Cannabinoids and the expanded endocannabinoid system in neurological disorders

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633

Molecular characterization of a peripheral receptor for cannabinoids

Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913

Determination and characterization of a cannabinoid receptor in rat brain

Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Devinsky, O., Cross, J. H., Laux, L., Marsh, E., Miller, I., Nabbout, R., Scheffer, I. E., Thiele, E. A., & Wright, S. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1611618 · Cited by 1,711

Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607

Evaluation of cannabinoid type 2 receptor expression and pyridine-based radiotracers in brains from a mouse model of Alzheimer’s disease

Kecheliev, V., Spinelli, F., Herde, A. M., Haider, A., Mu, L., Klohs, J., Ametamey, S. M., & Ni, R. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1018610 · Cited by 15

The Role of Cannabinoid Type 2 Receptors in Parkinson’s Disease

Basile, M. S., & Mazzon, E. (2022) · Biomedicines · doi:10.3390/biomedicines10112986 · Cited by 17

Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice

Santos‐García, I., Rodríguez‐Cueto, C., Villegas, P., Piscitelli, F., Lauritano, A., Shen, C.-K. J., Marzo, V. D., Fernández‐Ruíz, J., & de Lago, E. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02792-z · Cited by 14

Association of Cortical and Subcortical Microstructure With Clinical Progression and Fluid Biomarkers in Patients With Parkinson Disease

Wang, L., Zhou, C., Zhang, W., Zhang, M., Cheng, W., & Feng, J. (2023) · Neurology · doi:10.1212/wnl.0000000000207408 · Cited by 15

Cannabinoids and the endocannabinoid system in immunotherapy: helpful or harmful?

Sarsembayeva, A., & Schicho, R. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1296906 · Cited by 15

CB1 Receptor Activation Provides Neuroprotection in an Animal Model of Glutamate‐Induced Excitotoxicity Through a Reduction of NOX ‐2 Activity and Oxidative Stress

Martínez‐Torres, A. M., & Morán, J. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70099 · Cited by 15

Red-hot chili receptors: A systematic review of TRPV1 antagonism in animal models of psychiatric disorders and addiction

Escelsior, A., Sterlini, B., Murri, M. B., Serafini, G., Aguglia, A., da Silva, B. P., Corradi, A. M., Valente, P., & Amore, M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112734 · Cited by 16

Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch

Briand‐Mésange, F., Pons, V., Allart, S., Masquelier, J., Chicanne, G., Beton, N., Payrastre, B., Muccioli, G. G., Ausseil, J., Davignon, J., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015278 · Cited by 15

Rabies: Presentation, case management and therapy

Hemachudha, P., & Hemachudha, T. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.117413 · Cited by 15

The independent and combined effects of cannabis use and systemic inflammation during the early stages of psychosis: exploring the two-hit hypothesis

Zuelli, F. M. D. G. C., Marques, L. A. D. C., da Roza, D. L., Loureiro, C. M., Shuhama, R., Forti, M. D., Menezes, P. R., Louzada‐Júnior, P., & Del‐Ben, C. M. (2021) · Psychological Medicine · doi:10.1017/s0033291721000726 · Cited by 15

A Systematic Review on Cannabinoids for Neuropathic Pain Administered by Routes Other than Oral or Inhalation

Quintero, J.-M., Pulido, G., Giraldo‐Cadavid, L. F., Leon, M.-X., Díaz, L. E., & Bustos, R. (2022) · Plants · doi:10.3390/plants11101357 · Cited by 17

A longitudinal study of cannabis use and risk for cognitive and functional decline among older adults with HIV

Watson, C. W., Sundermann, E. E., Helm, J. L., Paolillo, E. W., Hong, S., Ellis, R. J., Letendre, S. L., Marcotte, T. D., Heaton, R. K., Morgan, E. E., et al. (2023) · AIDS and Behavior · doi:10.1007/s10461-023-04056-6 · Cited by 15

Targeting the central and peripheral nervous system to regulate bone homeostasis: mechanisms and potential therapies

Liang, T., Jin, Z., Lin, Y., Chen, Z., Li, Y., Xu, J., Yang, F., & Qin, L. (2025) · Military Medical Research · doi:10.1186/s40779-025-00600-8 · Cited by 15

