Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum
Open accessAbstract
Aldehyde dehydrogenase 1 (ALDH1A1)-positive dopaminergic (DA) neurons at the ventral substantia nigra pars compacta (SNpc) preferentially degenerate in Parkinson's disease (PD). Their projection pattern and dopamine release properties, however, remains uncharacterized. Here we show that ALDH1A1-positive axons project predominantly to the rostral two-thirds of dorsal striatum. A portion of these axons converge on a small fraction of striosome compartments restricted to the dorsolateral striatum (DLS), where less dopamine release was measured compared to the adjacent matrix enriched with the ALDH1A1-negative axons. Genetic ablation of Aldh1a1 substantially increases the dopamine release in striosomes, but not in matrix. Additionally, the presence of PD-related human α-synuclein A53T mutant or dopamine transporter (DAT) blockers also differentially affects the dopamine output in striosomes and matrix. Together, these results demonstrate distinct dopamine release characteristics of ALDH1A1-positive DA fibers, supporting a regional specific function of ALDH1A1 in regulating dopamine availability/release in striatum.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ALDH1A1+ dopamine neurons of the substantia nigra pars compacta project prominently to the dorsal caudate putamen, with fibers being denser in rostral sections and less dense caudally.
“Prominent projections of ALDH1A1+ DA neurons of the SNc have been observed in the dorsal caudate putamen (CP; [20–22]), with fibers being more dense in rostral sections and less so in caudal regions.”
From Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches (2020) · cites this paper as [21]
In the dorsal caudate putamen, ALDH1A1+ dopamine neurons preferentially innervate some mu-opioid receptor-positive patches, known as striosomes, although this preference is not exclusive.
“In the dorsal CP, these neurons preferentially innervate some μ-opioid receptor+ (MOR) patches (commonly known as striosomes), although this is not exclusive [20–22].”
From Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches (2020) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY
FEARNLEY, J. M., & LEES, A. J. (1991) · Brain · doi:10.1093/brain/114.5.2283 · Cited by 3,529 · see citing works
Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396 · see citing works
Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease
Kish, S. J., Shannak, K. S., & Hornykiewicz, O. (1988) · New England Journal of Medicine · doi:10.1056/nejm198804073181402 · Cited by 1,945 · see citing works
Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease
Kordower, J. H., Olanow, C. W., Dodiya, H. B., Chu, Y., Beach, T. G., Adler, C. H., Halliday, G. M., & Bartus, R. T. (2013) · Brain · doi:10.1093/brain/awt192 · Cited by 1,294 · see citing works
Tyrosine hydroxylase and regulation of dopamine synthesis
Daubner, S. C., Le, T., & Wang, S. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.12.017 · Cited by 1,092 · see citing works
Gerfen, C. R., Herkenham, M. A., & Thibault, J. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-12-03915.1987 · Cited by 804 · see citing works
Intact-brain analyses reveal distinct information carried by SNc dopamine subcircuits
Lerner, T. N., Shilyansky, C., Davidson, T. J., Evans, K. E., Beier, K. T., Zalocusky, K. A., Crow, A. K., Malenka, R. C., Luo, L., Tomer, R., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.014 · Cited by 794 · see citing works
Gerfen, C. R., Baimbridge, K. G., & Miller, J. J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8780 · Cited by 636 · see citing works
Nicotine amplifies reward-related dopamine signals in striatum
Rice, M. E., & Cragg, S. J. (2004) · Nature Neuroscience · doi:10.1038/nn1244 · Cited by 594 · see citing works
Duester, G. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01497.x · Cited by 570 · see citing works
Herkenham, M. A., & Pert, C. B. (1981) · Nature · doi:10.1038/291415a0 · Cited by 544 · see citing works
Lin, X. Z., Parisiadou, L., Gu, X., Wang, L., Shim, H., Sun, L., Xie, C., Long, C.-X., Yang, W.-J., Ding, J., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.006 · Cited by 513 · see citing works
Self-citationBasal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments
Crittenden, J. R., & Graybiel, A. M. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00059 · Cited by 470 · see citing works
Mechanisms of dopamine transporter regulation in normal and disease states
Vaughan, R. A., & Foster, J. D. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.07.005 · Cited by 419 · see citing works
Graybiel, A. M., Ragsdale, C. W., Yoneoka, E. S., & Elde, R. P. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90131-7 · Cited by 396 · see citing works
Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism
Vasiliou, V., Pappa, A., & Petersen, D. R. (2000) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(00)00211-8 · Cited by 392 · see citing works
Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling
Poulin, J.-F., Zou, J., Drouin-Ouellet, J., Kim, K.-Y. A., Cicchetti, F., & Awatramani, R. B. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.008 · Cited by 352 · see citing works
Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target
Parker, N. F., Cameron, C. M., Taliaferro, J. P., Lee, J., Choi, J. Y., Davidson, T. J., Daw, N. D., & Witten, I. B. (2016) · Nature Neuroscience · doi:10.1038/nn.4287 · Cited by 340 · see citing works
Yorgason, J. T., España, R. A., & Jones, S. R. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.03.001 · Cited by 318 · see citing works
Neuronal vulnerability, pathogenesis, and Parkinson's disease
Sulzer, D. L., & Surmeier, D. J. (2012) · Movement Disorders · doi:10.1002/mds.25095 · Cited by 315 · see citing works
Marchitti, S. A., Deitrich, R. A., & Vasiliou, V. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.2.1 · Cited by 282 · see citing works
High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system.
