Skeletal infections: microbial pathogenesis, immunity and clinical management

Pathogen Recognition and Innate Immunity

Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 12,401

Myeloid-derived-suppressor cells as regulators of the immune system

Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753

Definitions and guidelines for research on antibiotic persistence

Balaban, N. Q., Helaine, S., Lewis, K., Ackermann, M., Aldridge, B., Andersson, D. I., Brynildsen, M. P., Bumann, D., Camilli, A., Collins, J. J., et al. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0196-3 · Cited by 1,313

Immune evasion by staphylococci

Foster, T. J. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1289 · Cited by 1,214

MSCRAMM-MEDIATED ADHERENCE OF MICROORGANISMS TO HOST TISSUES

Patti, J. M., Allen, B. L., McGavin, M. J., & Höök, M. (1994) · Annual Review of Microbiology · doi:10.1146/annurev.mi.48.100194.003101 · Cited by 1,191

Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections

Proctor, R. A., von Eiff, C., Kahl, B. C., Becker, K., McNamara, P., Herrmann, M., & Peters, G. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1384 · Cited by 1,175

2015 Infectious Diseases Society of America (IDSA) Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adultsa

Berbari, E. F., Kanj, S. S., Kowalski, T. J., Darouiche, R. O., Widmer, A. F., Schmitt, S. K., Hendershot, E. F., Holtom, P. D., Huddleston, P. M., Petermann, G. W., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ482 · Cited by 1,170

The Intercellular Adhesion ( ica ) Locus Is Present in Staphylococcus aureus and Is Required for Biofilm Formation

Cramton, S. E., Gerke, C., Schnell, N. F., Nichols, W. W., & Götz, F. (1999) · Infection and Immunity · doi:10.1128/iai.67.10.5427-5433.1999 · Cited by 1,126

Pseudomonas aeruginosa Biofilms

Thi, M. T. T., Wibowo, D., & Rehm, B. H. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228671 · Cited by 1,004

Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation

Drenkard, E., & Ausubel, F. M. (2002) · Nature · doi:10.1038/416740a · Cited by 997

Osteomyelitis: A Review of Clinical Features, Therapeutic Considerations and Unusual Aspects

Waldvogel, F. A., Medoff, G., & Swartz, M. N. (1970) · New England Journal of Medicine · doi:10.1056/nejm197001222820406 · Cited by 988

Oral versus Intravenous Antibiotics for Bone and Joint Infection

Li, H. K., Rombach, I., Zambellas, R., Walker, A. S., McNally, M., Atkins, B. L., Lipsky, B. A., Hughes, H. C., Bose, D., Kümin, M., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1710926 · Cited by 942

Antibiotic resistance and persistence—implications for human health and treatment perspectives

Huemer, M., Mairpady Shambat, S., Brugger, S. D., & Zinkernagel, A. S. (2020) · The EMBO Reports · doi:10.15252/embr.202051034 · Cited by 850

The Classic: A Clinical Staging System for Adult Osteomyelitis

Cierný, G., Mader, J. T., & Penninck, J. J. (2003) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000088564.81746.62 · Cited by 803

Staphylococcus aureus Biofilms Prevent Macrophage Phagocytosis and Attenuate Inflammation In Vivo

Thurlow, L. R., Hanke, M. L., Fritz, T., Angle, A., Aldrich, A., Williams, S. H., Engebretsen, I. L., Bayles, K. W., Horswill, A. R., & Kielian, T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002794 · Cited by 704

Propionibacterium acnes: from Commensal to Opportunistic Biofilm-Associated Implant Pathogen

Achermann, Y., Goldstein, E. J. C., Coenye, T., & Shirtliff, M. E. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00092-13 · Cited by 658

Collective cell durotaxis emerges from long-range intercellular force transmission

Sunyer, R., Conte, V., Escribano, J. M. G., Elósegui-Artola, A., Labernadie, A., Valon, L., Navajas, D., García‐Aznar, J. M., Muñoz, J. J., Roca‐Cusachs, P., et al. (2016) · Science · doi:10.1126/science.aaf7119 · Cited by 632

Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy"

Masters, E. A., Trombetta, R. P., de Mesy Bentley, K. L., Boyce, B. F., Gill, A. L., Gill, S. R., Nishitani, K., Ishikawa, M., Morita, Y., Ito, H., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0061-z · Cited by 575

Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions

Kavanagh, N., Ryan, E. J., Widaa, A., Sexton, G., Fennell, J., O'Rourke, S., Cahill, K. C., Kearney, C. J., O’Brien, F. J., & Kerrigan, S. W. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00084-17 · Cited by 569

Sorting of protein a to the staphylococcal cell wall

Schneewind, O., Model, P., & Fischetti, V. A. (1992) · Cell · doi:10.1016/0092-8674(92)90101-h · Cited by 552

Quorum-sensing regulation in staphylococci—an overview

LE, K. Y., & Otto, M. J. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01174 · Cited by 529

Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity

Graille, M., Stura, E. A., Corper, A. L., Sutton, B. J., Taussig, M., Charbonnier, J., & Silverman, G. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5399 · Cited by 522

Trends in the Epidemiology of Osteomyelitis

Kremers, H. M., Nwojo, M. E., Ransom, J. E., Wood‐Wentz, C. M., Melton, L. J., & Huddleston, P. M. (2015) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.n.01350 · Cited by 509

Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis: an open-label, non-inferiority, randomised, controlled trial

Bernard, L., Dinh, A., Ghout, I., Simo, D., Zeller, V., Issartel, B., Moing, V. L., Belmatoug, N., Lesprit, P., Bru, J. P., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61233-2 · Cited by 501

Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

Hajjar, A. M., O’Mahony, D. S., Ozinsky, A., Underhill, D. M., Aderem, A. A., Klebanoff, S. J., & Wilson, C. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.15 · Cited by 465

Neutrophils in innate host defense against Staphylococcus aureus infections

Rigby, K. M., & DeLeo, F. R. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-011-0295-3 · Cited by 400

Diagnosing Periprosthetic Joint Infection: Has the Era of the Biomarker Arrived?

Deirmengian, C. A., Kardos, K. W., Kilmartin, P., et al. (2014) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-014-3543-8 · Cited by 393

Diagnosis and management of osteomyelitis.

