Cannabinoids and the expanded endocannabinoid system in neurological disorders

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633

Molecular characterization of a peripheral receptor for cannabinoids

Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913

Determination and characterization of a cannabinoid receptor in rat brain

Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Devinsky, O., Cross, J. H., Laux, L., Marsh, E., Miller, I., Nabbout, R., Scheffer, I. E., Thiele, E. A., & Wright, S. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1611618 · Cited by 1,711

Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607

Gut microbiome and health: mechanistic insights

de Vos, W. M., Tilg, H., Van Hul, M., & Cani, P. D. (2022) · Gut · doi:10.1136/gutjnl-2021-326789 · Cited by 2,388

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415

Bioactive lipids, inflammation and chronic diseases

Leuti, A., Fazio, D., Fava, M., Piccoli, A., Oddi, S., & Maccarrone, M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.028 · Cited by 376

The effects of microglia-associated neuroinflammation on Alzheimer’s disease

Wang, C., Zong, S., Cui, X., Wang, X., Wu, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1117172 · Cited by 331

Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals

Legare, C. A., Raup‐Konsavage, W. M., & Vrana, K. E. (2022) · Pharmacology · doi:10.1159/000521683 · Cited by 320

The Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation

Li, N., Guo, Y., Gong, Y., Zhang, Y., Fan, W., Yao, K., Chen, Z., Dou, B., Lin, X., Chen, B., et al. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s341581 · Cited by 284

Production of bioactive plant secondary metabolites through in vitro technologies—status and outlook

Wawrosch, C., & Zotchev, S. B. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11539-w · Cited by 252

Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential

Jiang, B., Liu, T., & Gao, Y. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107581 · Cited by 242

Cannabinoids: Therapeutic Use in Clinical Practice

Pagano, C., Navarra, G., Coppola, L., Avilia, G., Bifulco, M., & Laezza, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063344 · Cited by 261

Consequences of adolescent drug use

Steinfeld, M. R., & Torregrossa, M. M. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02590-4 · Cited by 237

Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review

Burback, L., Brémault‐Phillips, S., Nijdam, M. J., McFARLANE, A. C., & Vermetten, E. H. G. J. M. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230428091433 · Cited by 251

Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products

An, D., Peigneur, S., Hendrickx, L. A., & Tytgat, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145064 · Cited by 201

Disorders of cancer metabolism: The therapeutic potential of cannabinoids

Sun, D., Li, X., Nie, S., Liu, J., & Wang, S. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113993 · Cited by 195

Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years

Maccarrone, M., Di Marzo, V., Gertsch, J., Grether, U., Howlett, A. C., Hua, T., Makriyannis, A., Piomelli, D., Ueda, N., & van der Stelt, M. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000600 · Cited by 183

Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain

Stella, B., Baratta, F., Pepa, C. D., Arpicco, S., Gastaldi, D., & Dosio, F. (2021) · Drugs · doi:10.1007/s40265-021-01579-x · Cited by 181

Sex differences and the endocannabinoid system in pain

Blanton, H. L., Barnes, R. C., McHann, M. C., Bilbrey, J. A., Wilkerson, J. L., & Guindon, J. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173107 · Cited by 151

Revisiting Excitotoxicity in Traumatic Brain Injury: From Bench to Bedside

Baracaldo-Santamaría, D., Ariza-Salamanca, D. F., Corrales-Hernández, M. G., Pachón-Londoño, M. J., Hernández-Duarte, I., & Calderón‐Ospina, C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14010152 · Cited by 139

Structural biology and molecular pharmacology of voltage-gated ion channels

Huang, J., Pan, X., & Yan, N. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00763-7 · Cited by 147

CB1 Cannabinoid Receptor Signaling and Biased Signaling

Leo, L. M., & Abood, M. E. (2021) · Molecules · doi:10.3390/molecules26175413 · Cited by 121

Small molecules in the treatment of COVID-19

Lei, S., Chen, X., Wu, J., Duan, X., & Men, K. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01249-8 · Cited by 119

