The DOI matches its Crossref record; 246 of the 248 references it cites were found in a registry or an index.
Adipogenesis and metabolic health
Abstract
Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health issue of major proportion. The expansion of adipose depots can be driven either by the increase in adipocyte size (hypertrophy) or by the formation of new adipocytes from precursor differentiation in the process of adipogenesis (hyperplasia). Notably, adipocyte expansion through adipogenesis can offset the negative metabolic effects of obesity, and the mechanisms and regulators of this adaptive process are now emerging. Over the past several years, we have learned a considerable amount about how adipocyte fate is determined and how adipogenesis is regulated by signalling and systemic factors. We have also gained appreciation that the adipogenic niche can influence tissue adipogenic capability. Approaches aimed at increasing adipogenesis over adipocyte hypertrophy can now be explored as a means to treat metabolic diseases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A key outcome of muscle–adipose crosstalk is the promotion of metabolic flexibility”
From Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging (2025) · cites this paper as [89]
In the citing paper
“The expansion of adipose depots can be driven either by the increase in adipocyte size (hypertrophy), or by the formation of new adipocytes from perivascular preadipocytes and pericytes (hyperplasia).[ 23 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [23]
In the citing paper
“During transient hyperlipidaemia after food intake, adipose tissues are driven to expand.”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [23]
In the citing paper
“Thus, even before obesity becomes obvious, persistent hyperlipidaemia contributes to fat redistribution, for example, subcutaneous adipose inflammation and lipolysis, fuelling visceral adipose tissue (VAT) expansion.[ 23 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [23]
In the citing paper
“Chronic inflammation in extant adipose depots and other tissues also contribute to the pathophysiology of adipose tissue dysfunction, including the gradual impairment of adipogenesis that contributes to IR and metabolic disease.[ 23 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [23]
In the citing paper
“But after a long period of systemic inflammaging, chronic inflammation in adipose depots would lead to the systemic atrophy and wasting observed in cachexia and full‐blown sarcopenia.[ 23 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [23]
In the citing paper
“In fact, AT is remarkably capable of expanding to more than double its original size by hypertrophy (enlargement of the cell size) and/or hyperplasia (increase in cell number) [3].”
From Adipose Tissue: A Novel Target of the Incretin Axis? A Paradigm Shift in Obesity-Linked Insulin Resistance (2024) · cites this paper as [3]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238
Self-citationKim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
Fetal and infant growth and impaired glucose tolerance at age 64
Hales, C. N., Barker, D. J., Clark, P. M., Cox, L. J., Fall, C., Osmond, C., & Winter, P. D. (1991) · BMJ · doi:10.1136/bmj.303.6809.1019 · Cited by 2,708
Cited by
Sorted by citations
Items 101–200 of 999
Liu, K., Lin, L., Li, Q., Xue, Y., Zheng, F., Wang, G., Zheng, C., Du, L., Hu, M., Huang, Y., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914553117 · Cited by 73
Modeling Adipogenesis: Current and Future Perspective
Bahmad, H. F., Daouk, R., Azar, J. H., Sapudom, J., Teo, J. C. M., Abou-Kheir, W. G., & Al‐Sayegh, M. (2020) · Cells · doi:10.3390/cells9102326 · Cited by 74
YAP and TAZ protect against white adipocyte cell death during obesity
Wang, L., Wang, S., Shi, Y. X., Li, R., Günther, S., Ong, Y. T., Potente, M., Yuan, Z., Liu, E., & Offermanns, S. (2020) · Nature Communications · doi:10.1038/s41467-020-19229-3 · Cited by 75