Carek, P. J., Dickerson, L. M., & Sack, J. L. (2001) · PubMed · Cited by 391

Pathogenesis of Staphylococcus aureus Abscesses

Kobayashi, S. D., Małachowa, N., & DeLeo, F. R. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.11.030 · Cited by 382

Effect of an Investigational Vaccine for Preventing Staphylococcus aureus Infections After Cardiothoracic Surgery

Fowler, V. G., Allen, K. B., Moreira, E. D., Moustafa, M., Isgro, F., Boucher, H. W., Corey, G. R., Carmeli, Y., Betts, R. F., Hartzel, J. S., et al. (2013) · JAMA · doi:10.1001/jama.2013.3010 · Cited by 376

Diagnosing Fracture-Related Infection: Current Concepts and Recommendations

Govaert, G. A. M., Küehl, R., Atkins, B. L., et al. (2019) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000001614 · Cited by 374

Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors

Spaan, A. N., van Strijp, J. A. G., & Torres, V. J. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.27 · Cited by 370

Staphylococcal protein A consists of five IgG-binding domains

Moks, T., Abrahmsén, L., Nilsson, B., Hellman, U., Sjöquist, J., & Uhlén, M. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09625.x · Cited by 367

Prognostic Factors for Bacterial Cultures Positive for Propionibacterium acnes and Other Organisms in a Large Series of Revision Shoulder Arthroplasties Performed for Stiffness, Pain, or Loosening

Pottinger, P. S., Butler‐Wu, S. M., Neradilek, M. B., et al. (2012) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.k.00861 · Cited by 350

Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections

Kahl, B. C., Becker, K., & Löffler, B. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00069-15 · Cited by 325

Clinical Practice Guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2021 Guideline on Diagnosis and Management of Acute Hematogenous Osteomyelitis in Pediatrics

Woods, C. R., Bradley, J. S., Chatterjee, A., Copley, L. A., Robinson, J., Kronman, M. P., Arrieta, A. C., Fowler, S. L., Harrison, C., Carrillo-Marquez, M. A., et al. (2021) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piab027 · Cited by 325

2018 International Consensus Meeting on Musculoskeletal Infection: Research Priorities from the General Assembly Questions

Schwarz, E. M., Parvizi, J., Gehrke, T. A., Aiyer, A. A., Battenberg, A. K., Brown, S., Callaghan, J. J., Çıtak, M., Egol, K. A., Garrigues, G. E., et al. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24293 · Cited by 323

A play in four acts: Staphylococcus aureus abscess formation

Cheng, A. G., DeDent, A. C., Schneewind, O., & Missiakas, D. M. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.01.007 · Cited by 320

Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?

Thwaites, G. E., & Gant, V. A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2508 · Cited by 319

Cutibacterium acnes as an Opportunistic Pathogen: An Update of Its Virulence-Associated Factors

Mayslich, C., Grange, P., & Dupin, N. (2021) · Microorganisms · doi:10.3390/microorganisms9020303 · Cited by 304

Fibronectin Binding Protein and Host Cell Tyrosine Kinase Are Required for Internalization of Staphylococcus aureus by Epithelial Cells

Dziewanowska, K., Patti, J. M., Deobald, C. F., Bayles, K. W., Trumble, W. R., & Bohach, G. A. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4673-4678.1999 · Cited by 299

Staphylococcus aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis

Josse, J., Velard, F., & Gangloff, S. C. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00085 · Cited by 299

Bone and Joint Infections

Saavedra‐Lozano, J., Falup‐Pecurariu, O., Faust, S. N., et al. (2017) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001635 · Cited by 287

Guidelines on the classification of diabetic foot ulcers (IWGDF 2019)

Monteiro‐Soares, M., Russell, D., Boyko, E. J., Jeffcoate, W. J., Mills, J. L., Morbach, S., Game, F. L., & on behalf of the International Working Group on the Diabetic Foot (IWGDF) (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3273 · Cited by 274

The Surgical Care Improvement Project and Prevention of Post-Operative Infection, Including Surgical Site Infection

Rosenberger, L. H., Politano, A. D., & Sawyer, R. G. (2011) · Surgical Infections · doi:10.1089/sur.2010.083 · Cited by 272

Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis

Bentley, K. L. D. M., Trombetta, R. P., Nishitani, K., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3055 · Cited by 263

Identification of Prosthetic Joint Infection Pathogens Using a Shotgun Metagenomics Approach

Thoendel, M., Jeraldo, P., Greenwood‐Quaintance, K. E., Yao, J. Z., Chia, N., Hanssen, A. D., Abdel, M. P., & Patel, R. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy303 · Cited by 259

Pathogenic Mechanisms and Host Interactions in Staphylococcus epidermidis Device-Related Infection

Bresco, M. S., Harris, L. G., Thompson, K., Stanić, B., Morgenstern, M., O’Mahony, L., Richards, R. G., & Moriarty, T. F. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01401 · Cited by 256

Antibiotic-Loaded Polymethylmethacrylate Beads and Spacers in Treatment of Orthopedic Infections and the Role of Biofilm Formation

van Vugt, T. A. G., Arts, J. J. C., & Geurts, J. A. P. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01626 · Cited by 243

Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms

Miller, L. S., Fowler, V. G., Shukla, S. K., Rose, W. E., & Proctor, R. A. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz030 · Cited by 242

Where does a Staphylococcus aureus vaccine stand?

Fowler, V. G., & Proctor, R. A. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12570 · Cited by 241

Anti-opsonic properties of staphylokinase

Rooijakkers, S. H. M., van Wamel, W. J. B., Ruyken, M., van Kessel, K. P. M., & van Strijp, J. A. G. (2005) · Microbes and Infection · doi:10.1016/j.micinf.2004.12.014 · Cited by 237

Staphylococcus aureus Small Colony Variants in Prosthetic Joint Infection

Sendi, P., Rohrbach, M., Graber, P., Frei, R., Ochsner, P. E., & Zimmerli, W. (2006) · Clinical Infectious Diseases · doi:10.1086/507633 · Cited by 232

Role of Rifampin against Staphylococcal Biofilm Infections In Vitro , in Animal Models, and in Orthopedic-Device-Related Infections

Zimmerli, W., & Sendi, P. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01746-18 · Cited by 221

Staphylococcus aureus pore-forming toxins: The interface of pathogen and host complexity

Seilie, E. S., & Wardenburg, J. B. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.04.003 · Cited by 217

Six-Week Versus Twelve-Week Antibiotic Therapy for Nonsurgically Treated Diabetic Foot Osteomyelitis: A Multicenter Open-Label Controlled Randomized Study

Tone, A., Nguyen, S., Devemy, F., et al. (2014) · Diabetes Care · doi:10.2337/dc14-1514 · Cited by 211

Staphylococcus epidermidis—Skin friend or foe?

Severn, M. M., & Horswill, A. R. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1009026 · Cited by 205

Propionibacterium acnes Induces IL-1β Secretion via the NLRP3 Inflammasome in Human Monocytes

Qin, M., Pirouz, A., Kim, M., Krutzik, S. R., Garbán, H., & Kim, J. J. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.309 · Cited by 201

Myeloid-Derived Suppressor Cells Contribute to Staphylococcus aureus Orthopedic Biofilm Infection

Heim, C. E., Vidlak, D., Scherr, T. D., Kozel, J. A., Holzapfel, M. S., Muirhead, D. E., & Kielian, T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303408 · Cited by 199

Chronic Implant-Related Bone Infections—Can Immune Modulation be a Therapeutic Strategy?

