The trinity of COVID-19: immunity, inflammation and intervention

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884

Clinical characteristics of coronavirus disease 2019 in China

Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969

Epidemiological and clinical characteristics of 99 cases of 2019 novel Coronavirus pneumonia in Wuhan, China: a descriptive study.

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286

Clinical characteristics of 138 hospitalized patients with 2019 Novel Coronavirus-Infected pneumonia in Wuhan, China

Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148

La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19

Martínez González, M. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,463

Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia

Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001316 · Cited by 16,575

Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19

Ahn, J. H., Kim, J., Hong, S. P., Choi, S. Y., Yang, M. J., Ju, Y. S., Kim, Y. T., Kim, H. M., Rahman, M. T., Chung, M. K., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148517 · Cited by 295

Baricitinib restrains the immune dysregulation in patients with severe COVID-19

Bronte, V., Ugel, S., Tinazzi, E., Vella, A., De Sanctis, F., Canè, S., Batani, V., Trovato, R., Fiore, A., Petrova, V., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci141772 · Cited by 281

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes

Ravindra, N. G., Alfajaro, M. M., Gasque, V., Huston, N. C., Wan, H., Szigeti-Buck, K., Yasumoto, Y., Greaney, A. M., Habet, V., Chow, R. D., et al. (2021) · PLOS Biology · doi:10.1371/journal.pbio.3001143 · Cited by 258

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Moustaqil, M. D., Ollivier, E., Chiu, H.-P., van Tol, S., Rudolffi-Soto, P., Stevens, C. S., Bhumkar, A., Hunter, D. J. B., Freiberg, A. N., Jacques, D. A., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1870414 · Cited by 289

DNA vaccines against COVID-19: Perspectives and challenges

Silveira, M. M., Moreira, G. M. S. G., & Mendonça, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118919 · Cited by 298

Risk Factors for Severe Disease and Efficacy of Treatment in Patients Infected With COVID-19: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis

Zhang, J. J. Y., Lee, K. S., Ang, L. W., Leo, Y., & Young, B. E. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa576 · Cited by 282

Outcomes of Coronavirus Disease 2019 (COVID-19) Related Hospitalization Among People With Human Immunodeficiency Virus (HIV) in the ISARIC World Health Organization (WHO) Clinical Characterization Protocol (UK): A Prospective Observational Study

Geretti, A. M., Stockdale, A. J., Kelly, S. H., Çevik, M., Collins, S., Waters, L. J., Villa, G. C. F., Docherty, A. B., Harrison, E. M., Turtle, L. C. W., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1605 · Cited by 284

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Hoepel, W., Chen, H., Geyer, C. E., Allahverdiyeva, S., Manz, X. D., de Taeye, S. W., Aman, J., Mes, L., Steenhuis, M., Griffith, G. R., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abf8654 · Cited by 282

SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19

Gusev, E., Sarapultsev, A., Владимировна, С. Л., & Черешнев, В. А. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031716 · Cited by 326

Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection

Hernández, J. L., Nan, D., Fernández‐Ayala, M., García‐Unzueta, M. T., Hernández‐Hernández, M. A., López‐Hoyos, M., Muñoz, P., Olmos, J. M., Gutiérrez‐Cuadra, M., Ruiz-Cubillán, J. J., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa733 · Cited by 281

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes

Ferreira, A. C., Soares, V. C., de Azevedo-Quintanilha, I. G., Dias, S. D. S. G., Rodrigues, N. F., Sacramento, C. Q., Mattos, M., de Freitas, C. S., Temerozo, J. R., Teixeira, L., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00428-w · Cited by 283

Obesity is a risk factor for developing critical condition in COVID‐19 patients: A systematic review and meta‐analysis

Földi, M., Farkas, N., Kiss, S., Zádori, N., Váncsa, S., Szakó, L., Dembrovszky, F., Solymár, M., Bartalis, E., Szakács, Z., et al. (2020) · Obesity Reviews · doi:10.1111/obr.13095 · Cited by 274

Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity

Mercola, J. M., Grant, W. B., & Wagner, C. L. (2020) · Nutrients · doi:10.3390/nu12113361 · Cited by 268

An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study

Yang, Z., Bogdan, P., & Nazarian, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-81749-9 · Cited by 271

Nutritional status of patients with COVID-19

Im, J. H., Je, Y. S., Baek, J. H., Chung, M., Kwon, H. Y., & Lee, J. S. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.08.018 · Cited by 270

