Immunopathology of Hyperinflammation in COVID-19

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884 · see citing works

Clinical characteristics of coronavirus disease 2019 in China

Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246 · see citing works

A novel coronavirus from patients with pneumonia in China, 2019

Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001017 · Cited by 28,244 · see citing works

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263 · see citing works

Epidemiological and clinical characteristics of 99 cases of 2019 novel Coronavirus pneumonia in Wuhan, China: a descriptive study.

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415 · see citing works

Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia

Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001316 · Cited by 16,575 · see citing works

Pathogen Recognition and Innate Immunity

Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Song, H., Huang, B., Zhu, N., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30251-8 · Cited by 11,907 · see citing works

Dexamethasone in Hospitalized Patients with Covid-19

The RECOVERY Collaborative Group (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2021436 · Cited by 11,477 · see citing works

COVID-19: consider cytokine storm syndromes and immunosuppression

Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., & Manson, J. J. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30628-0 · Cited by 9,664 · see citing works

Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area

Richardson, S., Hirsch, J. S., Narasimhan, M., Crawford, J. M., McGinn, T., Davidson, K. W., and the Northwell COVID-19 Research Consortium, Barnaby, D. P., Becker, L. B., Chelico, J. D., et al. (2020) · JAMA · doi:10.1001/jama.2020.6775 · Cited by 9,254 · see citing works

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30076-x · Cited by 8,545 · see citing works

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

Wu, C., Chen, X., Cai, Y., Xia, J., Zhou, X., Xu, S., Huang, H., Zhang, L., Zhou, X., Du, C., et al. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.0994 · Cited by 8,249 · see citing works

Virological assessment of hospitalized patients with COVID-2019

Wölfel, R., Corman, V. M., Guggemos, W., Seilmaier, M., Zange, S., Müller, M. A., Niemeyer, D., Jones, T. C., Vollmar, P., Rothe, C., et al. (2020) · Nature · doi:10.1038/s41586-020-2196-x · Cited by 6,661 · see citing works

Endothelial cell infection and endotheliitis in COVID-19

Varga, Z., Flammer, A. J., Steiger, P., Haberecker, M., Andermatt, R., Zinkernagel, A. S., Mehra, M. R., Schuepbach, R. A., Ruschitzka, F., & Moch, H. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30937-5 · Cited by 6,358 · see citing works

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Ackermann, M., Verleden, S. E., Kuehnel, M., Haverich, A., Welte, T., Laenger, F., Vanstapel, A., Werlein, C., Stark, H., Tzankov, A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2015432 · Cited by 5,613 · see citing works

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

Maude, S. L., Frey, N., Shaw, P. A., Aplenc, R., Barrett, D. M., Bunin, N. J., Chew, A., Gonzalez, V. E., Zheng, Z., Lacey, S. F., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1407222 · Cited by 5,413 · cited 1× · see citing works

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

Ruan, Q., Yang, K., Wang, W., Jiang, L., & Song, J. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05991-x · Cited by 4,898 · see citing works

Clinical and immunological features of severe and moderate coronavirus disease 2019

Chen, G., Wu, D., Guo, W., Cao, Y., Huang, D., Wang, H., Wang, T., Zhang, X., Chen, H., Yu, H., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137244 · Cited by 4,750 · see citing works

The trinity of COVID-19: immunity, inflammation and intervention

Tay, M. Z., Poh, C. M., Rénia, L., MacAry, P. A., & Ng, L. F. P. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0311-8 · Cited by 4,360 · see citing works

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Blanco-Melo, D., Nilsson-Payant, B. E., Liu, W.-C., Uhl, S., Hoagland, D., Møller, R., Jordan, T. X., Oishi, K., Panis, M., Sachs, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.026 · Cited by 4,222 · see citing works

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287 · see citing works

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Hadjadj, J., Yatim, N., Barnabei, L., Corneau, A., Boussier, J., Smith, N., Péré, H., Charbit, B., Bondet, V., Chenevier-Gobeaux, C., et al. (2020) · Science · doi:10.1126/science.abc6027 · Cited by 2,984 · see citing works

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents

Feldstein, L. R., Rose, E. B., Horwitz, S. M., Collins, J. P., Newhams, M. M., Son, M. B. F., Newburger, J. W., Kleinman, L. C., Heidemann, S. M., Martin, A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2021680 · Cited by 2,660 · see citing works

