The DOI matches its Crossref record; 319 of the 319 references it cites were found in a registry or an index.
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Open accessAbstract
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular constituents and eliminate damaged organelles and aggregate-prone proteins. Their postmitotic nature and extremely polarized morphologies make neurons particularly vulnerable to disruptions caused by autophagy-lysosomal defects, especially as the brain ages. Consequently, mutations in genes regulating autophagy and lysosomal functions cause a wide range of neurodegenerative diseases. Here, we review the role of autophagy and lysosomes in neurodegenerative diseases such as Alzheimer disease, Parkinson disease and frontotemporal dementia. We also consider the strong impact of cellular ageing on lysosomes and autophagy as a tipping point for the late-age emergence of related neurodegenerative disorders. Many of these diseases have primary defects in autophagy, for example affecting autophagosome formation, and in lysosomal functions, especially pH regulation and calcium homeostasis. We have aimed to provide an integrative framework for understanding the central importance of autophagic-lysosomal function in neuronal health and disease.
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“Currently, 14 NCLs have been described, each with their own identified lipo-protein ultrastructural aggregate and causative gene mutation.119”
From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [119]
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“Previous work has linked disruptions to autophagy and lysosomal biology with AD72–74.”
From APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics (2026) · cites this paper as [73]
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Cites
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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
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Cited by
Sorted by citations
Autophagy–lysosomal-associated neuronal death in neurodegenerative disease
Nixon, R. A. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02799-7 · Cited by 126
Self-citationLiu, T., Kong, X., Qiao, J., & Wei, J. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103787 · Cited by 112
Lipid metabolism, remodelling and intercellular transfer in the CNS
Vanherle, S., Loix, M., Miron, V. E., Hendriks, J. J. A., & Bogie, J. F. J. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00908-3 · Cited by 96
Autophagy-dependent versus autophagy-independent ferroptosis
Zhu, Y., Fujimaki, M., & Rubinsztein, D. C. (2025) · Trends in Cell Biology · doi:10.1016/j.tcb.2025.01.005 · Cited by 64
Self-citationGao, L., Wang, J., & Bi, Y. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s549893 · Cited by 52
“166,167 A recent study developed a TPP-functionalized MoS 2 nanocomposite system with catalase and superoxide dismutase mimetic activities, which effectively scavenged ROS in AD models.”
Metadata
- Authors
- Nixon, R. A., & Rubinsztein, D. C.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- University of Cambridge (GB)
- Corresponding author
- Nixon, Ralph A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2024-08-06
- Volume
- 25
- Issue
- 11
- Pages
- 926-946
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC12239022
- OpenAlex
- W4401363901
- Cited by
- 435
- References
- 319
- Citations by year
- 2026: 260 · 2025: 160 · 2024: 14
- FWCI
- 26.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- CHDI Foundation
- Rainwater Charitable Foundation
- Alzheimer's Society
- National Institute for Health and Care Research ((NIHR203312)
- Department of Health and Social Care
- Parkinson's UK
- Rosetrees Trust
- UK Dementia Research Institute
- Medical Research Council (NIHR203312)
- NIHR Cambridge Biomedical Research Centre (NIHR 203312)
- National Institute on Aging (P01AG017617, R01AG062376)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagy, lysosomes, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, frontotemporal dementia, neuronal aging, autophagosome formation, calcium homeostasis, protein aggregate clearance, lysosomal storage disease
- MeSH terms
- Autophagosomes, Animals, Autophagy, Humans, Lysosomes, Neurons, Neurodegenerative Diseases
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