Vanderhaeghen, Pierre

An RNA gene expressed during cortical development evolved rapidly in humans

Pollard, K. S., Salama, S. R., Lambert, N., Lambot, M.-A., Coppens, S., Pedersen, J. S., Katzman, S., King, B., Onodera, C., Siepel, A., et al. (2006) · Nature

Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders

Cited by 1,005

An intrinsic mechanism of corticogenesis from embryonic stem cells

Gaspard, N., Bouschet, T., Hourez, R., Dimidschstein, J., Naeije, G., van den Ameele, J., Espuny-Camacho, I., Herpoel, A., Passante, L., Schiffmann, S. N., et al. (2008) · Nature

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 641

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

Espuny-Camacho, I., Michelsen, K. A., Gall, D., Linaro, D., Hasche, A., Bonnefont, J., Bali, C., Orduz, D., Bilheu, A., Herpoel, A., et al. (2013) · Neuron

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 568

Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation

Suzuki, I. K., Gacquer, D., Van Heurck, R., Kumar, D., Wojno, M., Bilheu, A., Herpoel, A., Lambert, N., Cheron, J., Polleux, F., et al. (2018) · Cell

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 471

Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation

Charrier, C., Joshi, K., Coutinho-Budd, J., Kim, J.-E., Lambert, N., de Marchena, J., Jin, W.-L., Vanderhaeghen, P., Ghosh, A., Sassa, T., et al. (2012) · Cell

Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders

Cited by 454

Mitochondria metabolism sets the species-specific tempo of neuronal development

Iwata, R., Casimir, P., Erkol, E., Boubakar, L., Planque, M., Gallego López, I. M., Ditkowska, M., Gaspariunaite, V., Beckers, S., Remans, D., et al. (2023) · Science

Neurogenesis and neuroplasticity mechanismsMitochondrial Function and Pathology

Cited by 312

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

Espuny-Camacho, I., Arranz, A. M., Fiers, M., Snellinx, A., Ando, K., Munck, S., Bonnefont, J., Lambot, L., Corthout, N., Omodho, L., et al. (2017) · Neuron

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 244

Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits

Linaro, D., Vermaercke, B., Iwata, R., Ramaswamy, A., Davis, B. A., Boubakar, L., Libé-Philippot, B., Bilheu, A., Bruyne, L. D., Gall, D., et al. (2019) · Neuron

Neurogenesis and neuroplasticity mechanismsXenotransplantation and immune response

Cited by 210

Developmental mechanisms underlying the evolution of human cortical circuits

Vanderhaeghen, P., & Polleux, F. (2023) · Nature Reviews Neuroscience

Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders

Cited by 173

Area-Specific Reestablishment of Damaged Circuits in the Adult Cerebral Cortex by Cortical Neurons Derived from Mouse Embryonic Stem Cells

Michelsen, K. A., Acosta-Verdugo, S., Benoit-Marand, M., Espuny-Camacho, I., Gaspard, N., Saha, B., Gaillard, A., & Vanderhaeghen, P. (2015) · Neuron

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 138

Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1

van den Berghe, V., Stappers, E., Vandesande, B., Dimidschstein, J., Kroes, R., Francis, A., Conidi, A., Lesage, F., Dries, R., Cazzola, S., et al. (2013) · Neuron

Neurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

Cited by 120

Altered neuronal network and rescue in a human MECP2 duplication model

Nageshappa, S., Carromeu, C., Trujillo, C. A., Mesci, P., Espuny-Camacho, I., Pasciuto, E., Vanderhaeghen, P., Verfaillie, C. M., Raitano, S., Kumar, A., et al. (2016) · Molecular Psychiatry

Genetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation

Cited by 117

Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells

Suzuki, I. K., & Vanderhaeghen, P. (2015) · Development

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 110

Thinking out of the dish: what to learn about cortical development using pluripotent stem cells

van den Ameele, J., Tiberi, L., Vanderhaeghen, P., & Espuny-Camacho, I. (2014) · Trends in Neurosciences

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 110

Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way

Espuny-Camacho, I., Michelsen, K. A., Linaro, D., Bilheu, A., Acosta-Verdugo, S., Herpoel, A., Giugliano, M., Gaillard, A., & Vanderhaeghen, P. (2018) · Cell Reports

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 88

Cellular and Molecular Mechanisms Linking Human Cortical Development and Evolution

Libé-Philippot, B., & Vanderhaeghen, P. (2021) · Annual Review of Genetics

Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders

Cited by 78

Genes Expressed in Specific Areas of the Human Fetal Cerebral Cortex Display Distinct Patterns of Evolution

Lambert, N., Lambot, M.-A., Bilheu, A., Albert, V., Englert, Y., Libert, F., Noel, J.-C., Sotiriou, C., Holloway, A. K., Pollard, K. S., et al. (2011) · PLoS ONE

Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders

Cited by 73

Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity

Anderson, S., & Vanderhaeghen, P. (2014) · Current Opinion in Neurobiology

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 40

Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition

Libé-Philippot, B., Iwata, R., Recupero, A. J., Wierda, K., Bernal Garcia, S., Hammond, L., van Benthem, A., Limame, R., Ditkowska, M., Beckers, S., et al. (2024) · Neuron

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 38

Laminar fate specification in the cerebral cortex

Gaspard, N., & Vanderhaeghen, P. (2011) · F1000 Biology Reports

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 36

From Human Pluripotent Stem Cells to Cortical Circuits

Astick, M., & Vanderhaeghen, P. (2018) · Current Topics in Developmental Biology

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 34

CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny

Assendorp, N., Fossati, M., Libé-Philippot, B., Christopoulou, E., Depp, M., Rapone, R., Dingli, F., Loew, D., Vanderhaeghen, P., & Charrier, C. (2024) · Cell Reports

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 32

Metabolic mechanisms of species-specific developmental tempo

Iwata, R., & Vanderhaeghen, P. (2024) · Developmental Cell

Developmental Biology and Gene RegulationGenetics, Aging, and Longevity in Model Organisms

Cited by 32

Linking mitochondria metabolism, developmental timing, and human brain evolution

Casimir, P., Iwata, R., & Vanderhaeghen, P. (2024) · Current Opinion in Genetics & Development

Neurogenesis and neuroplasticity mechanismsMitochondrial Function and Pathology

Cited by 27