The DOI matches its Crossref record; 349 of the 351 references it cites were found in a registry or an index.
Cannabinoids and the expanded endocannabinoid system in neurological disorders
Abstract
Anecdotal evidence that cannabis preparations have medical benefits together with the discovery of the psychotropic plant cannabinoid Δ 9-tetrahydrocannabinol (THC) initiated efforts to develop cannabinoid-based therapeutics. These efforts have been marked by disappointment, especially in relation to the unwanted central effects that result from activation of cannabinoid receptor 1 (CB1), which have limited the therapeutic use of drugs that activate or inactivate this receptor. The discovery of CB2 and of endogenous cannabinoid receptor ligands (endocannabinoids) raised new possibilities for safe targeting of this endocannabinoid system. However, clinical success has been limited, complicated by the discovery of an expanded endocannabinoid system - known as the endocannabinoidome - that includes several mediators that are biochemically related to the endocannabinoids, and their receptors and metabolic enzymes. The approvals of nabiximols, a mixture of THC and the non-psychotropic cannabinoid cannabidiol, for the treatment of spasticity and neuropathic pain in multiple sclerosis, and of purified botanical cannabidiol for the treatment of otherwise untreatable forms of paediatric epilepsy, have brought the therapeutic use of cannabinoids and endocannabinoids in neurological diseases into the limelight. In this Review, we provide an overview of the endocannabinoid system and the endocannabinoidome before discussing their involvement in and clinical relevance to a variety of neurological disorders, including Parkinson disease, Alzheimer disease, Huntington disease, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, stroke, epilepsy and glioblastoma.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The ECS is widespread throughout the central nervous system and is known to play important roles in many cognitive and behavioral processes [84, 85].”
From Consequences of adolescent drug use (2023) · cites this paper as [85]
In the citing paper
“The ECS modulates a multitude of physiological processes, including the HPA axis (241), cognition, learning and memory (242), intestinal-barrier function (243), inflammation (244), energy metabolism (245), among others (reviewed recently (239)).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [239]
Citations
Cites
1 retracted
Anti-carcinogenic activity of anandamide on human glioma in vitro and in vivo
Ma, C., Wu, T., Jiang, P., Li, Z., Chen, X., FU, K., WANG, W., & Gong, R. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4721 · Cited by 27
RetractedIsolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443
2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
Devinsky, O., Cross, J. H., Laux, L., Marsh, E., Miller, I., Nabbout, R., Scheffer, I. E., Thiele, E. A., & Wright, S. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1611618 · Cited by 1,711
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607
Cited by
Sorted by citations
Items 101–200 of 984
Cannabinoids-Promising Antimicrobial Drugs or Intoxicants with Benefits?
Klahn, P. (2020) · Antibiotics · doi:10.3390/antibiotics9060297 · Cited by 43
Reddy, V. P., Grogan, D. P., Ahluwalia, M., Salles, É. L., Ahluwalia, P. K., Khodadadi, H., Alverson, K., Nguyen, A., Raju, S. P., Gaur, P., et al. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00203-4 · Cited by 45
Targeting the endocannabinoid system with microbial interventions to improve gut integrity
Jansma, J., Brinkman, F. N., van Hemert, S., & Aidy, S. E. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110169 · Cited by 45
Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome
Brierley, S. M., Meerveld, B. G., Sarnelli, G., Sharkey, K. A., Storr, M., & Tack, J. F. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00682-y · Cited by 41