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

Kaptein, S. J. F., Jacobs, S., Langendries, L., Seldeslachts, L., ter Horst, S., Liesenborghs, L., Hens, B., Vergote, V., Heylen, E., Barthélémy, K., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2014441117 · Cited by 283

Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients

Valizadeh, H., Abdolmohammadi‐Vahid, S., Danshina, S. D., Gençer, M., Ammari, A., Sadeghi, A., Roshangar, L., Aslani, S., Esmaeilzadeh, A., Ghaebi, M., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107088 · Cited by 272

Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening

Abián, O., Ortega-Alarcón, D., Jiménez-Alesanco, A., Ceballos-Laita, L., Vega, S., Reyburn, H. T., Rizzuti, B., & Velázquez‐Campoy, A. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.235 · Cited by 268

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Boudewijns, R., Thibaut, H. J., Kaptein, S. J. F., Li, R., Vergote, V., Seldeslachts, L., Weyenbergh, J. V., Keyzer, C. D., Bervoets, L., Sharma, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19684-y · Cited by 283

Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression

Bohn, M. K., Hall, A., Sepiashvili, L., Jung, B., Steele, S., & Adeli, K. (2020) · Physiology · doi:10.1152/physiol.00019.2020 · Cited by 273

SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

Mulay, A., Konda, B. M., Garcia, G., Yao, C., Beil, S., Villalba, J. M., Koziol, C., Sen, C., Purkayastha, A., Kolls, J. K., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109055 · Cited by 262

Impact of COVID-19 in the Mental Health in Elderly: Psychological and Biological Updates

Grolli, R. E., Mingoti, M. E. D., Bertollo, A. G., Luzardo, A. R., Quevedo, J., Réus, G. Z., & Ignácio, Z. M. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02249-x · Cited by 286

A Comprehensive Review of COVID-19 Virology, Vaccines, Variants, and Therapeutics

Forchette, L., Sebastian, W., & Liu, T. (2021) · Current Medical Science · doi:10.1007/s11596-021-2395-1 · Cited by 275

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Tian, M., Liu, W., Li, X., Zhao, P., Shereen, M. A., Zhu, C., Huang, S., Liu, S., Yu, X., Yue, M., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00726-w · Cited by 249

Post-COVID-19 Fatigue: Potential Contributing Factors

Rudroff, T., Fietsam, A. C., Deters, J. R., Bryant, A., & Kamholz, J. A. (2020) · Brain Sciences · doi:10.3390/brainsci10121012 · Cited by 259

Chemokines and chemokine receptors during COVID-19 infection

Khalil, B. A., Elemam, N. M., & Maghazachi, A. A. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.01.034 · Cited by 248

The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection

Gallo, O., Locatello, L. G., Mazzoni, A., Novelli, L., & Annunziato, F. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00359-2 · Cited by 253

mRNA vaccines in disease prevention and treatment

Zhang, G., Tang, T., Chen, Y., Huang, X., & Liang, T. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01579-1 · Cited by 273

The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications

Jung, E., Romero, R. J., Yeo, L., Primera, R. J. D., Marin‐Concha, J., Para, R., Lopez, A. M., Pacora, P., Gomez‐Lopez, N., Yoon, B. H., et al. (2020) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2020.101146 · Cited by 264

Azithromycin in the treatment of COVID-19: a review

Echeverría-Esnal, D., Martín‐Ontiyuelo, C., Navarrete-Rouco, M. E., de Antonio-Cuscó, M., Ferrández, O., Horcajada, J. P., & Grau, S. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1813024 · Cited by 257

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

Mann, E. R., Menon, M., Knight, S., Konkel, J. E., Jagger, C. P., Shaw, T. N., Krishnan, S., Rattray, M., Ustianowski, A., Bakerly, N. D., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abd6197 · Cited by 237

Coronavirus Disease (COVID-19): Comprehensive Review of Clinical Presentation

Mehta, O. P., Bhandari, P., Raut, A. P., Kacimi, S. E. O., & Huy, N. T. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2020.582932 · Cited by 242

Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

Sherif, Z. A., Gómez, C. R., Connors, T. J., Henrich, T. J., Reeves, W. B., & RECOVER Mechanistic Pathway Task Force (2023) · eLife · doi:10.7554/elife.86002 · Cited by 248

