites on blood-brain barrier integrity and brain function in sepsis-associated encephalopathy (2023) · cites this paper as Dalile et al., 2019
In the citing paper
“Altered SCFA production has also been demonstrated in a variety of neuropathologies (42, 116, 127, 130, 132, 292–295).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [132]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634
Self-citationCommensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622
Cited by
Sorted by citations
Items 601–700 of 1,008
Agnihotri, N., & Mohajeri, M. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415934 · Cited by 47
Gut microbiota and cardiac arrhythmia
Fan, H., Liu, X., Ren, Z., Fei, X., Luo, J., Yang, X., Xue, Y., Zhang, F., & Liang, B. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1147687 · Cited by 48
Heidt, C., Kämmerer, U., Fobker, M., Rüffer, A., Marquardt, T., & Reuss-Borst, M. A. (2023) · Nutrients · doi:10.3390/nu15102386 · Cited by 48
Ayakdaş, G., & Ağagündüz, D. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19888 · Cited by 47
Cao, H., Li, C., Lei, L., Wang, X., Liu, S., Liu, Q., Huan, Y., Sun, S., & Shen, Z. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.578943 · Cited by 47
Gesù, C. M. D., Matz, L. M., & Buffington, S. A. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.05.003 · Cited by 47
Changes in gut microbiota composition with age and correlations with gut inflammation in rats
Chen, M., Feng, S., Hao, Z., Dong, C., & Liu, H. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265430 · Cited by 47
Communication between the gut microbiota and peripheral nervous system in health and chronic disease
Cook, T. M., & Mansuy‐Aubert, V. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2068365 · Cited by 47
Effects of Oral Glucose-Lowering Agents on Gut Microbiota and Microbial Metabolites
Wang, D., Liu, J. Y., Zhou, L., Zhang, Q., Li, M., & Xiao, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.905171 · Cited by 48
Glinert, A., Turjeman, S., Elliott, E., & Koren, O. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12812 · Cited by 48
Potential Roles of Enterochromaffin Cells in Early Life Stress-Induced Irritable Bowel Syndrome
Tao, E., Zhu, Z., Hu, C., Long, G., Chen, B., Guo, R. C., Fang, M., & Jiang, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.837166 · Cited by 47
Experiencing social exclusion changes gut microbiota composition
Kim, C.-S., Shin, G.-E., Cheong, Y., Shin, J., Shin, D., & Chun, W. Y. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02023-8 · Cited by 46
Liu, S., Cheng, L., Liu, Y., Zhan, S., Wu, Z., & Zhang, X. (2023) · Foods · doi:10.3390/foods12061309 · Cited by 46
Interplay between Phytochemicals and the Colonic Microbiota
Kwon, C., Ediriweera, M. K., & Cho, S. K. (2023) · Nutrients · doi:10.3390/nu15081989 · Cited by 46
Sun, K., Gao, Y., Wu, H., & Huang, X. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1255059 · Cited by 46
Martin, F., Cominetti, O., Berger, B. W., Combremont, S., Marquis, J., Xie, G., Jia, W. P., Pinto-Sánchez, M. I., Berčík, P., & Bergonzelli, G. E. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2347715 · Cited by 50
Xiao, X., Zhou, Y., Li, X., Jin, J., Durham, J., Ye, Z., Wang, Y., Hennig, B., & Deng, P. (2024) · Microbiome · doi:10.1186/s40168-024-01808-x · Cited by 46
Młynarska, E., Wasiak, J., Gajewska, A., Steć, G., Jasińska, J., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16121938 · Cited by 46
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice
Toledo, M., Martínez-Martínez, S., Hul, M. V., Laudo, B., Eyre, E., Pelicaen, R., Puel, A., Altirriba, J., Gómez-Valadés, A. G., Inderhees, J., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01280-3 · Cited by 46
Guardia-Escote, L., Basaure, P., Biosca-Brull, J., Cabré, M., Blanco, J., Pérez-Fernández, C., Sánchez-Santed, F., Domingo, J. L., & Colomina, M. T. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110872 · Cited by 46
Defaye, M., Nourrisson, C., Baudu, E., Lashermes, A., Meynier, M., Méleine, M., Wawrzyniak, I., Bonnin, V., Barbier, J., Chassaing, B., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66156-w · Cited by 46
Tain, Y., Jheng, L., Chang, S. K. C., Chen, Y., Huang, L., Liao, J.-X., & Hou, C. (2020) · Molecules · doi:10.3390/molecules25184199 · Cited by 46
Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis
