Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884

Clinical characteristics of coronavirus disease 2019 in China

Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263

Epidemiological and clinical characteristics of 99 cases of 2019 novel Coronavirus pneumonia in Wuhan, China: a descriptive study.

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415

COVID-19: consider cytokine storm syndromes and immunosuppression

Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., & Manson, J. J. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30628-0 · Cited by 9,664

Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area

Richardson, S., Hirsch, J. S., Narasimhan, M., Crawford, J. M., McGinn, T., Davidson, K. W., and the Northwell COVID-19 Research Consortium, Barnaby, D. P., Becker, L. B., Chelico, J. D., et al. (2020) · JAMA · doi:10.1001/jama.2020.6775 · Cited by 9,254

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30076-x · Cited by 8,545

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

Wu, C., Chen, X., Cai, Y., Xia, J., Zhou, X., Xu, S., Huang, H., Zhang, L., Zhou, X., Du, C., et al. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.0994 · Cited by 8,249

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

Hamming, I., Timens, W., Bulthuis, M., Lely, A., Navis, G., & van Goor, H. (2004) · The Journal of Pathology · doi:10.1002/path.1570 · Cited by 5,676

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

Ruan, Q., Yang, K., Wang, W., Jiang, L., & Song, J. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05991-x · Cited by 4,898

Visceral fat shows the strongest association with the need of intensive care in patients with COVID-19

Watanabe, M., Caruso, D., Tuccinardi, D., Risi, R., Zerunian, M., Polici, M., Pucciarelli, F., Tarallo, M., Strigari, L., Manfrini, S., et al. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154319 · Cited by 204

A single-cell transcriptomic landscape of the lungs of patients with COVID-19

Wang, S., Yao, X., Ma, S., Ping, Y., Fan, Y., Sun, S., He, Z., Shi, Y., Sun, L., Xiao, S., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00796-6 · Cited by 195

Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia

Gibellini, L., Biasi, S. D., Paolini, A., Borella, R., Boraldi, F., Mattioli, M., Tartaro, D. L., Fidanza, L., Caro‐Maldonado, A., Meschiari, M., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202013001 · Cited by 200

Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19

Alon, R., Sportiello, M., Kozlovski, S., Kumar, A., Reilly, E. C., Zarbock, A., Garbi, N., & Topham, D. J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00470-2 · Cited by 197

Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases

Carsetti, R., Zaffina, S., Mortari, E. P., Terreri, S., Corrente, F., Capponi, C., Palomba, P., Mirabella, M., Cascioli, S., Palange, P., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.610300 · Cited by 201

Fungal co-infection in COVID-19 patients: Should we be concerned?

Pemán, J., Gaitán, A. C. R., García‐Vidal, C., Salavert, M., Ramírez, P., Gimeno, F. P., García-Hita, M., Alastruey‐Izquierdo, A., & Quindós, G. (2020) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2020.07.001 · Cited by 193

Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19

Shaath, H., Vishnubalaji, R., Elkord, E., & Alajez, N. M. (2020) · Cells · doi:10.3390/cells9112374 · Cited by 192

Activation or exhaustion of CD8+ T cells in patients with COVID-19

Rha, M., & Shin, E. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00750-4 · Cited by 201

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

Xia, B., Shen, X.-R., He, Y., Pan, X., Liu, F., Wang, Y., Yang, F., Fang, S., Wu, Y. L., Duan, Z., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00519-4 · Cited by 197

Monocytes and Macrophages, Targets of Severe Acute Respiratory Syndrome Coronavirus 2: The Clue for Coronavirus Disease 2019 Immunoparalysis

Boumaza, A. F., Gay, L., Mezouar, S., Bestion, E., Diallo, A. B., Michel, M., Desnues, B., Raoult, D., Scola, B. L., Halfon, P., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab044 · Cited by 200

The pulmonary pathology of COVID-19

Bösmüller, H., Matter, M., Fend, F., & Tzankov, A. (2021) · Virchows Archiv · doi:10.1007/s00428-021-03053-1 · Cited by 180

Alzheimer's‐like signaling in brains of COVID‐19 patients

Reiken, S. R., Sittenfeld, L. R., Dridi, H., Yang, L., Liu, X., & Marks, A. R. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12558 · Cited by 190

