The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and improves olfactory dysfunction of APP/PS1 mice by nasal delivery
Open accessAbstract
Background: Dysbiosis or imbalance of gut microbiota in Alzheimer's disease (AD) affects the production of short-chain fatty acids (SCFAs), whereas exogenous SCFAs supplementation exacerbates brain Aβ burden in APP/PS1 mice. Bifidobacterium is the main producer of SCFAs in the gut flora, but oral administration of Bifidobacterium is ineffective due to strong acids and bile salts in the gastrointestinal tract. Therefore, regulating the levels of SCFAs in the gut is of great significance for AD treatment. Methods: We investigated the feasibility of intranasal delivery of MSNs-Bifidobacterium (MSNs-Bi) to the gut and their effect on behavior and brain pathology in APP/PS1 mice. Results: Mesoporous silica nanospheres (MSNs) were efficiently immobilized on the surface of Bifidobacterium. After intranasal administration, fluorescence imaging of MSNs-Bi in the abdominal cavity and gastrointestinal tract revealed that intranasally delivered MSNs-Bi could be transported through the brain to the peripheral intestine. Intranasal administration of MSNs-Bi not only inhibited intestinal inflammation and reduced brain Aβ burden but also improved olfactory sensitivity in APP/PS1 mice. Conclusions: These findings suggested that restoring the balance of the gut microbiome contributes to ameliorating cognitive impairment in AD, and that intranasal administration of MSNs-Bi may be an effective therapeutic strategy for the prevention of AD and intestinal disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Probiotic and prebiotic interventions aimed at elevating SCFA levels have neuroprotective effects in AD mouse models by inhibiting glial activation and Aβ deposition.
“Moreover, probiotic and prebiotic interventions aimed at elevating SCFA levels have demonstrated neuroprotective effects in AD mouse models by inhibiting glial activation and Aβ deposition.301–306”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [301]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357
The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
Frost, G., Sleeth, M. L., Sahuri-Arisoylu, M., Lizarbe, B., Cerdan, S., Brody, L., Anastasovska, J., Ghourab, S., Hankir, M., Zhang, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4611 · Cited by 1,771
The pros, cons, and many unknowns of probiotics
Suez, J., Zmora, N., Segal, E., & Elinav, E. (2019) · Nature Medicine · doi:10.1038/s41591-019-0439-x · Cited by 1,398
Kim, S., Kwon, S.-H., Kam, T.-I., Panicker, N., Karuppagounder, S. S., Lee, S., Lee, J. H., Kim, W. R., Kook, M., Foss, C. A., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.035 · Cited by 1,397
Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382
Brain-Gut-Microbiota Axis in Alzheimer’s Disease
Kowalski, K., & Mulak, A. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18087 · Cited by 826
Gut Bifidobacteria Populations in Human Health and Aging
Arboleya, S., Watkins, C., Stanton, C., & Ross, R. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01204 · Cited by 701
Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Chougule, M. B., Shoyele, S. A., & Alexander, A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.011 · Cited by 630
Sochocka, M., Donskow-Łysoniewska, K., Diniz, B. S., Kurpas, D., Brzozowska, E., & Leszek, J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1188-4 · Cited by 584
Probiotics: determinants of survival and growth in the gut
Bezkorovainy, A. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.399s · Cited by 531
Plaza‐Díaz, J., Ruiz‐Ojeda, F. J., Vilchez-Padial, L. M., & Gil, Á. (2017) · Nutrients · doi:10.3390/nu9060555 · Cited by 441
Olfactory and other sensory impairments in Alzheimer disease
Murphy, C. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0097-5 · Cited by 425
Kobayashi, Y., Sugahara, H., Shimada, K., Mitsuyama, E., Kuhara, T., Yasuoka, A., Kondo, T., Abe, K., & Xiao, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13368-2 · Cited by 411
Gut microbial molecules in behavioural and neurodegenerative conditions
Needham, B. D., Kaddurah-Daouk, R., & Mazmanian, S. K. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00381-0 · Cited by 379
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Colombo, A. V., Sadler, R. K., Llovera, G., Singh, V., Roth, S., Heindl, S., Sebastian Monasor, L., Verhoeven, A., Peters, F., Parhizkar, S., et al. (2021) · eLife · doi:10.7554/elife.59826 · Cited by 354
Li, Z., Zhang, Y., & Feng, N. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1575806 · Cited by 331
