Cannabinoids and the expanded endocannabinoid system in neurological disorders

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

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Molecular characterization of a peripheral receptor for cannabinoids

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Structure of a cannabinoid receptor and functional expression of the cloned cDNA

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Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

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Determination and characterization of a cannabinoid receptor in rat brain

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2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

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Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

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Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

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The endocannabinoid system, a new gatekeeper in the pharmacology of human hepatocellular carcinoma

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Melatonin and cannabinoids: mitochondrial-targeted molecules that may reduce inflammaging in neurodegenerative diseases.

García, S., Giménez, V. M. M., Marón, F. J. M., Reiter, R. J., & Manucha, W. A. (2020) · PubMed · doi:10.14670/hh-18-212 · Cited by 25

Diacylglycerol lipase alpha in astrocytes is involved in maternal care and affective behaviors

Schüle, L., Glasmacher, S., Gertsch, J., Roggan, M. D., Transfeld, J. L., Bîndilă, L., Lutz, B., Kolbe, C., Bilkei‐Gorzó, A., Zimmer, A., et al. (2020) · Glia · doi:10.1002/glia.23903 · Cited by 25

Neuropathic Pain in Multiple Sclerosis and Its Animal Models: Focus on Mechanisms, Knowledge Gaps and Future Directions

Mirabelli, E., & Elkabes, S. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.793745 · Cited by 23

Endocannabinoid System and Metabolism: The Influences of Sex

Forner-Piquer, I., Giommi, C., Sella, F., Lombó, M., Montik, N., Valle, L. D., & Carnevali, O. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211909 · Cited by 23

The Endocannabinoid System in Human Disease: Molecular Signaling, Receptor Pharmacology, and Therapeutic Innovation

Șerban, M., Toader, C., & Covache-Busuioc, R.-A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211132 · Cited by 26

Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist

Polini, B., Cervetto, C., Carpi, S., Pelassa, S., Gado, F., Ferrisi, R., Bertini, S., Nieri, P., Marcoli, M., & Manera, C. (2020) · Life · doi:10.3390/life10120333 · Cited by 22

Neurobiological Processes Induced by Aerobic Exercise through the Endocannabinoidome

Forteza, F., Giorgini, G., & Raymond, F. (2021) · Cells · doi:10.3390/cells10040938 · Cited by 23

Genetically-targeted photorelease of endocannabinoids enables optical control of GPR55 in pancreatic β-cells

Tobias, J. M., Rajic, G., Viray, A. E. G., Icka-Araki, D., & Frank, J. A. (2021) · Chemical Science · doi:10.1039/d1sc02527a · Cited by 20

A new UHPLC-MS/MS method for cannabinoids determination in human plasma: A clinical tool for therapeutic drug monitoring

Manca, A., Chiara, F., Mula, J., Palermiti, A., Maiese, D., Zeaiter, S., Nicolò, A. D., Imperiale, D., Filippis, G. D., Vischia, F., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113899 · Cited by 22

Rare Phytocannabinoids Exert Anti-Inflammatory Effects on Human Keratinocytes via the Endocannabinoid System and MAPK Signaling Pathway

Tortolani, D., Meo, C. D., Standoli, S., Ciaramellano, F., Kadhim, S., Hsu, E., Rapino, C., & Maccarrone, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032721 · Cited by 22

Therapeutic Potential of Cannabinoids in Glaucoma

Lindner, T., Schmidl, D., Peschorn, L., Pai, V., Popa‐Cherecheanu, A., Chua, J., Schmetterer, L. F., & Garhöfer, G. (2023) · Pharmaceuticals · doi:10.3390/ph16081149 · Cited by 23

Circulating Endocannabinoids and N-Acylethanolamines in Individuals with Cannabis Use Disorder—Preliminary Findings

Boachie, N., Gaudette, E. V., Bazinet, R. P., Lin, L., Tyndale, R. F., Mansouri, E., Huestis, M. A., Tong, J., Foll, B. L., Kish, S. J., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13101375 · Cited by 22

Cannabis as a Source of Approved Drugs: A New Look at an Old Problem

Gabarin, A., Yarmolinsky, L., Budovsky, A., Khalfin, B., & Ben‐Shabat, S. (2023) · Molecules · doi:10.3390/molecules28237686 · Cited by 28