Myers, M. N., Zachut, M., Tam, J., & Contreras, G. A. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00549-3 · Cited by 43
The impact of cannabinoid type 2 receptors (CB2Rs) in neuroprotection against neurological disorders
Xin, Q., Xu, F., Taylor, D. H., Zhao, J., & Wu, J. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00530-2 · Cited by 41
Bryk, M., & Starowicz, K. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00270-y · Cited by 40
Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization
Grieco, M., Caris, M. G. D., Maggi, E., Armeli, F., Coccurello, R., Bisogno, T., D’Erme, M., Maccarrone, M., Mancini, P., & Businaro, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147711 · Cited by 39
Self-citationBarak, T., Eden, S., Steinberg, D., Feldman, M., Sionov, R. V., & Shalish, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415878 · Cited by 39
Sarsembayeva, A., Kienzl, M., Gruden, E., Ristić, D., Maitz, K. S., Valadez-Cosmes, P., Santiso, A., Hasenoehrl, C., Brčić, L., Lindenmann, J., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.997115 · Cited by 39
The endocannabinoid system – current implications for drug development
Fowler, C. J. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13229 · Cited by 38
Natural and Synthetic Cannabinoids: Pharmacology, Uses, Adverse Drug Events, and Drug Interactions
Brown, J. D., Rivera, K. J. R., Hernandez, L. Y. C., Doenges, M. R., Auchey, I., Pham, T., & Goodin, A. J. (2021) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.1871 · Cited by 43
Cannabinoid receptor 1 signaling in hepatocytes and stellate cells does not contribute to NAFLD
Wang, S., Zhu, Q., Liang, G., Franks, T., Boucher, M., Bence, K. K., Lu, M., Castorena, C. M., Zhao, S., Elmquist, J. K., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci152242 · Cited by 38
Metabolic Messengers: endocannabinoids
Busquets-García, A., Bolaños, J. P., & Marsicano, G. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00600-1 · Cited by 43
Aziz, A.-I., Nguyen, L. C., Oumeslakht, L., Bensussan, A., & Mkaddem, S. B. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0133 · Cited by 41
Lins, B. R., Anyaegbu, C. C., Hellewell, S. C., Papini, M. G., McGonigle, T. A., Prato, L. D., Shales, M., & Fitzgerald, M. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02734-9 · Cited by 40
Neuroinflammation of Microglial Regulation in Alzheimer’s Disease: Therapeutic Approaches
Chen, H., Zeng, Y., Wang, D., Li, Y., Xing, J., Zeng, Y., Liu, Z., Zhou, X., & Fan, H. J. (2024) · Molecules · doi:10.3390/molecules29071478 · Cited by 41
Zhang, H., Shen, H., Gao, M., Ma, Z., Hempel, B. J., Bi, G., Gardner, E. L., Wu, J., & Xi, Z. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108538 · Cited by 38
Han, S., Wang, J., Zhang, W., & Tian, X. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04073-z · Cited by 39
Fernández-Trapero, M., Pérez-Díaz, C., Espejo‐Porras, F., de Lago, E., & Fernández‐Ruíz, J. (2020) · Biomolecules · doi:10.3390/biom10020279 · Cited by 37
Kuchenbuch, M., D’Onofrio, G., Chémaly, N., Barcia, G., Teng, T., & Nabbout, R. (2020) · Epilepsia Open · doi:10.1002/epi4.12411 · Cited by 39
Ortega, G. A., Ahmed, S. R., Tuteja, S. K., Srinivasan, S., & Rajabzadeh, A. R. (2021) · Talanta · doi:10.1016/j.talanta.2021.122863 · Cited by 37
Abd‐Nikfarjam, B., Dolati‐Somarin, A., Rahimi, V. B., & Askari, V. R. (2023) · BioFactors · doi:10.1002/biof.1936 · Cited by 37
Yang, S., Hu, B., Wang, Z., Zhang, C., Jiao, H., Mao, Z.-G., Wei, L., Jia, J., & Zhao, J. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00338-3 · Cited by 36
Armeli, F., Bonucci, A., Maggi, E., Pinto, A., & Businaro, R. (2021) · Biomolecules · doi:10.3390/biom11060790 · Cited by 40
Wang, D., Kang, K., Sun, J., Lin, Q. D., Lv, Q., & Hai, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4139330 · Cited by 36
