Cited by 2,472COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchImmune cells in cancer

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Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

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Merad, Miriam, Martin, Jerome C.·2020·Nature Reviews Immunology

DOI 10.1038/s41577-020-0331-4PMC PMC7201395

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Abstract

The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients. Macrophages are a population of innate immune cells that sense and respond to microbial threats by producing inflammatory molecules that eliminate pathogens and promote tissue repair. However, a dysregulated macrophage response can be damaging to the host, as is seen in the macrophage activation syndrome induced by severe infections, including in infections with the related virus SARS-CoV. Here we describe the potentially pathological roles of macrophages during SARS-CoV-2 infection and discuss ongoing and prospective therapeutic strategies to modulate macrophage activation in patients with COVID-19.

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Authors: Merad, M., & Martin, J. C.
Affiliations: Inserm (FR)
Corresponding author: Martin, Jerome C.
ORCID: Martin, Jerome C.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2020-05-06
Volume: 20
Issue: 6
Pages: 355-362
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/s41577-020-0331-4
PMC: PMC7201395
OpenAlex: W3023982717
Cited by: 2,472
References: 65
Citations by year: 2026: 89 · 2025: 133 · 2024: 196 · 2023: 330 · 2022: 529 · 2021: 753 · 2020: 435
FWCI: 24.29
Type: journal article
Language: en
Update notices: correction (2020-06-02)
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Icahn School of Medicine at Mount Sinai
Agence Nationale de la Recherche (ANR-16-IDEX-0007)
Institut National de la Santé et de la Recherche Médicale
Université de Nantes
Topics: Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: COVID-19 pandemic, SARS-CoV-2, monocytes, macrophages, hyperinflammation, macrophage activation syndrome, innate immunity, inflammatory signaling
MeSH terms: Betacoronavirus, COVID-19, SARS-CoV-2, Animals, Humans, Inflammation, Macrophage Activation, Macrophages, Monocytes, Pneumonia, Viral, Coronavirus Infections, Pandemics

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