Role of gut microbiota in infectious and inflammatory diseases

Maciel-Fiuza, M. F., Müller, G. C., Campos, D. M. S., Costa, P. D. S. S., Peruzzo, J., Bonamigo, R. R., Veit, T. D., & Vianna, F. S. L. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1098386 · Cited by 263

The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing

Xu, G., Qi, F., Li, H., Yang, Q., Wang, H., Wang, X., Liu, X., Zhao, J., Liao, X., Liu, Y., et al. (2020) · Cell Discovery · doi:10.1038/s41421-020-00225-2 · Cited by 236

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

Hayn, M., Hirschenberger, M., Koepke, L., Nchioua, R., Straub, J. H., Klute, S., Hunszinger, V., Zech, F., Bozzo, C. P., Aftab, W., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109126 · Cited by 236

SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

Wérion, A., Belkhir, L., Perrot, M., Schmit, G., Aydın, S., Chen, Z., Penaloza, A., Greef, J. D., Yıldız, H., Pothen, L., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.07.019 · Cited by 233

Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2

Garcia‐Flores, V., Romero, R. J., Xu, Y., Theis, K. R., Arenas‐Hernandez, M., Miller, D., Peyvandipour, A., Bhatti, G., Galaz, J., Gershater, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27745-z · Cited by 234

The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2

Krasemann, S., Haferkamp, U., Pfefferle, S., Woo, M. S., Heinrich, F., Schweizer, M., Appelt‐Menzel, A., Cubukova, A., Barenberg, J., Leu, J., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.12.011 · Cited by 232

Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

Agrati, C., Sacchi, A., Bordoni, V., Cimini, E., Notari, S., Grassi, G., Casetti, R., Tartaglia, E., Lalle, E., D’Abramo, A., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0572-6 · Cited by 218

Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2020

Neale, R. E., Barnes, P. W., Robson, T. M., Neale, P. J., Williamson, C. E., Zepp, R. G., Wilson, S. R., Madronich, S., Andrady, A. L., Heikkilä, A. M., et al. (2021) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-020-00001-x · Cited by 225

Coronavirus 2019 and People Living With Human Immunodeficiency Virus: Outcomes for Hospitalized Patients in New York City

Sigel, K. M., Swartz, T. H., Golden, E., Paranjpe, I., Somani, S. S., Richter, F., Freitas, J. K. D., Miotto, R., Zhao, S., Polak, P. P., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa880 · Cited by 226

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

Sanders, D. W., Jumper, C. C., Ackerman, P. J., Bracha, D., Donlic, A., Kim, H., Kenney, D., Castello-Serrano, I., Suzuki, S., Tamura, T., et al. (2021) · eLife · doi:10.7554/elife.65962 · Cited by 224

A time-resolved proteomic and prognostic map of COVID-19

Demichev, V., Tober-Lau, P., Lemke, O., Nazarenko, T., Thibeault, C., Whitwell, H., Röhl, A., Freiwald, A., Szyrwiel, L., Ludwig, D., et al. (2021) · Cell Systems · doi:10.1016/j.cels.2021.05.005 · Cited by 200

SARS‐CoV‐2, bacterial co‐infections, and AMR: the deadly trio in COVID‐19?

Bengoechea, J. A., & Bamford, C. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012560 · Cited by 229

T cell regeneration after immunological injury

Velardi, E., Tsai, J. J., & van den Brink, M. R. M. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00457-z · Cited by 222

Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression

Schönrich, G., Raftery, M. J., & Samstag, Y. (2020) · Advances in Biological Regulation · doi:10.1016/j.jbior.2020.100741 · Cited by 226

Viral Dynamics and Real-Time RT-PCR Ct Values Correlation with Disease Severity in COVID-19

Rabaan, A. A., Tirupathi, R., Sule, A. A., Aldali, J., Mutair, A. S. A., Alhumaid, S., Muzaheed, M., Gupta, N. R., Koritala, T., Adhikari, R., et al. (2021) · Diagnostics · doi:10.3390/diagnostics11061091 · Cited by 233

Assessment of SARS-CoV-2 serological tests for the diagnosis of COVID-19 through the evaluation of three immunoassays: Two automated immunoassays (Euroimmun and Abbott) and one rapid lateral flow immunoassay (NG Biotech)

Nicol, T., Lefeuvre, C., Serri, O., Pivert, A., Joubaud, F., Dubée, V., Kouatchet, A., Ducancelle, A., Lunel, F., & Guillou‐Guillemette, H. L. (2020) · Journal of Clinical Virology · doi:10.1016/j.jcv.2020.104511 · Cited by 218