Effective treatment of severe COVID-19 patients with tocilizumab

Xu, X., Han, M., Li, T., Sun, W., Wang, D., Fu, B., Zhou, Y., Zheng, X., Yang, Y., Li, X., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005615117 · Cited by 2,636 · see citing works

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Liao, M., Liu, Y., Yuan, J., Wen, Y., Xu, G., Zhao, J., Cheng, L., Li, J., Wang, X., Wang, F., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0901-9 · Cited by 2,614 · see citing works

An inflammatory cytokine signature predicts COVID-19 severity and survival

Del Valle, D. M., Kim-Schulze, S., Huang, H.-H., Beckmann, N. D., Nirenberg, S., Wang, B., Lavin, Y., Swartz, T. H., Madduri, D., Stock, A., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1051-9 · Cited by 2,605 · see citing works

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study

Verdoni, L., Mazza, A., Gervasoni, A., Martelli, L., Ruggeri, M., Ciuffreda, M., Bonanomi, E., & D’Antiga, L. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31103-x · Cited by 2,379 · see citing works

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Ziegler, C. G. K., Allon, S. J., Nyquist, S. K., Mbano, I. M., Miao, V. N., Tzouanas, C. N., Cao, Y., Yousif, A. S., Bals, J., Hauser, B. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.035 · Cited by 2,284 · see citing works

Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells

Fink, S. L., & Cookson, B. T. (2005) · Infection and Immunity · doi:10.1128/iai.73.4.1907-1916.2005 · Cited by 2,206 · see citing works

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

Monteil, V., Kwon, H., Prado, P., Hagelkrüys, A., Wimmer, R. A., Stahl, M., Leopoldi, A., Garreta, E., Hurtado del Pozo, C., Prosper, F., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.004 · Cited by 2,122 · see citing works

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Giamarellos-Bourboulis, E. J., Netea, M. G., Rovina, N., Akinosoglou, K., Antoniadou, A., Antonakos, N., Damoraki, G., Gkavogianni, T., Adami, M.-E., Katsaounou, P., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.04.009 · Cited by 2,045 · see citing works

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

Zheng, M., Gao, Y., Wang, G., Song, G., Liu, S., Sun, D., Xu, Y., & Tian, Z. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0402-2 · Cited by 1,768 · see citing works

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19

Geleris, J., Sun, Y., Platt, J., Zucker, J., Baldwin, M., Hripcsak, G., Labella, A., Manson, D. K., Kubin, C., Barr, R. G., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2012410 · Cited by 1,625 · see citing works

Immunology of COVID-19: Current State of the Science

Vabret, N., Britton, G. J., Gruber, C., Hegde, S., Kim, J., Kuksin, M., Levantovsky, R., Malle, L., Moreira, A., Park, M. D., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.002 · Cited by 1,623 · see citing works

Neutrophil extracellular traps in COVID-19

Zuo, Y., Yalavarthi, S., Shi, H., Gockman, K., Zuo, M., Madison, J. A., Blair, C., Weber, A. G., Barnes, B. J., Egeblad, M., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.138999 · Cited by 1,602 · see citing works

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

Fox, S., Akmatbekov, A., Harbert, J. L., Li, G., Brown, J. Q., & Heide, R. S. V. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30243-5 · Cited by 1,524 · see citing works

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

Wilk, A. J., Rustagi, A., Zhao, N. Q., Roque, J., Martínez-Colón, G. J., McKechnie, J. L., Ivison, G. T., Ranganath, T., Vergara, R., Hollis, T., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0944-y · Cited by 1,493 · see citing works

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

Barnes, B. J., Adrover, J. M., Baxter-Stoltzfus, A., Borczuk, A., Cools-Lartigue, J., Crawford, J. M., Daßler-Plenker, J., Guerci, P., Huynh, C., Knight, J. S., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20200652 · Cited by 1,486 · see citing works

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

Middleton, E. A., He, X., Denorme, F., Campbell, R. A., Ng, D. C., Salvatore, S., Mostyka, M., Baxter-Stoltzfus, A., Borczuk, A., Loda, M. F., et al. (2020) · Blood · doi:10.1182/blood.2020007008 · Cited by 1,482 · see citing works