Seebach, E., & Kubatzky, K. F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01724 · Cited by 197

Death by a B Cell Superantigen

Goodyear, C. S., & Silverman, G. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20020552 · Cited by 195

Staphylococcal superantigens in colonization and disease

Xu, S. X., & McCormick, J. K. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00052 · Cited by 194

Quantifying the natural history of biofilm formation in vivo during the establishment of chronic implant‐associated Staphylococcus aureus osteomyelitis in mice to identify critical pathogen and host factors

Nishitani, K., Sutipornpalangkul, W., Bentley, K. L. D. M., Varrone, J. J., Bello‐Irizarry, S. N., Ito, H., Matsuda, S., Kates, S. L., Daiss, J. L., & Schwarz, E. M. (2015) · Journal of Orthopaedic Research® · doi:10.1002/jor.22907 · Cited by 190

Novel Insights into Staphylococcus aureus Deep Bone Infections: the Involvement of Osteocytes

Yang, D., Wijenayaka, A. R., Solomon, L. B., Pederson, S., Findlay, D. M., Kidd, S. P., & Atkins, G. J. (2018) · mBio · doi:10.1128/mbio.00415-18 · Cited by 188

Staphylococcus aureus Evasion of Host Immunity in the Setting of Prosthetic Joint Infection: Biofilm and Beyond

Ricciardi, B. F., Muthukrishnan, G., Masters, E. A., Ninomiya, M. J., Lee, C. C., & Schwarz, E. M. (2018) · Current Reviews in Musculoskeletal Medicine · doi:10.1007/s12178-018-9501-4 · Cited by 182

2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections

Saeed, K. B. A., McLaren, A. C., Schwarz, E. M., et al. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24229 · Cited by 181

Staphylococcal Biofilms: Challenges and Novel Therapeutic Perspectives

Kranjec, C., Angeles, D. M., Mårli, M. T., Fernández, L., García, P., Kjos, M., & Diep, D. B. (2021) · Antibiotics · doi:10.3390/antibiotics10020131 · Cited by 181

Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection

Reyes-Robles, T., Alonzo, F., Kozhaya, L., Lacy, D. B., Unutmaz, D., & Torres, V. J. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.09.005 · Cited by 179

Staphylococcus aureus Host Cell Invasion and Virulence in Sepsis Is Facilitated by the Multiple Repeats within FnBPA

Edwards, A. M., Potts, J. R., Josefsson, E., & Massey, R. C. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000964 · Cited by 171

Antimicrobial coated implants in trauma and orthopaedics–A clinical review and risk-benefit analysis

Alt, V. (2016) · Injury · doi:10.1016/j.injury.2016.12.011 · Cited by 165

Infections in spinal instrumentation

Gérometta, A., Olaverri, J. C. R., & Bitan, F. D. (2012) · International Orthopaedics · doi:10.1007/s00264-011-1426-0 · Cited by 162

Life-Threatening Infectious Complications in Sickle Cell Disease: A Concise Narrative Review

Ochocinski, D., Dalal, M., Black, L. V., Carr, S. B., Lew, J., Sullivan, K., & Kissoon, N. “. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00038 · Cited by 162

Mutational analysis of the interaction between staphylococcal protein A and human IgG1

Cedergren, L., Andersson, R., Jansson, B., Uhlén, M., & Nilsson, B. (1993) · Protein Engineering Design and Selection · doi:10.1093/protein/6.4.441 · Cited by 159

Staphylococcus aureusFibronectin Binding Proteins Are Essential for Internalization by Osteoblasts but Do Not Account for Differences in Intracellular Levels of Bacteria

Ahmed, S., Meghji, S., Williams, R. J., et al. (2001) · Infection and Immunity · doi:10.1128/iai.69.5.2872-2877.2001 · Cited by 158

IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge

Kim, H. K., DeDent, A., Cheng, A. G., McAdow, M., Bagnoli, F., Missiakas, D. M., & Schneewind, O. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.02.097 · Cited by 158

Early expression of SCIN and CHIPS drives instant immune evasion by Staphylococcus aureus

Rooijakkers, S. H. M., Ruyken, M., van Roon, J., van Kessel, K. P. M., van Strijp, J. A. G., & van Wamel, W. J. B. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00709.x · Cited by 157

Sonication of Arthroplasty Implants Improves Accuracy of Periprosthetic Joint Infection Cultures

Rothenberg, A. C., Wilson, A. E., Hayes, J. P., et al. (2017) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-017-5315-8 · Cited by 156

Quantitative mouse model of implant‐associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity

Li, D., Gromov, K., Søballé, K., et al. (2007) · Journal of Orthopaedic Research® · doi:10.1002/jor.20452 · Cited by 154

Adjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work

Schwarz, E. M., McLaren, A. C., Sculco, T. P., et al. (2020) · Journal of Orthopaedic Research® · doi:10.1002/jor.24616 · Cited by 152

IntracellularStaphylococcus aureus

Ellington, J. K., Harris, M., Webb, L., et al. (2003) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.85b6.13509 · Cited by 151

IL-12 Promotes Myeloid-Derived Suppressor Cell Recruitment and Bacterial Persistence during Staphylococcus aureus Orthopedic Implant Infection

Heim, C. E., Vidlak, D., Scherr, T. D., Hartman, C. W., Garvin, K. L., & Kielian, T. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402689 · Cited by 148

Lower Antibody Levels to Staphylococcus aureus Exotoxins Are Associated With Sepsis in Hospitalized Adults With Invasive S. aureus Infections

Adhikari, R. P., Ajao, A. O., Aman, M. J., Karaüzüm, H., Sarwar, J., Lydecker, A. D., Johnson, J. K., Nguyen, C., Chen, W. H., & Roghmann, M. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis462 · Cited by 146

Internalization of Staphylococcus aureus by Human Keratinocytes

Kintarak, S., Whawell, S. A., Speight, P. M., Packer, S., & Nair, S. P. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5668-5675.2004 · Cited by 139

The T Cell Response to Staphylococcus aureus

Bröker, B. M., Mrochen, D. M., & Péton, V. (2016) · Pathogens · doi:10.3390/pathogens5010031 · Cited by 139

Can next generation sequencing play a role in detecting pathogens in synovial fluid?