Therapeutic potential of cannabidivarin for epilepsy and autism spectrum disorder
Zamberletti, E., Rubino, T., & Parolaro, D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107878 · Cited by 36
Wang, D., Jin, K.-Y., Zhao, P., Lin, Q. D., Kang, K., & Hai, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s307335 · Cited by 35
A Proteomic View of Cellular and Molecular Effects of Cannabis
Abyadeh, M., Gupta, V., Paulo, J. A., Gupta, V. B., Chitranshi, N., Godinez, A., Saks, D., Hasan, M. T., Amirkhani, A., McKay, M. J., et al. (2021) · Biomolecules · doi:10.3390/biom11101411 · Cited by 35
Roles of the Cannabinoid System in the Basal Ganglia in Parkinson’s Disease
Wang, M., Liu, H., & Ma, Z. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.832854 · Cited by 36
Key Genes and Biochemical Networks in Various Brain Regions Affected in Alzheimer’s Disease
Abyadeh, M., Tofigh, N., Hosseinian, S., Hasan, M. T., Amirkhani, A., Fitzhenry, M. J., Gupta, V. B., Chitranshi, N., Salekdeh, G. H., Haynes, P. A., et al. (2022) · Cells · doi:10.3390/cells11060987 · Cited by 35
Paes-Colli, Y., Aguiar, A. F. L., Isaac, A. R., Ferreira, B. K., Campos, R. M. P., Trindade, P. M. P., Reis, R. A. D. M., & Sampaio, L. D. S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.917164 · Cited by 39
Bapir, L., Erridge, S., Nicholas, M., Pillai, M., Dalavaye, N., Holvey, C., Coomber, R., Hoare, J. M., Khan, S. A., Weatherall, M. W., et al. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2181696 · Cited by 59
Bukowska, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312738 · Cited by 42
Protective Effects of N-Oleoylglycine in a Mouse Model of Mild Traumatic Brain Injury
Piscitelli, F., Guida, F., Luongo, L., Iannotti, F. A., Boccella, S., Verde, R., Lauritano, A., Imperatore, R., Smoum, R., Cristino, L., et al. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00633 · Cited by 34
Self-citationRodríguez‐Cueto, C., García‐Toscano, L., Santos‐García, I., Gómez‐Almería, M., Gonzalo‐Consuegra, C., Espejo‐Porras, F., Fernández‐Ruíz, J., & de Lago, E. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15386 · Cited by 34
Incontro, S., Sammari, M., Azzaz, F., Inglebert, Y., Ankri, N., Russier, M., Fantini, J., & Debanne, D. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1279-21.2021 · Cited by 32
Li, S., Xiao, J., Huang, C., & Sun, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-27977-7 · Cited by 35
Fellous, T. G., Maio, F. D., Kalkan, H., Carannante, B., Boccella, S., Petrosino, S., Maione, S., Marzo, V. D., & Iannotti, F. A. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113859 · Cited by 37
Weinstein, G., & Sznitman, S. R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101041 · Cited by 33
Charytoniuk, T., Żywno, H., Konstantynowicz-Nowicka, K., Berk, K., Bzdęga, W., & Chabowski, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124221 · Cited by 33
Therapeutic potential of cannabinoids in combination cancer therapy
Malhotra, P., Casari, I., & Falasca, M. (2021) · Advances in Biological Regulation · doi:10.1016/j.jbior.2020.100774 · Cited by 33
Cannabinoids: a class of unique natural products with unique pharmacology
Piscitelli, F., & Marzo, V. D. (2021) · RENDICONTI LINCEI · doi:10.1007/s12210-020-00966-y · Cited by 33
Lataliza, A. A. B., de Assis, P. M., Laurindo, L. R., Gonçalves, E. C. D., Raposo, N. R. B., & Dutra, R. C. (2021) · Phytotherapy Research · doi:10.1002/ptr.7318 · Cited by 33
Rebelatto, E. R. L., Rauber, G. S., & Caon, T. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122727 · Cited by 34
Lin, W., Zhao, L., Liang, G., Zhou, R., Zheng, X., Tao, R., Huo, Q., Su, C.-F., Li, M., Xu, N., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02698-w · Cited by 32
Chu, F.-X., Wang, X., Li, B., Xu, L., & Di, B. (2024) · Inflammation Research · doi:10.1007/s00011-023-01831-y · Cited by 33