Mechanisms of action of hydroxychloroquine and chloroquine:implications for rheumatology

Schrezenmeier, E., & Dörner, T. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0372-x · Cited by 1,468 · see citing works

Adult haemophagocytic syndrome

Ramos‐Casals, M., Brito‐Zerón, P., López‐Guillermo, A., Khamashta, M. A., & Bosch, X. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61048-x · Cited by 1,445 · see citing works

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

Carsana, L., Sonzogni, A., Nasr, A., Rossi, R. S., Pellegrinelli, A., Zerbi, P., Rech, R., Colombo, R., Antinori, S., Corbellino, M., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30434-5 · Cited by 1,402 · see citing works

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

Channappanavar, R., Fehr, A. R., Vijay, R., Mack, M., Zhao, J., Meyerholz, D. K., & Perlman, S. M. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.01.007 · Cited by 1,400 · see citing works

Multisystem Inflammatory Syndrome in Children in New York State

Dufort, E. M., Koumans, E. H. A., Chow, E. J., Rosenthal, E. M., Muse, A., Rowlands, J. V., Barranco, M. A., Maxted, A. M., Rosenberg, E. S., Easton, D. E., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2021756 · Cited by 1,353 · see citing works

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

Boulware, D. R., Pullen, M. F., Bangdiwala, A. S., Pastick, K. A., Lofgren, S. M., Okafor, E. C., Skipper, C. P., Nascene, A. A., Nicol, M. R., Abassi, M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2016638 · Cited by 1,320 · see citing works

Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

Zhou, Y., Fu, B., Zheng, X., Wang, D., Zhao, C., Qi, Y., Sun, R., Tian, Z., Xu, X., & Wei, H. (2020) · National Science Review · doi:10.1093/nsr/nwaa041 · Cited by 1,295 · see citing works

Tocilizumab treatment in COVID‐19: A single center experience

Luo, P., Liu, Y., Qiu, L., Liu, X., Liu, D., & Li, J. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25801 · Cited by 1,235 · see citing works

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

Bao, L., Deng, W., Huang, B., Gao, H., Liu, J., Ren, L., Wei, Q., Yu, P., Xu, Y., Qi, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2312-y · Cited by 1,126 · see citing works

Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia

Wang, F., Nie, J., Wang, H., Zhao, Q., Xiong, Y., Deng, L., Song, S., Ma, Z., Mo, P., & Zhang, Y. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa150 · Cited by 1,125 · see citing works

Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome

Arabi, Y. M., Mandourah, Y., Al-Hameed, F. M., Sindi, A., Almekhlafi, G. A., Hussein, M. A., Jose, J., Pinto, R. L., Al‐Omari, A., Kharaba, A. M., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201706-1172oc · Cited by 1,122 · see citing works

Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19

Cavalcanti, A. B., Zampieri, F. G., Rosa, R. G., Azevedo, L. C. P., Veiga, V. C., Avezum, Á., Damiani, L. P., Marcadenti, A., Kawano-Dourado, L. B., Lisboa, T. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2019014 · Cited by 1,082 · see citing works

Lung pathology of fatal severe acute respiratory syndrome

Nicholls, J. M., Poon, L. L., Lee, K. C., Ng, W. F., Lai, S. T., Leung, C. Y., Chu, C. M., Hui, P. K., Mak, K. L., Lim, W., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13413-7 · Cited by 1,076 · see citing works

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

Xiong, Y., Liu, Y., Cao, L., Wang, D., Guo, M., Jiang, A., Guo, D., Hu, W., Yang, J., Tang, Z., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1747363 · Cited by 1,076 · see citing works

Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study

Cavalli, G., Luca, G. D. D., Campochiaro, C., Della‐Torre, E., Ripa, M., Canetti, D., Oltolini, C., Castiglioni, B., Din, C. T., Boffini, N., et al. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30127-2 · Cited by 971 · see citing works

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

Zhou, Z. L., Ren, L., Zhang, L., Zhong, J., Xiao, Y., Jia, Z., Guo, L., Yang, J., Wang, C., Jiang, S., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.04.017 · Cited by 963 · see citing works

Temporal Changes of CT Findings in 90 Patients with COVID-19 Pneumonia: A Longitudinal Study