McCaffery, P., & Dräger, U. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7772 · Cited by 266 · see citing works
Exley, R. A., & Cragg, S. J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707510 · Cited by 249 · see citing works
Meaningful silences: how dopamine listens to the ACh pause
Cragg, S. J. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.01.003 · Cited by 245 · see citing works
Aggregation of α-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine
Burke, W. J., Kumar, V. B., Pandey, N., Panneton, W. M., Gan, Q., Franko, M. W., Odell, M., Li, S. W., Pan, Y., Chung, H. D., et al. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0303-9 · Cited by 243 · see citing works
Fan, X., Molotkov, A., Manabe, S.-I., Donmoyer, C. M., Deltour, L., Foglio, M. H., Cuenca, A. E., Blaner, W. S., Lipton, S. A., & Duester, G. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4637-4648.2003 · Cited by 230 · see citing works
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors
Mei, C. D., Ramos, M., Iitaka, C., & Borrelli, E. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.002 · Cited by 220 · see citing works
Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons
Kim, J.-I., Ganesan, S., Luo, S. X., Wu, Y.-W., Park, E., Huang, E. J., Chen, L., & Ding, J. B. (2015) · Science · doi:10.1126/science.aac4690 · Cited by 217 · see citing works
RAPIER, C. M., Lunt, G. G., & Wonnacott, S. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb10582.x · Cited by 206 · see citing works
Lin, X. Z., Parisiadou, L., Sgobio, C., Liu, G., Yu, J. H., Sun, L., Shim, H., Gu, X., Luo, J., Long, C., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1731-12.2012 · Cited by 188 · see citing works
Self-citationImpaired intracellular trafficking defines early Parkinson's disease
Hunn, B. H. M., Cragg, S. J., Bolam, J. P., Spillantini, M., & Wade‐Martins, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.12.009 · Cited by 185 · see citing works
Genetic-Based Dissection Unveils the Inputs and Outputs of Striatal Patch and Matrix Compartments
Smith, J. B., Klug, J. R., Ross, D. L., Howard, C. D., Hollon, N. G., Ko, V. I., Hoffman, H., Callaway, E. M., Gerfen, C. R., & Jin, X. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.046 · Cited by 176 · see citing works
Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation
Liu, G., Yu, J., Ding, J., Xie, C., Sun, L., Rudenko, I., Zheng, W., Sastry, N., Luo, J., Rudow, G., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72176 · Cited by 166 · see citing works
Self-citationCai, H., Lin, X. Z., Xie, C., Laird, F. M., Lai, C., Wen, H., Chiang, H., Shim, H., Farah, M. H., Höke, A., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1645-05.2005 · Cited by 123 · see citing works
Self-citationRees, J. N., Florang, V. R., Eckert, L. L., & Doorn, J. A. (2009) · Chemical Research in Toxicology · doi:10.1021/tx9000557 · Cited by 121 · see citing works
Bentivoglio, M., & Morelli, M. (2005) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(05)80005-3 · Cited by 111 · see citing works
Casida, J. E., Ford, B., Jinsmaa, Y., Sullivan, P., Cooney, A. M., & Goldstein, D. S. (2014) · Chemical Research in Toxicology · doi:10.1021/tx5002223 · Cited by 78 · see citing works
Salinas, A. G., Davis, M. I., Lovinger, D. M., & Mateo, Y. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.049 · Cited by 69 · see citing works
Self-citationFunctional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system
Anderson, D. W., Schray, R. C., Duester, G., & Schneider, J. S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.06.051 · Cited by 65 · see citing works
α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals
Xu, J., Wu, X.-S., Sheng, J., Zhang, Z., Yue, H., Sun, L., Sgobio, C., Lin, X. Z., Peng, S., Jin, Y., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3627-15.2016 · Cited by 62 · see citing works
Self-citationSubstance P Weights Striatal Dopamine Transmission Differently within the Striosome-Matrix Axis