Therapeutic applicability of cannabidiol and other phytocannabinoids in epilepsy, multiple sclerosis and Parkinson's disease and in comorbidity with psychiatric disorders

Sampaio, M. D. F. D. S., de Paiva, Y. B., Sampaio, T. B., Pereira, M. G., & Coimbra, N. C. (2024) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13997 · Cited by 28

Medicinal Chemistry approach, pharmacology and neuroprotective benefits of CB2R modulators in neurodegenerative diseases

Ferrisi, R., Ceni, C., Bertini, S., Macchia, M., Manera, C., & Gado, F. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105607 · Cited by 23

Regulation of cannabinoid CB1 and CB2 receptors, neuroprotective mTOR and pro-apoptotic JNK1/2 kinases in postmortem prefrontal cortex of subjects with major depressive disorder

Salort, G., Hernández‐Hernández, E., García-Fuster, M. J., & Garcı́a-Sevilla, J. A. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.074 · Cited by 21

LTBP1 plays a potential bridge between depressive disorder and glioblastoma

Fu, X., Zhang, P., Song, H., Wu, C., Li, S., Li, S., & Yan, C. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02509-3 · Cited by 23

Differential Interaction of Cannabidiol with Biomembranes Dependent on Cholesterol Concentration

Perez, E., Ceja-Vega, J., Krmic, M., Hernandez, A. G., Gudyka, J., Porteus, R., & Lee, S. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00040 · Cited by 22

Role of CB 1 receptors in the acute regulation of small intestinal permeability: effects of high-fat diet

Cuddihey, H., Cavin, J., Keenan, C. M., Wallace, L. E., Vemuri, K. V., Makriyannis, A., MacNaughton, W. K., & Sharkey, K. A. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00341.2021 · Cited by 24

Clinical Outcome Data of Children Treated with Cannabis-Based Medicinal Products for Treatment Resistant Epilepsy—Analysis from the UK Medical Cannabis Registry

Erridge, S., Holvey, C., Coomber, R., Hoare, J. M., Khan, S. A., Platt, M. W., Rucker, J., Weatherall, M. W., Beri, S., & Sodergren, M. H. (2022) · Neuropediatrics · doi:10.1055/a-2002-2119 · Cited by 21

Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase

Intranuovo, F., Brunetti, L., Delre, P., Mangiatordi, G. F., Stefanachi, A., Laghezza, A., Niso, M., Leonetti, F., Loiodice, F., Ligresti, A., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01084 · Cited by 21

Recent Research on Cannabis sativa L.: Phytochemistry, New Matrices, Cultivation Techniques, and Recent Updates on Its Brain-Related Effects (2018–2023)

Siracusa, L., Ruberto, G., & Cristino, L. (2023) · Molecules · doi:10.3390/molecules28083387 · Cited by 27

Redox Imbalance in Neurological Disorders in Adults and Children

Rey, F., Berardo, C., Maghraby, E., Mauri, A., Messa, L., Esposito, L., Casili, G., Ottolenghi, S., Bonaventura, E., Cuzzocrea, S., et al. (2023) · Antioxidants · doi:10.3390/antiox12040965 · Cited by 23

Saturated Cannabinoids: Update on Synthesis Strategies and Biological Studies of These Emerging Cannabinoid Analogs

Palacios, M. L. D., Ramirez, G. A., Tesfatsion, T., Okhovat, A., Pittiglio, M. K., Ray, K. P., & Cruces, W. (2023) · Molecules · doi:10.3390/molecules28176434 · Cited by 21

Impact of TRPV1 on Pathogenesis and Therapy of Neurodegenerative Diseases

Wang, W., & Sun, T. (2023) · Molecules · doi:10.3390/molecules29010181 · Cited by 24

Emerging Lipid Targets in Glioblastoma

Darwish, A., Pammer, M., Gallyas, F., Vígh, L., Balogi, Z., & Juhász, K. (2024) · Cancers · doi:10.3390/cancers16020397 · Cited by 22

Advances in the discovery of fatty acid amide hydrolase inhibitors: what does the future hold?

