Cited by 173Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental DisordersDevelopmental Biology and Gene Regulation

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Developmental mechanisms underlying the evolution of human cortical circuits

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Vanderhaeghen, Pierre, Polleux, Franck·2023·Nature Reviews Neuroscience

DOI 10.1038/s41583-023-00675-zPMC PMC10064077

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Abstract

The brain of modern humans has evolved remarkable computational abilities that enable higher cognitive functions. These capacities are tightly linked to an increase in the size and connectivity of the cerebral cortex, which is thought to have resulted from evolutionary changes in the mechanisms of cortical development. Convergent progress in evolutionary genomics, developmental biology and neuroscience has recently enabled the identification of genomic changes that act as human-specific modifiers of cortical development. These modifiers influence most aspects of corticogenesis, from the timing and complexity of cortical neurogenesis to synaptogenesis and the assembly of cortical circuits. Mutations of human-specific genetic modifiers of corticogenesis have started to be linked to neurodevelopmental disorders, providing evidence for their physiological relevance and suggesting potential relationships between the evolution of the human brain and its sensitivity to specific diseases.

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Authors: Vanderhaeghen, P., & Polleux, F.
Affiliations: VIB-KU Leuven Center for Brain & Disease Research (BE)
Columbia University Irving Medical Center (US)
Corresponding author: Vanderhaeghen, Pierre
Polleux, Franck
ORCID: Vanderhaeghen, Pierre
Polleux, Franck
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2023-02-15
Volume: 24
Issue: 4
Pages: 213-232
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-023-00675-z
PMC: PMC10064077
OpenAlex: W4320913079
Cited by: 173
References: 231
Citations by year: 2026: 36 · 2025: 60 · 2024: 53 · 2023: 24
FWCI: 6.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Lirias (submittedVersion, other-oa)
Funders: AXA Research Fund
Fonds De La Recherche Scientifique - FNRS
Fonds Wetenschappelijk Onderzoek
NOMIS Stiftung
National Institutes of Health
National Institute of Neurological Disorders and Stroke (R01NS067557, RO1NS067557, R35NS127232)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: human brain evolution, cortical development, neurogenesis, synaptogenesis, cortical circuits, neurodevelopmental disorders, higher cognition
MeSH terms: Brain, Cerebral Cortex, Humans, Neurogenesis

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Developmental mechanisms underlying the evolution of human cortical circuits

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