T Cell Responses to SARS-CoV-2

Sette, A., Sidney, J., & Crotty, S. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101721-061120 · Cited by 191

Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses

Mackman, N., Antoniak, S., Wolberg, A. S., Kasthuri, R. S., & Key, N. S. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314514 · Cited by 190

Dexamethasone nanomedicines for COVID-19

Lammers, T., Sofias, A. M., van der Meel, R., Schiffelers, R. M., Storm, G., Tacke, F., Koschmieder, S., Brümmendorf, T. H., Kiessling, F. M., & Metselaar, J. M. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0752-z · Cited by 186

T Cells: Warriors of SARS-CoV-2 Infection

de Candia, P., Prattichizzo, F., Garavelli, S., & Matarese, G. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.11.002 · Cited by 189

Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19

Bernard, I., Limonta, D., Mahal, L. K., & Hobman, T. C. (2020) · Viruses · doi:10.3390/v13010029 · Cited by 187

Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions

Wang, B., Zhang, L., Wang, Y., Dai, T., Qin, Z., Zhou, F., & Zhang, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00986-0 · Cited by 187

A review of cytokine-based pathophysiology of Long COVID symptoms

Low, R. N., Low, R. J., & Akrami, A. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1011936 · Cited by 205

COVID-19 and Respiratory System Disorders

Brosnahan, S. B., Jonkman, A. H., Kugler, M. C., Munger, J. S., & Kaufman, D. A. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314515 · Cited by 182

Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly

Pereira, B. I., Xu, X., & Akbar, A. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583019 · Cited by 190

Of Mice and Men: The Coronavirus MHV and Mouse Models as a Translational Approach to Understand SARS-CoV-2

Körner, R. W., Majjouti, M., Alcazar, M. A. A., & Mahabir, E. (2020) · Viruses · doi:10.3390/v12080880 · Cited by 184

Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome

Sukocheva, O. A., Maksoud, R., Beeraka, N. M., Madhunapantula, S. V., Sinelnikov, M. Y., Nikolenko, V. N., Неганова, М. Е., Klochkov, S. G., Kamal, M. A., Staines, D., et al. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.11.013 · Cited by 182

JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy

Satarker, S., Tom, A. A., Shaji, R. A., Alosious, A., Luvis, M., & Nampoothiri, M. (2020) · Postgraduate Medicine · doi:10.1080/00325481.2020.1855921 · Cited by 171

Novel Systemic Inflammation Markers to Predict COVID-19 Prognosis

Karimi, A., Shobeiri, P., Kulasinghe, A., & Rezaei, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.741061 · Cited by 171

Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases

Bleve, A., Motta, F., Durante, B., Pandolfo, C., Selmi, C., & Sica, A. (2022) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08909-7 · Cited by 185

COVAN is the new HIVAN: the re-emergence of collapsing glomerulopathy with COVID-19

Velez, J. C. Q., Caza, T. N., & Larsen, C. P. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-0332-3 · Cited by 168

Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection

Li, F., Piattini, F., Pohlmeier, L. M., Feng, Q., Rehrauer, H., & Köpf, M. (2022) · Science Immunology · doi:10.1126/sciimmunol.abj5761 · Cited by 160

Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs

Xie, Y., Meijer, A. H., & Schaaf, M. J. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.620984 · Cited by 164

Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19

Theobald, S. J., Simonis, A., Georgomanolis, T., Kreer, C., Zehner, M., Eisfeld, H. S., Albert, M., Chhen, J., Motameny, S., Erger, F., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114150 · Cited by 172

Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions

Bunders, M. J., & Altfeld, M. A. (2020) · Immunity · doi:10.1016/j.immuni.2020.08.003 · Cited by 167

Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration

Chen, R., Lan, Z., Ye, J., Pang, L., Liu, Y., Wu, W., Qin, X., Guo, Y., & Zhang, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.589095 · Cited by 165

Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection

Smith, N., Gonçalves, P., Charbit, B., Grzelak, L., Beretta, M., Planchais, C., Bruel, T., Rouilly, V., Bondet, V., Hadjadj, J., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01028-7 · Cited by 161