Cannabinoids as Glial Cell Modulators in Ischemic Stroke: Implications for Neuroprotection

Vicente-Acosta, A., Ceprián, M., Sobrino, P., Pazos, M. R., & Loría, F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.888222 · Cited by 15

Toll-like receptor 4 in the interface between neuroimmune response and behavioral alterations caused by stress

de Souza-Júnior, F. J. C., Cunha, L. C., & Lisboa, S. F. D. S. (2022) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2022.00028 · Cited by 16

Emerging Roles of Endocannabinoids as Key Lipid Mediators for a Successful Pregnancy

Rava, A., & Trezza, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065220 · Cited by 16

The role of PPAR-γ in memory deficits induced by prenatal and lactation alcohol exposure in mice

García-Baos, A., Pastor, A., Gallego‐Landin, I., de la Torre, R., Sanz, F., & Valverde, O. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02191-z · Cited by 15

NIR-hyperspectral imaging and machine learning for non-invasive chemotype classification in Cannabis sativa L

Nicolás, M. S., Villate, A., Alvarez-Mora, I., Olivares, M., Aizpurua‐Olaizola, O., Usobiaga, A., & Amigo, J. M. (2023) · Computers and Electronics in Agriculture · doi:10.1016/j.compag.2023.108551 · Cited by 14

Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs

Zhao, H., Liu, Y., Cai, N., Liao, X., Tang, L., & Wang, Y. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s462785 · Cited by 15

Cannabinoid receptor 1 ligands: Biased signaling mechanisms driving functionally selective drug discovery

Tian, L., Qiang, T., Liu, S., Zhang, B., Zhang, Y., Zhang, B., Hu, J., Zhang, J., Qi, L., Ke, C., et al. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108795 · Cited by 14

Management of Neuropathic Pain in Polyneuropathy

Peltier, A., & Wood, D. (2020) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000928 · Cited by 14

Role of Nuclear Imaging to Understand the Neural Substrates of Brain Disorders in Laboratory Animals: Current Status and Future Prospects

D’Elia, A., Schiavi, S., Soluri, A., Massari, R., Soluri, A., & Trezza, V. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.596509 · Cited by 14

Analogues of cannabinoids as multitarget drugs in the treatment of Alzheimer's disease

Montero, J. M. S., Agís-Torres, Á., Solano, D., Söllhuber, M. M., Fernandez, M., Villaro, W., Gómez‐Cañas, M., Garcı́a-Arencibia, M., Fernández‐Ruíz, J., Egea, J., et al. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173875 · Cited by 14

Endocannabinoid system in the neurodevelopment of GABAergic interneurons: implications for neurological and psychiatric disorders

Song, C., Kang, X., Yang, F., Du, W., Zhang, J., Liu, L., Kang, J., Jia, N., Yue, H., Fan, L., et al. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0134 · Cited by 15

Gene Expression Analysis of the Endocannabinoid System in Presymptomatic APP/PS1 Mice

Vidal-Palencia, L., Ramon‐Duaso, C., González-Parra, J. A., & Busquets-García, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.864591 · Cited by 16

Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine

Greco, R., Demartini, C., Zanaboni, A. M., Francavilla, M., Reggiani, A. M., Realini, N., Scarpelli, R., Piomelli, D., & Tassorelli, C. (2022) · The Journal of Headache and Pain · doi:10.1186/s10194-022-01449-1 · Cited by 16

UK medical cannabis registry: assessment of clinical outcomes in patients with headache disorders

Nicholas, M., Erridge, S., Bapir, L., Pillai, M., Dalavaye, N., Holvey, C., Coomber, R., Rucker, J., Weatherall, M. W., & Sodergren, M. H. (2023) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2023.2174017 · Cited by 16

Choosing the right drug: status and future of endocannabinoid research for the prevention of drug-seeking reinstatement

Luján, M. Á., Cheer, J. F., & Melis, M. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.08.014 · Cited by 12

Lipid Signaling through G Proteins

Cannon, A. E., & Chapman, K. D. (2021) · Trends in Plant Science · doi:10.1016/j.tplants.2020.12.012 · Cited by 14

Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1

Echeazarra, L., del Caño, G. G., Barrondo, S., González‐Burguera, I., Saumell-Esnaola, M., Aretxabala, X., de Jesús, M. L., Roman, L. B., Mato, S., Ledent, C. A., et al. (2021) · Histochemistry and Cell Biology · doi:10.1007/s00418-021-02025-5 · Cited by 13

Cannabis, Cannabinoids, and Stroke: Increased Risk or Potential for Protection—A Narrative Review

Carter, C., Laviolette, L., Bietar, B., Zhou, J., & Lehmann, C. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46040196 · Cited by 13

From Polyphenols to Prodrugs: Bridging the Blood–Brain Barrier with Nanomedicine and Neurotherapeutics

Tanaka, M., Araujo, A. C., Valenti, V. E., Guiguer, E. L., Catharin, V. C. S., Gualhardi, C. M., de Souza Bastos Mazuqueli Pereira, E., de Alvares Goulart, R., de Argolo Haber, R. S., de Carvalho, A. C. A., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052370 · Cited by 13

Determination of endocannabinoids and their conjugated congeners in the brain by means of μSPE combined with UHPLC-MS/MS

Fanti, F., Vincenti, F., Imparato, G., Montesano, C., Scipioni, L., Ciaramellano, F., Tortolani, D., Oddi, S., Maccarrone, M., Compagnone, D., et al. (2023) · Talanta · doi:10.1016/j.talanta.2023.124392 · Cited by 13

Cannabinoid Analgesia in Postoperative Pain Management: From Molecular Mechanisms to Clinical Reality

Carrascosa, A. J., Navarrete, F., Saldaña, R., García‐Gutiérrez, M. S., Moreno, B. M., Navarro, D., Gómez-Guijarro, F. M., Gasparyan, A., Murcia-Sánchez, E., Torregrosa, A. B., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116268 · Cited by 16

The State of Synthetic Cannabinoid Medications for the Treatment of Pain

Maglaviceanu, A., Peer, M., Rockel, J. S., Bonin, R. P., Fitzcharles, M., Ladha, K. S., Bhatia, A., Leroux, T. S., Kotra, L. P., Kapoor, M., et al. (2024) · CNS Drugs · doi:10.1007/s40263-024-01098-9 · Cited by 14

Unveiling the Potential of Phytocannabinoids: Exploring Marijuana’s Lesser-Known Constituents for Neurological Disorders

Basavarajappa, B. S., & Subbanna, S. (2024) · Biomolecules · doi:10.3390/biom14101296 · Cited by 14

Acute cannabis intoxication among the paediatric population

Malta, G., Albano, G. D., Lavanco, G., Brancato, A., Cannizzaro, C., Argo, A., Contorno, S., Plescia, F., & Zerbo, S. (2025) · Frontiers in Toxicology · doi:10.3389/ftox.2025.1558721 · Cited by 16

Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models

Depommier, C., Flamand, N., Pelicaen, R., Maiter, D. M., Thissen, J., Loumaye, A., Hermans, M. P., Everard, A., Delzenne, N. M., Marzo, V. D., et al. (2021) · Cells · doi:10.3390/cells10010071 · Cited by 13

Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis

Duan, W., Sun, Y., Wu, M., Zhang, Z., Zhang, T., Wang, H., Li, F., Yang, L., Xu, Y., Liu, Z., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113878 · Cited by 13

Nanotechnology in Improving the Treatment of Huntington’s Disease: a Systematic Review

Valadão, K. M. G., Luizeti, B. O., Yamaguchi, M. U., Issy, A. C., & Bernuci, M. P. (2022) · Neurotoxicity Research · doi:10.1007/s12640-021-00468-1 · Cited by 13

Partial protective effects of cannabidiol against PTZ-induced acute seizures in female rats during the proestrus–estrus transition

Janisset, N. R. L. L., Romariz, S. A. A., Hashiguchi, D., Quintella, M. L., Gimenes, C., Yokoyama, T. S., Filev, R., Carlini, E. A., da Silva, R. B., Faber, J., et al. (2022) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2022.108615 · Cited by 14

The Endocannabinoid System and Physical Activity—A Robust Duo in the Novel Therapeutic Approach against Metabolic Disorders

Charytoniuk, T., Żywno, H., Berk, K., Bzdęga, W., Kołakowski, A., Chabowski, A., & Konstantynowicz-Nowicka, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063083 · Cited by 13