The Molecular Brakes of Adipose Tissue Lipolysis
Li, Y., Li, Z., Ngandiri, D. A., Perez, M. L., Wolf, A., & Wang, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.826314 · Cited by 82
Sugiyama, T., Kanaji, Y., Hoshino, M., Yamaguchi, M., Hada, M., Ohya, H., Sumino, Y., Hirano, H., Kanno, Y., Horie, T., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016202 · Cited by 71
Choi, W. G., Choi, W., Oh, T. J., Cha, H.-N., Hwang, I., Lee, Y. K., Lee, S. Y., Shin, H., Lim, A., Ryu, D., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145331 · Cited by 71
S100 proteins in obesity: liaisons dangereuses
Riuzzi, F., Chiappalupi, S., Arcuri, C., Giambanco, I., Sorci, G., & Donato, R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03257-4 · Cited by 70
Zhao, G., Tian, Z., Tian, T., Zhu, Z.-P., Zhao, W.-J., Tian, H., Cheng, X., Hu, F., Hu, M., Tian, S., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.014 · Cited by 73
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2
Dong, H., Sun, W., Shen, Y., Baláž, M., Balážová, L., Ding, L., Löffler, M. C., Hamilton, B. S., Klöting, N., Blüher, M., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-021-00509-1 · Cited by 73
Yu, T., Wang, L., Zhang, L., & Deuster, P. A. (2023) · Antioxidants · doi:10.3390/antiox12061163 · Cited by 72
Consensus on the key characteristics of metabolism disruptors
Merrill, M. A. L., Smith, M. T., McHale, C. M., Heindel, J. J., Atlas, E., Cave, M. C., Collier, D. N., Guyton, K. Z., Koliwad, S. K., Nadal, Á., et al. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01059-8 · Cited by 73
Sánchez-Ceinos, J., Rangel-Zúñiga, O. A., Clemente‐Postigo, M., Podadera-Herreros, A., Camargo, A., Alcala-Diaz, J. F., Guzmán‐Ruiz, R., López‐Miranda, J., & Malagón, M. M. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.01.014 · Cited by 67
Alternative fat: redefining adipocytes for biomanufacturing cultivated meat
Sugii, S., Wong, C. Y. Q., Lwin, A. K. O., & Chew, L. J. M. (2022) · Trends in biotechnology · doi:10.1016/j.tibtech.2022.08.005 · Cited by 67
Zielińska‐Bliźniewska, H., Sitarek, P., Merecz-Sadowska, A., Malinowska, K., Zajdel, K., Jabłońska, M. R., Śliwiński, T., & Zajdel, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184556 · Cited by 68
Ponce, A. J., Galván-Salas, T., Lerma-Alvarado, R. M., Ruíz‐Herrera, X., Hernández-Cortés, T., Valencia-Jiménez, R., Cárdenas-Rodríguez, L. E., de la Escalera, G. M., Clapp, C., & Macotela, Y. (2020) · Endocrine · doi:10.1007/s12020-019-02170-x · Cited by 66
Autoimmune responses and inflammation in type 2 diabetes
Prasad, M., Chen, E. W., Toh, S.-A. E. S., & Gascoigne, N. R. J. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0220-243r · Cited by 68
Rivera-Yañez, N., Rivera-Yañez, C. R., Pozo‐Molina, G., Méndez-Catalá, C. F., Méndez‐Cruz, A. R., & Nieto-Yáñez, Ó. (2020) · Nutrients · doi:10.3390/nu13010078 · Cited by 69
Cai, R., Tang, G., Zhang, Q., Yong, W., Zhang, W., Xiao, J., Wei, C., He, C., Yang, G., & Pang, W. (2019) · Cells · doi:10.3390/cells8050477 · Cited by 65
Early-life programming of adipose tissue
Moreno‐Méndez, E., Quintero-Fabián, S., Fernández‐Mejía, C., & Lazo-de-la-Vega-Monroy, M.-L. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422420000037 · Cited by 72
Lazarescu, O., Ziv, M., Haim, Y., Hekselman, I., Jubran, J., Shneyour, A., Muallem, H., Zemer, A., Rosengarten-Levin, M., Kitsberg, D., et al. (2025) · Nature Genetics · doi:10.1038/s41588-024-02048-3 · Cited by 69
Peroxisomal regulation of redox homeostasis and adipocyte metabolism
Liu, J., Lu, W., Shi, B., Klein, S., & Su, X. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101167 · Cited by 67
Ahmad, B., Vohra, M. S., Saleemi, M. A., Serpell, C. J., Fong, I. L., & Wong, E. H. (2021) · Biochimie · doi:10.1016/j.biochi.2021.01.015 · Cited by 68