Wang, Y., Dong, C., Hu, Y., Li, C., Ren, Q., Zhang, X., Shi, H., & Zhou, M. (2020) · Radiology · doi:10.1148/radiol.2020200843 · Cited by 959 · see citing works

Tocilizumab in patients with severe COVID-19: a retrospective cohort study

Guaraldi, G., Meschiari, M., Cozzi-Lepri, A., Milic, J., Tonelli, R., Menozzi, M., Franceschini, E., Cuomo, G., Orlando, G., Borghi, V., et al. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30173-9 · Cited by 939 · see citing works

The BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19–infected patients

Treon, S. P., Castillo, J. J., Skarbnik, A. P. Z., Soumerai, J. D., Ghobrial, I. M., Guerrera, M. L., Meid, K., & Yang, G. (2020) · Blood · doi:10.1182/blood.2020006288 · Cited by 909 · see citing works

Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial*

Shakoory, B., Carcillo, J. A., Chatham, W. W., Amdur, R. L., Zhao, H., Dinarello, C. A., Cron, R. Q., & Opal, S. M. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001402 · Cited by 867 · see citing works

Abnormal pulmonary function in COVID-19 patients at time of hospital discharge

Mo, X., Jian, W., Su, Z., Chen, M., Peng, H., Peng, P., Lei, C., Chen, R., Zhong, N., & Li, S. (2020) · European Respiratory Journal · doi:10.1183/13993003.01217-2020 · Cited by 810 · see citing works

Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing

Wen, W., Su, W., Tang, H., Le, W., Zhang, X., Zheng, Y., Liu, X., Xie, L., Li, J., Ye, J., et al. (2020) · Cell Discovery · doi:10.1038/s41421-020-0168-9 · Cited by 730 · see citing works

Clinical characteristics of 82 cases of death from COVID-19

Zhang, B., Zhou, X., Qiu, Y., Feng, F., Feng, J., Feng, J., Zhu, H., Hu, K., JiaSheng, L., Liu, Z., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235458 · Cited by 688 · see citing works

Anakinra for severe forms of COVID-19: a cohort study

Huet, T., Beaussier, H., Voisin, O., Jouveshomme, S., Dauriat, G., Lazareth, I., Sacco, E., Naccache, J., Bézie, Y., Laplanche, S., et al. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30164-8 · Cited by 643 · see citing works

Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients

Lee, N. L. S., Chan, K. C. A., Hui, D. S. C., Ng, E. K. O., Wu, A. K., Chiu, R. W. K., Wong, V. W., Chan, P. K. S., Wong, K. T., Wong, E., et al. (2004) · Journal of Clinical Virology · doi:10.1016/j.jcv.2004.07.006 · Cited by 636 · see citing works

Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy

Teachey, D. T., Rheingold, S. R., Maude, S. L., Zugmaier, G., Barrett, D. M., Seif, A. E., Nichols, K. E., Suppa, E. K., Kalos, M., Berg, R. A., et al. (2013) · Blood · doi:10.1182/blood-2013-02-485623 · Cited by 613 · see citing works

Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data

Mahévas, M., Tran, V.-T., Roumier, M., Chabrol, A., Paule, R., Guillaud, C., Foïs, E., Lepeule, R., Szwebel, T., Lescure, F.-X., et al. (2020) · BMJ · doi:10.1136/bmj.m1844 · Cited by 566 · see citing works

Treatment with hydroxychloroquine, azithromycin, and combination in patients hospitalized with COVID-19

Arshad, S., Kilgore, P. E., Chaudhry, Z., Jacobsen, G., Wang, D. D., Huitsing, K., Brar, I., Alangaden, G. J., Ramesh, M. S., McKinnon, J. E., et al. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.06.099 · Cited by 543 · see citing works

Ibrutinib for chronic graft-versus-host disease after failure of prior therapy

Miklos, D. B., Cutler, C. S., Arora, M., Waller, E. K., Jagasia, M., Pusic, I., Flowers, M. E. D., Logan, A. C., Nakamura, R., Blazar, B. R., et al. (2017) · Blood · doi:10.1182/blood-2017-07-793786 · Cited by 520 · see citing works