Fazio, D., Criscuolo, E., Piccoli, A., Barboni, B., Fezza, F., & Maccarrone, M. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1751118 · Cited by 21

Phytocannabinoids and endocannabinoids: different in nature

Maccarrone, M. (2020) · RENDICONTI LINCEI · doi:10.1007/s12210-020-00957-z · Cited by 24

Synthesis of the Cannabimovone and Cannabifuran Class of Minor Phytocannabinoids and Their Anti-inflammatory Activity

Dennis, D. G., Anand, S. D., Lopez, A. J., Petrovčič, J., Das, A., & Šarlah, D. (2022) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.2c00336 · Cited by 21

A head-to-head comparison of MM/PBSA and MM/GBSA in predicting binding affinities for the CB1 cannabinoid ligands

Yau, M. Q., Liew, C. W. Y., Toh, J. H., & Loo, J. S. E. (2024) · Journal of Molecular Modeling · doi:10.1007/s00894-024-06189-4 · Cited by 22

Fecal microbiota transplantation improves bile acid malabsorption in patients with inflammatory bowel disease: results of microbiota and metabolites from two cohort studies

Lu, G., Zhang, S., Wang, R., Wu, X., Chen, Y., Wen, Q., Cui, B., Zhang, F., & Li, P. (2025) · BMC Medicine · doi:10.1186/s12916-025-04353-y · Cited by 21

A Delightful Trip Along the Pathway of Cannabinoid and Endocannabinoid Chemistry and Pharmacology

Mechoulam, R. (2022) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051921-083709 · Cited by 22

UHPLC-ESI-MS/MS assay for quantification of endocannabinoids in cerebrospinal fluid using surrogate calibrant and surrogate matrix approaches

Aydin, E., Cebo, M., Mielnik, J., Richter, H., Schüle, R., Sievers‐Engler, A., Młynarz, P., & Lämmerhofer, M. (2022) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2022.115090 · Cited by 20

Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders

Kolesárová, M., Simko, P., Urbanská, N., & Kisková, T. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010204 · Cited by 20

Small molecules to perform big roles: The search for Parkinson's and Huntington's disease therapeutics

Pérez-Arancibia, R., Cisternas-Olmedo, M., Sepúlveda, D., Troncoso-Escudero, P., & Vidal, R. L. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1084493 · Cited by 21

Antitumor Potential of Antiepileptic Drugs in Human Glioblastoma: Pharmacological Targets and Clinical Benefits

Stella, M., Baiardi, G., Pasquariello, S., Sacco, F., Dellacasagrande, I., Corsaro, A., Mattioli, F., & Barbieri, F. (2023) · Biomedicines · doi:10.3390/biomedicines11020582 · Cited by 23

Molecular basis of FAAH-OUT -associated human pain insensitivity

Mikaeili, H., Habib, A. M., Yeung, C., Santana‐Varela, S., Luiz, A. P., Panteleeva, K., Zuberi, S. R., Athanasiou‐Fragkouli, A., Houlden, H., Wood, J. N., et al. (2023) · Brain · doi:10.1093/brain/awad098 · Cited by 20

An enquiry to the role of CB1 receptors in neurodegeneration

Fernández‐Moncada, I., Eraso‐Pichot, A., Tor, T. D., Fortunato-Marsol, B., & Marsicano, G. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106235 · Cited by 23

Cannabis, e-cigarettes and anesthesia

Lynn, R. R., & Galinkin, J. L. (2020) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000872 · Cited by 23

Therapeutic potential of cannabinoids in neurological conditions: a systematic review of clinical trials

Hakami, A. Y., & Alshehri, F. S. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1521792 · Cited by 20

Cannabinoid CB2 receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission

Xu, K., Liu, X., Zeng, Q., Liu, Y., Shan, L., Ji, L., Wu, Y., Wu, J., Chen, Y., Li, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115559 · Cited by 18

Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors

Paraíso‐Luna, J., Aguareles, J., Martín, R., Ayo-Martin, A. C., Simón-Sánchez, S., García-Rincón, D., Costas‐Insua, C., García-Taboada, E., de Salas-Quiroga, A., Díaz-Alonso, J., et al. (2020) · Development · doi:10.1242/dev.192161 · Cited by 21

Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists

Jiang, S. H., Iliopoulos‐Tsoutsouvas, C., Tong, F., Brust, C. A., Keenan, C. M., Raghav, J. G., Hua, T., Wu, S., Ho, J., Wu, Y., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c02053 · Cited by 19

Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer

Cherkasova, V., Kovalchuk, O., & Kovalchuk, I. (2021) · Cancers · doi:10.3390/cancers13174353 · Cited by 20

Inhibiting Endocannabinoid Hydrolysis as Emerging Analgesic Strategy Targeting a Spectrum of Ion Channels Implicated in Migraine Pain

Pietra, A. D., Savinainen, J. R., & Giniatullin, R. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084407 · Cited by 19

Whole-genome resequencing of wild and cultivated cannabis reveals the genetic structure and adaptive selection of important traits

Chen, X., Guo, H., Zhang, Q.-Y., Wang, L., Guo, R., Zhan, Y.-X., Lv, P., Xu, Y., Guo, M., Zhang, Y., et al. (2022) · BMC Plant Biology · doi:10.1186/s12870-022-03744-0 · Cited by 19

Effects of cannabinoids on ligand-gated ion channels

Öz, M., Yang, K. S., & Mahgoub, M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1041833 · Cited by 19

Cytotoxic Effects of Cannabidiol on Neonatal Rat Cortical Neurons and Astrocytes: Potential Danger to Brain Development

Jurič, D. M., Rozman, K. B., Lipnik‐Štangelj, M., Šuput, D., & Brvar, M. (2022) · Toxins · doi:10.3390/toxins14100720 · Cited by 20

Examining the role of cannabinoids on osteoporosis: a review

Clouse, G., Penman, S. L., Hadjiargyrou, M., Komatsu, D. E., & Thanos, P. K. (2022) · Archives of Osteoporosis · doi:10.1007/s11657-022-01190-x · Cited by 19

Antitumor mechanism of cannabidiol hidden behind cancer hallmarks

Yan, C., Li, Y., Liu, H., Chen, D., & Wu, J. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188905 · Cited by 19

Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders

Coelho, A. A., Bastos, S., Gobira, P. H., & Lisboa, S. F. D. S. (2023) · Neuronal Signaling · doi:10.1042/ns20220034 · Cited by 22

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS‐Induced Colitis Mice

Sun, Q., Iniguez, A. B., Tian, Q., Du, ‬., & Zhu, M. J. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300446 · Cited by 19

Cyclic AMP‐dependent protein kinase and D1 dopamine receptors regulate diacylglycerol lipase‐α and synaptic 2‐arachidonoyl glycerol signaling

Shonesy, B. C., Stephenson, J. R., Marks, C. R., & Colbran, R. J. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14972 · Cited by 19

Cannabidiol as a multifaceted therapeutic agent: mitigating Alzheimer's disease pathology and enhancing cognitive function

Raïch, I., Lillo, J., Rebassa, J. B., Griñán‐Ferré, C., Bellver‐Sanchís, A., Reyes‐Resina, I., Franco, R., Pallàs, M., & Navarro, G. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01756-0 · Cited by 21

The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets

Iannotti, F. A., & Marzo, V. D. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100070 · Cited by 23

Cannabinoid Receptor Type 1 in Parkinson's Disease: A Positron Emission Tomography Study with [ 18 F ] FMPEP ‐ d 2

Ajalin, R., Al‐Abdulrasul, H., Tuisku, J., Hirvonen, J., Vahlberg, T. J., Lahdenpohja, S., Rinne, J. O., & Brück, A. (2022) · Movement Disorders · doi:10.1002/mds.29117 · Cited by 18

Effects of Δ 9 -THC and Type-1 Cannabinoid Receptor Agonists in the Elevated Plus Maze Test of Anxiety: A Systematic Review and Meta-Analysis

Iglesias, L. P., Bedeschi, L. G., de Aguiar, D. C., Asth, L., & Moreira, F. A. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0078 · Cited by 17