Adipogenic Activity of Chemicals Used in Plastic Consumer Products
Völker, J., Ashcroft, F. J., Vedøy, Å., Zimmermann, L., & Wagner, M. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.1c06316 · Cited by 65
The Genetic Basis of Childhood Obesity: A Systematic Review
Vourdoumpa, A., Paltoglou, G., & Charmandari, E. (2023) · Nutrients · doi:10.3390/nu15061416 · Cited by 84
Kasai, S., Kokubu, D., Mizukami, H., & Itoh, K. (2023) · Biomolecules · doi:10.3390/biom13101544 · Cited by 75
The Impact of Single-Cell Genomics on Adipose Tissue Research
Deutsch, A., Feng, D., Pessin, J. E., & Shinoda, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134773 · Cited by 64
The crosstalk between metabolism and translation
Biffo, S., Ruggero, D., & Santoro, M. M. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.07.022 · Cited by 66
Adomshick, V., Pu, Y., & Veiga‐Lopez, A. (2020) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2020.1747124 · Cited by 68
Obesity, Adipose Tissue, and Inflammation Answered in Questions
Guerreiro, V. A., Carvalho, D. M., & Freitas, P. (2022) · Journal of Obesity · doi:10.1155/2022/2252516 · Cited by 73
Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity
Guo, Z., Yang, Y., Liao, Y., Shi, Y., & Zhang, L. (2021) · JID Innovations · doi:10.1016/j.xjidi.2021.100064 · Cited by 66
Selective targeting of visceral adiposity by polycation nanomedicine
Wan, Q., Huang, B., Li, T., Xiao, Y., He, Y., Du, W. J., Wang, B. Z., Dakin, G. F., Rosenbaum, M. S., Goncalves, M. D., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01249-3 · Cited by 64
Lee, H. A., Cho, J.-H., Afinanisa, Q., An, G.-H., Han, J., Kang, H., Choi, S. H., & Seong, H. (2020) · Nutrients · doi:10.3390/nu12113338 · Cited by 61
Generation of immune cell containing adipose organoids for in vitro analysis of immune metabolism
Taylor, J., Sellin, J., Kuerschner, L., Krähl, L., Majlesain, Y., Förster, I., Thiele, C., Weighardt, H., & Weber, E. (2020) · Scientific Reports · doi:10.1038/s41598-020-78015-9 · Cited by 68
Al-Ghadban, S. I., Diaz, Z. T., Singer, H. J., Mert, K. B., & Bunnell, B. A. (2020) · Cells · doi:10.3390/cells9020430 · Cited by 58
Zhang, L., Guerrero‐Juarez, C. F., Chen, S., Zhang, X., Yin, M., Li, F., Wu, S., Chen, J., Li, M., Liu, Y., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb5280 · Cited by 61
Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesisPreprint
Anderson, W. D., Soh, J. Y., Innis, S. E., Dimanche, A., Ma, L., Langefeld, C. D., Comeau, M. E., Das, S. K., Schadt, E. E., Björkegren, J., et al. (2020) · Genome Research · doi:10.1101/gr.264614.120 · Cited by 60
Metaflammation in glucolipid metabolic disorders: Pathogenesis and treatment
Xiong, P., Zhang, F., Liu, F., Zhao, J., Huang, X., Luo, D., & Guo, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114545 · Cited by 59
Bio-engineering a prevascularized human tri-layered skin substitute containing a hypodermis
Zimoch, J., Zielinska, D., Michalak-Micka, K., Rütsche, D., Böni, R., Biedermann, T., & Klar, A. S. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.07.033 · Cited by 57
Liu, S., Wu, D., Fan, Z., Yang, J. M., Li, Y., Meng, Y., Gao, C., & Zhan, H. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.973955 · Cited by 64
Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis
Stefkovich, M. L., Traynor, S., Cheng, L., Merrick, D., & Seale, P. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101357 · Cited by 58
Adipogenesis or osteogenesis: destiny decision made by mechanical properties of biomaterials
Su, T., Xu, M., Lu, F., & Chang, Q. (2022) · RSC Advances · doi:10.1039/d2ra02841g · Cited by 56
Collagens Regulating Adipose Tissue Formation and Functions
Jääskeläinen, I., Petäistö, T., Dahagi, E. M., Mahmoodi, M., Pihlajaniemi, T. A., Kaartinen, M. T., & Heljäsvaara, R. (2023) · Biomedicines · doi:10.3390/biomedicines11051412 · Cited by 61