Folick, A., Koliwad, S. K., & Valdearcos, M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.668396 · Cited by 48
Sun, C., Zheng, Z., Chen, C., Lu, B.-W., & Liu, D. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.859206 · Cited by 47
The gut microbiota: a double-edged sword in endometriosis
Talwar, C., Singh, V., & Kommagani, R. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioac147 · Cited by 48
Liu, N., Yang, C., Liang, X., Cao, K., Xie, J., Luo, Q., & Luo, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01642-z · Cited by 45
Cross-Sectional Study on the Gut Microbiome of Parkinson’s Disease Patients in Central China
Mao, L., Zhang, Y., Tian, J., Sang, M., Zhang, G., Zhou, Y., & Wang, P. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.728479 · Cited by 45
Heravi, F. S., & Hu, H. (2023) · Nutrients · doi:10.3390/nu15030709 · Cited by 45
Chaudhari, D. S., Jain, S., Yata, V. K., Mishra, S. P., Kumar, A., Fraser, A., Kociolek, J., Dangiolo, M. B., Smith, A., Golden, A. G., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00799-1 · Cited by 45
Cai, B., Zhong, L., Wang, Q., Xu, W., Li, X., & Chen, T. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1198335 · Cited by 45
Dietary fibre confers therapeutic effects in a preclinical model of Huntington’s disease
Gubert, C., Kong, G., Costello, C., Adams, C. D., Masson, B. A., Qin, W., Choo, J. M., Narayana, V. K., Rogers, G. B., Renoir, T., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.12.023 · Cited by 45
Jiang, H., Zeng, W. G., Zhang, X., Li, Y., Wang, Y., Peng, A., & Cao, D. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1211855 · Cited by 45
Chilton, P. M., Ghare, S. S., Charpentier, B. T., Myers, S., Rao, A. V., Petrosino, J. F., Hoffman, K. L., Greenwell, J. C., Tyagi, N., Behera, J., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2389319 · Cited by 45
Gut microbiota derived short‐chain fatty acids in physiology and pathology: An update
Archana, Gupta, A. K., Noumani, A., Panday, D. K., Zaidi, F., Sahu, G. K., Joshi, G., Yadav, M., Borah, S. J., Susmitha, V., et al. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4108 · Cited by 45
Slykerman, R. F., Davies, N., Vlčková, K., O’Riordan, K. J., Bassett, S. A., Dekker, J., Schellekens, H., Hyland, N. P., Clarke, G. A., & Patterson, E. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70079 · Cited by 47
Metatranscriptomics for Understanding the Microbiome in Food and Nutrition Science
Butowski, C. F., Dixit, Y., dos Reis, M. M., & Mu, C. (2025) · Metabolites · doi:10.3390/metabo15030185 · Cited by 45
Yang, J., Chen, W., Chen, J., Xie, D., Wang, Y., & Zhou, J. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100545 · Cited by 45
Gastrointestinal tissue as a “new” target of pollution exposure
Pambianchi, E., Pecorelli, A., & Valacchi, G. (2021) · IUBMB Life · doi:10.1002/iub.2530 · Cited by 45
Yang, Y., Zhong, Z., Wang, B., & Wang, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113902 · Cited by 44
Wang, D., Wang, L., Han, L., Wang, B., Shi, R., Jin, Y., Xia, B., Zhao, Z., Zhao, B., & Liu, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c01524 · Cited by 44
Yao, Y., Liu, Y., Xu, Q., & Mao, L. (2024) · Molecules · doi:10.3390/molecules29020379 · Cited by 44
Butyrate as a potential therapeutic agent for neurodegenerative disorders
Chakraborty, P., Gamage, H. K. A. H., & Laird, A. S. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105745 · Cited by 44
Kim, J., Jo, Y., Lim, G., Ji, Y., Roh, J., Kim, W.-G., Yi, H., Choi, D. W., Cho, D., & Ryu, D. (2024) · Nature Communications · doi:10.1038/s41467-024-55015-1 · Cited by 44
Cheng, W., Lam, K., Kong, A. P. S., & Cheung, P. C. K. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109437 · Cited by 44
Bai, J., Bruner, D. W., Fedirko, V., Beitler, J. J., Zhou, C., Gu, J., Zhao, H., Lin, I., Chico, C. E., Higgins, K. A., et al. (2020) · Cancers · doi:10.3390/cancers12092531 · Cited by 44
Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight
Angoa‐Pérez, M., & Kuhn, D. M. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000144 · Cited by 44
la Fuente, M. D. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201587 · Cited by 44
A Novel Strategy to Produce a Soluble and Bioactive Wheat Bran Ingredient Rich in Ferulic Acid
