Cited by 128Neurotransmitter Receptor Influence on BehaviorNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

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Development, wiring and function of dopamine neuron subtypes

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Garritsen, Oxana, van Battum, Eljo Y., Grossouw, Laurens M., Pasterkamp, R. Jeroen·2023·Nature reviews. Neuroscience

DOI 10.1038/s41583-022-00669-3

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Abstract

The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. Considerable progress has been made in identifying mDA neuron subtypes, and recent work has begun to unveil how these neuronal subtypes develop and organize into functional brain structures. This progress is important for further understanding the disparate physiological functions of mDA neurons and their selective vulnerability in disease, and will ultimately accelerate therapy development. This Review discusses recent advances in our understanding of molecularly defined mDA neuron subtypes and their circuits, ranging from early developmental events, such as neuron migration and axon guidance, to their wiring and function, and future implications for therapeutic strategies.

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Authors: Garritsen, O., van Battum, E. Y., Grossouw, L. M., & Pasterkamp, R. J.
Affiliations: Utrecht University (NL)
Corresponding author: Pasterkamp, R. Jeroen
ORCID: Garritsen, Oxana
Pasterkamp, R. Jeroen
Venue: Nature reviews. Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2023-01-18
Volume: 24
Issue: 3
Pages: 134-152
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-022-00669-3
OpenAlex: W4317234536
Cited by: 128
References: 289
Citations by year: 2026: 32 · 2025: 40 · 2024: 41 · 2023: 15
FWCI: 4.93
Type: journal article
Language: en
Open access: green
dspace.library.uu.nl
Licence: other-oa
www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek (865.14.004)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: midbrain dopaminergic neurons, neuronal development, neuronal migration, axon guidance, molecular identity, treatment options
MeSH terms: Brain, Brain Diseases, Dopamine, Humans, Mesencephalon, Dopaminergic Neurons

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