Rial, S. A., Jutras-Carignan, A., Bergeron, K., & Mounier, C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158582 · Cited by 57
Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects
Hu, Y., Chen, X., Hu, M., Zhang, D., Yuan, S., Li, P., & Feng, L. (2022) · Chinese Medicine · doi:10.1186/s13020-022-00666-9 · Cited by 61
Lee, M. M. S., Lin, D. M., Chau, J. H. C., Yu, E. Y., Ding, D., Kwok, R. T. K., Wang, D., & Tang, B. Z. (2023) · ACS Nano · doi:10.1021/acsnano.3c03654 · Cited by 57
Wu, S.-C., Lo, Y.-M., Lee, J., Chen, C., Chen, T.-W., Liu, H., Lian, W.-N., Hua, K., Liao, C., Lin, W.-J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31825-z · Cited by 56
Huang, W., Queen, N. J., McMurphy, T. B., Ali, S., & Cao, L. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.008 · Cited by 52
Queiroz, M., & Sena, C. M. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02549-9 · Cited by 53
tRNA-Derived Small Non-Coding RNAs as Novel Epigenetic Molecules Regulating Adipogenesis
Shen, L., Tan, Z., Gan, M., Li, Q., Chen, L., Niu, L., Jiang, D., Zhao, Y., Wang, J., Li, X., et al. (2019) · Biomolecules · doi:10.3390/biom9070274 · Cited by 52
Song, T., Yang, Y., Jiang, S., & Peng, J. (2020) · Advanced Science · doi:10.1002/advs.202001563 · Cited by 52
Inflammatory and immune etiology of type 2 diabetes
Blériot, C., Dalmas, É., Ginhoux, F., & Venteclef, N. (2023) · Trends in Immunology · doi:10.1016/j.it.2022.12.004 · Cited by 53
Bae, H., Hong, K. Y., Lee, C.-K., Jang, C., Lee, S.-J., Choe, K., Offermanns, S., He, Y., Lee, H. J., & Koh, G. Y. (2020) · Nature Communications · doi:10.1038/s41467-020-16795-4 · Cited by 52
Obesity and Pregnancy, the Perfect Metabolic Storm
Corrales, P., Vidal-Puig, A., & Medina-Gómez, G. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00914-5 · Cited by 51
Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue
Homan, E. P., Brandão, B. B., Softic, S., Ouaamari, A. E., O'Neill, B. T., Kulkarni, R. N., Kim, J. K., & Kahn, C. R. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143328 · Cited by 51
Zwartjes, M., Gerdes, V. E. A., & Nieuwdorp, M. (2021) · Metabolites · doi:10.3390/metabo11080531 · Cited by 52
Chao, Y.-Q., Jiang, Y., Zhong, M., Wei, K., Hu, C., Qin, Y., Zuo, Y., Yang, L., Shen, Z., & Zou, C. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00581-w · Cited by 54
Mitochondrial heterogeneity and adaptations to cellular needs
Granath-Panelo, M., & Kajimura, S. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01410-1 · Cited by 50
Exosomal miR‐122 promotes adipogenesis and aggravates obesity through the VDR/SREBF1 axis
Huang, X., Chen, J.-X., Ren, Y., Fan, L.-C., Xiang, W., & He, X. (2022) · Obesity · doi:10.1002/oby.23365 · Cited by 52
Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis
Yamakawa, D., Katoh, D., Kasahara, K., Shiromizu, T., Matsuyama, M., Matsuda, C., Maeno, Y., Watanabe, M., Nishimura, Y., & Inagaki, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108817 · Cited by 49
Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes
Grabner, G. F., Guttenberger, N., Mayer, N., Migglautsch, A. K., Lembacher‐Fadum, C., Fawzy, N., Bulfon, D., Hofer, P., Züllig, T., Hartig, L., et al. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.1c10836 · Cited by 48
Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology
Lecoutre, S., Lambert, M., Drygalski, K., Dugail, I., Maqdasy, S., Hautefeuille, M., & Clément, K. (2022) · Cells · doi:10.3390/cells11152310 · Cited by 56
Litzenburger, T., Huber, E.-K., Dinger, K., Wilke, R., Vohlen, C., Selle, J., Kadah, M., ten Persigehl, T., Heneweer, C., Dötsch, J., et al. (2020) · Clinical Science · doi:10.1042/cs20191229 · Cited by 48
Gupta, A., Shamsi, F., Altemose, N., Dorlhiac, G. F., Cypess, A. M., White, A. P., Yosef, N., Patti, M., Tseng, Y.-H., & Streets, A. (2022) · Genome Research · doi:10.1101/gr.275509.121 · Cited by 54