A bibliometrics analysis and visualization study of TRPV1 channel

Gao, N., Li, M., Wang, W., Liu, Z., & Guo, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1076921 · Cited by 13

Distribution of the Cannabinoid Receptor Type 1 in the Brain of the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal

Fuerte-Hortigón, A., Gonçalves-Sánchez, J., Zeballos, L., Masa, R., Gómez‐Nieto, R., & López, D. E. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.613798 · Cited by 16

Dose-dependent effects of oral cannabidiol and delta-9-tetrahydrocannabinol on serum anandamide and related N-acylethanolamines in healthy volunteers

Couttas, T. A., Boost, C., Pahlisch, F., Sykorova, E. B., Mueller, J. K., Jieu, B., Leweke, J. E., Dammann, I., Hoffmann, A., Löffler, M., et al. (2024) · BMJ Mental Health · doi:10.1136/bmjment-2024-301027 · Cited by 12

Integrating endocannabinoid signaling, CCK interneurons, and hippocampal circuit dynamics in behaving animals

Malhotra, S., Donneger, F., Farrell, J. S., Dudok, B., Losonczy, A., & Soltész, I. (2025) · Neuron · doi:10.1016/j.neuron.2025.03.016 · Cited by 14

Transcriptome Profiling of miRNA-mRNA Interactions and Associated Mechanisms in Chemotherapy-Induced Neuropathic Pain

Yang, X.-H., Huang, X., Lu, W., Yan, F., Ye, Y., Wang, L., Tang, X., Zeng, W., Huang, J., & Xie, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03398-5 · Cited by 12

Long-Term Treatment with Cannabidiol-Enriched Cannabis Extract Induces Synaptic Changes in the Adolescent Rat Hippocampus

Aguiar, A. F. L., Campos, R. M. P., Isaac, A. R., Paes-Colli, Y., Carvalho, V. M., Sampaio, L. D. S., & Reis, R. A. D. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411775 · Cited by 13

The Exploration of Cannabis and Cannabinoid Therapies for Migraine

Chandwani, B. P., Bradley, B. A., Pace, A., Buse, D. C., Singh, R., & Kuruvilla, D. E. (2023) · Current Pain and Headache Reports · doi:10.1007/s11916-023-01144-z · Cited by 12

Rethinking the First Episode of Schizophrenia: Identifying Convergent Mechanisms During Development and Moving Toward Prediction

Forsyth, J. K., & Bearden, C. E. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230736 · Cited by 12

UK Medical Cannabis Registry: Assessment of clinical outcomes in patients with insomnia

Vivek, K., Karagozlu, Z., Erridge, S., Holvey, C., Coomber, R., Rucker, J., Weatherall, M. W., & Sodergren, M. H. (2024) · Brain and Behavior · doi:10.1002/brb3.3410 · Cited by 12

Recent Progress in Poly (Lactic-co-Glycolic Acid)-Based Biodegradable Drug Delivery Carriers for Pain Management

Tao, L., Gao, J., Feng, R., Zheng, Y., Tian, K., Chen, J., & Xu, X. (2024) · Processes · doi:10.3390/pr12071372 · Cited by 12

Potential Neuroprotective Effect of the Endocannabinoid System on Parkinson’s Disease

Urmeneta-Ortíz, M. F., Tejeda-Martínez, A. R., González‐Reynoso, O., & Flores-Soto, M. E. (2024) · Parkinson s Disease · doi:10.1155/2024/5519396 · Cited by 14

Circulating endocannabinoidome signatures of disease activity in amyotrophic lateral sclerosis

Dubbioso, R., Iannotti, F. A., Senerchia, G., Verde, R., Iuzzolino, V. V., Spisto, M., Fasolino, I., Manganelli, F., Marzo, V. D., & Piscitelli, F. (2024) · European Journal of Neurology · doi:10.1111/ene.16400 · Cited by 12

Efficiency and safety of cannabinoid medical use: an analysis of discussions and observed trends on Instagram

Litvinova, O., Baral, B., Wochele‐Thoma, T., Matin, M., Tzvetkov, N. T., Adamska, O., Kamińska, A., Łapiński, M., Stolarczyk, A., & Atanasov, A. G. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1494018 · Cited by 13

Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice

Hodges, E. L., Marshall, J. P. S., & Ashpole, N. M. (2020) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-020-0045-7 · Cited by 13

Endocannabinoid Signaling for GABAergic-Microglia (Mis)Communication in the Brain Aging

Carrera, J., Tomberlin, J., Kurtz, J., Karakaya, E., Bostancıklıoğlu, M., & Albayram, Ö. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.606808 · Cited by 12

The Endocannabinoid System in Glial Cells and Their Profitable Interactions to Treat Epilepsy: Evidence from Animal Models

Huguet, J. E., Gómez, E. S., & Grandes, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413231 · Cited by 14

Detection of Eight Cannabinoids and One Tracer in Wastewater and River Water by SPE-UPLC–ESI-MS/MS

Milan, S., Lelario, F., Scrano, L., Ottati, C., Bufo, S. A., & Alpendurada, M. F. (2022) · Water · doi:10.3390/w14040588 · Cited by 12

The Endocannabinoid System as a Biomarker for Diagnostic and Therapeutic Applications in Depression and Anxiety

Murillo‐Rodríguez, E., Alcaraz-Silva, J., Feingold, D., Viana-Torre, G., Budde, H., Imperatori, C., & Machado, S. E. D. C. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220405114402 · Cited by 14

The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor

Leo, L. M., Al-Zoubi, R. M., Hurst, D. P., Stephan, A. P., Zhao, P., Tilley, D. G., Miess, E., Schulz, S., Abood, M. E., & Reggio, P. H. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2021.0223 · Cited by 12

Linking medicinal cannabis to autotaxin–lysophosphatidic acid signaling

Eymery, M., McCarthy, A. A., & Hausmann, J. (2023) · Life Science Alliance · doi:10.26508/lsa.202201595 · Cited by 12

CB2 cannabinoid receptor agonist selectively inhibits the mechanosensitivity of mucosal afferents in the guinea pig bladder

Christie, S., & Zagorodnyuk, V. P. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00065.2021 · Cited by 12

Cannabis Medicine 2.0: Nanotechnology-Based Delivery Systems for Synthetic and Chemically Modified Cannabinoids for Enhanced Therapeutic Performance

Żółnowska, I., Gostyńska, A., Jelińska, A., & Stawny, M. (2025) · Nanomaterials · doi:10.3390/nano15161260 · Cited by 14

A Lipidomics- and Transcriptomics-Based Analysis of the Intestine of Genetically Obese (ob/ob) and Diabetic (db/db) Mice: Links with Inflammation and Gut Microbiota

Suriano, F., Manca, C., Flamand, N., Hul, M. V., Delzenne, N. M., Silvestri, C., Cani, P. D., & Marzo, V. D. (2023) · Cells · doi:10.3390/cells12030411 · Cited by 11

Effects of oral β-caryophyllene (BCP) treatment on perioperative neurocognitive disorders: Attenuation of neuroinflammation associated with microglial activation and reinforcement of autophagy activity in aged mice

Chen, F., Bai, N., Fang, Y., Hao, Y., Wang, H., He, Y., & Lu, K. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148425 · Cited by 11

Sphingosine Kinases at the Intersection of Pro-Inflammatory LPS and Anti-Inflammatory Endocannabinoid Signaling in BV2 Mouse Microglia Cells

Standoli, S., Rapino, C., Meo, C. D., Rudowski, A., Kämpfer‐Kolb, N., Volk, L. M., Thomas, D., Trautmann, S., Schreiber, Y., zu Heringdorf, D. M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108508 · Cited by 11

CB2 regulates oxidative stress and osteoclastogenesis through NOX1-dependent signaling pathway in titanium particle-induced osteolysis

Tao, H., Li, X., Chu, M., Wang, Q., Li, P., Han, Q., Chen, K., Zhu, P., Hao, Y., Yang, X., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01761-y · Cited by 11

Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome

Cosentino, L., Urbinati, C., Lanzillotta, C., Rasmo, D. D., Valenti, D., Pellas, M., Quattrini, M. C., Piscitelli, F., Kostrzewa, M., Domenico, F. D., et al. (2024) · Molecular Autism · doi:10.1186/s13229-024-00617-1 · Cited by 11