High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study

Schroeder, M. L., Schaumburg, B., Müller, Z., Parplys, A. C., Jarczak, D., Nierhaus, A., Kloetgen, A., Schneider, B., Peschka, M., Stoll, F., et al. (2021) · Emerging Microbes & Infections · doi:10.1080/22221751.2021.1969869 · Cited by 164

The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

Zhao, N., Di, B., & Xu, L. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.06.002 · Cited by 161

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

Beltrán-García, J., Osca-Verdegal, R., Pallardó, F. V., Ferreres, J., Rodríguez, M. D. P., Mulet, S., Sanchis‐Gomar, F., Carbonell, N., & García‐Giménez, J. L. (2020) · Antioxidants · doi:10.3390/antiox9100936 · Cited by 162

COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Barrier Relevance

Achar, A., & Ghosh, C. (2020) · Cells · doi:10.3390/cells9112360 · Cited by 160

Fungal and bacterial coinfections increase mortality of severely ill COVID-19 patients

da Silva, D. L., Lima, C. M., Magalhães, V. C. R., Baltazar, L. M., Peres, N. T. A., Caligiorne, R. B., Moura, A. S., Fereguetti, T., Martins, J. C., Rabelo, L. F., et al. (2021) · Journal of Hospital Infection · doi:10.1016/j.jhin.2021.04.001 · Cited by 161

Emerging Technologies for Use in the Study, Diagnosis, and Treatment of Patients with COVID-19

Tsikala Vafea, M., Atalla, E., Georgakas, J., Shehadeh, F., Mylona, E. K., Kalligeros, M., & Mylonakis, E. (2020) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-020-00629-w · Cited by 153

Severe Acute Respiratory Syndrome Coronavirus 2–Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells

Zheng, J. H., Wang, Y., Li, K., Meyerholz, D. K., Allamargot, C., & Perlman, S. M. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa753 · Cited by 165

Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection

Zhu, B., Wu, Y., Huang, S., Zhang, R., Son, Y. M., Li, C., Cheon, I. S., Gao, X., Wang, M., Yao, C., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.001 · Cited by 153

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

Qiao, L., Liu, J., Zhao, S., Castro, M. F. G., Laurent-Rolle, M., Dong, J., Ran, X., Damani‐Yokota, P., Tang, H., Karakousi, T. R., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.006 · Cited by 156

Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages

Lv, J., Wang, Z., Qu, Y., Zhu, H., Zhu, Q., Tong, W., Bao, L., Lv, Q., Cong, J., Li, D., et al. (2021) · Cell Discovery · doi:10.1038/s41421-021-00258-1 · Cited by 156

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

Stravalaci, M., Pagani, I., Paraboschi, E. M., Pedotti, M., Doni, A., Scavello, F., Mapelli, S. N., Sironi, M., Perucchini, C., Varani, L., et al. (2022) · Nature Immunology · doi:10.1038/s41590-021-01114-w · Cited by 161

Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19

Brunetta, E., Folci, M., Bottazzi, B., Santis, M. D., Gritti, G., Protti, A., Mapelli, S. N., Bonovas, S., Piovani, D., Leone, R., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-00832-x · Cited by 156

Pathogenesis of Respiratory Viral and Fungal Coinfections

Salazar, F., Bignell, E., Brown, G. D., Cook, P. C., & Warris, A. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00094-21 · Cited by 164

COVID-19 and cellular senescence

Schmitt, C. A., Tchkonia, T., Niedernhofer, L. J., Robbins, P. D., Kirkland, J. L., & Lee, S. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00785-2 · Cited by 153

Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies

Market, M., Angka, L., Martel, A. B., Bastin, D. J., Olanubi, O., Tennakoon, G., Boucher, D. M., Ng, J., Ardolino, M., & Auer, R. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01512 · Cited by 158

Anti-inflammatory therapy for COVID-19 infection: the case for colchicine

Reyes, A. Z., Hu, K. A., Teperman, J., Muskardin, T. W., Tardif, J., Shah, B., & Pillinger, M. H. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2020-219174 · Cited by 161

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

Mullen, P. J., Garcia, G., Purkayastha, A., Matulionis, N., Schmid, E. W., Momcilovic, M., Sen, C., Langerman, J., Ramaiah, A., Shackelford, D. B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22166-4 · Cited by 149

