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Developmental mechanisms underlying the evolution of human cortical circuits
Open accessAbstract
The brain of modern humans has evolved remarkable computational abilities that enable higher cognitive functions. These capacities are tightly linked to an increase in the size and connectivity of the cerebral cortex, which is thought to have resulted from evolutionary changes in the mechanisms of cortical development. Convergent progress in evolutionary genomics, developmental biology and neuroscience has recently enabled the identification of genomic changes that act as human-specific modifiers of cortical development. These modifiers influence most aspects of corticogenesis, from the timing and complexity of cortical neurogenesis to synaptogenesis and the assembly of cortical circuits. Mutations of human-specific genetic modifiers of corticogenesis have started to be linked to neurodevelopmental disorders, providing evidence for their physiological relevance and suggesting potential relationships between the evolution of the human brain and its sensitivity to specific diseases.
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“Neoteny of cortical neuron development is thought to play a major role in the emergence of HS features of developmental plasticity and adult brain functional properties.3,4,51”
From Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition (2024) · cites this paper as [3]
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“A salient feature of human brain development is the considerably prolonged, or neotenic, tempo of cortical neuronal maturation, taking months to years in humans instead of days to months observed in other mammals, including non-human primates.1,2,3,4,5,6”
From Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition (2024) · cites this paper as [3]
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Metadata
- Authors
- Vanderhaeghen, P., & Polleux, F.
- Affiliations
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Vanderhaeghen, Pierre
- Polleux, Franck
- Venue
- Nature Reviews Neuroscience
- Published
- 2023-02-15
- Volume
- 24
- Issue
- 4
- Pages
- 213-232
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC10064077
- OpenAlex
- W4320913079
- Cited by
- 173
- References
- 231
- Citations by year
- 2026: 36 · 2025: 60 · 2024: 53 · 2023: 24
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Lirias (submittedVersion, other-oa)
- Funders
- AXA Research Fund
- Fonds De La Recherche Scientifique - FNRS
- Fonds Wetenschappelijk Onderzoek
- NOMIS Stiftung
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS067557, RO1NS067557, R35NS127232)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- human brain evolution, cortical development, neurogenesis, synaptogenesis, cortical circuits, neurodevelopmental disorders, higher cognition
- MeSH terms
- Brain, Cerebral Cortex, Humans, Neurogenesis
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