The DOI matches its Crossref record; 319 of the 319 references it cites were found in a registry or an index.
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Open accessAbstract
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular constituents and eliminate damaged organelles and aggregate-prone proteins. Their postmitotic nature and extremely polarized morphologies make neurons particularly vulnerable to disruptions caused by autophagy-lysosomal defects, especially as the brain ages. Consequently, mutations in genes regulating autophagy and lysosomal functions cause a wide range of neurodegenerative diseases. Here, we review the role of autophagy and lysosomes in neurodegenerative diseases such as Alzheimer disease, Parkinson disease and frontotemporal dementia. We also consider the strong impact of cellular ageing on lysosomes and autophagy as a tipping point for the late-age emergence of related neurodegenerative disorders. Many of these diseases have primary defects in autophagy, for example affecting autophagosome formation, and in lysosomal functions, especially pH regulation and calcium homeostasis. We have aimed to provide an integrative framework for understanding the central importance of autophagic-lysosomal function in neuronal health and disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Currently, 14 NCLs have been described, each with their own identified lipo-protein ultrastructural aggregate and causative gene mutation.119”
From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [119]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Previous work has linked disruptions to autophagy and lysosomal biology with AD72–74.”
From APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics (2026) · cites this paper as [73]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500
Protein aggregation and neurodegenerative disease
Ross, C. A., & Poirier, M. A. (2004) · Nature Medicine · doi:10.1038/nm1066 · Cited by 3,454
TFEB Links Autophagy to Lysosomal Biogenesis
Settembre, C., Di Malta, C., Polito, V. A., Arencibia, M. G., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., et al. (2011) · Science · doi:10.1126/science.1204592 · Cited by 3,365
Self-citationThe role of autophagy during the early neonatal starvation period
Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015) · Nature · doi:10.1038/nature14893 · Cited by 2,774
mTOR at the nexus of nutrition, growth, ageing and disease
Liu, G. Y., & Sabatini, D. M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0199-y · Cited by 2,737
The Beclin 1 network regulates autophagy and apoptosis
Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.191 · Cited by 2,485
Research works printed but not linked: 3
- Lees, M. B. Basic Neurochemistry 5th edn, Vol. 39 (Raven Press, 1994).
- de Duve, C. Lysosomes, a New Group of Cytoplasmic Particle (Ronald Press, 1959).
- Chou, C. C. et al. Proteostasis and lysosomal quality control deficits in Alzheimer’s disease neurons. Preprint at bioRxiv https://doi.org/10.1101/2023.03.27.534444 (2023). · DOI
Cited by
Sorted by citations
Items 201–300 of 433
Autophagy degradation: a promising dimension in drug discovery for neurodegenerative diseases
Liu, S., Cai, C., Zhu, H.-P., Li, X., & Han, B. (2024) · Future Medicinal Chemistry · doi:10.1080/17568919.2024.2431477 · Cited by 3
Mehrabani-Tabari, A. A., Hegdekar, N., Herb, B. R., Kachi, S. A., Sarkar, C., Thapa, S., Nguyen, D. P., Morel, Y., Weldemariam, M. M., Muller, L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.04.674092 · Cited by 2
Genetic architecture of Alzheimer’s disease is enriched in peripheral immune and metabolic programsPreprint
Cunha, C., Avelli, M. P., Romero-Lado, M. J., Martínez, R., Belanich, J. R., Jones, T. R., Claussnitzer, M., Loos, R. J. F., & Kilpeläinen, T. O. (2026) · medRxiv · doi:10.64898/2026.02.09.26344392 · Cited by 2
Chen, Y., Peng, H., Wang, Z., Zhang, D., Lang, L., Lu, J., & Guan, S. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c07933 · Cited by 1
Shao, R., Li, J., Wu, F., Meng, W., Li, C., Huang, F., Qu, T., Zhou, H., Liao, Y. H., & Chen, M. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.168063 · Cited by 1
Noël, E., Guimiot, F., Capri, Y., Alison, M., Baskaran, A., Delcour, C., Germanaud, D., Lebon, S., Storey, C., de Roux, N., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02204-8 · Cited by 1
