Cited by 289Sleep and Wakefulness ResearchNeuroscience of respiration and sleepSleep and related disorders

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The neurobiological basis of narcolepsy

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Mahoney, Carrie E., Cogswell, Andrew, Koralnik, Igor J., Scammell, Thomas E.·2019·Nature Reviews Neuroscience

DOI 10.1038/s41583-018-0097-xPMC PMC6492289

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Abstract

Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery about 20 years ago that narcolepsy is caused by selective loss of the neurons producing orexins (also known as hypocretins) sparked great advances in the field. Here, we review the current understanding of how orexin neurons regulate sleep-wake behaviour and the consequences of the loss of orexin neurons. We also summarize the developing evidence that narcolepsy is an autoimmune disorder that may be caused by a T cell-mediated attack on the orexin neurons and explain how these new perspectives can inform better therapeutic approaches.

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Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Self-citation
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Self-citation
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., et al. (2000) · Nature Medicine · doi:10.1038/79690 · Cited by 2,118
Reduced Number of Hypocretin Neurons in Human Narcolepsy
Thannickal, T. C., Moore, R. Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., & Siegel, J. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00058-1 · Cited by 2,089
Hypocretin (orexin) deficiency in human narcolepsy
Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05582-8 · Cited by 1,776
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,401

Show all 209 references

Research works printed but not linked: 2

Chemelli, R., Sinton, C. & Yanagisawa, M. Polysomnographic characterization of orexin-2 receptor knockout mice. Sleep 23, A296–A297 (2000).
Kisanuki, Y. et al. Behavioral and polysomnographic characterization of orexin-1 receptor and orexin-2 receptor double knockout mice. Sleep 24, A22 (2001).

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Ding, Y., Zhang, F., Li, M., & Wang, J. (2025) · Intelligent Medicine · doi:10.1016/j.imed.2024.11.005 · Cited by 2
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Authors: Mahoney, C. E., Cogswell, A., Koralnik, I. J., & Scammell, T. E.
Affiliations: Beth Israel Deaconess Medical Center (US)
Rush University Medical Center (US)
Corresponding author: Scammell, Thomas E.
ORCID: Mahoney, Carrie E.
Cogswell, Andrew
Koralnik, Igor J.
Scammell, Thomas E.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2018-12-13
Volume: 20
Issue: 2
Pages: 83-93
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-018-0097-x
PMC: PMC6492289
OpenAlex: W2904386018
Cited by: 289
References: 209
Citations by year: 2026: 30 · 2025: 58 · 2024: 45 · 2023: 43 · 2022: 43 · 2021: 30 · 2020: 20 · 2019: 19
FWCI: 2.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (P01HL095491)
National Institute of Neurological Disorders and Stroke (R21NS099787, R01NS106032)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: narcolepsy, orexin neurons, orexin, sleep-wake regulation, autoimmune disease, neurodegeneration, treatment options
MeSH terms: Orexins, Animals, Autoimmune Diseases, Humans, Narcolepsy, Nervous System, Neurobiology

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