Monocytes and macrophages in COVID-19: Friends and foes

Meidaninikjeh, S., Sabouni, N., Marzouni, H. Z., Bengar, S., Khalili, A., & Jafari, R. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.119010 · Cited by 156

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Karagiannis, F., Peukert, K., Surace, L., Michla, M., Nikolka, F., Fox, M., Weiss, P., Feuerborn, C., Maier, P., Schulz, S., et al. (2022) · Nature · doi:10.1038/s41586-022-05128-8 · Cited by 152

Effect of COVID-19 on the Organs

Jain, U. (2020) · Cureus · doi:10.7759/cureus.9540 · Cited by 165

Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19

Caterino, M., Gelzo, M., Sol, S., Fedele, R., Annunziata, A., Calabrese, C., Fiorentino, G., D’Abbraccio, M., Dell’Isola, C., Fusco, F. M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-82426-7 · Cited by 150

The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review

James, P. T., Ali, Z., Armitage, A. E., Bonell, A., Cerami, C., Drakesmith, H., Jobe, M., Jones, K. S., Liew, Z., Moore, S. E., et al. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab059 · Cited by 147

SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8

Salvi, V., Nguyen, H. O., Sozio, F., Schioppa, T., Gaudenzi, C., Laffranchi, M., Scapini, P., Passari, M., Barbazza, I., Tiberio, L., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.150542 · Cited by 153

The human genetic epidemiology of COVID-19

Niemi, M., Daly, M. J., & Ganna, A. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00478-5 · Cited by 147

Signaling pathways in macrophages: molecular mechanisms and therapeutic targets

Li, M., Wang, M., Wen, Y., Zhang, H., Zhao, G., & Gao, Q. (2023) · MedComm · doi:10.1002/mco2.349 · Cited by 165

Covid-19: Perspectives on Innate Immune Evasion

Taefehshokr, N., Taefehshokr, S., Hemmat, N., & Heit, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.580641 · Cited by 152

A cohort autopsy study defines COVID-19 systemic pathogenesis

Yao, X.-H., Luo, T., Shi, Y., He, Z.-C., Tang, R., Zhang, P.-P., Cai, J., Zhou, X.-D., Jiang, D., Fei, X., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00523-8 · Cited by 148

Genetic architecture of host proteins involved in SARS-CoV-2 infection

Pietzner, M., Wheeler, E., Carrasco-Zanini, J., Raffler, J., Kerrison, N. D., Oerton, E., Auyeung, V. P. W., Luan, J., Finan, C., Casas, J. P., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19996-z · Cited by 147

A tertiary center experience of multiple myeloma patients with COVID-19: lessons learned and the path forward

Wang, B., Oekelen, O. V., Mouhieddine, T. H., Valle, D. M. D., Richter, J. R., Cho, H. J., Richard, S., Chari, A., Gnjatic, S., Mérad, M., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00934-x · Cited by 147

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

Keyhanian, K., Umeton, R. P., Mohit, B., Davoudi, V., Hajighasemi, F., & Ghasemi, M. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577436 · Cited by 148

Cell-Type-Specific Immune Dysregulation in Severely Ill COVID-19 Patients

Yao, C., Bora, S. A., Parimon, T., Zaman, T., Friedman, O., Palatinus, J. A., Surapaneni, N. S., Matusov, Y. P., Chiang, G. C., Kassar, A. G., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108590 · Cited by 145

Dysregulation of immune response in PCOS organ system

Wang, J., Yin, T., & Liu, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1169232 · Cited by 157

A distinct innate immune signature marks progression from mild to severe COVID-19

Chevrier, S., Zurbuchen, Y., Cervia, C., Adamo, S., Raeber, M. E., de Souza, N., Sivapatham, S., Jacobs, A., Bächli, E., Rudiger, A., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100166 · Cited by 136

Update Advances on C-Reactive Protein in COVID-19 and Other Viral Infections

Luan, Y., Yin, C., & Yao, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720363 · Cited by 150

The Role of Cytokines and Chemokines in Severe Acute Respiratory Syndrome Coronavirus 2 Infections

Hsu, R., Yu, W.-C., Peng, G.-R., Ye, C.-H., Hu, S., Chong, P. C. T., Yap, K. Y., Lee, J. Y. C., Lin, W., & Yu, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.832394 · Cited by 148

Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID

Woodruff, M. C., Bonham, K. S., Anam, F. A., Walker, T. A., Faliti, C. E., Ishii, Y., Kaminski, C. Y., Runnstrom, M. C., Cooper, K. R., Truong, A. D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40012-7 · Cited by 138

Azithromycin: The First Broad-spectrum Therapeutic

Firth, A., & Prathapan, P. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112739 · Cited by 147

The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved

Coperchini, F., Chiovato, L., Ricci, G., Croce, L., Magri, F., & Rotondi, M. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.12.005 · Cited by 135

Diabetes, obesity, and insulin resistance in COVID-19: molecular interrelationship and therapeutic implications

Santos, A., Magro, D. O., Poderoso, R. E., & Saad, M. J. A. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-021-00639-2 · Cited by 143

Cell‐Based Delivery Systems: Emerging Carriers for Immunotherapy

Li, Z., Wang, Y., Ding, Y., Repp, L., Kwon, G. S., & Hu, Q. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100088 · Cited by 138

Two Years into the COVID-19 Pandemic: Lessons Learned

da Silva, S. J. R., do Nascimento, J. C. F., Mendes, R. P. G., Guarines, K. M., da Silva, C. T. A., da Silva, P. G., de Magalhães, J. J. F., Vigar, J. R. J., Silva‐Júnior, A., Kohl, A., et al. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00204 · Cited by 155

Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages

Anil, S. M., Shalev, N., Vinayaka, A. C., Nadarajan, S., Namdar, D., Belausov, E., Shoval, I., Mani, K. A., Mechrez, G., & Koltai, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-81049-2 · Cited by 135

Endothelial cells are not productively infected by SARS‐CoV‐2

Schimmel, L., Chew, K. Y., Stocks, C. J., Yordanov, T. E., Essebier, P., Kulasinghe, A., Monkman, J. H., Miggiolaro, A. F. R. D. S., Cooper, C. L., de Noronha, L., et al. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1350 · Cited by 136

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Cardona-Ospina, J. A., Arteaga‐Livias, K., Villamil‐Gómez, W. E., Díaz, C. E. P., Bonilla‐Aldana, D. K., Mondragón-Cardona, Á. E., Solarte-Portilla, M. A., Martínez, E., Oñate, J., López‐Medina, E., et al. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26194 · Cited by 134

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Gauthier, T., & Chen, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.780839 · Cited by 137

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Corley, M. J., Pang, A. P. S., Dody, K., Mudd, P. A., Patterson, B. K., Seethamraju, H., Bram, Y., Peluso, M. J., Torres, L., Iyer, N. S., et al. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.5hi0720-466r · Cited by 136

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Michalski, J. E., Kurche, J. S., & Schwartz, D. A. (2021) · Translational research · doi:10.1016/j.trsl.2021.09.001 · Cited by 139

Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity

Chakraborty, S., González, J. C., Sievers, B. L., Mallajosyula, V. V. A., Chakraborty, S., Dubey, M., Ashraf, U., Cheng, B. Y.-L., Kathale, N. D., Tran, K. Q. T., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm7853 · Cited by 137

Immunological co-ordination between gut and lungs in SARS-CoV-2 infection

Ahlawat, S., Asha, A., & Sharma, K. K. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198103 · Cited by 137

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Juybari, K. B., Pourhanifeh, M. H., Hosseinzadeh, A., Hemati, K., & Mehrzadi, S. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198108 · Cited by 130

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Kvedaraite, E., Hertwig, L., Sinha, I., Ponzetta, A., Myrberg, I. H., Lourda, M., Dzidic, M., Akber, M., Klingström, J., Folkesson, E., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2018587118 · Cited by 128

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Katneni, U., Alexaki, A., Hunt, R., Schiller, T., DiCuccio, M. N., Buehler, P. W., Ibla, J. C., & Kimchi‐Sarfaty, C. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1715841 · Cited by 132

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Milne, G., Hames, T., Scotton, C. J., Gent, N., Johnsen, A., Anderson, R. M., & Ward, T. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00407-0 · Cited by 123

Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice

Zeng, J., Xie, X., Feng, X., Xu, L., Han, J.-B., Yu, D., Zou, Q., Liu, Q., Li, X., Ma, G., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103803 · Cited by 130