Zhen, L., Peng, J., Cui, H., Tao, J., Liu, Y., Cao, J., El-Seedi, H. R., Cheng, G., & Wang, Z. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157942 · Cited by 1
Wan, J., Lu, Q., Xu, Z., Hao, X., Luo, R., & 邸迎彤 (2026) · Molecules · doi:10.3390/molecules31091388 · Cited by 1
Bolikhova, A. K., Alferova, V. A., Izzi, A. R., Nikandrova, A. A., Kudryakova, G. K., Zhitlov, M. Y., Guseva, E. A., Karpov, D. S., Lukianov, D. A., Dontsova, O. A., et al. (2026) · Metabolites · doi:10.3390/metabo16050311 · Cited by 1
Zhang, C., Zhang, C., Yang, C., & Zhang, L. (2026) · Pharmacology · doi:10.1159/000551971 · Cited by 1
Trace Elements Dyshomeostasis and Toxic Metals Neurotoxicity in Neurodegenerative Diseases
Tang, M., Fleming, E., Gu, J., Shi, H., Xu, Y., & Gong, X. (2026) · Biological Trace Element Research · doi:10.1007/s12011-026-05187-2 · Cited by 1
The autophagy-senescence-inflammasome axis: A novel triad in neurodegenerative diseases?
Ellappan, S., Kujur, P. P., & Mondal, A. C. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103248 · Cited by 1
Roles of autophagy in brain homeostasis and disease
Kim, H., Wickstead, E. S., Zhou, X., Choi, I., & Yue, Z. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02426-6 · Cited by 1
Bartolo, M. I. D., Belvisi, D., Costanzo, M., Caturano, C., Bellomi, F. E., Cutrona, C., Aiello, F., Leodori, G., Marano, M., Mancinelli, R., et al. (2025) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.70178 · Cited by 1
Zhang, M., Hai, S., Gao, X., Cui, Z., Yang, T., Wang, A., Lin, J., & Sun, X. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115492 · Cited by 1
Zhuang, J., Xu, Y., Lu, Y., Lyu, S., Tan, J., & Feng, J. (2025) · Advanced Science · doi:10.1002/advs.202510837 · Cited by 1
Dolanbay, S. N. (2025) · Toxicology Research · doi:10.1093/toxres/tfaf155 · Cited by 1
Chen, Z., Wang, F., Li, Y., Wu, M., Chen, M., Huang, F., Wen, Y., Wang, X., Yu, L., Wu, J., et al. (2025) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2025.12.003 · Cited by 1
Subramanian, J. (2026) · The Neuroscientist · doi:10.1177/10738584251414384 · Cited by 1
The Dynamic Role of the Golgi Apparatus in Neuronal Function and Alzheimer’s Disease
Fourrière, L., & Gleeson, P. A. (2026) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-032-16833-7_18 · Cited by 1
Wang, H., Chen, Y.-L., Chiu, T.-J., Chiu, C., Weng, Y.-H., Liu, S.-Y., Li, A. H.-L., & Yeh, T. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-026-01317-8 · Cited by 1
Hu, W., Li, W. Y., Yang, A., Jiao, X., Zhang, A., Li, J., Zhao, L., Zhao, B., Wan, D., Zhang, X., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121574 · Cited by 1
Wang, C., Xu, X., Zhu, H., Wu, D., Liang, J., Wang, X., Song, R., Shen, L., Hu, Y., Wang, D., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121606 · Cited by 1
Lee, H., & Chae, H. (2026) · Innovations in Acupuncture and Medicine · doi:10.1186/s44424-026-00052-4 · Cited by 1
Rab27b: A Modulator of Lysosomal Function and Alpha-Synuclein Clearance in Parkinson's Disease
Badell‐Grau, R. A. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.0917-25.2026 · Cited by 1
Hernández-Gerez, E., Goya‐Iglesias, N., Viedma-Poyatos, Á., Pajares, M. A., & Pérez‐Sala, D. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.280 · Cited by 1
The multifaceted regulation of autophagy protein ATG16L1 and its implications in human diseases
Wei, F., Liu, Z., Yu, X., Sun, Y., Zhao, Y., Wang, Y., Feng, Z., Zhao, X., Ke, X., Yang, A., et al. (2026) · Autophagy · doi:10.1080/15548627.2026.2672698 · Cited by 2
Liu, M., Peng, Q., Zhai, H., Wu, Y., Ma, Z., Tang, Z., Ouyang, H., Chang, A., Cao, X., Xu, Y., et al. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s607870 · Cited by 1
Zuo, X., Chen, Z., Chen, X., Guan, D., Shaw, P. X., Johnstone, A. D., Becker, A., Das, U., & Mobley, W. C. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-026-01382-z · Cited by 1
Kawachi, Y., Koçak, G., Korolchuk, V. I., Kataura, T., & Sarkar, S. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1857866 · Cited by 2
Wang, M., Li, X., Xiao, Y., & Liu, F. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110039 · Cited by 1
Role of ESCRT pathway and autophagy in neurodegenerative diseases
Dongre, S., Soni, N., & Bissa, B. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.05.022 · Cited by 1
Diagnosis and management of frontotemporal dementia: a narrative review.