Honey Targets Ribosome Biogenesis Components to Suppress the Growth of Human Pancreatic Cancer Cells

Bangash, A. A., Alvi, S. S., Bangash, M. A., Ahsan, H., Khan, S., Shareef, R., Villanueva, G., Bansal, D., Ahmad, M., Kim, D. J., et al. (2024) · Cancers · doi:10.3390/cancers16193431 · Cited by 11

Maternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age

Compagno, M. Z. K., Silver, C. R., Cox-Holmes, A., Basso, K. B. G., Bishop, C., Bernstein, A. M., Carley, A., Cazorla, J., Claydon, J., Crane, A., et al. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173902 · Cited by 11

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Rao, V. K., Lewis‐Bakker, M. M., Wasilewski, E., Clarke, H. A., & Kotra, L. P. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.118019 · Cited by 11

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Chiarugi, S., Margheriti, F., Lorenzi, V. D., Martino, E., Margheritis, E. G., Moscardini, A., Marotta, R., Chaves-Sanjuán, A., Seppia, C. D., Federighi, G., et al. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.01.008 · Cited by 11

Noncanonical Potentiation of Evoked Quantal Release of Acetylcholine by Cannabinoids Anandamide and 2-Arachidonoylglycerol in Mouse Motor Synapses

Tarasova, E. O., Хоткина, Н. А., Bogacheva, P. O., Chernyshev, K. A., Gaydukov, A. E., & Balezina, O. P. (2021) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s199074782106012x · Cited by 11

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Greco, R., Francavilla, M., Demartini, C., Zanaboni, A. M., Facchetti, S., Palmisani, M., Franco, V., & Tassorelli, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210102 · Cited by 11

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Shahen-Zoabi, S., Smoum, R., Bingor, A., Grad, E., Nemirovski, A., Shekh‐Ahmad, T., Mechoulam, R., & Yaka, R. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02574-4 · Cited by 11

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Kuzumi, A., Yamashita, T., Fukasawa, T., Yoshizaki‐Ogawa, A., Sato, S., & Yoshizaki, A. (2024) · Experimental Dermatology · doi:10.1111/exd.15064 · Cited by 11

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Mäder, P., Bartholomäus, R., Nicolussi, S., Baumann, A., Weis, M., Chicca, A., Rau, M., Simão, A. C., Gertsch, J., & Altmann, K. (2020) · ChemMedChem · doi:10.1002/cmdc.202000153 · Cited by 11

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Narwani, V., Bourdillon, A. T., Nalamada, K., Manes, R. P., & Hildrew, D. M. (2020) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.479 · Cited by 11

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Tian, X., Qin, Y., Tian, Y., Ge, X., Cui, J., Han, H., Liu, L., & Yu, H. (2021) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1860966 · Cited by 11

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Khalid, M., Alqarni, M. H., Shoaib, A., Wahab, S., Foudah, A. I., Aljarba, T. M., Akhtar, J., Alamri, M. A., & Ahmad, S. (2022) · Plants · doi:10.3390/plants11091158 · Cited by 12

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Arjmand, S., Landau, A. M., Varastehmoradi, B., Andreatini, R., Joca, S. R. L., & Wegener, G. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01598-4 · Cited by 11

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Golub, V. M., Ramakrishnan, S., & Reddy, D. S. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114294 · Cited by 12

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Ferreira, P. C. L., Bellaver, B., Povala, G., Brum, W. S., Tissot, C., Badji, A., Sloan, M. E., Benedet, A. L., Rosa‐Neto, P., Ashton, N. J., et al. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0151 · Cited by 11

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de Andrade, C. M. L., Caetano, T. T. V., Campos, F. K., Gandra, V. M., Alves, F. H. F., & Stein, V. C. (2023) · South African Journal of Botany · doi:10.1016/j.sajb.2023.08.008 · Cited by 10

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Rodríguez–Serrano, L. M., & Chávez–Hernández, M. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417516 · Cited by 10

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Jana, A., Nath, A., Sen, P., Kundu, S., Alghamdi, B. S. A., Abujamel, T. S., Saboor, M., Chan, W., Alexiou, A. T., Papadakis, M., et al. (2024) · NeuroMolecular Medicine · doi:10.1007/s12017-024-08781-6 · Cited by 11