Tarabichi, M., Shohat, N., Goswami, K., & Parvizi, J. (2018) · The Bone & Joint Journal · doi:10.1302/0301-620x.100b2.bjj-2017-0531.r2 · Cited by 138

Analysis of postoperative and hematogenous prosthetic joint-infection microbiological patterns in a large cohort

Zeller, V., Kerroumi, Y., Meyssonnier, V., et al. (2018) · Journal of Infection · doi:10.1016/j.jinf.2017.12.016 · Cited by 135

Outcome Following Debridement, Antibiotics, and Implant Retention in Hip Periprosthetic Joint Infection—An 18-Year Experience

Grammatopoulos, G. A., Kendrick, B. J. L., McNally, M. A., et al. (2017) · The Journal of Arthroplasty · doi:10.1016/j.arth.2017.02.066 · Cited by 131

Polymicrobial–Host Interactions during Infection

Tay, W. H., Chong, K. K. L., & Kline, K. A. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.05.006 · Cited by 128

Murine Immune Response to a Chronic Staphylococcus aureus Biofilm Infection

Prabhakara, R., Harro, J. M., Leid, J. G., Harris, M. L., & Shirtliff, M. E. (2011) · Infection and Immunity · doi:10.1128/iai.01386-10 · Cited by 126

Adult native septic arthritis: a review of 10 years of experience and lessons for empirical antibiotic therapy

Clerc, O. F., Prod’hom, G., Greub, G., Zanetti, G. M. R., & Senn, L. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr047 · Cited by 124

Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly

Krauss, J. L., Roper, P. M., Ballard, A., et al. (2019) · mBio · doi:10.1128/mbio.02447-19 · Cited by 123

Recent Advances and Ongoing Challenges in the Diagnosis of Microbial Infections by MALDI-TOF Mass Spectrometry

Florio, W., Tavanti, A., Barnini, S., Ghelardi, E., & Lupetti, A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01097 · Cited by 120

Periprosthetic Joint Infections Treated with Two-Stage Revision over 14Years: An Evolving Microbiology Profile

Bjerke-Kroll, B. T., Christ, A. B., McLawhorn, A. S., et al. (2013) · The Journal of Arthroplasty · doi:10.1016/j.arth.2013.09.053 · Cited by 115

Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes

Bentley, K. L. D. M., MacDonald, A., Schwarz, E. M., & Oh, I. C. (2018) · JBJS Case Connector · doi:10.2106/jbjs.cc.17.00154 · Cited by 115

The function of TLR2 during staphylococcal diseases

Fournier, B. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00167 · Cited by 113

Time-dependent differences in management and microbiology of orthopaedic internal fixation-associated infections: an observational prospective study with 229 patients

Küehl, R., Tschudin‐Sutter, S., Morgenstern, M., Dangel, M., Egli, A., Nowakowski, A. M., Suhm, N., Theilacker, C., & Widmer, A. F. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.03.040 · Cited by 112

Human skin commensals augment Staphylococcus aureus pathogenesis

Boldock, E., Surewaard, B. G. J., Shamarina, D., Na, M., Fei, Y., Ali, A. M., Williams, A., Pollitt, E. J. G., Szkuta, P. T., Morris, P., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0198-3 · Cited by 108

Return of the Trojan horse: intracellular phenotype switching and immune evasion by Staphylococcus aureus

Garzoni, C., & Kelley, W. L. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100123 · Cited by 107

The microbiology of chronic osteomyelitis: Changes over ten years

Dudareva, M., Hotchen, A., Ferguson, J. Y., Hodgson, S. H. C., Scarborough, M., Atkins, B. L., & McNally, M. (2019) · Journal of Infection · doi:10.1016/j.jinf.2019.07.006 · Cited by 104

Effects of the Staphylococcus aureus and Staphylococcus epidermidis Secretomes Isolated from the Skin Microbiota of Atopic Children on CD4+ T Cell Activation

Laborel-Préneron, E., Bianchi, P., Boralévi, F., Lehours, P., Fraysse, F., Morice‐Picard, F., Sugai, M., Sato’o, Y., Badiou, C., Lina, G., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141067 · Cited by 103

Introduction: Proceedings of International Consensus on Orthopedic Infections

Parvizi, J., Gehrke, T. A., Mont, M. A., et al. (2018) · The Journal of Arthroplasty · doi:10.1016/j.arth.2018.09.038 · Cited by 101

Acute Hematogenous Osteomyelitis in Children

Thakolkaran, N., & Shetty, A. K. (2019) · Ochsner Journal · doi:10.31486/toj.18.0138 · Cited by 101

Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction

Alder, K. D., Lee, I., Munger, A. M., Kwon, H., Morris, M. T., Cahill, S. V., Back, J., Yu, K. E., & Lee, F. Y. (2020) · Bone · doi:10.1016/j.bone.2020.115568 · Cited by 101

Evaluating the microbial pattern of periprosthetic joint infections of the hip and knee

Rosteius, T., Jansen, O., Fehmer, T., et al. (2018) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000835 · Cited by 97

Bone and joint infections in adults: a comprehensive classification proposal

Romanò, C. L., Romanò, D., Logoluso, N., et al. (2011) · European Orthopaedics and Traumatology · doi:10.1007/s12570-011-0056-8 · Cited by 96

Effects of shear stress on endothelial cell haptotaxis on micropatterned surfaces

Hsu, S. H., Thakar, R. G., Liepmann, D., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.272 · Cited by 92

The Macrophage Inflammatory Proteins MIP1 α (CCL3) and MIP2 α (CXCL2) in Implant-Associated Osteomyelitis: Linking Inflammation to Bone Degradation

Dapunt, U., Maurer, S., Giese, T., Gaida, M. M., & Hänsch, G. M. (2014) · Mediators of Inflammation · doi:10.1155/2014/728619 · Cited by 90

Culturing Periprosthetic Joint Infection: Number of Samples, Growth Duration, and Organisms

Kheir, M. M., Tan, T. L., Ackerman, C. T., et al. (2018) · The Journal of Arthroplasty · doi:10.1016/j.arth.2018.06.018 · Cited by 90

Innate Immunity to Staphylococcus aureus: Evolving Paradigms in Soft Tissue and Invasive Infections

Brandt, S. L., Putnam, N. E., Cassat, J. E., & Serezani, C. H. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701574 · Cited by 88

Current actual success rate of the two-stage exchange arthroplasty strategy in chronic hip and knee periprosthetic joint infection

Corona, P. S., Vicente, M., Carrera, L., et al. (2020) · The Bone & Joint Journal · doi:10.1302/0301-620x.102b12.bjj-2020-0792.r1 · Cited by 87

Internalization of Bacteria by Osteoblasts in a Patient with Recurrent, Long-Term Osteomyelitis: A Case Report

Bosse, M. J., Gruber, H. E., & Ramp, W. K. (2005) · JBJS Case Connector · doi:10.2106/jbjs.d.02649 · Cited by 84

Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus megaclusters

Varrone, J. J., Bentley, K. L. D. M., Bello‐Irizarry, S. N., Nishitani, K., Mack, S., Hunter, J. G., Kates, S. L., Daiss, J. L., & Schwarz, E. M. (2014) · Journal of Orthopaedic Research® · doi:10.1002/jor.22672 · Cited by 81

Staphylococcus aureus keratinocyte invasion is dependent upon multiple high-affinity fibronectin-binding repeats within FnBPA

Edwards, A. M., Potter, U., Meenan, N. A. G., Potts, J. R., & Massey, R. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018899 · Cited by 80

Assessment of the human bone lacuno-canalicular network at the nanoscale and impact of spatial resolution

Yu, B., Pacureanu, A., Olivier, C., Cloetens, P., & Peyrin, F. (2020) · Scientific Reports · doi:10.1038/s41598-020-61269-8 · Cited by 79

Novel Peptide from Commensal Staphylococcus simulans Blocks Methicillin-Resistant Staphylococcus aureus Quorum Sensing and Protects Host Skin from Damage

Severn, M. M., Kwiecinski, J. M., Cruz, L. M., Shahbandi, A., Todd, D. A., Cech, N. B., & Horswill, A. R. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00172-20 · Cited by 79

Vancomycin Povidone-Iodine Protocol Improves Survivorship of Periprosthetic Joint Infection Treated With Irrigation and Debridement

Riesgo, A. M., Park, B. K., Herrero, C. P., et al. (2017) · The Journal of Arthroplasty · doi:10.1016/j.arth.2017.10.044 · Cited by 78

Musculoskeletal Infection in Orthopaedic Trauma

Obremskey, W. T., Metsemakers, W., Schlatterer, D., et al. (2020) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.19.01070 · Cited by 78

Success Rates of Debridement, Antibiotics, and Implant Retention in 230 Infected Total Knee Arthroplasties: Implications for Classification of Periprosthetic Joint Infection

Zhu, M. F., Kim, K., Cavadino, A., et al. (2020) · The Journal of Arthroplasty · doi:10.1016/j.arth.2020.07.081 · Cited by 77

Clinical and bacteriological profile of diabetic foot infections in a tertiary care

Goh, T. C., Bajuri, M. Y., Nadarajah, S. C., et al. (2020) · Journal of Foot and Ankle Research · doi:10.1186/s13047-020-00406-y · Cited by 76

Phenotypic variation of Staphylococcus epidermidis in infection of transvenous endocardial pacemaker electrodes

Baddour, L. M., Barker, L. P., Christensen, G. D., Parisi, J. T., & Simpson, W. A. (1990) · Journal of Clinical Microbiology · doi:10.1128/jcm.28.4.676-679.1990 · Cited by 72

Staphylococcal Protein A, Panton-Valentine Leukocidin and Coagulase Aggravate the Bone Loss and Bone Destruction in Osteomyelitis

Jin, T., Zhu, Y. L., Li, J., Shi, J., He, X. Q., Ding, J. L., & Xu, Y. Q. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000354440 · Cited by 72

Cell Wall-Anchored Surface Proteins of Staphylococcus aureus: Many Proteins, Multiple Functions

Geoghegan, J. A., & Foster, T. J. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_5002 · Cited by 72

INTERNALIZATION OF BACTERIA BY OSTEOBLASTS IN A PATIENT WITH RECURRENT, LONG-TERM OSTEOMYELITIS

Bosse, M. J., Gruber, H. E., & Ramp, W. K. (2005) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200506000-00022 · Cited by 72

Poor Outcomes of Irrigation and Debridement in Acute Periprosthetic Joint Infection With Antibiotic-Impregnated Calcium Sulfate Beads

Flierl, M. A., Culp, B. M., Okroj, K. T., et al. (2017) · The Journal of Arthroplasty · doi:10.1016/j.arth.2017.03.051 · Cited by 72

A NET Outcome

Lu, T., Kobayashi, S. D., Quinn, M. T., & DeLeo, F. R. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00365 · Cited by 71

Delayed Propionibacterium acnes surgical site infections occur only in the presence of an implant

Shiono, Y., Ishii, K., Nagai, S., et al. (2016) · Scientific Reports · doi:10.1038/srep32758 · Cited by 69

Recommendations for design and conduct of preclinical in vivo studies of orthopedic device‐related infection

Moriarty, T. F., Harris, L. G., Mooney, R. A., Wenke, J. C., Riool, M., Zaat, S. A. J., Moter, A., Schaer, T. P., Khanna, N., Küehl, R., et al. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24230 · Cited by 69

Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice

Masters, E. A., Bentley, K. L. D. M., Gill, A. L., Hao, S. P., Galloway, C. A., Salminen, A. T., Guy, D. R., McGrath, J. L., Awad, H. A., Gill, S. R., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008988 · Cited by 68

Adaptive processes of Staphylococcus aureus isolates during the progression from acute to chronic bone and joint infections in patients

Trouillet‐Assant, S., Lelièvre, L., Martins-Simões, P., Gonzaga, L., Tasse, J., Valour, F., Rasigade, J., Vandenesch, F., Guedes, R. L. M., de Vasconcelos, A. T. R., et al. (2016) · Cellular Microbiology · doi:10.1111/cmi.12582 · Cited by 67

Clinical experiences in the use of a gentamicin-coated titanium nail in tibia fractures

Schmidmaier, G., Kerstan, M., Schwabe, P., et al. (2017) · Injury · doi:10.1016/j.injury.2017.07.008 · Cited by 67

3D Bioprinted Scaffolds Containing Viable Macrophages and Antibiotics Promote Clearance of Staphylococcus aureus Craniotomy-Associated Biofilm Infection

Aldrich, A. L., Kuss, M. A., Duan, B., & Kielian, T. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b00264 · Cited by 65

Vancomycin Powder and Dilute Povidone-Iodine Lavage for Infection Prophylaxis in High-Risk Total Joint Arthroplasty

Iorio, R. R., Yu, S. W., Anoushiravani, A. A., et al. (2020) · The Journal of Arthroplasty · doi:10.1016/j.arth.2020.02.060 · Cited by 65

Outcomes and Risk Factors for Polymicrobial Posttraumatic Osteomyelitis

Jorge, L. S., Fucuta, P. S., Maria Gabriele, L., et al. (2018) · Journal of Bone and Joint Infection · doi:10.7150/jbji.22566 · Cited by 64

Single-stage versus two-stage revision for shoulder periprosthetic joint infection: a systematic review and meta-analysis

Belay, E. S., Danilkowicz, R. M., Bullock, G. S., Wall, K. C., & Garrigues, G. E. (2020) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2020.05.034 · Cited by 63

Global Transcriptome Analysis of Staphylococcus aureus Biofilms in Response to Innate Immune Cells