The abundance of bifidobacterium in relation to visceral obesity and serum uric acid
Gong, H., Gao, H., Ren, Q., & He, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-17417-3 · Cited by 51
Pranoto, A., Cahyono, M. B. A., Yakobus, R., Izzatunnisa, N., Ramadhan, R. N., Rejeki, P. S., Miftahussurur, M., Effendi, W. I., Wungu, C. D. K., & Yamaoka, Y. (2023) · Sports · doi:10.3390/sports11030054 · Cited by 57
Obesity and Adipose Tissue Dysfunction: From Pediatrics to Adults
Menendez, A., Wanczyk, H., Walker, J. M., Zhou, B., Santos, M., & Finck, C. M. (2022) · Genes · doi:10.3390/genes13101866 · Cited by 54
On the Immunometabolic Role of NF-κB in Adipocytes
Griffin, M. J. (2022) · Immunometabolism · doi:10.20900/immunometab20220003 · Cited by 48
Raheem, J., Sliz, E., Shin, J., Holmes, M. V., Pike, G. B., Richer, L., Gaudet, D., Paus, T., & Pausová, Z. (2022) · Communications Medicine · doi:10.1038/s43856-022-00140-5 · Cited by 46
Understanding Adipose Tissue Dysfunction
Blüher, M. (2024) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes24013 · Cited by 55
Annexins in Adipose Tissue: Novel Players in Obesity
Grewal, T., Enrich, C., Rentero, C., & Buechler, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143449 · Cited by 46
Zhao, M. L., Rabiee, A., Kovary, K. M., Bahrami-Nejad, Z., Taylor, B. E., & Teruel, M. N. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107769 · Cited by 43
Shen, Y., Wu, Y., Fu, M., Zhu, K., & Wang, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1159055 · Cited by 45
Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARγ expression
Xue, P., Hou, Y., Zuo, Z., Wang, Z., Ren, S., Dong, J., Fu, J., Wang, H., Andersen, M. E., Zhang, Q., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101414 · Cited by 45
Cheng, Z., Xiong, X., Zhou, Y., Wu, F., Shao, Q., Dong, R., Liu, Q., Li, L., & Chen, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112491 · Cited by 47
Gutierrez, A. D., Gao, Z., Hamidi, V., Zhu, L., Saint Andre, K. B., Riggs, K., Ruscheinsky, M., Wang, H., Yu, Y., Miller, C., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100813 · Cited by 44
Hu, Y., Yu, J., Cui, X., Zhang, Z., Li, Q., Guo, W., Zhao, C., Chen, X., Meng, M., Yu, L., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.642000 · Cited by 42
Obesity: an evolutionary context
Speakman, J. R., & Elmquist, J. K. (2022) · Life Metabolism · doi:10.1093/lifemeta/loac002 · Cited by 52
MHO or MUO? White adipose tissue remodeling
Zhao, J. Y., Li, Z., Ma, K. L., Hao, R., & Li, M. (2024) · Obesity Reviews · doi:10.1111/obr.13691 · Cited by 49
Distinct adipose progenitor cells emerging with age drive active adipogenesis
Wang, G., Li, G., Song, A., Zhao, Y., Yu, J., Wang, Y., Dai, W., Salas, M. C., Qin, H., Medrano, L. J., et al. (2025) · Science · doi:10.1126/science.adj0430 · Cited by 47
Rey, F., Urrata, V., Gilardini, L., Bertoli, S., Calcaterra, V., Zuccotti, G., Cancello, R., & Carelli, S. (2021) · Obesity Reviews · doi:10.1111/obr.13203 · Cited by 45
Zafer, M., Tavaglione, F., Romero‐Gómez, M., & Loomba, R. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70196 · Cited by 47
Lu, S., Wang, J., Kakongoma, N., Hua, W., Xu, J., Wang, Y., He, S., Gu, H., Shi, J., & Hu, W. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01289-5 · Cited by 45
Yang, X., Ma, X., Mei, C., & Zan, L. (2022) · BMC Genomics · doi:10.1186/s12864-022-08911-z · Cited by 44
Schreiber, C., Saraswati, S., Harkins, S. K., Gruber, A., Cremers, N., Thiele, W., Rothley, M., Plaumann, D., Korn, C., Armant, O., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008216 · Cited by 43
Mandl, M., Viertler, H. P., Hatzmann, F. M., Brucker, C., Großmann, S., Waldegger, P., Rauchenwald, T., Mattesich, M., Zwierzina, M., Pierer, G., et al. (2022) · Adipocyte · doi:10.1080/21623945.2022.2044601 · Cited by 42
Adipose extracellular matrix deposition is an indicator of obesity and metabolic disorders