Cenacchi, V., Lombardo, T., Palacino, F., Cattaruzza, T., Manganotti, P., & Benussi, A. (2026) · Neurodegenerative Disease Management · doi:10.1080/17582024.2026.2687481
Álvarez, J. V., Lis-López, L., Rodrigues, D., Pena, C., Bravo, S. B., Díaz-Tomé, V., Cuello-Rodríguez, S., López-Valverde, L., Rodiño‐Janeiro, B. K., Colon, C., et al. (2026) · Drug Delivery and Translational Research · doi:10.1007/s13346-026-02130-9 · Cited by 1
mRAVE governs lysosomal catabolism through basal and mTORC1-regulated V-ATPase assembly
Siefert, N., Zanotti, A., Paneva, A., Schneider, M., Helm, D., & Palm, W. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00838-5 · Cited by 1
Wrasidlo, W., & Masliah, E. (2026) · Cells · doi:10.3390/cells15131177 · Cited by 1
Li, S., Gao, L., Mu, L., Lu, J. H., Chen, H., 屠文展, Wu, Q., & Lin, Z. (2026) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.70146 · Cited by 1
Local autophagy impairment triggers brain-wide presynaptic remodeling and resilience
Toppe, D., Huang, S., Lützkendorf, J., Jiang, P., Suárez-Grimalt, R., Neumann, A., Zhao, Z., Lőrincz, P., Scheunemann, L., Juhász, G., et al. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00847-4 · Cited by 1
Wei, S., Zhou, S., Tu, J., Zhi, T., Wang, Y., Shen, Q.-H., Ni, C., Yao, M., & Ni, H. (2026) · Chinese Medicine · doi:10.1186/s13020-026-01466-1 · Cited by 1
Beneficially Stressing the Peripheral Nervous System to Repair
Verge, V. M. K., Ying, Z., Mustafa, W. A., Naniong, J. M. A., Nadeau, J. R., Hasmatali, J. C. D., Magno, M. E., Misra, V., & Muir, G. D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146327 · Cited by 1
Oxidative stress and inflammation in neurodegenerative disorders
Jomová, K., Alomar, S. Y., Valko, R., Nepovimová, E., Kuča, K., & Valko, M. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04518-5 · Cited by 1
Al-Dhahi, A. S., Al‐kuraishy, H. M., Fawzy, M. N., & Batiha, G. E. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111925 · Cited by 1
Lysosomal dysfunction in neurodegenerative disease
Brooker, S. M., Coukos, R., & Krainc, D. (2026) · Nature Reviews Neurology · doi:10.1038/s41582-026-01262-3 · Cited by 1
Okawa, S., Shi, Y., Banerjee, S., Tai, Y., Nabhanizadeh, J., (5992991), S. G., Shah, A. N., Jiang, S., Kim, T., Aaraj, Y. A., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci195110 · Cited by 1
Qiao, Q., Song, A., Jiang, G., Zhou, Y., Ruan, Y., Jia, W., Liu, X., & Xu, Z. (2025) · Angewandte Chemie · doi:10.1002/ange.202503177 · Cited by 1
Tuo, C.-M., Sui, X., Cui, C., Han, F., Jiao, J., Cai, H.-Y., & Wu, M. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115503 · Cited by 1
Small Interfering RNAs in Neurodegenerative Diseases: A Therapeutic Horizon
El-Nablaway, M. (2025) · Advanced Health Science and Technology Journal · doi:10.4103/ahstj.ahstj_8_25 · Cited by 1
Falcão, A. S., Lopes‐da‐Silva, M., Antas, P., Escrevente, C., Pedro, M., Felgueiras, B., Caires, B., Coelho, R., Ferreira, I. S., Santos, I. P., et al. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.111215 · Cited by 1
Autophagic enhancer rescues Tau accumulation in a stem cell model of frontotemporal dementiaPreprint
Mirfakhar, F. S., Marsh, J. A., Minaya, M., Pak, S. C., Silverman, G. A., Perlmutter, D. H., Macauley, S. L., & Karch, C. M. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.30.615921 · Cited by 1