Neurobiology of cannabinoid receptor signaling

Lutz, B. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.3/blutz · Cited by 119

Synthetic Cannabinoids: A Pharmacological and Toxicological Overview

Bravo, R. R., Silva, R. S., Malheiro, R. F., Carmo, H., Carvalho, F. D., da Silva, D. D., & Silva, J. P. (2022) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-031122-113758 · Cited by 106

Role of Neuroimmune Crosstalk in Mediating the Anti-inflammatory and Analgesic Effects of Acupuncture on Inflammatory Pain

Dou, B., Li, Y., Ma, J., Xu, Z., Fan, W., Tian, L., Chen, Z., Li, N., Gong, Y., Lyu, Z., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.695670 · Cited by 92

Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use

Blebea, N. M., Pricopie, A. I., Vlad, R.-A., & Hancu, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084204 · Cited by 92

The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders

Marzo, V. D. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.3/vdimarzo · Cited by 97

The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation

Young, A. P., & Denovan‐Wright, E. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.806417 · Cited by 92

Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets

Alles, S. R. A., & Smith, P. A. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.750583 · Cited by 96

The neuroprotective effects of targeting key factors of neuronal cell death in neurodegenerative diseases: The role of ER stress, oxidative stress, and neuroinflammation

Karvandi, M. S., Hesari, F. S., Aref, A. R., & Mahdavi, M. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1105247 · Cited by 97

Endocannabinoid signaling in astrocytes

Eraso‐Pichot, A., Pouvreau, S., Oliveira-Pinto, A., Gómez-Sotres, P., Skupio, U., & Marsicano, G. (2022) · Glia · doi:10.1002/glia.24246 · Cited by 89

Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression

Gallego‐Landin, I., García-Baos, A., Castro‐Zavala, A., & Valverde, O. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.762738 · Cited by 85

Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective

Suryavanshi, S. V., Kovalchuk, I., & Kovalchuk, O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.613613 · Cited by 87

Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid‐induced osteonecrosis of the femoral head

Yang, N., Sun, H., Xue, Y., Zhang, W., Wang, H., Tao, H., Liang, X., Li, M., Xu, Y., Chen, L., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.447 · Cited by 77

Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis

Bruno, A., Dolcetti, E., Rizzo, F. R., Fresegna, D., Musella, A., Gentile, A., Vito, F. D., Caioli, S., Guadalupi, L., Bullitta, S., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00169 · Cited by 87

Role of the endocannabinoid system in the regulation of intestinal homeostasis

Cuddihey, H., MacNaughton, W. K., & Sharkey, K. A. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.05.015 · Cited by 79

Statement on safety of cannabidiol as a novel food: data gaps and uncertainties

EFSA Panel on Nutrition, N. F. A. F. A. (., Turck, D., Bohn, T., Castenmiller, J. J. M., Henauw, S. D., Hirsch‐Ernst, K. I., Maciuk, A., Mangelsdorf, I., McArdle, H. J., Naska, A., et al. (2022) · EFSA Journal · doi:10.2903/j.efsa.2022.7322 · Cited by 88

Serotonin 2A Receptor (5-HT 2A R) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants

Duan, W., Cao, D., Wang, S., & Cheng, J. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00375 · Cited by 81

Endocannabinoid system in psychotic and mood disorders, a review of human studies

Ramesh, R. G., Watts, J. J., & Mizrahi, R. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110096 · Cited by 83

Inhibiting degradation of 2-arachidonoylglycerol as a therapeutic strategy for neurodegenerative diseases

Chen, C. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108394 · Cited by 78

Cannabis and cannabinoids for symptomatic treatment for people with multiple sclerosis

Filippini, G., Minozzi, S., Borrelli, F., Cinquini, M., & Dwan, K. (2022) · Cochrane Database Systematic Reviews · doi:10.1002/14651858.cd013444.pub2 · Cited by 75

Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?