Chen, H.-J., Yan, X., Sun, A., Zhang, L., Zhang, J., & Yan, Y. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109159 · Cited by 47
Barthelemy, J., Bogard, G., & Wolowczuk, I. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1083191 · Cited by 46
Tero-Vescan, A., Degens, H., Matsakas, A., Ștefănescu, R., Ősz, B. E., & Slevin, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081222 · Cited by 44
Straub, L. G., Efthymiou, V., Grandl, G., Baláž, M., Challa, T. D., Truscello, L., Horváth, C., Moser, C., Rachamin, Y., Arnold, M., et al. (2019) · Diabetologia · doi:10.1007/s00125-019-4937-7 · Cited by 41
Wang, Q., Mu, R., Liu, X., Zhou, H., Xu, Y., Qin, W., Yang, C., Wang, L., Li, H., & Xiong, W. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00746 · Cited by 41
Fano, M. D., Bartolini, D., Tortoioli, C., Vermigli, C., Malara, M., Galli, F., & Murdolo, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105511 · Cited by 44
Coordinated metabolic transitions and gene expression by NAD+ during adipogenesis
Sánchez-Ramírez, E., Ung, T. P. L., del Carmen, A. A., del Toro-Ríos, X., Fajardo-Orduña, G. R., Noriega, L. G., Cortés-Morales, V. A., Tovar, A. R., Montesinos, J. J., Orozco-Solís, R., et al. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202111137 · Cited by 41
A Lipid Perspective on Regulated Pyroptosis
Qiu, Y., Shi, Y., Zhu, N., Zhang, S., Zhang, C., Gu, J. L., He, P., Dai, A., & Li, Q. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.81017 · Cited by 44
Adipose Tissue Dynamics: Cellular and Lipid Turnover in Health and Disease
Palacios‐Marin, I., Serra, D., Jiménez‐Chillarón, J. C., Herrero, L., & Todorčević, M. (2023) · Nutrients · doi:10.3390/nu15183968 · Cited by 47
Trapped fat: Obesity pathogenesis as an intrinsic disorder in metabolic fuel partitioning
Friedman, M. I., Sørensen, T. I. A., Taubes, G., Lund, J. T., & Ludwig, D. S. (2024) · Obesity Reviews · doi:10.1111/obr.13795 · Cited by 47
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Lecoutre, S., Rebière, C., Maqdasy, S., Lambert, M., Dussaud, S., Abatan, J. B., Dugail, I., Gautier, E. L., Clément, K., & Marcelin, G. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01071-y · Cited by 52
Remodeling of Murine Mammary Adipose Tissue during Pregnancy, Lactation, and Involution
Wang, Q. A., & Scherer, P. E. (2019) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-019-09434-2 · Cited by 38
Self-citationAdipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences
Eckel‐Mahan, K. L., Ribas‐Latre, A., & Kolonin, M. G. (2020) · Cells · doi:10.3390/cells9040863 · Cited by 41
Differential molecular mechanistic behavior of HDACs in cancer progression
Singh, T., Kaur, P., Singh, P., Singh, S., & Munshi, A. (2022) · Medical Oncology · doi:10.1007/s12032-022-01770-4 · Cited by 42
Key Roles of Brown, Subcutaneous, and Visceral Adipose Tissues in Obesity and Insulin Resistance
Dobre, M.-Z., Vîrgolici, B., & Timnea, O. C. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47050343 · Cited by 49
Metadata
- Authors
- Ghaben, A. L., & Scherer, P. E.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Scherer, Philipp E.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2019-01-04
- Volume
- 20
- Issue
- 4
- Pages
- 242-258
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2908320623
- Semantic Scholar
- 4fcd08092b207de7bf166354cd3000e12504500a
- Cited by
- 1,395
- References
- 248
- Citations by year
- 2026: 128 · 2025: 209 · 2024: 212 · 2023: 218 · 2022: 219 · 2021: 207 · 2020: 140 · 2019: 61
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adipogenesis, obesity, metabolic health, adipocyte hypertrophy, adipocyte hyperplasia, adipose tissue expansion, white adipose tissue, metabolic disorders, cancer risk
- MeSH terms
- Animals, Cell Differentiation, Health, Humans, Obesity, Signal Transduction, Adipocytes, Adipogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