Tocilizumab for Treatment of Mechanically Ventilated Patients With COVID-19

Somers, E. C., Eschenauer, G. A., Troost, J. P., Golob, J. L., Gandhi, T. N., Wang, L., Zhou, N., Petty, L. A., Baang, J. H., Dillman, N. O., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa954 · Cited by 495 · see citing works

Histopathologic Changes and SARS-CoV-2 Immunostaining in the Lung of a Patient With COVID-19

Zhang, H., Zhou, P., Wei, Y., Yue, H., Wang, Y., Hu, M., Zhang, S., Cao, T., Yang, H., Li, M., et al. (2020) · Annals of Internal Medicine · doi:10.7326/m20-0533 · Cited by 474 · see citing works

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

Ito, M., Shichita, T., Okada, M., Komine, R., Noguchi, Y., Yoshimura, A., & Morita, R. (2015) · Nature Communications · doi:10.1038/ncomms8360 · Cited by 417 · see citing works

Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children

Lee, P. Y., Day‐Lewis, M., Henderson, L. A., Friedman, K. G., Lo, J., Roberts, J. E., Lo, M. S., Platt, C. D., Chou, J. S., Hoyt, K. J., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci141113 · Cited by 391 · see citing works

The Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Directly Decimates Human Spleens and Lymph NodesPreprint

Feng, Z., Diao, B., Wang, R., Wang, G., Wang, C., Tan, Y., Liu, L., Wang, C., Liu, Y., Liu, Y., et al. (2020) · medRxiv · doi:10.1101/2020.03.27.20045427 · Cited by 369 · see citing works

Expression of elevated levels of pro‐inflammatory cytokines in SARS‐CoV‐infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS

He, L., Ding, Y., Zhang, Q., Che, X., He, Y., Shen, H., Wang, H., Li, Z., Zhao, L., Geng, J., et al. (2006) · The Journal of Pathology · doi:10.1002/path.2067 · Cited by 365 · see citing works

Inhibition of Bruton tyrosine kinase in patients with severe COVID-19

Roschewski, M. J., Lionakis, M. S., Sharman, J. P., Roswarski, J., Goy, A. H., Monticelli, M. A., Roshon, M. J., Wrzesinski, S. H., Desai, J. V., Zarakas, M. A., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abd0110 · Cited by 350 · see citing works

Neutrophil Extracellular Traps in Pulmonary Diseases: Too Much of a Good Thing?

Porto, B. N., & Stein, R. T. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00311 · Cited by 317 · see citing works

Pilot prospective open, single-arm multicentre study on off-label use of tocilizumab in patients with severe COVID-19.

Sciascia, S., Aprà, F., Baffa, A., Baldovino, S., Boaro, D., Boero, R., Bonora, S., Calcagno, A., Cecchi, I., Cinnirella, G., et al. (2020) · PubMed · Cited by 303 · see citing works

Hydroxychloroquine for Early Treatment of Adults With Mild Coronavirus Disease 2019: A Randomized, Controlled Trial

Mitjà, O., Corbacho‐Monné, M., Ubals, M., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1009 · Cited by 291 · see citing works

A Dynamic Immune Response Shapes COVID-19 Progression

Ong, E. Z., Chan, Y. F. Z., Leong, W. Y., Lee, N. M. Y., Kalimuddin, S., Mohideen, S. M. H., Chan, K. S., Tan, A. T., Bertoletti, A., Ooi, E. E., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.03.021 · Cited by 290 · see citing works

Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients

Wang, N., Zhan, Y., Zhu, L., Hou, Z., Liu, F., Song, P., Qiu, F., Wang, X., Zou, X., Wan, D., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.07.005 · Cited by 290 · see citing works

Silencing the cytokine storm: the use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome

Mehta, P., Cron, R. Q., Hartwell, J., Manson, J. J., & Tattersall, R. S. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30096-5 · Cited by 287 · see citing works

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

Chen, X., Yang, X., Zheng, Y., Yang, Y., Xing, Y., & Chen, Z. (2014) · Protein & Cell · doi:10.1007/s13238-014-0026-3 · Cited by 275 · see citing works

Inhibition of Natural Killer Cell Cytotoxicity by Interleukin‐6: Implications for the Pathogenesis of Macrophage Activation Syndrome

Cifaldi, L., Prencipe, G., Caiello, I., Bracaglia, C., Locatelli, F., Benedetti, F. D., & Strippoli, R. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39295 · Cited by 267 · see citing works