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease
Bairamian, D., Sha, S., Rolhion, N., Sokol, H., Dorothée, G., Lemere, C. A., & Krantic, S. M. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00522-2 · Cited by 326
Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model
Brandscheid, C., Schuck, F., Reinhardt, S., Schäfer, K.-H., Pietrzik, C. U., Grimm, M., Hartmann, T., Schwiertz, A., & Endres, K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160926 · Cited by 318
Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications
Mohammadpour, R., Dobrovolskaia, M. A., Cheney, D. L., Greish, K. F., & Ghandehari, H. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.07.006 · Cited by 296
Sensitive ELISA detection of amyloid‐β protofibrils in biological samples
Englund, H., Sehlin, D., Johansson, A., Nilsson, L. N. G., Gellerfors, P., Paulie, S., Lannfelt, L., & Pettersson, F. E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04759.x · Cited by 292
Olfactory Dysfunction Correlates with Amyloid-β Burden in an Alzheimer's Disease Mouse Model
Wesson, D. W., Levy, E., Nixon, R. A., & Wilson, D. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4622-09.2010 · Cited by 290
Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer’s therapy
Rassu, G., Soddu, E., Posadino, A. M., Pintus, G., Sarmento, B., Giunchedi, P., & Gavini, E. (2017) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2017.01.031 · Cited by 239
Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative
Navarro, V., Sanchez-Mejias, E., Jimenez, S., Muñoz-Castro, C., Sanchez-Varo, R., Davila, J. C., Vizuete, M., Gutierrez, A., & Vitorica, J. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00140 · Cited by 229
The role of gut microbiota in pathogenesis of Alzheimer's disease
Bostancıklıoğlu, M. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14264 · Cited by 209
Chen, C., Ahn, E. H., Kang, S. S., Liu, X., Alam, A., & Ye, K. (2020) · Science Advances · doi:10.1126/sciadv.aba0466 · Cited by 205
Stranahan, A. M., & Mattson, M. P. (2010) · Neural Plasticity · doi:10.1155/2010/108190 · Cited by 198 · cited 1×
“The entorhinal cortex can preprocess information entering the hippocampus and facilitate learning and memory, while Aβ deposits in the entorhinal cortex-hippocampus connection [58].”
BackgroundTowards non-invasive diagnostic imaging of early-stage Alzheimer's disease
Viola, K. L., Sbarboro, J., Sureka, R., De, M., Bicca, M. A., Wang, J., Vasavada, S. R., Satpathy, S., Wu, S., Joshi, H. M., et al. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.254 · Cited by 196
Intranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders
Islam, S. U., Shehzad, A., Ahmed, M. B., & Lee, Y. S. (2020) · Molecules · doi:10.3390/molecules25081929 · Cited by 191
Noriega, L., Gueimonde, M., Sánchez, B., Margollés, A., & Reyes‐Gavilán, C. G. D. L. (2004) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2004.01.003 · Cited by 149
Polymeric Nanoparticles for Nasal Drug Delivery to the Brain: Relevance to Alzheimer's Disease
Rabiee, N., Ahmadi, S., Afshari, R., Khalaji, S., Rabiee, M., Bagherzadeh, M., Fatahi, Y., Dinarvand, R., Tahriri, M., Tayebi, L., et al. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000076 · Cited by 144
Microbial Sources of Amyloid and Relevance to Amyloidogenesis and Alzheimer’s Disease (AD)
P, Z. Y. D. (2015) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000177 · Cited by 141
Lipid Nanoparticles for Nasal/Intranasal Drug Delivery
Cunha, S., Amaral, M. H., Lobo, J. M. S., & Silva, A. C. (2017) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2017018693 · Cited by 138
Chen, C., Zhou, Y., Wang, H., Alam, A. M., Kang, S. S., Ahn, E. H., Liu, X., Jia, J., & Ye, K. (2021) · The EMBO Journal · doi:10.15252/embj.2020106320 · Cited by 138
Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer’s disease
Alharthi, S., Alavi, S. E., Radwan, M. A., El-Khatib, M. M., & Alsarra, I. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-46032-y · Cited by 137
Ruíz, L., Ruas‐Madiedo, P., Gueimonde, M., Reyes‐Gavilán, C. G. D. L., Margollés, A., & Sánchez, B. (2011) · Genes & Nutrition · doi:10.1007/s12263-010-0207-5 · Cited by 127
Filali, M., & Lalonde, R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.066 · Cited by 121
Jin, W., Shen, L., Bu, X., Zhang, W., Chen, S., Huang, Z., Xiong, J., Gao, C., Dong, Z., He, Y., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1721-y · Cited by 121
Organic–Inorganic Mesoporous Nanocarriers Integrated with Biogenic Ligands
Gu, J., Fan, W., Shimojima, A., et al. (2007) · Small · doi:10.1002/smll.200700311 · Cited by 120