Efficacy of the FDA-approved cannabidiol on the development and persistence of temporal lobe epilepsy and complex focal onset seizures

Reddy, D. S., Mbilinyi, R. H., & Ramakrishnan, S. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114240 · Cited by 19

Positive association between plasmatic levels of orexin A and the endocannabinoid-derived 2-arachidonoyl lysophosphatidic acid in Alzheimer’s disease

Forte, N. R., Fernández-Rilo, A. C., Palomba, L., Marfella, B., Piscitelli, F., de Girolamo, P., Costanzo, A. D., Marzo, V. D., & Cristino, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1004002 · Cited by 18

Activation of cannabinoid-2 receptor protects against Pseudomonas aeruginosa induced acute lung injury and inflammation

Nagre, N. N., Nicholson, G., Cong, X., Lockett, J., Pearson, A. C., Chan, V., Kim, W., Vinod, K. Y., & Catravas, J. D. (2022) · Respiratory Research · doi:10.1186/s12931-022-02253-w · Cited by 17

Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?

Fernández‐Moncada, I., & Marsicano, G. (2023) · Essays in Biochemistry · doi:10.1042/ebc20220089 · Cited by 18

Mobilization of endocannabinoids by midbrain dopamine neurons is required for the encoding of reward prediction

Luján, M. Á., Covey, D. P., Young-Morrison, R., Zhang, L.-Y., Kim, A., Morgado, F., Patel, S., Bass, C. E., Paladini, C. A., & Cheer, J. F. (2023) · Nature Communications · doi:10.1038/s41467-023-43131-3 · Cited by 20

Alleviating CB2-Dependent ER Stress and Mitochondrial Dysfunction Improves Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment

Wang, D. P., Kang, K., Hai, J., Lv, Q. L., & Wu, Z. B. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10098-x · Cited by 18

Cannabinoids modulate food preference and consumption in Drosophila melanogaster

He, J., Tan, A. M. X., Ng, S. Y., Rui, M., & Yu, F. (2021) · Scientific Reports · doi:10.1038/s41598-021-84180-2 · Cited by 24

Noncanonical Activity of Endocannabinoids and Their Receptors in Central and Peripheral Synapses

Balezina, O. P., Tarasova, E. O., & Gaydukov, A. E. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921070038 · Cited by 18

Contents of Cannabinoids in Hemp Varieties Grown in Maryland

Chen, X., Deng, H. F., Heise, J. A., Puthoff, D. P., Bou-Abboud, N., Yu, H., & Peng, J. (2021) · ACS Omega · doi:10.1021/acsomega.1c04992 · Cited by 18

An Update on the Behavioral and Neurobiological Effects of Cannabis Use in Adolescents: A Translational Perspective

Hurd, Y. L. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20250444 · Cited by 18

The Endocannabinoid System as Modulator of Exercise Benefits in Mental Health

Amatriain‐Fernández, S., Budde, H., Gronwald, T., Quiroga, C., Carreón, C., Viana-Torre, G., Yamamoto, T., Imperatori, C., Machado, S. E. D. C., & Murillo‐Rodríguez, E. (2020) · Current Neuropharmacology · doi:10.2174/1570159x19666201218112748 · Cited by 18

Endocannabinoid-Like Lipid Neuromodulators in the Regulation of Dopamine Signaling: Relevance for Drug Addiction

Sagheddu, C., Torres, L. H., Marcourakis, T., & Pistis, M. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.588660 · Cited by 15

Neurotoxicity of psychoactive substances: A mechanistic overview

da Silva, D. D., Silva, J. P., Carmo, H., & Carvalho, F. D. (2021) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2021.10.002 · Cited by 17

EVs-mediated delivery of CB2 receptor agonist for Alzheimer's disease therapy

Zhu, Y.-J., Huang, R., Wang, D.-H., Yu, L.-Q., Liu, Y., Huang, R., Yin, S., He, X.-L., Chen, B., Liu, Z.-B., et al. (2023) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2023.100835 · Cited by 22

Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin

Kalkan, H., Panza, E., Pagano, E., Ercolano, G., Moriello, C., Piscitelli, F., Sztretye, M. T., Capasso, R., Marzo, V. D., & Iannotti, F. A. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06080-9 · Cited by 18