Saini, M., Agarwala, S., Wagle, B., Spurlock, B., Golchha, B., Parker, D. J., & Mitra, K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.26.630414 · Cited by 1
Senescent cell survival relies on upregulation of lysosomal quality control mechanismsPreprint
Curnock, R., & Carroll, B. (2025) · bioRxiv · doi:10.1101/2025.03.31.646397 · Cited by 1
Rosignol, I., Dokuzluoglu, Z., Caldarelli, A., Oprişoreanu, A., Ushakova, S., Siddiqui, T., Grover, R., Guerlich, H., Falkenburger, B. H., Diez, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.07.663525 · Cited by 1
Aly, A. A. A., Jia, H., Andres‐Alonso, M., & Karpova, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.23.677999 · Cited by 1
Graß, T., Cosacak, I. M., Ordureau, A., Price, F. D., Kavali, S., Caldarelli, A., Qiao, M. N., Vardarajan, B. N., Paulo, J. A., Marass, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.19.706886 · Cited by 1
Kanda, Y., Eguchi, T., Morishita, H., Hama, Y., Abe, M., Sakimura, K., & Mizushima, N. (2026) · eLife · doi:10.64898/2026.05.20.726446 · Cited by 1
Special Issue “Neuroinflammation and Neurodegeneration: Molecular Mechanism and Novel Therapy”
Lo, C. H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27136027 · Cited by 1
Cuní-López, C., Root, J. T., Hao, Y., Blomberg, N., Koppes-den Hertog, S. J., Sacks, D., Trujillo, A. E., Ghirlando, R., Kowal, I., Epstein, J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76565-6
Emerging and Promising Keywords in Biomolecules and Therapeutics for 21st Century Diseases
Ko, H., & Lee, C. H. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.007
Abdurakhmanova, E. G. (2025) · Astana Medical Journal · doi:10.54500/2790-1203-2025-3-125-amj005
Lin, L., Patel, N., Fernández-del-Río, L., Benica, C., Wilde, B. R., Christodoulou, E., Ohtake, S., Jeong, A., Kaba, A., Matulionis, N., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157654
Moazed, K. T. (2025) · Springer eBooks · doi:10.1007/978-3-032-05044-1_1
DCBLD1 Inhibits the Progression of Parkinson’s Disease by Regulating Apoptosis and Autophagy
Jia, J., Hou, X. S., Wang, X., Wang, Y., Gao, M., & Cheng, H. (2025) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2025060535
Glycophagy: A selective autophagy pathway for glycogen degradation
Sanz, P., & Garcia-Gimeno, M. A. (2025) · International review of cytology · doi:10.1016/bs.ircmb.2025.08.014
Shi, D., Bao, J., Wu, H., Huang, B., Zheng, Y., Xu, F., Wang, H., Liu, J. J., Guan, S., & Du, K. (2025) · Neurological Sciences · doi:10.1007/s10072-025-08472-5
Jinesh, G. G., Mtchedlidze, N., Devarapalli, V., Adhikary, S., Lockhart, J. H., Napoli, M., Isha, I., Reiser, M. A., Cen, L., Liu, X., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6805130/v1
Nutraceuticals for Brain Longevity and Autophagy Activation
Adhikary, K., Abubakar, M., Ganguly, K., Sarkar, R., Ambawatiya, A., Mohanty, P., & Kumar, N. (2025) · Nutritional neurosciences · doi:10.1007/978-981-95-2790-8_14
Inflammation and Autophagic Dysfunction in Parkinson’s Disease
Fanai, H. L., Chand, J., & Akhtar, A. (2025) · Springer eBooks · doi:10.1007/978-981-95-3945-1_9
Mechanisms of Autophagy and Its Dysregulation in Neurodegenerative Diseases
Singhmura, S., Tallapragada, S. D., Ganguly, A., Chakraborty, J., Basu, A., & Dey, Y. N. (2025) · Springer eBooks · doi:10.1007/978-981-95-3945-1_2