Martín‐Diana, A. B., Tomé-Sánchez, I., García‐Casas, M. J., Martínez‐Villaluenga, C., Frı́as, J., & Rico, D. (2021) · Antioxidants · doi:10.3390/antiox10060969 · Cited by 44
Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis
Jia, X., Yang, R., Li, J., Жао, Л., Zhou, X., & Xu, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.752708 · Cited by 44
Zhou, H., Zhao, J., Liu, C., Zhang, Z., Zhang, Y., & Meng, D. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153937 · Cited by 44
Impact of aging on animal models of Parkinson's disease
Klæstrup, I. H., Just, M. K., Holm, K. L., Alstrup, A. K. O., Romero‐Ramos, M., Borghammer, P., & Berge, N. V. D. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.909273 · Cited by 44
Zhang, Z., Li, J., Jiang, S., Xu, M. Y., Ma, T., Sun, Z., & Zhang, J. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114543 · Cited by 44
Li, Z., Zhang, F., Sun, M., Liu, J., Zhao, L., Liu, S., Li, S., & Wang, B. (2023) · PeerJ · doi:10.7717/peerj.15122 · Cited by 43
“…of orphan G protein-coupled receptors (GPCRs), and intracellular SCFAs can influence gene expression via histone deacetylation (HDAC) inhibition ( Dalile et al., 2019 ), which may directly modulate the differentiation, recruitment, and activation of various immune cells ( Rodrigues et al., 2016…”
Modulation of gut health using probiotics: the role of probiotic effector molecules
Gao, X., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2022) · Journal of Future Foods · doi:10.1016/j.jfutfo.2022.03.011 · Cited by 43
Xu, Y., Milburn, O., Beiersdorfer, T., Du, L., Akinbi, H. T., & Haslam, D. B. (2022) · Microbiome · doi:10.1186/s40168-022-01300-4 · Cited by 43
Shang, J., Yang, S., Tang, Z., Chen, Y., Duan, B., & Meng, X. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c02909 · Cited by 43
Gut microbiome dysbiosis in inflammatory bowel disease
Lal, S., Kandiyal, B., Ahuja, V., Takeda, K., & Das, B. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.09.003 · Cited by 43
Dietary fiber ameliorates sleep disturbance connected to the gut–brain axis
Tang, M., Song, X., Zhong, W., Xie, Y., Liu, Y., & Zhang, X. (2022) · Food & Function · doi:10.1039/d2fo01178f · Cited by 43
Yang, Y., Lu, M., Xu, Y., Qian, J., Le, G., & Xie, Y. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c04847 · Cited by 43
Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis
Zhai, Z., Su, P., Ma, L.-Y., Yang, H., Wang, T., Fei, Z.-G., Zhang, Y., Wang, Y., Ma, K., Han, B.-B., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114056 · Cited by 44
Wang, Q., Chen, C., Zuo, S., Cao, K., & Li, H. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04262-9 · Cited by 44
La, A. L. T. Z., Feng, Y., Hu, D., Feng, Y., Jin, X., Liu, D., Guo, Y., Cheng, G., & Hu, Y. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00887-4 · Cited by 43
Targeting metabolism in aortic aneurysm and dissection: from basic research to clinical applications
Wang, Q., Yesitayi, G., Liu, B., Siti, D., Ainiwan, M., Aizitiaili, A., & Ma, X. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85467 · Cited by 43
Gut-brain axis and Alzheimer's disease: Therapeutic interventions and strategies
Singh, H., Chopra, C., Singh, H., Malgotra, V., Wani, A. K., Dhanjal, D. S., Sharma, I., Nepovimová, E., Alomar, S. Y., Singh, R., et al. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105915 · Cited by 43
Peng, Y., Li, Y., Pi, Y., & Yue, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130098 · Cited by 43
Li, J., Zhao, J., Tian, C., Dong, L., Kang, Z., Wang, J., Zhao, S., Li, M., & Tong, X. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00829-5 · Cited by 43
Zhou, M., Wu, J., Shao, Y., Zhang, J., Zheng, R., Shi, Q. W., Wang, J., & Liu, B. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112881 · Cited by 43
Health benefits and risks of fermented foods—the PIMENTO initiative
Todorović, S., Akpınar, A., Assunção, R., Bär, C., Bavaro, S. L., Kaşıkçı, M. B., Domínguez-Soberanes, J., Capozzi, V., Cotter, P. D., Doo, E., et al. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1458536 · Cited by 43
Microbial signatures and therapeutic strategies in neurodegenerative diseases
Rob, M., Yousef, M., Lakshmanan, A. P., Mahboob, A., Terranegra, A., & Châari, A. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117905 · Cited by 43
Faecal Transplantation, Pro- and Prebiotics in Parkinson’s Disease; Hope or Hype?