A metabolome atlas of mouse brain on the global metabolic signature dynamics following short-term fasting

Shao, Y., Fu, Z., Wang, Y., Yang, Z., Lin, Y., Li, S., Cheng, C., Wei, M., Liu, Z., Xu, G., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01552-y · Cited by 17

Archaeosomes facilitate storage and oral delivery of cannabidiol

Sedlmayr, V. L., Horn, C., Wurm, D. J., Oliver Spadiut, A., & Quehenberger, J. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123434 · Cited by 17

Therapeutic use of medical Cannabis in neurological diseases: a clinical update

Hidding, U., Mainka, T., & Buhmann, C. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02719-1 · Cited by 42

A cohort study comparing the effects of medical cannabis for anxiety patients with and without comorbid sleep disturbance

Murphy, M., Erridge, S., Holvey, C., Coomber, R., Rucker, J., & Sodergren, M. H. (2023) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12407 · Cited by 17

The endocannabinoid system as a therapeutic target in neuropathic pain: a review

Quintero, J.-M., Díaz, L. E., Galve‐Roperh, I., Bustos, R., Leon, M.-X., Beltran, S., & Dodd, S. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2407824 · Cited by 18

Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks

Icco, R. D., Greco, R., Demartini, C., Vergobbi, P., Zanaboni, A., Tumelero, E., Reggiani, A. M., Realini, N., Sances, G., Grillo, V., et al. (2021) · Pain · doi:10.1097/j.pain.0000000000002223 · Cited by 17

Targeting Endocannabinoid System in Epilepsy: For Good or for Bad

Martínez-Aguirre, C., Çınar, R., & Rocha, L. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.12.013 · Cited by 18

Endocannabinoid-Binding Receptors as Drug Targets

Gómez‐Cañas, M., Rodríguez‐Cueto, C., Satta, V., Hernández-Fisac, I., Navarro, E., & Fernández‐Ruíz, J. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2728-0_6 · Cited by 17

The endocannabinoid system: a bridge between alzheimer’s disease and gut microbiota

Bisogno, T., Lauritano, A., & Piscitelli, F. (2021) · Life · doi:10.3390/life11090934 · Cited by 16

Impact of cannabinoids on cancer outcomes in patients receiving immune checkpoint inhibitor immunotherapy

Vigano, M., Wang, L., As’sadiq, A., Samarani, S., Ahmad, A., & Costiniuk, C. T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1497829 · Cited by 17

Update on Neuroprotection after Traumatic Brain Injury

Cook, A. M., Michas, M. E., & Robbins, B. T. (2025) · CNS Drugs · doi:10.1007/s40263-025-01173-9 · Cited by 16

Pain Perception and Modulation: Fundamental Neurobiology and Recent Advances

van Strien, W. W. J., & Hollmann, M. W. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70275 · Cited by 22

Cannabinoids in Neurology - Position paper from Scientific Departments from Brazilian Academy of Neurology

Brucki, S. M. D., Adoni, T., de Almeida, C. M. O., de Andrade, D. C., Anghinah, R., BARBOSA, L. M., Bazán, R., Carvalho, A. A. D. S., CARVALHO, W., Christo, P. P., et al. (2021) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x-anp-2020-0432 · Cited by 18

What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps?

Lacroix, C., Alleman-Brimault, I., Zalta, A., Rouby, F., Cassé‐Perrot, C., Jouve, É., Attolini, L., Guilhaumou, R., Micallef, J., & Blin, O. J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.883987 · Cited by 16

Cross-disorder GWAS meta-analysis of endocannabinoid DNA variations in major depressive disorder, bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorder, and schizophrenia

Kim, H. K., Gonçalves, V. F., Husain, M. I., Müller, D. J., Mulsant, B. H., Zai, G. C., & Kloiber, S. M. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115563 · Cited by 15

Integration of microbiota and metabolomics reveals the analgesic mechanisms of emodin against neuropathic pain

Wang, C., Wu, L., Zhou, R., Song, C., Chen, P., Huang, S., Khan, A. A., LU, D., Hu, Y., & Chen, L. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111170 · Cited by 16