Brimblecombe, K. R., & Cragg, S. J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0870-15.2015 · Cited by 58 · see citing works
Cai, H., Liu, G., Sun, L., & Ding, J. (2014) · Translational Neurodegeneration · doi:10.1186/2047-9158-3-27 · Cited by 52 · see citing works
Self-citationDavis, M. I., & Puhl, H. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016619 · Cited by 47 · see citing works
Self-citationPutaminal Mosaic Visualized by Tyrosine Hydroxylase Immunohistochemistry in the Human Neostriatum
Morigaki, R., & Goto, S. (2016) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2016.00034 · Cited by 33 · see citing works
Sgobio, C., Kupferschmidt, D. A., Cui, G., Sun, L., Li, Z., Cai, H., & Lovinger, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111749 · Cited by 21 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [19]McCaffery P Drager UC High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system Proceedings of the National Academy of Sciences of the United States of America 1994 91 7772 7776 10.1073/pnas.91.16.7772 8052659 PMC44484 · DOI · Paper page
Cited by
Sorted by citations
Poulin, J.-F., Caronia, G., Hofer, C., Cui, Q., Helm, B., Ramakrishnan, C., Chan, C. S., Dombeck, D. A., Deisseroth, K., & Awatramani, R. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0203-4 · Cited by 423 · see citing works
Impaired dopamine metabolism in Parkinson’s disease pathogenesis
Masato, A., Plotegher, N., Boassa, D., & Bubacco, L. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0332-6 · Cited by 331 · see citing works
Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches
Poulin, J.-F., Gaertner, Z., Moreno-Ramos, O. A., & Awatramani, R. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.01.004 · Cited by 238 · see citing works
Unique functional responses differentially map onto genetic subtypes of dopamine neurons
Azcorra, M., Gaertner, Z. A., Davidson, C., He, Q., Kim, H., Nagappan, S., Hayes, C. K., Ramakrishnan, C., Fenno, L. E., Kim, Y. S., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01401-9 · Cited by 170 · see citing works
Development, wiring and function of dopamine neuron subtypes
Garritsen, O., van Battum, E. Y., Grossouw, L. M., & Pasterkamp, R. J. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00669-3 · Cited by 128 · see citing works
Wu, J., Kung, J., Dong, J., Chang, L., Xie, C., Habib, A., Hawes, S., Yang, N., Chen, V., Liu, Z., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.095 · Cited by 87 · see citing works
Self-citationDavis, M. I., Crittenden, J. R., Feng, A. Y., Kupferschmidt, D. A., Naydenov, A. V., Stella, N., Graybiel, A. M., & Lovinger, D. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191436 · Cited by 72 · see citing works
Self-citationDopaminergic system and neurons: Role in multiple neurological diseases
Chen, H., Li, J., Huang, Z., Fan, X., Wang, X., Chen, X., Guo, H., Liu, H., Li, S., Yu, S., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110133 · Cited by 68 · see citing works
Self-citationStriosomes and Matrisomes: Scaffolds for Dynamic Coupling of Volition and Action
Graybiel, A. M., & Matsushima, A. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-121522-025740 · Cited by 55 · see citing works
Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake
Melani, R., & Tritsch, N. X. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110716 · Cited by 56 · see citing works
Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease
Chen, A. P. F., Chen, L., Kim, T. A., & Xiong, Q. (2021) · Biomedicines · doi:10.3390/biomedicines9060647 · Cited by 55 · see citing works
Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits
Lazaridis, I., Crittenden, J. R., Ahn, G., Hirokane, K., Wickersham, I. R., Yoshida, T., Mahar, A., Skara, V., Loftus, J., Parvataneni, K., et al. (2024) · Current Biology · doi:10.1016/j.cub.2024.09.070 · Cited by 55 · see citing works
Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson’s Disease
Marie, A., Darricau, M., Touyarot, K., Parr‐Brownlie, L. C., & Bosch‐Bouju, C. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212671 · Cited by 54 · see citing works