van Laar, T., Boertien, J. M., & Herranz, A. H. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-191802 · Cited by 43
Vafa, S., Zarrati, M., Malakootinejad, M., Totmaj, A. S., Zayeri, F., Salehi, M., Sanati, V., & Haghighat, S. (2020) · The Breast · doi:10.1016/j.breast.2020.08.008 · Cited by 43
Zhang, Z., Peng, Q., Huo, D., Jiang, S., Ma, C., Chang, H., Chen, K., Li, C., Pan, Y., & Zhang, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.678190 · Cited by 44
The impact of device-assisted therapies on the gut microbiome in Parkinson’s disease
Lubomski, M., Xu, X., Holmes, A. J., Yang, J. Y. H., Sue, C. M., & Davis, R. L. (2021) · Journal of Neurology · doi:10.1007/s00415-021-10657-9 · Cited by 43
Altered Gut Microbiota in Korean Children with Autism Spectrum Disorders
Ha, S., Oh, D., Lee, S., Park, J., Ahn, J., Choi, S., & Cheon, K.-A. A. (2021) · Nutrients · doi:10.3390/nu13103300 · Cited by 43
The gut microbiome and microbial metabolites in acute myocardial infarction
Liu, C., Sun, Z., Shali, S., Mei, Z., Chang, S., Mo, H., Xu, L., Pu, Y., Guan, H., Chen, G., et al. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.12.007 · Cited by 43
Deng, H., He, L., Wang, C., Zhang, T., Guo, H., Zhang, H., Song, Y., & Chen, B. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04255-w · Cited by 43
Role of the Gut Microbiome in Skeletal Muscle Physiology and Pathophysiology
Lefevre, C., & Bindels, L. B. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00752-9 · Cited by 41
Impact of obesity and diet on brain structure and function: a gut–brain–body crosstalk
Medawar, E., & Witte, A. V. (2022) · Proceedings of The Nutrition Society · doi:10.1017/s0029665122002786 · Cited by 42
Zhou, S., Guo, Z., Yang, Y., Qu, Y., & Jin, H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1081347 · Cited by 42
The gut-retina axis: a new perspective in the prevention and treatment of diabetic retinopathy
Zhang, H., & Mo, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1205846 · Cited by 42
Kwak, M., Kim, S. H., Kim, H. H., Tanpure, R. S., Kim, J. I., Jeon, B., & Park, H. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1238005 · Cited by 42
Wang, X., Liang, F., Dai, Z., Feng, X., & Qiu, F. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117050 · Cited by 42
de Vasconcelos, M. L., Oliveira, L. M. F. D. S., Hill, J. P., & Vidal, A. M. C. (2023) · Foods · doi:10.3390/foods12173151 · Cited by 42
Luo, Y., Guo, Y., Hu, X.-Y., Liu, W., Liu, B.-Q., Yang, J., Tu, Z., & Huang, Y. (2023) · LWT · doi:10.1016/j.lwt.2023.115257 · Cited by 42
Bonham, K. S., Bottino, G. F., McCann, S., Beauchemin, J., Weisse, E., Barry, F., Cano-Lorente, R., Huttenhower, C., Bruchhage, M. M. K., D’Sa, V. A., et al. (2023) · Science Advances · doi:10.1126/sciadv.adi0497 · Cited by 45
Metabolomics Insights into Gut Microbiota and Functional Constipation
Zheng, F., Yang, Y., Lu, G., Tan, J. S., Mageswary, M. U., Zhan, Y., Ayad, M. E., Lee, Y. Y., & Xie, D. (2025) · Metabolites · doi:10.3390/metabo15040269 · Cited by 42
Wang, F., Zhou, H., Deng, L., Wang, L., Chen, J., & Zhou, X. (2020) · Mediators of Inflammation · doi:10.1155/2020/5821428 · Cited by 42
Chen, Y., Meng, P., Cheng, S., Jia, Y., Wen, Y. F., Yang, X., Yao, Y., Pan, C., Li, C., Zhang, H., et al. (2021) · Molecular Brain · doi:10.1186/s13041-021-00843-1 · Cited by 43