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Pathania, A. S., Prathipati, P., Abdul, B. A., Chava, S. P., Katta, S. S., Gupta, S. C., Gangula, P. R., Pandey, M. K., Durden, D. L., Byrareddy, S. N., et al. (2020) · Theranostics · doi:10.7150/thno.51471 · Cited by 131

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Pfortmueller, C. A., Spinetti, T., Urman, R. D., Luedi, M. M., & Schefold, J. C. (2020) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2020.12.011 · Cited by 135

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Ahmed, S., Zimba, O., & Gasparyan, A. Y. (2021) · Clinical Rheumatology · doi:10.1007/s10067-021-05691-x · Cited by 131

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Mendiola, A. S., Yan, Z., Dixit, K., Johnson, J. R., Bouhaddou, M., Meyer-Franke, A., Shin, M.-G., Yong, Y., Agrawal, A., MacDonald, E., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01522-0 · Cited by 124

Application of methylene blue -vitamin C –N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trial

Alamdari, D. H., Moghaddam, A. B., Amini, S., Keramati, M. R., Zarmehri, A. M., Alamdari, A. H., Damsaz, M., Banpour, H., Yarahmadi, A., & Koliakos, G. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173494 · Cited by 120

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Reizine, F., Lesouhaitier, M., Grégoire, M., Pinceaux, K., Gacouin, A., Maamar, A., Painvin, B., Camus, C., Tulzo, Y. L., Tattevin, P., et al. (2021) · Journal of Clinical Immunology · doi:10.1007/s10875-020-00920-5 · Cited by 121

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Klaourakis, K., Vieira, J. M., & Riley, P. R. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00489-x · Cited by 122

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Patra, R., Das, N. C., & Mukherjee, S. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26387 · Cited by 120

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Krishnan, S., Nordqvist, H., Ambikan, A. T., Gupta, S., Sperk, M., Akusjärvi, S. S., Mikaeloff, F., Benfeitas, R., Saccon, E., Ponnan, S. M., et al. (2021) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2021.100159 · Cited by 112

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Simmons, D. P., Nguyen, H., Gomez-Rivas, E., Jeong, Y., Jonsson, A. H., Chen, A. F., Lange, J. K., Dyer, G. S. M., BLAZAR, P. E., Earp, B. E., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abf2846 · Cited by 118

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Ho, J., Mok, B. W.-Y., Campisi, L., Jordan, T. X., Yildiz, S., Parameswaran, S., Wayman, J. A., Gaudreault, N. N., Meekins, D. A., Indran, S. V., et al. (2021) · Cell · doi:10.1016/j.cell.2021.03.051 · Cited by 121

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Guimond, S. E., Mycroft‐West, C. J., Gandhi, N. S., Tree, J. A., Le, T. T., Spalluto, C. M., Humbert, M. V., Buttigieg, K. R., Coombes, N. S., Elmore, M. J., et al. (2022) · ACS Central Science · doi:10.1021/acscentsci.1c01293 · Cited by 120

Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity

Falck‐Jones, S., Vangeti, S., Yu, M., Falck‐Jones, R., Cagigi, A., Badolati, I., Österberg, B., Lautenbach, M. J., Åhlberg, E., Lin, A., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144734 · Cited by 116

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Meidaninikjeh, S., Sabouni, N., Marzouni, H. Z., Bengar, S., Khalili, A., & Jafari, R. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.119010 · Cited by 156

Targeting Mononuclear Phagocytes to Treat COVID-19

Pence, B. D., & Cory, T. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.98967

Immunopathology of Hyperinflammation in COVID-19

Gustine, J. N., & Jones, D. (2021) · The American Journal of Pathology · doi:10.1016/j.ajpath.2020.08.009 · Cited by 516

Monocytes and Macrophages in COVID-19

Knoll, R., Schultze, J. L., & Schulte-Schrepping, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720109 · Cited by 279

Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation

Lu, S., Zhao, J., Dong, J., Liu, H., Zhu, Y., Li, H., Liu, L., Yang, Y., Sun, S., Song, Y., et al. (2020) · Cell Research · doi:10.1038/s41422-020-00414-4 · Cited by 13