Sheehan, V. M., Sleator, R. D., Hill, C., & Fitzgerald, G. F. (2007) · Microbiology · doi:10.1099/mic.0.2007/006510-0 · Cited by 115
Akel, H., Ismail, R., & Csóka, I. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.12.014 · Cited by 113
Short-chain fatty acids production by Bifidobacterium species in the presence of salep
Usta, B., & Yilmaz‐Ersan, L. (2020) · Electronic Journal of Biotechnology · doi:10.1016/j.ejbt.2020.06.004 · Cited by 112
Multiple roles of short-chain fatty acids in Alzheimer disease
Chen, H., Meng, L., & Shen, L. (2021) · Nutrition · doi:10.1016/j.nut.2021.111499 · Cited by 110
Dietary Pattern, Gut Microbiota, and Alzheimer’s Disease
Zhang, M., Zhao, D., Zhou, G., & Li, C. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b08309 · Cited by 109
Li, H., Liu, C.-C., Zheng, H., & Huang, T. Y. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0139-3 · Cited by 103
Gastrointestinal Amyloidosis: Review of the Literature
Rowe, K. M., Pankow, J., Nehme, F., et al. (2017) · Cureus · doi:10.7759/cureus.1228 · Cited by 91
Bacteria as Nanoparticles Carrier for Enhancing Penetration in a Tumoral Matrix Model
Moreno, V., Álvarez, E., Izquierdo‐Barba, I., Baeza, A., Serrano‐López, J., & Vallet‐Regí, M. (2020) · Advanced Materials Interfaces · doi:10.1002/admi.201901942 · Cited by 65
Janus silver mesoporous silica nanobullets with synergistic antibacterial functions
Chang, Z., Wang, Z., Lu, M., et al. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.05.079 · Cited by 53
Nasopharyngeal Cancer-Specific Therapy Based on Fusion Peptide-Functionalized Lipid Nanoparticles
Luo, H., Lu, L., Yang, F., Wang, L., Yang, X., Luo, Q., & Zhang, Z. (2014) · ACS Nano · doi:10.1021/nn405989n · Cited by 45
Self-citationPeripheral alpha‐synuclein and Parkinson's disease
Olanow, C. W., Wakeman, D. R., & Kordower, J. H. (2014) · Movement Disorders · doi:10.1002/mds.25966 · Cited by 41
Formulation of Polymeric Nanoparticles of Antidepressant Drug for Intranasal Delivery
Jani, P., Vanza, J. D., Pandya, N., & Tandel, H. (2019) · Therapeutic Delivery · doi:10.4155/tde-2019-0060 · Cited by 39
Luo, H., Yang, J., Jin, H., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-174318 · Cited by 34
Self-citationCui, L.-H., Yan, C., Li, H.-S., et al. (2018) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1712.12008 · Cited by 34
Venema, K., Verhoeven, J., Verbruggen, S. E. L., Espinosa, L., & Courau, S. (2019) · Letters in Applied Microbiology · doi:10.1111/lam.13211 · Cited by 34
Zhang, L., Yang, C., Li, Y., Niu, S., Liang, X., Zhang, Z., Luo, Q., & Luo, H. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.723317 · Cited by 30
Self-citationYao, Z., Hua, F., Zhang, H., Li, Y., & Qin, Y. (2017) · Neuropathology · doi:10.1111/neup.12391 · Cited by 25
Flagged first, then by citations
Research works printed but not linked: 2
- Viola KL, Sbarboro J, Sureka R, De M, Bicca MA, Wang J, Vasavada S, Satpathy S, Wu S, Joshi H, et al. Towards non-invasive diagnostic imaging of early-stage Alzheimer’s disease. Nat Nanotechnol. 2015;10:91–8. · DOI
- Yao ZJHF, Zhang HZ, Li YY, Qin TJ. Olfactory dysfunction in the APP/PS1 transgenic mouse model of Alzheimer’s disease: morphological evaluations from the nose to the brain. Neuropathology. 2017;37:485–94. · DOI
Cited by
Sorted by citations
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193
Metadata
- Authors
- Liu, N., Yang, C., Liang, X., Cao, K., Xie, J., Luo, Q., & Luo, H.
- Affiliations
- Wuhan National Laboratory for Optoelectronics (CN)
- Hainan University (CN)
- Corresponding author
- Luo, Haiming
- Venue
- Journal of Nanobiotechnology
- Published
- 2022-10-07
- Volume
- 20
- Issue
- 1
- Pages
- 439-439
- ISSN
- 1477-3155 (ISSN-L)
- PMC
- PMC9547428
- OpenAlex
- W4303423601
- Cited by
- 45
- References
- 56
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 14 · 2023: 7
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Update notices
- correction (2024-04-06)
- Open access
- gold
- doi.org
- Locations
- Journal of Nanobiotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (91749209, 81971025)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Alzheimer's disease, Bifidobacterium, mesoporous silica nanoparticles, intranasal drug delivery, APP/PS1 mice, amyloid burden, olfactory dysfunction, gut microbiota, short-chain fatty acids, intestinal inflammation, gut-brain axis, probiotic delivery
- MeSH terms
- Alzheimer Disease, Animals, Olfaction Disorders, Bifidobacterium, Bile Acids and Salts, Brain, Disease Models, Animal, Fatty Acids, Volatile, Mice, Transgenic, Silicon Dioxide, Amyloid beta-Peptides, Mice, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