Filipiuc, L.-E., Ababei, D. C., Alexa‐Stratulat, T., Pricope, C. V., Bild, V., Ştefănescu, R., Stanciu, G. D., & Tamba, B.-I. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111823 · Cited by 78

Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma

Zhou, S., Huang, Y., Chen, Y., Liu, Y., Xie, L., You, Y., Tong, S., Xu, J., Jiang, G., Song, Q., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35957-8 · Cited by 74

Biosynthesis and synthetic biology of psychoactive natural products

Jamieson, C. S., Misa, J., Tang, Y., & Billingsley, J. M. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00065a · Cited by 74

The endocannabinoid system

Kilaru, A., & Chapman, K. D. (2020) · Essays in Biochemistry · doi:10.1042/ebc20190086 · Cited by 81

K+ Channels in Primary Afferents and Their Role in Nerve Injury-Induced Pain

Smith, P. A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.566418 · Cited by 77

The Importance of Tumor Stem Cells in Glioblastoma Resistance to Therapy

Mattei, V., Santilli, F., Martellucci, S., Monache, S. D., Fabrizi, J., Colapietro, A., Angelucci, A., & Festuccia, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083863 · Cited by 74

Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation

Iorio, R., Celenza, G., & Petricca, S. (2022) · Antioxidants · doi:10.3390/antiox11061199 · Cited by 75

Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

Liu, Z., Yang, N., Dong, J., Tian, W., Chang, L., Ma, J., Guo, J., Tan, J., Dong, A., He, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31168-9 · Cited by 67

CB2 receptor in the CNS: From immune and neuronal modulation to behavior

Grabon, W., Rheims, S., Smith, J., Bodennec, J., Belmeguenaï, A., & Bezin, L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105226 · Cited by 67

Novel cannabidiol−carbamate hybrids as selective BuChE inhibitors: Docking-based fragment reassembly for the development of potential therapeutic agents against Alzheimer's disease

Jiang, X., Zhang, Z., Zuo, J., Wu, C., Zha, L., Xu, Y., Wang, S., Shi, J., Liu, X., Zhang, J., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113735 · Cited by 65

Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions

Tadijan, A., Vlašić, I., Vlainić, J., Đikić, D., Oršolić, N., & Jembrek, M. J. (2022) · Antioxidants · doi:10.3390/antiox11102049 · Cited by 68

Mechanisms of endocannabinoid control of synaptic plasticity

Winters, B. L., & Vaughan, C. W. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108736 · Cited by 70

The Transdermal Delivery of Therapeutic Cannabinoids

Mahmoudinoodezh, H., Telukutla, S. R., Bhangu, S. K., Bachari, A., Cavalieri, F., & Mantri, N. L. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020438 · Cited by 63

A Critical Review of the Role of the Cannabinoid Compounds Δ9-Tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD) and their Combination in Multiple Sclerosis Treatment

Jones, É., & Vlachou, S. (2020) · Molecules · doi:10.3390/molecules25214930 · Cited by 61

A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

Miettinen, K., Leelahakorn, N., Almeida, A., Zhao, Y., Hansen, L. R., Nikolajsen, I. E., Andersen, J. B., Givskov, M., Stærk, D., Bak, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31357-6 · Cited by 60

Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury

Jiang, F., Xia, M., Zhang, Y., Chang, J., Cao, J., Zhang, Z., Qian, Z., & Yang, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.993168 · Cited by 61

The Chemistry of Cannabis and Cannabinoids

Duggan, P. J. (2021) · Australian Journal of Chemistry · doi:10.1071/ch21006 · Cited by 61

Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment

Campos, R. M. P., Aguiar, A. F. L., Paes-Colli, Y., Trindade, P. M. P., Ferreira, B. K., Reis, R. A. D. M., & Sampaio, L. D. S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.785176 · Cited by 59

The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects

Al-Khazaleh, A. K., Zhou, X., Bhuyan, D. J., Münch, G. W., Al-Dalabeeh, E. A., Jaye, K. M., & Chang, D. (2024) · Molecules · doi:10.3390/molecules29020410 · Cited by 66

Phytocannabinoids in Neurological Diseases: Could They Restore a Physiological GABAergic Transmission?