MAIT cell activation and dynamics associated with COVID-19 disease severity

Parrot, T., Gorin, J., Ponzetta, A., Maleki, K. T., Kammann, T., Emgård, J., Perez‐Potti, A., Sekine, T., Rivera‐Ballesteros, O., the Karolinska COVID-19 Study Group, et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abe1670 · Cited by 218

Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19

Liu, C., Martins, A. J., Lau, W. W., Rachmaninoff, N., Chen, J., Imberti, L., Mostaghimi, D., Fink, D. L., Burbelo, P. D., Dobbs, K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.018 · Cited by 214

The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis

Bassatne, A., Basbous, M., Chakhtoura, M., Zein, O. E., Rahme, M., & Fuleihan, G. E. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154753 · Cited by 217

Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity

Flament, H., Rouland, M., Beaudoin, L., Toubal, A., Bertrand, L., Lebourgeois, S., Rousseau, C., Soulard, P., Gouda, Z., Cagninacci, L., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00870-z · Cited by 219

Extremely potent human monoclonal antibodies from COVID-19 convalescent patients

Andreano, E., Nicastri, E., Paciello, I., Pileri, P., Manganaro, N., Piccini, G., Manenti, A., Pantano, E., Kabanova, A., Troisi, M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.035 · Cited by 199

The immune response to SARS-CoV-2 and COVID-19 immunopathology – Current perspectives

Boechat, J. L., Chora, I., Morais, A., & Delgado, L. (2021) · Pulmonology · doi:10.1016/j.pulmoe.2021.03.008 · Cited by 225

SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response

Fu, Y.-Z., Wang, S., Zheng, Z.-Q., Huang, Y., Li, W.-W., Xu, Z.-S., & Wang, Y. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00571-x · Cited by 219

Next generation sequencing of SARS-CoV-2 genomes: challenges, applications and opportunities

Chiara, M., D’Erchia, A. M., Gissi, C., Manzari, C., Parisi, A., Resta, N., Zambelli, F., Picardi, E., Pavesi, G., Horner, D. S., et al. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa297 · Cited by 214

The glycosylation in SARS-CoV-2 and its receptor ACE2

Gong, Y., Qin, S., Dai, L., & Tian, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00809-8 · Cited by 226

Rituximab for the treatment of multiple sclerosis: a review

Chisari, C. G., Sgarlata, E., Arena, S., Toscano, S., Luca, M., & Patti, F. (2021) · Journal of Neurology · doi:10.1007/s00415-020-10362-z · Cited by 209

Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2

Gu, Y., Cao, J., Zhang, X., Gao, H., Wang, Y., Wang, J., He, J., Jiang, X., Zhang, J., Shen, G., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00595-6 · Cited by 215

T‐cell responses and therapies against SARS‐CoV‐2 infection

Toor, S. M., Saleh, R., Nair, V. S., Taha, R. Z., & Elkord, E. (2020) · Immunology · doi:10.1111/imm.13262 · Cited by 208

The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options

Choudhary, S., Sharma, K., & Silakari, O. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104673 · Cited by 212

Drug repurposing for COVID-19 via knowledge graph completion

Zhang, R., Hristovski, D., Schutte, D., Kastrin, A., Marcelo Fiszman, B., & Halil Kilicoglu, B. (2021) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2021.103696 · Cited by 237

Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis

Tleyjeh, I. M., Kashour, Z., Damlaj, M., Riaz, M. A., Tlayjeh, H., Altannir, M., Altannir, Y., Al-Tannir, M. A., Tleyjeh, R., Hassett, L. C., et al. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.10.036 · Cited by 206

NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients

Kircheis, R., Haasbach, E., Lueftenegger, D., Heyken, W. T., Ocker, M., & Planz, O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.598444 · Cited by 207

SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling

Li, F., Li, J., Wang, P., Yang, N., Huang, J., Ou, J., Xu, T., Zhao, X., Liu, T., Huang, X., et al. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166260 · Cited by 211

A single-cell transcriptomic landscape of the lungs of patients with COVID-19

Wang, S., Yao, X., Ma, S., Ping, Y., Fan, Y., Sun, S., He, Z., Shi, Y., Sun, L., Xiao, S., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00796-6 · Cited by 195

Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity

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Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia

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