Scherr, T. D., Roux, C. M., Hanke, M. L., Angle, A., Dunman, P. M., & Kielian, T. (2013) · Infection and Immunity · doi:10.1128/iai.00819-13 · Cited by 62

No effect of vancomycin powder to prevent infection in primary total knee arthroplasty: a retrospective review of 976 cases

Yavuz, İ., Öken, Ö. F., Yıldırım, A. Ö., et al. (2019) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-019-05778-8 · Cited by 62

Bacteriophage therapy for bone and joint infections

Gibb, B., & Hadjiargyrou, M. (2021) · The Bone & Joint Journal · doi:10.1302/0301-620x.103b2.bjj-2020-0452.r2 · Cited by 61

A Humoral Immune Defect Distinguishes the Response to Staphylococcus aureus Infections in Mice with Obesity and Type 2 Diabetes from That in Mice with Type 1 Diabetes

Farnsworth, C. W., Shehatou, C., Maynard, R. D., Nishitani, K., Kates, S. L., Zuscik, M. J., Schwarz, E. M., Daiss, J. L., & Mooney, R. A. (2015) · Infection and Immunity · doi:10.1128/iai.03074-14 · Cited by 60

A Diagnostic Serum Antibody Test for Patients With Staphylococcus aureus Osteomyelitis

Nishitani, K., Beck, C. A., Rosenberg, A. F., Kates, S. L., Schwarz, E. M., & Daiss, J. L. (2015) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-015-4354-2 · Cited by 60

Biofilm formation and antimicrobial susceptibility of staphylococci and enterococci from osteomyelitis associated with percutaneous orthopaedic implants

Zaborowska, M., Tillander, J., Brånemark, R., et al. (2016) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33803 · Cited by 60

Contribution of Staphylococcus aureus Coagulases and Clumping Factor A to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection

Małachowa, N., Kobayashi, S. D., Porter, A. R., Braughton, K. R., Scott, D. P., Gardner, D. J., Missiakas, D. M., Schneewind, O., & DeLeo, F. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158293 · Cited by 59

Staphylococcus aureus Reactivation Osteomyelitis after 75 Years

Libraty, D. H., Patkar, C. G., & Torres, B. (2012) · New England Journal of Medicine · doi:10.1056/nejmc1111493 · Cited by 58

Safety, tolerability, and immunogenicity of a single dose 4-antigen or 3-antigen Staphylococcus aureus vaccine in healthy older adults: Results of a randomised trial

Creech, C. B., Frenck, R. W., Sheldon, E. A., Seiden, D., Kankam, M. K., Zito, E. T., Girgenti, D., Severs, J. M., Immermann, F. W., McNeil, L. K., et al. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.11.032 · Cited by 58

PBP4: A New Perspective on Staphylococcus aureus β-Lactam Resistance

da Costa, T. M., de Oliveira, C. R., Chambers, H. F. “., & Chatterjee, S. S. (2018) · Microorganisms · doi:10.3390/microorganisms6030057 · Cited by 58

Does Vancomycin Powder Decrease Surgical Site Infections in Growing Spine Surgery?

Thompson, G. H., Poe-Kochert, C., Hardesty, C. K., et al. (2018) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.17.00459 · Cited by 57

2020 John Charnley Award: The antimicrobial potential of bacteriophage-derived lysin in a murine debridement, antibiotics, and implant retention model of prosthetic joint infection

Sosa, B. R., Niu, Y., Turajane, K., et al. (2020) · The Bone & Joint Journal · doi:10.1302/0301-620x.102b7.bjj-2019-1590.r1 · Cited by 57

Three-Dimensional In Vitro Staphylococcus aureus Abscess Communities Display Antibiotic Tolerance and Protection from Neutrophil Clearance

Hofstee, M. I., Riool, M., Terjajevs, I., Thompson, K., Stoddart, M. J., Richards, R. G., Zaat, S. A. J., & Moriarty, T. F. (2020) · Infection and Immunity · doi:10.1128/iai.00293-20 · Cited by 57

Adaptive Upregulation of Clumping Factor A (ClfA) by Staphylococcus aureus in the Obese, Type 2 Diabetic Host Mediates Increased Virulence

Farnsworth, C. W., Schott, E. M., Jensen, S. E., Zukoski, J., Benvie, A. M., Refaai, M. A., Kates, S. L., Schwarz, E. M., Zuscik, M. J., Gill, S. R., et al. (2017) · Infection and Immunity · doi:10.1128/iai.01005-16 · Cited by 56

Specific serum IgG at diagnosis of Staphylococcus aureus bloodstream invasion is correlated with disease progression

Stentzel, S., Sundaramoorthy, N., Michalik, S., Nordengrün, M., Schulz, S., Kolata, J., Kloppot, P., Engelmann, S., Steil, L., Hecker, M., et al. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.06.018 · Cited by 55

Epidemiology, microbiology and therapeutic consequences of chronic osteomyelitis in northern China: A retrospective analysis of 255 Patients

Ma, X., Han, S., Ma, J., Chen, X., Bai, W., Yan, W., & Wang, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-33106-6 · Cited by 55

Short-Term Administration of Rifampin in the Prevention or Eradication of Infection Due to Foreign Bodies

Tshefu, K., Zimmerli, W., & Waldvogel, F. A. (1983) · Clinical Infectious Diseases · doi:10.1093/clinids/5.supplement_3.s474 · Cited by 54

Recent developments for Staphylococcus aureus vaccines: clinical and basic science challenges

Proctor, R. A. (2015) · European Cells and Materials · doi:10.22203/ecm.v030a22 · Cited by 54

A rabbit humerus model of plating and nailing osteosynthesis with and without Staphylococcus aureus osteomyelitis

Arens, D., Wilke, M., Calabro, L., et al. (2015) · European Cells and Materials · doi:10.22203/ecm.v030a11 · Cited by 52

Aminoglycoside-resistant mutants of Pseudomonas aeruginosa deficient in cytochrome d, nitrite reductase, and aerobic transport

Bryan, L. E., & Kwan, S. Y. (1981) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.19.6.958 · Cited by 51

Hematogenous osteomyelitis in infants and children in the northwestern region of Namibia. Management and two-year results.