Cifelli, P., Ruffolo, G., Felice, E. D., Alfano, V., van Vliet, E. A., Aronica, E., & Palma, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030723 · Cited by 61

Cannabidiol and brain function: current knowledge and future perspectives

Schouten, M., Dalle, S., Mantini, D., & Koppo, K. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1328885 · Cited by 64

Endocannabinoid system alterations in Alzheimer’s disease: A systematic review of human studies

Berry, A. J., Zubko, O., Reeves, S., & Howard, R. J. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147135 · Cited by 64

Quality of Life and a Surveillant Endocannabinoid System

Reis, R. A. D. M., Isaac, A. R., Freitas, H. R., de Almeida, M. M., Schuck, P. F., Ferreira, G. C., Andrade‐da‐Costa, B. L. D. S., & Trevenzoli, I. H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.747229 · Cited by 63

The Interplay between the Immune and the Endocannabinoid Systems in Cancer

Braile, M., Marcella, S., Marone, G., Galdiero, M. R., Varricchi, G., & Loffredo, S. (2021) · Cells · doi:10.3390/cells10061282 · Cited by 62

Cannabinoids in the Modulation of Oxidative Signaling

Pagano, C., Savarese, B., Coppola, L., Navarra, G., Avilia, G., Laezza, C., & Bifulco, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032513 · Cited by 62

Twelve-year neurocognitive decline in HIV is associated with comorbidities, not age: a CHARTER study

Heaton, R. K., Ellis, R. J., Tang, B., Marra, C. M., Rubin, L. H., Clifford, D. B., McCutchan, J. A., Gelman, B. B., Morgello, S., Franklin, D. R., et al. (2022) · Brain · doi:10.1093/brain/awac465 · Cited by 57

Mechanisms of endocannabinoid transport in the brain

Kaczocha, M., & Haj‐Dahmane, S. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15469 · Cited by 60

Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature

Moreira, G. A., Neto, R. M., Ribeiro, R. G., & Crippa, A. C. D. S. (2022) · Revista Paulista de Pediatria · doi:10.1590/1984-0462/2023/41/2021197 · Cited by 57

Bacillus and Paenibacillus as plant growth-promoting bacteria in soybean and cannabis

Tariq, H., Subramanian, S., Geitmann, A., & Smith, D. L. (2025) · Frontiers in Plant Science · doi:10.3389/fpls.2025.1529859 · Cited by 54

Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease

Brunetti, L., Leuci, R., Carrieri, A., Catto, M., Occhineri, S., Vinci, G., Gambacorta, L., Baltrukevich, H., Chaves, S., Laghezza, A., et al. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114358 · Cited by 52

Selective activation of cannabinoid receptor-2 reduces white matter injury via PERK signaling in a rat model of traumatic brain injury

Li, L., Luo, Q., Shang, B., Yang, X., Zhang, Y., Pan, Q., Wu, N., Tang, W., Du, D., Sun, X., et al. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113899 · Cited by 54

Use of Marijuana: Effect on Brain Health: A Scientific Statement From the American Heart Association

Testai, F. D., Gorelick, P. B., Aparicio, H. J., Filbey, F. M., Gonzalez, R., Gottesman, R. F., Melis, M., Piano, M. R., Rubino, T., & Song, S. Y. (2022) · Stroke · doi:10.1161/str.0000000000000396 · Cited by 52

Modulatory Effect of Gut Microbiota on the Gut-Brain, Gut-Bone Axes, and the Impact of Cannabinoids

Ibrahim, I., Soumyakrishnan, S., Ayariga, J. A., Xu, J., Robertson, B. K., SREEPRIYA, M., & Ajayi, O. S. (2022) · Metabolites · doi:10.3390/metabo12121247 · Cited by 57

Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism

Rakotoarivelo, V., Sihag, J., & Flamand, N. (2021) · Cells · doi:10.3390/cells10061279 · Cited by 55

Pharmacological Properties, Therapeutic Potential and Molecular Mechanisms of JWH133, a CB2 Receptor-Selective Agonist