Ginseng extract improves synaptic resiliency: A key factor for healthy cognitive aging
Almeida, M. F., Pait, M. C., Rentschler, K. M., Norton, C. J., Farizatto, K. L. G., & Bahr, B. A. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70818
Nakamura, H., Kondo, Y., Shimizu, M., Takahashi, R., & Mori, T. (2021) · Specialty journal of Pharmacognosy Phytochemistry and Biotechnology · doi:10.51847/lbkhfysqjg
Decoding acute neuroinflammatory states from the 3D architecture of in vitro microgliaPreprint
Chatzimpinou, A., Huber, J., Podlipensky, X., Cairns, J. L., Erozan, A. S., Chen, J.-H., Loconte, V., Gros, M. A. L., Hopf, C., Larabell, C. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.19.695376
Restarting synaptic remodeling and structural network: New treatment strategies for epilepsy
Cao, L., Pan, C., Wang, X., Zhang, B., Zhang, Z., Yu, C., & Xu, Z. (2026) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00826
He, Z., Zhou, J., Zhang, R., Meng, F., Nauen, D. W., Troncoso, J. C., Worley, P. F., & Zhang, W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.11.705390
Ma, J., Li, Y.-Z., Li, M.-X., Huang, M.-Q., Wang, H., Li, X.-Y., Wang, Z.-X., Wu, Y., Jin, J.-B., Feng, J., et al. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.117848
Li, Y., Ding, X., Ma, X., Jumai, A., Hao, X., Gu, Y., Qiu, H.-D., & Qiu, S. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109681
Yang, G. (2026) · Theoretical and Natural Science · doi:10.54254/2753-8818/2026.au31996
Mapping brain cell-type-specific diversity of lysosomal proteins
Golding, A. E., & Pace, R. D. (2026) · Cell Research · doi:10.1038/s41422-026-01242-8
Novás, M., Matos, M. J., & Chai, C. L. L. (2026) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2026.2646603
Identification and verification of the key genes, CCR1 and EGR2, in diabetes-associated lipophagy
Liu, J., Zhang, X., Wang, Y., Pei, W., & Zhang, Q. (2026) · Scientific Reports · doi:10.1038/s41598-026-43737-9
Su, J., Yang, M., Wang, X., Wu, P., & Zhai, Z. (2026) · Advanced Science · doi:10.1002/advs.202517862
Tang, H., Chen, X., Wang, S., Wu, Y., Li, X., Yuan, J., & Qiao, B. (2026) · Natural Product Communications · doi:10.1177/1934578x261433809
Programmed cell death: a promising management for Alzheimer’s disease
Yang, Q., Ren, X., Jia, R., Zheng, L., Ou, R., Xu, Y., Luo, Y., Yang, G., & Wang, X. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02330-1
Dilating the aging clock with light
Jing‐Yi, J. C., Ho, I. Y. M., Quah, C. B., Bai, Y. Y., Ren, J., Foo, A. S. C., & Teh, D. B. L. (2026) · The Innovation · doi:10.1016/j.xinn.2026.101368
Lin, Y. ‐., Jhuo, S., Tsai, W., Liu, Y., Chi, N.-Y., Huang, T. Y., Wu, W.-T., Lin, T.-H., Lai, W.-T., Sheu, S., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9239009/v1
Zapevalova, M. V., Guseva, E. A., Sokolskaya, S. Y., Golubeva, J. A., Myasnikov, B. P., Rubtsova, M. Y., (7313015), O. A. D., Владимирович, С. П., Fedorov, A. Y., & Shchegravina, E. S. (2026) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2026.118646
Wang, K., Jiang, B., Huang, X., Zhang, Y., Qi, H., Xu, S., Sun, L., & Liu, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1776868
Behl, C. (2026) · Springer eBooks · doi:10.1007/978-3-662-72210-7_20