Lauschke, F. H. M., & Frey, C. T. (1994) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199404000-00004 · Cited by 51

Immunotherapy synergizes with debridement and antibiotic therapy in a murine 1‐stage exchange model of MRSA implant‐associated osteomyelitis

Yokogawa, N., Ishikawa, M., Nishitani, K., Beck, C. A., Tsuchiya, H., Mesfin, A., Kates, S. L., Daiss, J. L., Xie, C. L., & Schwarz, E. M. (2018) · Journal of Orthopaedic Research® · doi:10.1002/jor.23801 · Cited by 51

Does intrawound vancomycin powder reduce surgical site infection after posterior instrumented spinal surgery? A propensity score-matched analysis

Horii, C., Yamazaki, T., Oka, H., et al. (2018) · The Spine Journal · doi:10.1016/j.spinee.2018.04.015 · Cited by 51

Irrigation and debridement with chronic antibiotic suppression for the management of infected total knee arthroplasty

Weston, J. T., Watts, C. D., Mabry, T. M., et al. (2018) · The Bone & Joint Journal · doi:10.1302/0301-620x.100b11.bjj-2018-0515.r1 · Cited by 51

An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis

Masters, E. A., Salminen, A. T., Begolo, S., Luke, E., Barrett, S. C., Overby, C. T., Gill, A. L., Bentley, K. L. D. M., Awad, H. A., Gill, S. R., et al. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102039 · Cited by 51

Staphylococcus aureus toxin suppresses antigen-specific T cell responses

Lee, B., Olaniyi, R., Kwiecinski, J. M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci130728 · Cited by 51

Clinical S. aureus Isolates Vary in Their Virulence to Promote Adaptation to the Host

Tuchscherr, L. P. N., Pöllath, C., Siegmund, A., Deinhardt‐Emmer, S., Hoerr, V., Svensson, C., Figge, M. T., Monecke, S., & Löffler, B. (2019) · Toxins · doi:10.3390/toxins11030135 · Cited by 49

New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis

Bloem, A., Bax, H. I., Yusuf, E., & Verkaik, N. J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081743 · Cited by 48

Quantifying the Effect of Diabetes on Surgical Hand and Forearm Infections

Sharma, K., Pan, D., Friedman, J. M., Yu, J. L., Mull, A., & Moore, A. M. (2017) · The Journal Of Hand Surgery · doi:10.1016/j.jhsa.2017.11.003 · Cited by 47

A Comprehensive View on the Human Antibody Repertoire Against Staphylococcus aureus Antigens in the General Population

Meyer, T. C., Michalik, S., Holtfreter, S., Weiß, S., Friedrich, N., Völzke, H., Kocher, T., Köhler, C., Schmidt, F., Bröker, B. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.651619 · Cited by 46

The prognosis of streptococcal prosthetic bone and joint infections depends on surgical management—A multicenter retrospective study

Mahieu, R., Dubée, V., Seegers, V., et al. (2019) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2019.06.012 · Cited by 45

The AO trauma CPP bone infection registry: Epidemiology and outcomes of Staphylococcus aureus bone infection

Morgenstern, M., Erichsen, C., Militz, M., et al. (2020) · Journal of Orthopaedic Research® · doi:10.1002/jor.24804 · Cited by 44

A polymer-type water-soluble peptidoglycan exhibited both Toll-like receptor 2- and NOD2-agonistic activities, resulting in synergistic activation of human monocytic cells

Natsuka, M., Uehara, A., Yang, S., et al. (2008) · Innate Immunity · doi:10.1177/1753425908096518 · Cited by 43

Small Colony Variants of Escherichia coli

Colwell, C. A. (1946) · Journal of Bacteriology · doi:10.1128/jb.52.4.417-422.1946 · Cited by 42

The Economics of Antibiotic Cement in Total Knee Arthroplasty: Added Cost with No Reduction in Infection Rates

Yayac, M. F., Rondon, A. J., Tan, T. L., et al. (2019) · The Journal of Arthroplasty · doi:10.1016/j.arth.2019.04.043 · Cited by 42

Retrospective analysis of diabetic foot osteomyelitis management and outcome at a tertiary care hospital in the UK

Arias, M., Hassan-Reshat, S., & Newsholme, W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216701 · Cited by 41

Selection of an appropriate empiric antibiotic regimen in hematogenous vertebral osteomyelitis

Park, K., Kim, D. Y., Lee, Y., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211888 · Cited by 40

A modified staging system for chronic osteomyelitis

Marais, L. C., Ferreira, N., Aldous, C. M., et al. (2015) · Journal of Orthopaedics · doi:10.1016/j.jor.2015.05.017 · Cited by 39

IsdB antibody–mediated sepsis following S. aureus surgical site infection

Nishitani, K., Ishikawa, M., Morita, Y., Yokogawa, N., Xie, C. L., Bentley, K. L. D. M., Ito, H., Kates, S. L., Daiss, J. L., & Schwarz, E. M. (2020) · JCI Insight · doi:10.1172/jci.insight.141164 · Cited by 39

Evaluation of the Enterococcus faecalis Biofilm-Associated Virulence Factors AhrC and Eep in Rat Foreign Body Osteomyelitis and In Vitro Biofilm-Associated Antimicrobial Resistance

Frank, K. L., Vergidis, P. I., Brinkman, C. L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130187 · Cited by 37

Development of a hematogenous implant-related infection in a rat model

Shiels, S. M., Bedigrew, K. M., & Wenke, J. C. (2015) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-015-0699-7 · Cited by 37

Musculoskeletal Infection in Pediatrics

Cooper, A. M., Shope, A. J., Javid, M., Parsa, A., Chinoy, M. A., & Parvizi, J. (2019) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.19.00572 · Cited by 37

Anti-glucosaminidase monoclonal antibodies as a passive immunization for methicillin-resistant Staphylococcus aureus (MRSA) orthopedic infections

Varrone, J. J., Li, D., Daiss, J. L., & Schwarz, E. M. (2011) · IBMS BoneKEy · doi:10.1138/20110506 · Cited by 36

The role of implant sonication in the diagnosis of periprosthetic shoulder infection

Akgün, D., Maziak, N., Plachel, F., et al. (2020) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2019.10.011 · Cited by 36

Local Delivery of Amikacin and Vancomycin from Chitosan Sponges Prevent Polymicrobial Implant-Associated Biofilm

Boles, L. R., Awais, R., Beenken, K. E., Smeltzer, M. S., Haggard, W. O., & Jennings, J. A. (2018) · Military Medicine · doi:10.1093/milmed/usx161 · Cited by 35

Antibiotic-Laden Bone Cement Use and Revision Risk After Primary Total Knee Arthroplasty in U.S. Veterans

Bendich, I., Zhang, N., Barry, J. J., et al. (2020) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.20.00102 · Cited by 35

Radiologic Classification of Chronic Hematogenous Osteomyelitis in Children

Jones, H. W., Harrison, J. W., Bates, J., et al. (2009) · Journal of Pediatric Orthopaedics · doi:10.1097/bpo.0b013e3181b76933 · Cited by 34

Musculoskeletal Infection in Orthopaedic Oncology

Strony, J. T., Brown, S. A., Choong, P., et al. (2019) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.19.00182 · Cited by 32

Multitasking by the OC Lineage during Bone Infection: Bone Resorption, Immune Modulation, and Microbial Niche