Carmichael, K., Evans, R. C., Lopez, E., Sun, L., Kumar, M., Ding, J., Khaliq, Z. M., & Cai, H. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.644776 · Cited by 48 · see citing works
Self-citationPan, J., Yu, J. H., Sun, L., Xie, C., Chang, L., Wu, J., Hawes, S., Sáez-Atiénzar, S., Zheng, W., Kung, J. E., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-40326-x · Cited by 40 · see citing works
Self-citationCarmichael, K., Sullivan, B. T., Lopez, E., Sun, L., & Cai, H. (2021) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2021.07 · Cited by 46 · see citing works
Self-citationPatel, J. C., Sherpa, A. D., Melani, R., Witkovsky, P., Wiseman, M., O’Neill, B., Aoki, C. J., Tritsch, N. X., & Rice, M. E. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113834 · Cited by 31 · see citing works
del Rey, N. L., Hernández-Pinedo, N., Carrillo, M., del Cerro, M., Esteban-García, N., Trigo‐Damas, I., Monje, M. H. G., Lanciego, J. L., Cavada, C., Obeso, J. A., et al. (2024) · npj Parkinson s Disease · doi:10.1038/s41531-024-00777-0 · Cited by 31 · see citing works
Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
Kosillo, P., Ahmed, K. M., Aisenberg, E. E., Karalis, V., Roberts, B. M., Cragg, S. J., & Bateup, H. S. (2022) · eLife · doi:10.7554/elife.75398 · Cited by 25 · see citing works
Cannabinoid Receptor 1 Is Required for Neurodevelopment of Striosome-Dendron Bouquets
Crittenden, J. R., Yoshida, T., Venu, S., Mahar, A., & Graybiel, A. M. (2022) · eNeuro · doi:10.1523/eneuro.0318-21.2022 · Cited by 24 · see citing works
Sun, F., Salinas, A. G., Filser, S., Blumenstock, S., Medina-Luque, J., Herms, J. W., & Sgobio, C. (2021) · Brain Pathology · doi:10.1111/bpa.13036 · Cited by 22 · see citing works
Self-citationLerner, S., Eilam, R., Adler, L. N., Baruteau, J., Kreiser, T., Tsoory, M., Brandis, A. S., Mehlman, T., Ryten, M., Botía, J. A., et al. (2021) · Human Genetics · doi:10.1007/s00439-021-02345-5 · Cited by 19 · see citing works
Marie, A., Leroy, J., Darricau, M., Alfos, S., Smedt, V. D., Richard, E., Vancassel, S., & Bosch‐Bouju, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.811843 · Cited by 17 · see citing works
Sgobio, C., Sun, L., Ding, J., Herms, J. W., Lovinger, D. M., & Cai, H. (2019) · Scientific Reports · doi:10.1038/s41598-019-41091-7 · Cited by 16 · see citing works
Self-citationZhang, X., Mantas, I., Alvarsson, A., Yoshitake, T., Shariatgorji, M., Pereira, M., Nilsson, A., Kehr, J., Andrén, P. E., Millan, M. J., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00166 · Cited by 16 · see citing works
Xiuping, S., Yu, X., Zhang, L., Zhao, W., Wang, M., Zhang, Y., Li, X., Gao, R., Breger, L. S., Doveró, S., et al. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06302 · Cited by 13 · see citing works
Aldehyde dehydrogenase 1 family: A potential molecule target for diseases
Duan, X., Hu, H., Wang, L., & Chen, L. (2024) · Cell Biology International · doi:10.1002/cbin.12188 · Cited by 11 · see citing works
Toward Generating Subtype-Specific Mesencephalic Dopaminergic Neurons in vitro
Cardoso, T., & Lévesque, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00443 · Cited by 12 · see citing works
Baik, S., Selvaraji, S., Fann, D. Y., Poh, L., Jo, D., Herr, D. R., Zhang, S. R., Kim, H. A., Silva, M. D., Lai, M. K. P., et al. (2021) · Aging · doi:10.18632/aging.203123 · Cited by 12 · see citing works
Lazaridis, I., Crittenden, J. R., Ahn, G., Hirokane, K., Yoshida, T., Wickersham, I. R., Mahar, A., Skara, V., Loftus, J. H., Parvataneni, K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.01.596922 · Cited by 12 · see citing works
Kim, M. J., Gibson, D. J., Hu, D., Yoshida, T., Hueske, E., Matsushima, A., Mahar, A., Schofield, C. J., Sompolpong, P., Tran, K. T., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53176-7 · Cited by 13 · see citing works
Zhao, H., Chen, P., Gao, X., Huang, Z., Yang, P., & Shen, H. (2025) · iScience · doi:10.1016/j.isci.2025.112115 · Cited by 6 · see citing works
