Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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Protein aggregation and neurodegenerative disease

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TFEB Links Autophagy to Lysosomal Biogenesis

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The role of autophagy during the early neonatal starvation period

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

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mTOR at the nexus of nutrition, growth, ageing and disease

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The Beclin 1 network regulates autophagy and apoptosis

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The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

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The role of autophagy in neurodegenerative disease

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mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

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Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

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Lysosomes as dynamic regulators of cell and organismal homeostasis

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Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

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Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

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Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

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The vacuolar (H+)-ATPases — nature's most versatile proton pumps

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Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

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Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

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Discovery of Atg5/Atg7-independent alternative macroautophagy

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Regulation of endoplasmic reticulum turnover by selective autophagy

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WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

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Plasma membrane contributes to the formation of pre-autophagosomal structures

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Lysosomal positioning coordinates cellular nutrient responses

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Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease

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ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

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Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

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α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

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Pathogenic Lysosomal Depletion in Parkinson's Disease

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Lysosomes as a therapeutic target

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Autophagy as a promoter of longevity: insights from model organisms

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TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

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Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

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Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

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Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

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Machinery, regulation and pathophysiological implications of autophagosome maturation

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Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

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β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease

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The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management

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Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

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Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease

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MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

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Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

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The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

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LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

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Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

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ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival

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The Itinerary of Autophagosomes: From Peripheral Formation to Kiss‐and‐Run Fusion with Lysosomes

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Presenilins and -Secretase: Structure, Function, and Role in Alzheimer DiseasePreprint

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Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

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Regulation of TFEB and V‐ATPases by mTORC1

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The Many Substrates of Presenilin/γ-Secretase

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NAADP Mobilizes Ca2+ from Reserve Granules, Lysosome-Related Organelles, in Sea Urchin Eggs

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Alzheimer Disease and Oxidative Stress

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Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes

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Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer’s disease ameliorates amyloid pathologies and memory deficits

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The lysosome turns fifty

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Dynein mutations impair autophagic clearance of aggregate-prone proteins

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Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

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Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease

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Autophagosome Precursor Maturation Requires Homotypic Fusion

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Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

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Complex Inhibitory Effects of Nitric Oxide on Autophagy

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An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

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The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

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A Dynamic Interface between Vacuoles and Mitochondria in Yeast

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Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

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Neurodegenerative lysosomal disorders: A continuum from development to late age

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Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification

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Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

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Polyglutamine tracts regulate beclin 1-dependent autophagy

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ATP13A2 deficiency disrupts lysosomal polyamine export

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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

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Lysosomal cathepsins and their regulation in aging and neurodegeneration

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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

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A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

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Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

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