Hashiesh, H. M., Sharma, C., Goyal, S. N., Jha, N. K., & Ojha, S. K. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.702675 · Cited by 52

Attenuation of Oxidative Stress by Cannabinoids and Cannabis Extracts in Differentiated Neuronal Cells

Raja, A., Ahmadi, S., de Costa, F., Li, N., & Kerman, K. (2020) · Pharmaceuticals · doi:10.3390/ph13110328 · Cited by 54

Cannabinoids and drug metabolizing enzymes: potential for drug-drug interactions and implications for drug safety and efficacy

Bardhi, K., Coates, S., Watson, C. J. W., & Lazarus, P. J. (2022) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2022.2148655 · Cited by 54

Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis

Sultan, M. A., Wilson, K. M., Abdulla, O. A., Busbee, P. B., Hall, A., Carter, T., Singh, N. P., Chatterjee, S., Nagarkatti, P. S., & Nagarkatti, M. (2021) · Cells · doi:10.3390/cells10123305 · Cited by 49

Cannabidiol converts NF-κB into a tumor suppressor in glioblastoma with defined antioxidative properties

Volmar, M. N. M., Cheng, J., Alenezi, H., Richter, S., Haug, A. V., Hassan, Z., Goldberg, M., Li, Y., Hou, M., Herold‐Mende, C. C., et al. (2021) · Neuro-Oncology · doi:10.1093/neuonc/noab095 · Cited by 50

Cannabidiol exerts anti-proliferative activity via a cannabinoid receptor 2-dependent mechanism in human colorectal cancer cells

Lee, H., Tamia, G., Song, H.-J., Amarakoon, D., Wei, C., & Lee, S. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108865 · Cited by 48

The Anti-Inflammatory Effects of Cannabis sativa Extracts on LPS-Induced Cytokines Release in Human Macrophages

Zaiachuk, M., Suryavanshi, S. V., Pryimak, N., Kovalchuk, I., & Kovalchuk, O. (2023) · Molecules · doi:10.3390/molecules28134991 · Cited by 48

Cannabinoids in the descending pain modulatory circuit: Role in inflammation

Bouchet, C. A., & Ingram, S. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107495 · Cited by 53

Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice

Forte, N. R., Boccella, S., Tunisi, L., Fernández-Rilo, A. C., Imperatore, R., Iannotti, F. A., Risi, M. D., Iannotta, M., Piscitelli, F., Capasso, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26388-4 · Cited by 47

Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells

Bernal‐Chico, A., Tepavčević, V., Manterola, A., Utrilla, C. L., Matute, C., & Mato, S. (2022) · Glia · doi:10.1002/glia.24172 · Cited by 50

Cannabidiol for the treatment of autism spectrum disorder: hope or hype?

Pedrazzi, J. F. C., Ferreira, F. R., Silva-Amaral, D., Lima, D. D. A., Hallak, J. E. C., Zuardi, A. W., Bel, E. A. D., Guimarães, F. S., Costa, K. C. M., Campos, A. C., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06196-4 · Cited by 53

Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential

Vuić, B., Milos, T., Tudor, L., Konjevod, M., Perković, M. N., Jembrek, M. J., Erjavec, G. N., & Štrac, D. Š. (2022) · Biomedicines · doi:10.3390/biomedicines10123000 · Cited by 49

Cannabinoid treatments in epilepsy and seizure disorders

Devinsky, O., Jones, N. A., Cunningham, M. O., Jayasekera, B. A. P., Devore, S., & Whalley, B. J. (2023) · Physiological Reviews · doi:10.1152/physrev.00049.2021 · Cited by 57

Epigenetics and the endocannabinoid system signaling: An intricate interplay modulating neurodevelopment

Gomes, T. M., da Silva, D. D., Carmo, H., Carvalho, F. D., & Silva, J. P. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105237 · Cited by 49

Cannabidiol attenuates cognitive deficits and neuroinflammation induced by early alcohol exposure in a mice model

García-Baos, A., Puig-Reyné, X., García‐Algar, Ó., & Valverde, O. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111813 · Cited by 46