Camberos-Barraza, J., Camacho-Zamora, A., Bátiz-Beltrán, J. C., Osuna‐Ramos, J. F., Rábago-Monzón, Á. R., Valdez-Flores, M. A., Angulo‐Rojo, C., Guadrón‐Llanos, A. M., Picos-Cárdenas, V. J., Calderón-Zamora, L., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063160 · Cited by 36
Role of cannabinoids in alcohol-induced neuroinflammation
García-Baos, A., Alegre-Zurano, L., Cantacorps, L., Martín‐Sánchez, A., & Valverde, O. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110054 · Cited by 34
Ligands for oral delivery of peptides across the blood-brain-barrier
Gailani, M. A., Liu, M., & Wen, J. (2022) · Acta Materia Medica · doi:10.15212/amm-2021-0007 · Cited by 31
Rodrigues, L. A., Caroba, M. E. S., Taba, F. K., Filev, R., & Gallassi, A. D. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172982 · Cited by 31
Meeran, M. F. N., Sharma, C., Goyal, S. N., Kumar, S., & Ojha, S. K. (2020) · Drug Development Research · doi:10.1002/ddr.21752 · Cited by 32
Targeting 2‐arachidonoylglycerol signalling in the neurobiology and treatment of depression
Silveira, K. M., Wegener, G., & Joca, S. R. L. (2021) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13595 · Cited by 30
Kibret, B. G., Canseco-Alba, A., Onaivi, E. S., & Engidawork, E. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1137957 · Cited by 30
Challenges of Cannabinoid Delivery: How Can Nanomedicine Help?
Onaivi, E. S., Chauhan, B. P. S., & Sharma, V. (2020) · Nanomedicine · doi:10.2217/nnm-2020-0221 · Cited by 30
Rapaka, D., Bitra, V. R., Challa, S. R., & Adiukwu, P. C. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102196 · Cited by 29
Greco, R., Demartini, C., Zanaboni, A. M., Francavilla, M., Icco, R. D., Ahmad, L., & Tassorelli, C. (2022) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14267 · Cited by 45
Ding, W., Yang, L., Shi, E., Kim, B., Low, S. A., Hu, K., Gao, L., Chen, P., Ding, W. Y., Borsook, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42283-6 · Cited by 29
Chemical Probes to Control and Visualize Lipid Metabolism in the Brain
Punt, J. M., van der Vliet, D., & van der Stelt, M. (2022) · Accounts of Chemical Research · doi:10.1021/acs.accounts.2c00521 · Cited by 29
Satta, V., Alonso, C., Díez, P., Martín‐Suárez, S., Rubio, M., Encinas, J. M., Fernández‐Ruíz, J., & Sagredo, O. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.602801 · Cited by 28
Reynoso-Moreno, I., Tietz, S., Vallini, E., Engelhardt, B., Gertsch, J., & Chicca, A. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00214 · Cited by 28
The CB2 cannabinoid receptor as a therapeutic target in the central nervous system
Cabañero, D., Martín‐García, E., & Maldonado, R. J. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1971196 · Cited by 30
Sphingolipid and Endocannabinoid Profiles in Adult Attention Deficit Hyperactivity Disorder
Brunkhorst-Kanaan, N., Trautmann, S., Schreiber, Y., Thomas, D., Kittel‐Schneider, S., Gurke, R., Geißlinger, G., Reif, A., & Tegeder, I. (2021) · Biomedicines · doi:10.3390/biomedicines9091173 · Cited by 28
Suriano, F., Manca, C., Flamand, N., Depommier, C., Hul, M. V., Delzenne, N. M., Silvestri, C., Cani, P. D., & Marzo, V. D. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159056 · Cited by 28
Hua, D., Li, S., Li, S., Wang, X., Wang, Y., Xie, Z., Zhao, Y., Zhang, J., & Luo, A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.806700 · Cited by 29
Cannabidiol and epilepsy in Brazil: a current review
Oshiro, C. A., & Castro, L. H. M. (2022) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x-anp-2022-s137 · Cited by 37
Greco, R., Demartini, C., Zanaboni, A. M., Tumelero, E., Icco, R. D., Sances, G., Allena, M., & Tassorelli, C. (2020) · Cephalalgia · doi:10.1177/0333102420949201 · Cited by 27
Oleson, E. B., Hamilton, L. R., & Gomez, D. M. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.660218 · Cited by 28