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Wang, F., Zang, Z., Zhao, Q., Xiaoyang, C., Lei, X., Wang, Y., Ma, Y., Cao, R., Song, X., Tang, L., et al. (2024) · ACS Synthetic Biology · doi:10.1021/acssynbio.4c00239 · Cited by 10

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Wen, J., Tanaka, M., & Zhang, Y. (2024) · The Journal of Headache and Pain · doi:10.1186/s10194-024-01817-z · Cited by 11

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Thompson, E. S., Alcorn, J., & Neary, J. P. (2024) · Sports Medicine · doi:10.1007/s40279-024-02094-1 · Cited by 10

Alterations of endocannabinoid signaling and microglia reactivity in the retinas of AD ‐like mice precede the onset of hippocampal β‐amyloid plaques

Tisi, A., Scipioni, L., Carozza, G., Re, L. D., Cimino, G., Meo, C. D., Palaniappan, S., Valle, F., Fanti, F., Giacovazzo, G., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16256 · Cited by 10

The Evolving Role of Cannabidiol-Rich Cannabis in People with Autism Spectrum Disorder: A Systematic Review

Jawed, B., Esposito, J. E., Pulcini, R., Zakir, S. K., Botteghi, M., Gaudio, F., Savio, D., Martinotti, C., Martinotti, S., & Toniato, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212453 · Cited by 10

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Tomaszewska-Zaremba, D., Gajewska, A., & Misztal, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146570 · Cited by 12

Cell type‐specific genetic reconstitution of CB1 receptor subsets to assess their role in exploratory behaviour, sociability, and memory

Giacomo, V. D., Ruehle, S., Lutz, B., Häring, M., & Remmers, F. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15069 · Cited by 10

Incorporation of natural assumption to deal with cancer

Karthika, C., & Sureshkumar, R. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-11479-4 · Cited by 10

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Grasso, S., Santonico, M., Pennazza, G., Zompanti, A., Piccoli, A., Bisogno, T., & Maccarrone, M. (2021) · Sensors · doi:10.3390/s21020489 · Cited by 10

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Hamilton, A. J., Payne, A. D., Mocerino, M., & Gunosewoyo, H. (2021) · Australian Journal of Chemistry · doi:10.1071/ch21007 · Cited by 11

N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice

Bottemanne, P., Guillemot‐Legris, O., Paquot, A., Masquelier, J., Malamas, M. S., Makriyannis, A., Alhouayek, M., & Muccioli, G. G. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01074-x · Cited by 10

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Du, Y., Coughlin, J. M., Brosnan, M. K., Chen, A. R., Shinehouse, L. K., Abdallah, R. H., Lodge, M. A., Mathews, W. B., Liu, C., Wu, Y., et al. (2023) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-023-06170-y · Cited by 10

Cannabinoid Receptor 1 Agonist ACEA and Cannabinoid Receptor 2 Agonist GW833972A Attenuates Cell-Mediated Immunity by Different Biological Mechanisms

Takheaw, N., Jindaphun, K., Pata, S., Laopajon, W., & Kasinrerk, W. (2023) · Cells · doi:10.3390/cells12060848 · Cited by 10

Endocannabinoidome and its role in neurological disorders-A comprehensive update of existing literature

Dutta, R. (2021) · Journal of Neuroscience and Neurological Disorders · doi:10.29328/journal.jnnd.1001049 · Cited by 1

Endocannabinoid Receptors in the CNS: Potential Drug Targets for the Prevention and Treatment of Neurologic and Psychiatric Disorders

Estrada, J. A., & Contreras, I. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200217140255 · Cited by 33

Discovery of the Endocannabinoid System: A Breakthrough in Neuroscience

Hassanzadeh, P. (2014) · Archives of Neuroscience · doi:10.5812/archneurosci.15030 · Cited by 3

Endocannabinoids Part II: pathological CNS conditions involving the endocannabinoid system and their possible treatment with endocannabinoid-based drugs

Marzo, V. D., Bisogno, T., & PETROCELLIS, L. D. (2001) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.5.3.349 · Cited by 4

Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies

Duncan, R. S., Riordan, S. M., Gernon, M. C., & Koulen, P. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382220 · Cited by 30