Clinical characteristics of 82 death cases with COVID-19Preprint

Zhang, B., Zhou, X., Qiu, Y., et al. (2020) · medRxiv · doi:10.1101/2020.02.26.20028191 · Cited by 249 · see citing works

Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trialPreprint

Horby, P., Mafham, M. M., Linsell, L., et al. (2020) · medRxiv · doi:10.1101/2020.07.15.20151852 · Cited by 247 · see citing works

Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19

Yap, J. K. Y., Moriyama, M., & Iwasaki, A. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000513 · Cited by 245 · see citing works

The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?

McKechnie, J. L., & Blish, C. A. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.05.009 · Cited by 218 · see citing works

MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV

Sheahan, T. P., Morrison, T. E., Funkhouser, W., Uematsu, S., Akira, S., Baric, R. S., & Heise, M. T. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000240 · Cited by 207 · see citing works

Cell Pyroptosis, a Potential Pathogenic Mechanism of 2019-nCoV InfectionPreprint

Yang, M. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3527420 · Cited by 207 · see citing works

Disruption of in vivo Chronic Lymphocytic Leukemia Tumor–Microenvironment Interactions by Ibrutinib – Findings from an Investigator-Initiated Phase II Study

Niemann, C. U., Herman, S. E. M., Marić, I., Gómez‐Rodríguez, J., Biancotto, A., Chang, B. Y., Martyr, S. E., Stetler‐Stevenson, M., Yuan, C. M., Calvo, K. R., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1965 · Cited by 205 · see citing works

Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm

Guo, C., Li, B., Ma, H., Wang, X., Cai, P., Yu, Q., Zhu, L., Jin, L., Jiang, C., Fang, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17834-w · Cited by 199 · see citing works

The structure of rotational bands in alpha-cluster nuclei

Bijker, R. (2015) · EPJ Web of Conferences · doi:10.1051/epjconf/20159301011 · Cited by 184 · see citing works

Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experiencePreprint

Bryce, C., Grimes, Z., Pujadas, E., et al. (2020) · medRxiv · doi:10.1101/2020.05.18.20099960 · Cited by 179 · see citing works

Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets

Yang, Y., Ye, F., Zhu, N., Wang, W., Deng, Y. L., Zhao, Z., & Tan, W. (2015) · Scientific Reports · doi:10.1038/srep17554 · Cited by 132 · see citing works

Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

Lui, P., Wong, L.-Y. R., Fung, C.-L., Siu, K., Yeung, M. L., Yuen, K., Chan, C., Woo, P. C. Y., Yuen, K., & Jin, D. (2016) · Emerging Microbes & Infections · doi:10.1038/emi.2016.33 · Cited by 131 · see citing works

Tocilizumab for treatment of mechanically ventilated patients with COVID-19Preprint

Somers, E. C., Eschenauer, G. A., Troost, J. P., et al. (2020) · medRxiv · doi:10.1101/2020.05.29.20117358 · Cited by 129 · see citing works

Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions reveal

Fantini, J., Chahinian, H., & Yahi, N. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.106020 · Cited by 117 · see citing works

Alveolar Epithelial Cells Are Critical in Protection of the Respiratory Tract by Secretion of Factors Able To Modulate the Activity of Pulmonary Macrophages and Directly Control Bacterial Growth

Chuquimia, O. D., Petursdottír, D. H., Períolo, N., & Fernández, C. (2012) · Infection and Immunity · doi:10.1128/iai.00950-12 · Cited by 102 · see citing works

Innate Immune Responses to Bacterial Ligands in the Peripheral Human Lung – Role of Alveolar Epithelial TLR Expression and Signalling

Thorley, A. J., Grandolfo, D., Lim, E. K. S., Goldstraw, P. G., Young, A., & Tetley, T. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021827 · Cited by 94 · see citing works

Inhibiting Bruton’s tyrosine kinase rescues mice from lethal influenza-induced acute lung injury

Florence, J., Krupa, A., Booshehri, L. M., Davis, S. A., Matthay, M. A., & Kurdowska, A. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00047.2018 · Cited by 91 · see citing works

Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose

Carlin, L. E., Hemann, E. A., Zacharias, Z. R., Heusel, J. W., & Legge, K. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00781 · Cited by 90 · see citing works

