Inter-homologue repair in fertilized human eggs?

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

Kosicki, M., Tomberg, K., & Bradley, A. (2018) · Nature Biotechnology · doi:10.1038/nbt.4192 · Cited by 1,883

A quantitative and cytological study of germ cells in human ovaries

Baker, T. G. (1963) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1963.0055 · Cited by 1,094

Correction of a pathogenic gene mutation in human embryos

Ma, H., Marti-Gutierrez, N., Park, S.-W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., et al. (2017) · Nature · doi:10.1038/nature23305 · Cited by 992

Correction of a genetic disease in mouse via use of CRISPR-Cas9

Wu, Y., Liang, D., Wang, Y., Bai, M., Tang, W., Bao, S., Yan, Z., Li, D., & Li, J. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.10.016 · Cited by 614

Large deletions induced by Cas9 cleavage

Adikusuma, F., Piltz, S., Corbett, M. A., Turvey, M., McColl, S. R., Helbig, K. J., Beard, M. R., Hughes, J., Pomerantz, R. T., & Thomas, P. Q. (2018) · Nature · doi:10.1038/s41586-018-0380-z · Cited by 371

Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos1

Whitworth, K. M., Lee, K., Benne, J. A., Beaton, B. P., Spate, L. D., Murphy, S. L., Samuel, M., Mao, J., O’Gorman, C., Walters, E. M., et al. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.121723 · Cited by 351

CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome

Shin, H. Y., Wang, C., Lee, H., Yoo, K. H., Zeng, X., Kuhns, T. M., Yang, C. M., Mohr, T., Liu, C., & Hennighausen, L. G. (2017) · Nature Communications · doi:10.1038/ncomms15464 · Cited by 317

Developmental reprogramming after chromosome transfer into mitotic mouse zygotes

Egli, D. M., Rosains, J., Birkhoff, G., & Eggan, K. C. (2007) · Nature · doi:10.1038/nature05879 · Cited by 301

Intense and highly localized gene conversion activity in human meiotic crossover hot spots

Jeffreys, A. J., & May, C. A. (2004) · Nature Genetics · doi:10.1038/ng1287 · Cited by 291

Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

Paull, D. J., Emmanuele, V., Weiss, K. A., Treff, N. R., Stewart, L. A., Hua, H., Zimmer, M., Kahler, D. J., Goland, R., Noggle, S., et al. (2012) · Nature · doi:10.1038/nature11800 · Cited by 259

The promise and challenge of therapeutic genome editing

Doudna, J. A. (2020) · Nature · doi:10.1038/s41586-020-1978-5 · Cited by 1,126

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

Leibowitz, M. L., Papathanasiou, S., Doerfler, P. A., Blaine, L. J., Sun, L., Yao, Y., Zhang, C.-Z., Weiss, M. J., & Pellman, D. (2021) · Nature Genetics · doi:10.1038/s41588-021-00838-7 · Cited by 583

Genome editing reveals a role for OCT4 in human embryogenesis

Fogarty, N. M. E., McCarthy, A., Snijders, K. E., Powell, B. E., Kubikova, N., Blakeley, P., Lea, R., Elder, K., Wamaitha, S. E., Kim, D., et al. (2017) · Nature · doi:10.1038/nature24033 · Cited by 392

Large deletions induced by Cas9 cleavage

Adikusuma, F., Piltz, S., Corbett, M. A., Turvey, M., McColl, S. R., Helbig, K. J., Beard, M. R., Hughes, J., Pomerantz, R. T., & Thomas, P. Q. (2018) · Nature · doi:10.1038/s41586-018-0380-z · Cited by 371

Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos

Zuccaro, M. V., Xu, J., Mitchell, C., Marin, D., Zimmerman, R., Rana, B., Weinstein, E., King, R. T., Palmerola, K. L., Smith, M. E., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.025 · Cited by 303

Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos

Alanis-Lobato, G., Zohren, J., McCarthy, A., Fogarty, N. M. E., Kubikova, N., Hardman, E., Greco, M., Wells, D., Turner, J. M. A., & Niakan, K. K. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004832117 · Cited by 234

CRISPR-based genome editing through the lens of DNA repair

Nambiar, T. S., Baudrier, L., Billon, P., & Ciccia, A. (2022) · Molecular Cell · doi:10.1016/j.molcel.2021.12.026 · Cited by 227