Wu, J.-T., Sun, C.-L., Lai, T.-T., Liou, C.-W., Lin, Y.-Y., Xue, J.-Y., Wang, H.-W., Chai, L. M. X., Lee, Y.-J., Chen, S., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109140 · Cited by 42
Kreuzer, K., Reiter, A., Birkl-Toeglhofer, A. M., Dalkner, N., Mörkl, S., Mairinger, M., Fleischmann, E., Fellendorf, F. T., Platzer, M., Lenger, M., et al. (2022) · Metabolites · doi:10.3390/metabo12080770 · Cited by 42
Guo, S., Chen, M., Wu, T., Liu, K., Zhang, H., & Wang, J. (2022) · Journal of Dairy Science · doi:10.3168/jds.2022-22003 · Cited by 42
The Bridge Between Ischemic Stroke and Gut Microbes: Short-Chain Fatty Acids
Fang, Z., Chen, M., Qian, J., Wang, C., & Zhang, J. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01209-4 · Cited by 41
Probiotics treatment for Parkinson disease: a systematic review and meta-analysis of clinical trials
Hong, C., Chen, J., & Huang, T. (2022) · Aging · doi:10.18632/aging.204266 · Cited by 41
Jiang, X., Liu, Z., Ma, Y., Miao, L., Zhao, K., Wang, D., Wang, M., Ruan, H., Xu, F., Zhou, Q., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110005 · Cited by 41
The Effect of Probiotic Supplementation on the Gut–Brain Axis in Psychiatric Patients
Sabit, H., Kassab, A., Alaa, D., Mohamed, S., Abdel-Ghany, S. E., mansy, M. I. A., Said, O. A. M., Khalifa, M. A., Hafiz, H., & Abushady, A. M. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45050260 · Cited by 41
Dissecting shared genetic architecture between obesity and multiple sclerosis
Zeng, R., Jiang, R., Huang, W., Wang, J., Zhang, L., Ma, Y., Wu, Y., Meng, M., Lan, H., Lian, Q., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104647 · Cited by 41
Fabiano, G. A., Shinn, L. M., & Antunes, A. E. C. (2023) · Nutrients · doi:10.3390/nu15163534 · Cited by 41
Gong, X., Geng, H., Yang, Y. K., Zhang, S., He, Z., Fan, Y., Yin, F., Zhang, Z., & Chen, G. (2023) · Metabolic Engineering · doi:10.1016/j.ymben.2023.09.008 · Cited by 41
Barman, M., Gio-Batta, M., Andrieux, L., Stråvik, M., Saalman, R., Fristedt, R., Rabe, H., Sandin, A., Wold, A. E., & Sandberg, A. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.104999 · Cited by 42
Wang, Y., Jia, X., & Cong, B. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1396031 · Cited by 42
Metadata
- Authors
- Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- Verbeke, Kristin
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2019-05-23
- Volume
- 16
- Issue
- 8
- Pages
- 461-478
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2946372752
- Cited by
- 3,357
- References
- 289
- Citations by year
- 2026: 631 · 2025: 685 · 2024: 567 · 2023: 511 · 2022: 429 · 2021: 334 · 2020: 174 · 2019: 25
- FWCI
- 21.30
- Type
- journal article
- Language
- en
- Open access
- green
- lirias.kuleuven.be
- Licence
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- short-chain fatty acids, microbiota-gut-brain axis, dietary fiber fermentation, gut microbiota, psychological functioning, emotional processing, cognitive processes, prebiotics, probiotics, microbiota-targeted interventions, immune signaling, hormone signaling, psychobiology
- MeSH terms
- Gastrointestinal Microbiome, Animals, Mental Disorders, Brain, Dietary Fiber, Disease Models, Animal, Fatty Acids, Volatile, Humans, Neural Pathways, Signal Transduction, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