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

Bittner, Z., Liu, X., Tortola, M. M., Tapia‐Abellán, A., Shankar, S., Andreeva, L., Mangan, M., Spalinger, M. R., Kalbacher, H., Duewell, P., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201656 · Cited by 82 · see citing works

CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II

Pechkovsky, D. V., Goldmann, T., Ludwig, C., et al. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-75 · Cited by 49 · see citing works

Early Insights into Immune Responses during COVID-19

John, A. L. S., & Rathore, A. P. S. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000526 · Cited by 48 · see citing works

TNFR2/BIRC3-TRAF1 signaling pathway as a novel NK cell immune checkpoint in cancer

Ivagnès, A., Messaoudene, M., Stoll, G., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1386826 · Cited by 41 · see citing works

Bruton's tyrosine kinase regulates TLR7/8-induced TNF transcription via nuclear factor-κB recruitment

Page, T. H., Urbaniak, A., Santo, A. I. E., Danks, L., Smallie, T., Williams, L. M., & Horwood, N. J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.140 · Cited by 31 · see citing works

CXCL13 levels are elevated in patients with Waldenström macroglobulinemia, and are predictive of major response to ibrutinib

Vos, J. M. I., Tsakmaklis, N., Patterson, C. J., et al. (2017) · Haematologica · doi:10.3324/haematol.2017.172627 · Cited by 24 · see citing works

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activityPreprint

Bittner, Z., Liu, X., Shankar, S., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/864702 · Cited by 16 · see citing works

Massive viral replication and cytopathic effects in early COVID-19 pneumoniaPreprint

Schifanella, L., Anderson, J. L., Galli, M., et al. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2005.00004 · Cited by 7 · see citing works

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

D’Agnillo, F., Walters, K.-A., Xiao, Y., Sheng, Z.-M., Scherler, K., Park, J., Gygli, S., Rosas, L. A., Sadtler, K., Kalish, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7790 · Cited by 237 · see citing works

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Georg, P., Astaburuaga-García, R., Bonaguro, L., Brumhard, S., Michalick, L., Lippert, L. J., Kostevc, T., Gäbel, C., Schneider, M., Streitz, M., et al. (2022) · Cell · doi:10.1016/j.cell.2021.12.040 · Cited by 218 · see citing works

Особенности сахароснижающей фармакотерапии у пациентов с SARS-CoV-2 (COVID-19)

Кухнина, Л. С., Сахарова, К. В., & Elina, D. (2021) · ТЕНДЕНЦИИ РАЗВИТИЯ НАУКИ И ОБРАЗОВАНИЯ · doi:10.18411/lj-04-2021-51

ОПЫТ ИССЛЕДОВАНИЯ СЕРОПРЕВАЛЕНТНОСТИ К ВИРУСУ SARS-CoV-2 НАСЕЛЕНИЯ ИРКУТСКОЙ ОБЛАСТИ В ПЕРИОД ВСПЫШКИ COVID-19Preprint

Popova, A. Y., Ezhlova, E. B., Melnikova, A. A., Балахонов, С. В., Chesnokova, M. V., Dubrovina, V. I., Лялина, Л., Смирнов, В. С., Ag, T., Николаевич, П. А., et al. (2020) · doi:10.21055/preprints-3111809 · Cited by 2 · see citing works

Chilblain‐like lesions after BNT162b2 mRNA COVID‐19 vaccine: a case report suggesting that ‘COVID toes’ are due to the immune reaction to SARS‐CoV‐2

Lesort, C., Kanitakis, J., Donzier, L., et al. (2021) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.17451 · Cited by 25 · see citing works

Спонтанний пневмоторакс у хворих на нову коронавірусну хворобу SARS-CoV-2 COVID-19

Горолюк, А. Ю. (2022) · Шпитальна хірургія Журнал імені Л Я Ковальчука · doi:10.11603/2414-4533.2022.1.12929

The Covid‐19 Pandemic Highlights Key Roles for Economists La pandémie de Covid‐19 met en évidence les rôles importants des économistes Die Covid‐19‐Pandemie unterstreicht die Schlüsselrolle von Ökonominnen und Ökonomen

Davis, J. S. (2020) · EuroChoices