Development of CRISPR-Cas systems for genome editing and beyond

Zhang, F. (2019) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583519000052 · Cited by 188

CRISPR/dCas9 Tools: Epigenetic Mechanism and Application in Gene Transcriptional Regulation

Cai, R., Lv, R., Shi, X., Yang, G., & Jin, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914865 · Cited by 189

Parental genome unification is highly error-prone in mammalian embryos

Cavazza, T., Takeda, Y., Politi, A. Z., Aushev, M., Aldag, P., Baker, C., Choudhary, M. K., Bucevičius, J., Lukinavičius, G., Elder, K. T., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.013 · Cited by 162

CRISPR/Cas9 gene-editing: Research technologies, clinical applications and ethical considerations

Memi, F., Ntokou, A., & Papangeli, I. (2018) · Seminars in Perinatology · doi:10.1053/j.semperi.2018.09.003 · Cited by 134

Targeted mutagenesis in a human-parasitic nematode

Gang, S. S., Castelletto, M. L., Bryant, A. S., Yang, E. C., Mancuso, N., Lopez, J. B., Pellegrini, M. A., & Hallem, E. A. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006675 · Cited by 123

Cardiovascular Precision Medicine in the Genomics Era

Dainis, A., & Ashley, E. A. (2018) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2018.01.003 · Cited by 119

Connecting past and present: single-cell lineage tracing

Chen, C., Liao, Y., & Peng, G. (2022) · Protein & Cell · doi:10.1007/s13238-022-00913-7 · Cited by 99

Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair

Wilde, J. J., Aida, T., del Rosario, R. C. H., Kaiser, T., Qi, P., Wienisch, M., Zhang, Q., Colvin, S. M., & Feng, G. (2021) · Cell · doi:10.1016/j.cell.2021.04.035 · Cited by 97

β Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus

Ma, S., Viola, R., Sui, L., Cherubini, V., Barbetti, F., & Egli, D. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.11.006 · Cited by 83

Principles of and strategies for germline gene therapy

Wolf, D. P., Mitalipov, P. A., & Mitalipov, S. M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0473-8 · Cited by 75

CRISPR Gene Editing in the Kidney

Cruz, N. M., & Freedman, B. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2018.02.347 · Cited by 69

CRISPR gene editing in human embryos wreaks chromosomal mayhem

Ledford, H. K. (2020) · Nature · doi:10.1038/d41586-020-01906-4 · Cited by 64

Human germline genome editing

Lea, R. A., & Niakan, K. K. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0424-0 · Cited by 62

ON-Target Adverse Events of CRISPR-Cas9 Nuclease: More Chaotic than Expected

Boutin, J., Cappellen, D., Rosier, J., Amintas, S., Dabernat, S., Bedel, A., & Moreau‐Gaudry, F. (2022) · The CRISPR Journal · doi:10.1089/crispr.2021.0120 · Cited by 59

Germline genome editing versus preimplantation genetic diagnosis: Is there a case in favour of germline interventions?

Ranisch, R. (2020) · Bioethics · doi:10.1111/bioe.12635 · Cited by 48

High-level correction of the sickle mutation is amplified in vivo during erythroid differentiation

Magis, W., DeWitt, M. A., Wyman, S. K., Vu, J. T., Heo, S., Shao, S. J., Hennig, F., Romero, Z. G., Campo-Fernández, B., Said, S., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104374 · Cited by 53

Could Failure in Preimplantation Genetic Diagnosis Justify Editing the Human Embryo Genome?

Steffann, J., Jouannet, P., Bonnefont, J.-P., Chneiweiss, H., & Frydman, N. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.01.004 · Cited by 47

Homology-based repair induced by CRISPR-Cas nucleases in mammalian embryo genome editing

Zhang, X., Li, T., Ou, J., Huang, J., & Liang, P. (2021) · Protein & Cell · doi:10.1007/s13238-021-00838-7 · Cited by 47

Gene-edited babies: What went wrong and what could go wrong

Wang, H., & Yang, H. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000224 · Cited by 46

The ethics of clinical applications of germline genome modification: a systematic review of reasons

van Dijke, I., Bosch, L., Bredenoord, A. L., Cornel, M. C., Repping, S., & Hendriks, S. (2018) · Human Reproduction · doi:10.1093/humrep/dey257 · Cited by 46