Biswal, B., Satapathy, B. S., Pattnaik, S., & Maharana, L. (2026) · PharmaNutrition · doi:10.1016/j.phanu.2026.100493
Alternative Hypothesen und Beobachtungen, die verloren gingen
Behl, C. (2026) · Springer eBooks · doi:10.1007/978-3-662-72210-7_17
Wu, Y., Luo, J., Tang, H., Wang, A., Duan, M., Liu, J., Wang, G., & Ouyang, L. (2026) · Fundamental Research · doi:10.1016/j.fmre.2026.04.015
Wang, J., Davis, C. T., Kunzelmann, S., Maslen, S., Kelly, G., Skehel, M. J., & Schreiber, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.16.718395
Fan, Y., Fan, F., Xie, J., Chen, G., Xu, J., & Yang, C. (2026) · Experimental Gerontology · doi:10.1016/j.exger.2026.113141
Yuan, H., Niu, H., Zheng, X., Sun, Y., Sun, Q., Lu, Q., & Jia, M. (2026) · Research Square · doi:10.21203/rs.3.rs-9323678/v1
Wang, Z., Pan, Y., Shu, M., & Li, Z. L. (2026) · Journal of Integrative Neuroscience · doi:10.31083/jin47903
Acetylation of STX17 promotes its autophagosomal translocation
Zhou, C., Li, P., Cheng, Y., Hu, Y., Wang, J., Tian, X., Wang, X., Liu, B., Teng, J., Zheng, P., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72476-8
Magnetic fields as biophysical activators of autophagy: A preclinical systematic review
Emanuele, E., Santos‐Lozano, A., López‐Ortiz, S., Khoramipour, K., García‐Chico, C., Lista, S., & Minoretti, P. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102613
Yan, J., Feng, H., Xia, Q., Shen, D., Jin, H. K., Sun, R., Sun, J. F., Tang, W., Yu, X., Guo, F., et al. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.5c08045
Lysosomes as Regulators of Cancer Stemness and Drug Resistance
Fa-Xiao, Z. H. O. U., Di-Ping, Y. U., Tan, S., Duan, H., & Xiao-Ming, W. U. (2026) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/j.pibb.2025.0553
García, L. G. (2026) · Gredos (University of Salamanca) · doi:10.14201/gredos.171270
Zhu, C., Lu, J., Zhu, B., Liu, B. Y., Li, G., Guo, Y., Guo, X., & Yin, Z. H. I. Y. I. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1743064
Metadata
- Authors
- Nixon, R. A., & Rubinsztein, D. C.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- University of Cambridge (GB)
- Corresponding author
- Nixon, Ralph A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2024-08-06
- Volume
- 25
- Issue
- 11
- Pages
- 926-946
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC12239022
- OpenAlex
- W4401363901
- Cited by
- 435
- References
- 319
- Citations by year
- 2026: 260 · 2025: 160 · 2024: 14
- FWCI
- 26.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- CHDI Foundation
- Rainwater Charitable Foundation
- Alzheimer's Society
- National Institute for Health and Care Research ((NIHR203312)
- Department of Health and Social Care
- Parkinson's UK
- Rosetrees Trust
- UK Dementia Research Institute
- Medical Research Council (NIHR203312)
- NIHR Cambridge Biomedical Research Centre (NIHR 203312)
- National Institute on Aging (P01AG017617, R01AG062376)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, lysosomes, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, frontotemporal dementia, neuronal aging, autophagosome formation, calcium homeostasis, protein aggregate clearance, lysosomal storage disease
- MeSH terms
- Autophagosomes, Animals, Autophagy, Humans, Lysosomes, Neurons, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