The Interplay between Cannabinoid Receptors and Microglia in the Pathophysiology of Alzheimer’s Disease

Ferrisi, R., Gado, F., Ricardi, C., Polini, B., Manera, C., & Chiellini, G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12237201 · Cited by 16

Opioid and Cannabinoid Systems in Pain: Emerging Molecular Mechanisms and Use in Clinical Practice, Health, and Fitness

Secondulfo, C., Mazzeo, F., Pastorino, G. M. G., Vicidomini, A., Meccariello, R., & Operto, F. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179407 · Cited by 22

In Silico and In Vitro Analysis of Major Cannabis-Derived Compounds as Fatty Acid Amide Hydrolase Inhibitors

Criscuolo, E., Sciscio, M. L. D., Fezza, F., & Maccarrone, M. (2020) · Molecules · doi:10.3390/molecules26010048 · Cited by 16

Safety considerations selecting antiseizure medications for the treatment of individuals with Dravet syndrome

Nabbout, R., Chémaly, N., Chiron, C., & Kuchenbuch, M. (2021) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2021.1890025 · Cited by 16

Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARγ in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol

Pandelides, Z., Aluru, N., Thornton, C., Watts, H. E., & Willett, K. L. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab046 · Cited by 18

Sex-Dependent Prescription Patterns and Clinical Outcomes Associated With the Use of Two Oral Cannabis Formulations in the Multimodal Management of Chronic Pain Patients in Colombia

Moreno‐Sanz, G., Madiedo, A., Hernández, P., Kratz, J. W., Aizpurua‐Olaizola, O., Brown, M. R. D., Lopez, J., Patiño, J., & Mendivelso, F. O. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.854795 · Cited by 16

Beyond monoamines: I. Novel targets and radiotracers for Positron emission tomography imaging in psychiatric disorders

Lopresti, B. J., Royse, S. K., Mathis, C. A., Tollefson, S., & Narendran, R. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15615 · Cited by 16

A Targeted, Bioinert LC–MS/MS Method for Sensitive, Comprehensive Analysis of Signaling Lipids

Rubenzucker, S., Manke, M.-C., Lehmann, R., Assinger, A., Borst, O., & Ahrends, R. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c01388 · Cited by 15

A comprehensive review: neuroinflammation and immune communication between the central nervous system and the periphery

Kaur, R., Kumar, S., & Singh, L. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156974 · Cited by 16

Cannabinoid Effect and Safety in Spasticity Following Stroke: A Double-Blind Randomized Placebo-Controlled Study

Marinelli, L., Puce, L., Mori, L., Leandri, M., Rosa, G. M., Currà, A., Fattapposta, F., & Trompetto, C. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.892165 · Cited by 15

Inducible Nitric Oxide Synthase Inhibition in the Medial Prefrontal Cortex Attenuates the Anxiogenic-Like Effect of Acute Restraint Stress via CB1 Receptors

Coelho, A. A., Vila-Verde, C., Sartim, A. G., Uliana, D. L., Braga, L. A., Guimarães, F. S., & Lisboa, S. F. D. S. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.923177 · Cited by 15

Endocannabinoidome and its role in neurological disorders-A comprehensive update of existing literature

Dutta, R. (2021) · Journal of Neuroscience and Neurological Disorders · doi:10.29328/journal.jnnd.1001049 · Cited by 1

Endocannabinoid Receptors in the CNS: Potential Drug Targets for the Prevention and Treatment of Neurologic and Psychiatric Disorders

Estrada, J. A., & Contreras, I. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200217140255 · Cited by 33

Discovery of the Endocannabinoid System: A Breakthrough in Neuroscience

Hassanzadeh, P. (2014) · Archives of Neuroscience · doi:10.5812/archneurosci.15030 · Cited by 3

Endocannabinoids Part II: pathological CNS conditions involving the endocannabinoid system and their possible treatment with endocannabinoid-based drugs

Marzo, V. D., Bisogno, T., & PETROCELLIS, L. D. (2001) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.5.3.349 · Cited by 4

Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies

Duncan, R. S., Riordan, S. M., Gernon, M. C., & Koulen, P. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382220 · Cited by 30