Cannabinoid-mediated targeting of mitochondria on the modulation of mitochondrial function and dynamics

Malheiro, R. F., Carmo, H., Carvalho, F. D., & Silva, J. P. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106603 · Cited by 51

THC and CBD: Villain versus Hero? Insights into Adolescent Exposure

Pintori, N., Caria, F., Luca, M. A. D., & Miliano, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065251 · Cited by 50

Beneficial effects of the phytocannabinoid Δ9-THCV in L-DOPA-induced dyskinesia in Parkinson's disease

Espadas, I., Keifman, E., Palomo‐Garo, C., Burgaz, S., García, C., Fernández‐Ruíz, J., & Moratalla, R. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104892 · Cited by 45

The Biochemistry of Phytocannabinoids and Metabolic Engineering of Their Production in Heterologous Systems

Blatt-Janmaat, K. L., & Qu, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052454 · Cited by 44

The endocannabinoidome in neuropsychiatry: Opportunities and potential risks

Morris, G., Walder, K. R., Kloiber, S. M., Amminger, G. P., Berk, M., Bortolasci, C. C., Maes, M. H. J., Puri, B. K., & Carvalho, A. F. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105729 · Cited by 48

Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles

Sionov, R. V., & Steinberg, D. (2022) · Biomedicines · doi:10.3390/biomedicines10030631 · Cited by 51

Fatty Acids: Structures and Properties

Lund, J., & Rustan, A. C. (2020) · Wiley eBooks · doi:10.1002/9780470015902.a0029198 · Cited by 45

Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration

Galán-Ganga, M., Rodríguez‐Cueto, C., Merchán‐Rubira, J., Hernández, F., Ávila, J., Posada-Ayala, M., Lanciego, J. L., Luengo, E., López, M. G., Rábano, A., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01196-5 · Cited by 46

The Immune Endocannabinoid System of the Tumor Microenvironment

Kienzl, M., Kargl, J., & Schicho, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238929 · Cited by 47

Low brain endocannabinoids associated with persistent non-goal directed nighttime hyperactivity after traumatic brain injury in mice

Vogel, A., Wilken‐Schmitz, A., Hummel, R., Lang, M., Gurke, R., Schreiber, Y., Schäfer, M. K. E., & Tegeder, I. (2020) · Scientific Reports · doi:10.1038/s41598-020-71879-x · Cited by 44

Effects of repeated lysergic acid diethylamide (LSD) on the mouse brain endocannabinoidome and gut microbiome

Inserra, A., Giorgini, G., Lacroix, S., Bertazzo, A., Choo, J. M., Markopolous, A., Grant, E., Abolghasemi, A., Gregorio, D. D., Flamand, N., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15977 · Cited by 41

The Epigenetics of Migraine

Zobdeh, F., Еременко, И. И., Akan, M. A., Tarasov, V. V., Chubarev, V. N., Schiöth, H. B., & Mwinyi, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119127 · Cited by 44

Endocannabinoidome and its role in neurological disorders-A comprehensive update of existing literature

Dutta, R. (2021) · Journal of Neuroscience and Neurological Disorders · doi:10.29328/journal.jnnd.1001049 · Cited by 1

Endocannabinoid Receptors in the CNS: Potential Drug Targets for the Prevention and Treatment of Neurologic and Psychiatric Disorders

Estrada, J. A., & Contreras, I. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200217140255 · Cited by 33

Discovery of the Endocannabinoid System: A Breakthrough in Neuroscience

Hassanzadeh, P. (2014) · Archives of Neuroscience · doi:10.5812/archneurosci.15030 · Cited by 3

Endocannabinoids Part II: pathological CNS conditions involving the endocannabinoid system and their possible treatment with endocannabinoid-based drugs

Marzo, V. D., Bisogno, T., & PETROCELLIS, L. D. (2001) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.5.3.349 · Cited by 4

Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies

Duncan, R. S., Riordan, S. M., Gernon, M. C., & Koulen, P. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382220 · Cited by 30