Cannabinoids and Cancer Chemotherapy-Associated Adverse Effects
Ward, S. J., Lichtman, A. H., Piomelli, D., & Parker, L. A. (2021) · JNCI Monographs · doi:10.1093/jncimonographs/lgab007 · Cited by 29
Challal, S., Skiba, A., Langlois, M., Esguerra, C. V., Wolfender, J., Crawford, A. D., & Skalicka‐Woźniak, K. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116740 · Cited by 29
Lombardi, M., Scaroni, F., Gabrielli, M., Raffaele, S., Bonfanti, E., Filipello, F., Giussani, P., Picciolini, S., de Rosbo, N. K., Uccelli, A., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1331210 · Cited by 29
Potential Therapeutic Targets to Modulate the Endocannabinoid System in Alzheimer’s Disease
Kanwal, H., Sangineto, M., Ciarnelli, M., Castaldo, P., Villani, R., Romano, A. D., Serviddio, G., & Cassano, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074050 · Cited by 28
Lysophosphatidylserine: A Signaling Lipid with Implications in Human Diseases
Chakraborty, A., & Kamat, S. S. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00701 · Cited by 24
Cannabinoid Receptor Type 2 Ligands: An Analysis of Granted Patents Since 2010
Brennecke, B., Gazzi, T., Atz, K., Fingerle, J., Kuner, P., Schindler, T., WECK, G. D., Nazaré, M., & Grether, U. (2021) · Pharmaceutical Patent Analyst · doi:10.4155/ppa-2021-0002 · Cited by 25
Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease
Gu, C., Chen, Y., Chen, Y., Liu, C., Zhu, Z., & Wang, M. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.768156 · Cited by 26
Lipid endocannabinoids in energy metabolism, stress and developmental programming
de Almeida, M. M., Dias-Rocha, C. P., Calviño, C., & Trevenzoli, I. H. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111522 · Cited by 27
Impact of the Cannabinoid System in Alzheimer's Disease
Li, S., Huang, Y., Yu, L., Ji, X., & Wu, J. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220201091006 · Cited by 28
Schiavi, S., Manduca, A., Carbone, E., Buzzelli, V., Rava, A., Feo, A., Ascone, F., Morena, M., Campolongo, P., Hill, M. N., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01454-7 · Cited by 26
Manipulation of the diet–microbiota–brain axis in Alzheimer’s disease
Lee, D. D., Lee, V. M. ‐., & Hur, S. K. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1042865 · Cited by 27
Phytocannabinoids—A Green Approach toward Non-Alcoholic Fatty Liver Disease Treatment
Berk, K., Bzdęga, W., Konstantynowicz-Nowicka, K., Charytoniuk, T., Żywno, H., & Chabowski, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030393 · Cited by 25
Endocannabinoids in Bladder Sensory Mechanisms in Health and Diseases
Christie, S., Brookes, S. J., & Zagorodnyuk, V. P. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.708989 · Cited by 25
Microglial Endocannabinoid Signalling in AD
Scipioni, L., Ciaramellano, F., Carnicelli, V., Leuti, A., Lizzi, A. R., Dominicis, N. D., Oddi, S., & Maccarrone, M. (2022) · Cells · doi:10.3390/cells11071237 · Cited by 26
Liu, Y., Li, Z., Xu, Z., Zhang, B., Liu, A., He, Q., Zheng, F., & Zhan, J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.04.011 · Cited by 28
Effects of Rare Phytocannabinoids on the Endocannabinoid System of Human Keratinocytes
Meo, C. D., Tortolani, D., Standoli, S., Angelucci, C. B., Fanti, F., Leuti, A., Sergi, M., Kadhim, S., Hsu, E., Rapino, C., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105430 · Cited by 24
CBGA ameliorates inflammation and fibrosis in nephropathy
Suzuki, S., Fleig, A., & Penner, R. (2023) · Scientific Reports · doi:10.1038/s41598-023-33507-2 · Cited by 25
Zhou, Y., Xu, Y., Yang, J., Yu, Z., Wang, W., Yuan, M., Wang, Y., Bai, Q., & Li, Z. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1061220 · Cited by 24
Structural basis of THC analog activity at the Cannabinoid 1 receptor