Ma et al. reply

Ma, H., Martí‐Gutiérrez, N., Park, S.-W., Wu, J., Hayama, T., Darby, H., Dyken, C. V., Li, Y., Koski, A., Liang, D., et al. (2018) · Nature · doi:10.1038/s41586-018-0381-y · Cited by 45

Progress Toward Zygotic and Germline Gene Drives in Mice

Pfitzner, C., White, M. A., Piltz, S. G., Scherer, M., Adikusuma, F., Hughes, J. N., & Thomas, P. Q. (2020) · The CRISPR Journal · doi:10.1089/crispr.2020.0050 · Cited by 39

A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias

Verkuijl, S. A. N., González, E., Li, M., Ang, J. X. D., Kandul, N. P., Anderson, M. A. E., Akbari, O. S., Bonsall, M. B., & Alphey, L. (2022) · Nature Communications · doi:10.1038/s41467-022-34739-y · Cited by 40

CRISPR babies: when will the world be ready?

Ledford, H. K. (2019) · Nature · doi:10.1038/d41586-019-01906-z · Cited by 39

CRISPR and Target-Specific DNA Endonucleases for Efficient DNA Knock-in in Eukaryotic Genomes.

Lee, S. H., Kim, S., & Hur, J. K. (2018) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2018.0408 · Cited by 32

The technical risks of human gene editing

Davies, B. (2019) · Human Reproduction · doi:10.1093/humrep/dez162 · Cited by 37

FREQUENT GENE CONVERSION IN HUMAN EMBRYOS INDUCED BY DOUBLE STRAND BREAKSPreprint

Liang, D., Gutiérrez, N. M., Chen, T., Lee, Y., Park, S.-W., Ma, H., Koski, A., Ahmed, R., Darby, H., Li, Y., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.19.162214 · Cited by 31

Lentiviral Capsid-Mediated Streptococcus pyogenes Cas9 Ribonucleoprotein Delivery for Efficient and Safe Multiplex Genome Editing

Lu, Z., Yao, X., Lyu, P., Yadav, M., Yoo, K. W., Atala, A., & Lu, B. (2021) · The CRISPR Journal · doi:10.1089/crispr.2020.0106 · Cited by 32

Base editing repairs an SGCA mutation in human primary muscle stem cells

Escobar, H., Krause, A., Keiper, S., Kieshauer, J., Müthel, S., de Paredes, M. G., Metzler, E., Kühn, R., Heyd, F., & Spuler, S. (2021) · JCI Insight · doi:10.1172/jci.insight.145994 · Cited by 29

Off- and on-target effects of genome editing in mouse embryos

Ayabe, S., NAKASHIMA, K., & Yoshiki, A. (2018) · Journal of Reproduction and Development · doi:10.1262/jrd.2018-128 · Cited by 31

CRISPR Diagnosis and Therapeutics with Single Base Pair Precision

Lee, S. H., Park, Y., Jin, Y. B., Kim, S., & Hur, J. K. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.09.008 · Cited by 29

CRISPR/Cas9 increases mitotic gene conversion in human cells

Javidi-Parsijani, P., Lyu, P., Makani, V. S., Sarhan, W. M., Yoo, K. W., El-Korashi, L. A., Atala, A., & Lu, B. (2020) · Gene Therapy · doi:10.1038/s41434-020-0126-z · Cited by 29

CRISPR/Cas9-mediated gene knockout and interallelic gene conversion in human induced pluripotent stem cells using non-integrative bacteriophage-chimeric retrovirus-like particles

Mianné, J., Nasri, A., Van, C. N., Bourguignon, C., Fieldès, M., Ahmed, E., Duthoit, C. T., Martin, N., Parrinello, H., Louis, A., et al. (2022) · BMC Biology · doi:10.1186/s12915-021-01214-x · Cited by 23

Limitations of gene editing assessments in human preimplantation embryos

Liang, D., Mikhalchenko, A. E., Ma, H., Gutiérrez, N. M., Chen, T., Lee, Y., Park, S.-W., Tippner-Hedges, R., Koski, A., Darby, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36820-6 · Cited by 26

Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells

Wu, L., Jiang, S., Shi, M., Yuan, T., Li, Y., Huang, P., Li, Y., Zuo, E., Zhou, C., & Sun, Y. (2024) · Genome biology · doi:10.1186/s13059-024-03434-0 · Cited by 28

