The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
Open accessAbstract
T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T cells and assess their association with COVID-19 disease severity and vaccine responses. Recent studies have shown T cell reactivity to SARS-CoV-2 in 20–50% of unexposed individuals; it is speculated that this is due to T cell memory to common cold coronaviruses. Here, Crotty and Sette discuss the potential implications of these findings for disease severity, herd immunity and vaccine development.
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Cites
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
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SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
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Cited by
Adaptive immunity to SARS-CoV-2 and COVID-19
Sette, A., & Crotty, S. (2021) · Cell · doi:10.1016/j.cell.2021.01.007 · Cited by 1,860
Self-citationThe T cell immune response against SARS-CoV-2
Moss, P. (2022) · Nature Immunology · doi:10.1038/s41590-021-01122-w · Cited by 1,235
Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., Dejnirattisai, W., Rostron, T., Supasa, P., Liu, C., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0782-6 · Cited by 1,179
Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
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Self-citationAging in COVID-19: Vulnerability, immunity and intervention
Chen, Y., Klein, S. L., Garibaldi, B. T., Li, H., Wu, C., Osevala, N. M., Li, T., Margolick, J. B., Pawelec, G., & Leng, S. X. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101205 · Cited by 1,007
Metadata
- Authors
- Sette, A., & Crotty, S.
- Venue
- Nature Reviews Immunology
- Published
- 2020-07-07
- Volume
- 20
- Issue
- 8
- Pages
- 457-458
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W3038964751
- Cited by
- 347
- References
- 4
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-08-17)
- Open access
- bronze
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
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