Impact of dietary vitamin A on striatal function in adult rats
Marie, A., Kinet, R., Helbling, J., Darricau, M., Alfos, S., Miceli, M. D., Angelo, M., Foury, A., Richard, E., Trifilieff, P., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202300133r · Cited by 4 · see citing works
Neuronal vulnerability in Parkinson’s disease: insights from murine α-synuclein pathology models
Asadpoordezaki, Z., & Prehn, J. H. M. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.04.007 · Cited by 2 · see citing works
Rocha, G. S., Freire, M. A. M., & Brimblecombe, K. R. (2026) · Journal of Neurophysiology · doi:10.1152/jn.00527.2025 · Cited by 2 · see citing works
Calbindin stratifies midbrain dopaminergic neurons governing distinct aspects of locomotion
Bolduc, C., Oram, C., Donovan, S., Bach, H., Liu, M., Marier, R., Sharpe, M., Liu, S., Campeau, C., Spencer, C. D., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2613593123 · Cited by 1 · see citing works
Thomas, M. H., Karout, M., Rodriguez, B. P., Gui, Y., Jaeger, C., Michelucci, A., Kollmus, H., Schughart, K., Coowar, D., Balling, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.30.404293 · Cited by 1 · see citing works
Striosomes constrain locomotor vigor with respect to an innate valence differentialPreprint
Hawes, S., Liang, B., Oldham, B. B., Song, B., Chang, L., Lin, D., & Cai, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.17.492302 · Cited by 1 · see citing works
Self-citationDeterminants of selective neuronal vulnerability in Parkinson's disease
del Rey, N. L., Blesa, J., & Obeso, J. A. (2021) · ANALES RANM · doi:10.32440/ar.2021.138.02.rev01
The Role of Dopamine in Training Automaticity
Lerner, T. N., Miller-Hansen, A. J., & Ambrosi, P. (2024) · Springer eBooks · doi:10.1007/978-3-031-55889-4_9
Molecular heterogeneity of midbrain dopamine neurons
Awatramani, R., & Poulin, J.-F. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-29867-7.00002-5 · Cited by 2 · see citing works
Beyond dopamine: Cotransmission by dopamine neurons
Melani, R., & Tritsch, N. X. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-29867-7.00015-3
Building an action circuit with nigrostriatal dopaminergic neurons and striatonigral neurons
Cai, H., & Gerfen, C. R. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-29867-7.00012-8
Self-citationTsyba, Е. Т., Kuzhuget, S., Birioukova, L. M., Midzyanovskaya, I. S., & Abbasova, K. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700850
Harbert, D. H. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1806505
Smith, V. M. M., Dong, J., Paletzki, R. F., Chang, L., Wang, L., Gerfen, C. R., & Cai, H. (2026) · Frontiers in Neural Circuits · doi:10.3389/fncir.2026.1895042
Self-citationStriosomes: Small Circuits With a Large Role in Locomotion
Okunomiya, T., Watanabe, D., Takahashi, R., & Inoue, H. (2026) · The Neuroscientist · doi:10.1177/10738584261479729
- Authors
- Sgobio, C., Wu, J., Zheng, W., Chen, X., Pan, J., Salinas, A. G., Davis, M. I., Lovinger, D. M., & Cai, H.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Cai, Huaibin
- Venue
- Scientific Reports
- Published
- 2017-07-13
- Volume
- 7
- Issue
- 1
- Pages
- 5283-5283
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5509666
- OpenAlex
- W2727629153
- Cited by
- 47
- References
- 45
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 3
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (R01AA016022)
- National Institute on Aging
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ALDH1, ALDH1A1, nigrostriatal dopaminergic neurons, substantia nigra pars compacta, dorsal striatum, striosomes, striatal matrix, dopamine release, axonal projection patterns, Parkinson's disease, mice
- MeSH terms
- Aldehyde Dehydrogenase 1 Family, Aldehyde Dehydrogenase, Animals, Cells, Cultured, Corpus Striatum, Dopamine, Mice, Inbred C57BL, Mice, Transgenic, Transcription Factors, Mice, Knockout, Homeodomain Proteins, Retinal Dehydrogenase, Mice, alpha-Synuclein, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