Roper, P. M., Shao, C. G., & Novack, D. V. (2020) · Cells · doi:10.3390/cells9102157 · Cited by 32

Outcomes and Risk Factors Associated With Failures of Debridement, Antibiotics, and Implant Retention in Patients With Acute Hematogenous Periprosthetic Joint Infection

Chen, W., Klemt, C., Smith, E. J., et al. (2021) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/jaaos-d-20-00939 · Cited by 32

Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated Staphylococcus aureus Osteomyelitis

Muthukrishnan, G., Wallimann, A., Rangel‐Moreno, J., Bentley, K. L. D. M., Hildebrand, M., Mys, K., Kenney, H. M., Sumrall, E. T., Daiss, J. L., Zeiter, S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.651515 · Cited by 32

Safety and immunogenicity of a recombinant Staphylococcus aureus α-toxoid and a recombinant Panton-Valentine leukocidin subunit, in healthy adults

Landrum, M. L., Lalani, T., Niknian, M., Maguire, J. D., Hospenthal, D. R., Fattom, A., Taylor, K. L., Fraser, J., Wilkins, K. J., Ellis, M. W., et al. (2016) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2016.1248326 · Cited by 29

Deep Infections After Pediatric Spinal Arthrodesis

Sullivan, B. T., Abousamra, O., Puvanesarajah, V., et al. (2019) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.19.00425 · Cited by 29

Poly(Aspartic Acid) Functionalized Poly(ϵ-Caprolactone) Microspheres with Enhanced Hydroxyapatite Affinity as Bone Targeting Antibiotic Carriers

Rotman, S. G., Moriarty, T. F., Nottelet, B., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090885 · Cited by 29

Biofilm Producing Staphylococcus epidermidis (RP62A Strain) Inhibits Osseous Integration Without Osteolysis and Histopathology in a Murine Septic Implant Model

Tomizawa, T., Ishikawa, M., Bello‐Irizarry, S. N., et al. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24512 · Cited by 27

The Rationale for Using Bacteriophage to Treat and Prevent Periprosthetic Joint Infections

Belleghem, J. D. V., Manasherob, R., Międzybrodzki, R., Rogóż, P., Górski, A., Suh, G. A., Bollyky, P. L., & Amanatullah, D. F. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.591021 · Cited by 27

Lack of Humoral Immunity Against Glucosaminidase Is Associated with Postoperative Complications in Staphylococcus aureus Osteomyelitis

Kates, S. L., Owen, J. R., Beck, C. A., et al. (2020) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.20.00029 · Cited by 25

Distinct vasculotropic versus osteotropic features ofS. agalactiaeversusS. aureusimplant‐associated bone infection in mice

Masters, E. A., Hao, S. P., Kenney, H. M., Morita, Y., Galloway, C. A., Bentley, K. L. D. M., Ricciardi, B. F., Boyce, B. F., Schwarz, E. M., & Oh, I. C. (2020) · Journal of Orthopaedic Research® · doi:10.1002/jor.24962 · Cited by 25

Preclinical models of vertebral osteomyelitis and associated infections: Current models and recommendations for study design

Joyce, K., Sakai, D., & Pandit, A. S. (2021) · JOR Spine · doi:10.1002/jsp2.1142 · Cited by 25

Superantigen-induced CD4 memory T cell anergy. I. Staphylococcal enterotoxin B induces Fyn-mediated negative signaling

Watson, A. R. O., Janik, D. K., & Lee, W. T. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.02.003 · Cited by 24

Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid

Adjei‐Sowah, E., Peng, Y. H., Weeks, J., et al. (2021) · Antibiotics · doi:10.3390/antibiotics10060732 · Cited by 24

Staphylococcal Enterotoxins Dose-Dependently Modulate the Generation of Myeloid-Derived Suppressor Cells

Stoll, H., Ost, M., Singh, A., Mehling, R., Neri, D., Schäfer, I., Velić, A., Maček, B., Kretschmer, D., Weidenmaier, C., et al. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00321 · Cited by 23

Microbiological pattern of prosthetic hip and knee infections: a high-volume, single-centre experience in China

Yu, Y., Kong, Y., Ye, J., et al. (2021) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001305 · Cited by 23

Forces guiding staphylococcal adhesion

Herman‐Bausier, P., Formosa‐Dague, C., Feuillie, C., Valotteau, C., & Dufrêne, Y. F. (2015) · Journal of Structural Biology · doi:10.1016/j.jsb.2015.12.009 · Cited by 22

In Vivo Bioluminescence Imaging in a Rabbit Model of Orthopaedic Implant-Associated Infection to Monitor Efficacy of an Antibiotic-Releasing Coating

Miller, R. J., Thompson, J. M., Zheng, J., et al. (2019) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.18.00425 · Cited by 22

Bio‐inspired self‐renewing implant surfaces with sequential biofunctional adaptation for infectious diabetic tissue repair

Cui, B., Wen, M., Cai, Z., Si, Y., Liu, F., Zheng, Y., Zhang, C., & Jia, Z. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202418092 · Cited by 31

pH-responsive and nanoenzyme-loaded artificial nanocells relieved osteomyelitis efficiently by synergistic chemodynamic and cuproptosis therapy

Li, Y., Li, J., Zhong, Y., Zhang, Q., Wu, Y., Huang, J., Pang, K., Zhou, Y., Xiao, T., Wu, Z., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2024.122762 · Cited by 25

Nanocatalytic magnesium osteoimplants with biodegradable self-adaptive interfaces for therapeutic repair of infected bone defects

Wu, Y., Cai, Z., Zhang, Y., Zheng, Y., Liao, L., & Jia, Z. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.12.018 · Cited by 7

Utility of 99mTc-labelled antimicrobial peptide ubiquicidin (29-41) in the diagnosis of diabetic foot infection

Saeed, S., Zafar, J., Khan, B., et al. (2013) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-012-2327-1 · Cited by 52

IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes

Lipsky, B. A., Aragón‐Sánchez, J., Diggle, M. A., Embil, J. M., Kono, S., Lavery, L. A., Senneville, É., Urbančič‐Rovan, V., van Asten, S. A. V., & on behalf of the International Working Group on the Diabetic Foot (IWGDF) (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2699 · Cited by 584

Osteomyelitis of the Long Bones

Calhoun, J. H., Manring, M. M., & Shirtliff, M. E. (2009) · Seminars in Plastic Surgery · doi:10.1055/s-0029-1214158 · Cited by 289

Osteomyelitis of the Foot in Diabetic Patients

Lipsky, B. A. (1997) · Clinical Infectious Diseases · doi:10.1086/516148 · Cited by 363

SA-7 Os Humerus Amputation in Cat with Osteomyelitis

Fitriana, E., Ardiansyah, D., Rahmiati, D. U., et al. (2018) · Hemera Zoa