Thorsen, T. S., Kulkarni, Y., Sykes, D. A., Bøggild, A., Drace, T., Hompluem, P., Iliopoulos‐Tsoutsouvas, C., Nikas, S. P., Daver, H., Makriyannis, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55808-4 · Cited by 28
Palomba, L., Motta, A., Imperatore, R., Piscitelli, F., Capasso, R., Mastroiacovo, F., Battaglia, G., Bruno, V., Cristino, L., & Marzo, V. D. (2020) · Cells · doi:10.3390/cells9061507 · Cited by 24
Self-citationCannabinoids, Medical Cannabis, and Colorectal Cancer Immunotherapy
Zaiachuk, M., Pryimak, N., Kovalchuk, O., & Kovalchuk, I. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.713153 · Cited by 24
Pietropaolo, S., & Marsicano, G. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.031 · Cited by 23
Cannabinoid and endocannabinoid system: a promising therapeutic intervention for multiple sclerosis
Khan, H., Ghori, F. K., Ghani, U., Javed, A., & Zahid, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07223-5 · Cited by 24
Oral cannabidiol for prevention of acute and transient chemotherapy-induced peripheral neuropathy
Nielsen, S. W., Hasselsteen, S. D., Dominiak, H. S. H., Labudovic, D., Reiter, L., Dalton, S. O., & Herrstedt, J. (2022) · Supportive Care in Cancer · doi:10.1007/s00520-022-07312-y · Cited by 24
Update on the controversial identity of cells expressing cnr2 gene in the nervous system
Grabon, W., Bodennec, J., Rheims, S., Belmeguenaï, A., & Bezin, L. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13977 · Cited by 24
Fang, S., Kang, W.-T., Li, H., Cai, Q., Liang, W., Zeng, M., Yu, Q., Zhong, R., Tao, Y., Liu, S., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116149 · Cited by 24
The role of the endocannabinoid system in autism spectrum disorders: Evidence from mouse studies
Pietropaolo, S., Bellocchio, L., Bouzón‐Arnáiz, I., & Yee, B. K. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.016 · Cited by 24
Alexandre, J., Malheiro, R. F., da Silva, D. D., Carmo, H., Carvalho, F. D., & Silva, J. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176277 · Cited by 24
Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells
Jing, H., Reed, A., Ulanovskaya, O. A., Grigoleit, J.-S., Herbst, D. M., Henry, C. L., Li, H., Barbas, S., Germain, J., Masuda, K., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112971118 · Cited by 24
Shen, S., Wu, C., Yang, Z., Wang, K., Shao, Z., & Yan, W. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01472-9 · Cited by 23
Chester, L. A., Englund, A., Chesney, E., Oliver, D., Wilson, J., Sovi, S., Dickens, A. M., Orešič, M., Linderman, T., Hodsoll, J. P., et al. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0174 · Cited by 24
Kamaruzzaman, M. A., Romli, M. H., Abas, R., Vidyadaran, S., Baharuldin, M. T. H., Nasaruddin, M. L., Vishnumukkala, T., Sura, S., Warsito, K., Nor, N. H. M., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1053680 · Cited by 25
Metadata
- Authors
- Cristino, L., Bisogno, T., & Di Marzo, V.
- Affiliations
- Istituto di Chimica Biomolecolare (IT)
- Istituto di Farmacologia Traslazionale (IT)
- Venue
- Nature Reviews Neurology
- Published
- 2019-12-12
- Volume
- 16
- Issue
- 1
- Pages
- 9-29
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W2996080671
- Cited by
- 970
- References
- 351
- Citations by year
- 2026: 79 · 2025: 126 · 2024: 173 · 2023: 185 · 2022: 183 · 2021: 142 · 2020: 82
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- cannabinoids, endocannabinoid system, endocannabinoidome, neurological disorders, CB1 receptor, CB2 receptor, nabiximols, cannabidiol, THC, multiple sclerosis, spasticity, neuropathic pain, pediatric epilepsy, Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, stroke, glioblastoma
- MeSH terms
- Analgesics, Animals, Cannabidiol, Cannabinoids, Drug Combinations, Humans, Nervous System Diseases, Dronabinol, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2, Endocannabinoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review