Human Embryo Editing: Opportunities and Importance of Transnational Cooperation

Pei, D., Beier, D. W., Levy‐Lahad, E., Marchant, G. E., Rossant, J., Belmonte, J. C. I., Lovell-Badge, R. H., Jaenisch, R., Charo, A., & Baltimore, D. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.09.010 · Cited by 21

CRISPR/Cas gene editing in the human germline

Bekaert, B., Boel, A., Cosemans, G., Witte, L. D., Menten, B., & Heindryckx, B. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.012 · Cited by 21

Targeting DNA polymerase to DNA double-strand breaks reduces DNA deletion size and increases templated insertions generated by CRISPR/Cas9

Yoo, K. W., Yadav, M., Song, Q., Atala, A., & Lu, B. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac186 · Cited by 19

The Wisdom of Germline Editing: An Ethical Analysis of the Use of CRISPR-Cas9 to Edit Human Embryos

Gumer, J. (2019) · The New Bioethics · doi:10.1080/20502877.2019.1606151 · Cited by 20

Tissue specificity of DNA repair: the CRISPR compass

da Silva, J. F., Meyenberg, M., & Loizou, J. I. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.07.010 · Cited by 18

Development of CRISPR technology for precise single-base genome editing: a brief review

Lee, H. K., Oh, Y., Hong, J., Lee, S. H., & Hur, J. K. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.2.217 · Cited by 20

Blossom of CRISPR technologies and applications in disease treatment

Liu, H., Wang, L., & Luo, Y. (2018) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2018.10.003 · Cited by 19

Characterizing off-target effects of genome editors

Rao, X., Zhao, H., Shao, C., & Yi, C. (2023) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2023.100480 · Cited by 19

Efficient Zygotic Genome Editing via RAD51-Enhanced Interhomolog RepairPreprint

Wilde, J. J., Aida, T., Wienisch, M., Zhang, Q., Qi, P., & Feng, G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/263699 · Cited by 17

Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells

Tomita, A., Sasanuma, H., Owa, T., Nakazawa, Y., Shimada, M., Fukuoka, T., Ogi, T., & Nakada, S. (2023) · Nature Communications · doi:10.1038/s41467-023-41048-5 · Cited by 17

CRISPR GENOME SURGERY IN THE RETINA IN LIGHT OF OFF-TARGETING

Cho, G. Y., Schaefer, K. A., Bassuk, A. G., Tsang, S. H., & Mahajan, V. B. (2018) · Retina · doi:10.1097/iae.0000000000002197 · Cited by 15

Active genetics comes alive

Gantz, V. M., & Bier, E. (2022) · BioEssays · doi:10.1002/bies.202100279 · Cited by 14

Site-specific genome editing in treatment of inherited diseases: possibility, progress, and perspectives

Huang, C., Li, Q., & Li, J. (2022) · Medical Review · doi:10.1515/mr-2022-0029 · Cited by 20

Delivery challenges for CRISPR—Cas9 genome editing for Duchenne muscular dystrophy

Padmaswari, M. H., Agrawal, S., Jia, M. S., Ivy, A., Maxenberger, D. A., Burcham, L. A., & Nelson, C. E. (2023) · Biophysics Reviews · doi:10.1063/5.0131452 · Cited by 18

Counterpoint: The Potential Harms of Human Gene Editing Using CRISPR-Cas9

Baylis, F. E. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2017.278317 · Cited by 13

Daisy-chain gene drives: The role of low cut-rate, resistance mutations, and maternal deposition

Verkuijl, S. A. N., Anderson, M. A. E., Alphey, L., & Bonsall, M. B. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010370 · Cited by 12

Treatment of heritable diseases using CRISPR: Hopes, fears, and reality

Kofler, N. M., & Kraschel, K. L. (2018) · Seminars in Perinatology · doi:10.1053/j.semperi.2018.09.012 · Cited by 13

Carry on editing

Greenfield, A. (2018) · British Medical Bulletin · doi:10.1093/bmb/ldy020 · Cited by 12

Responsible Translational Pathways for Germline Gene Editing?

Cwik, B. (2020) · Current Stem Cell Reports · doi:10.1007/s40778-020-00179-x · Cited by 13

A Practical Guide to Genome Editing Using Targeted Nuclease Technologies

Porter, S. N., Levine, R. M., & Pruett‐Miller, S. M. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180022 · Cited by 18

The CRIPSR /Cas gene‐editing system—an immature but useful toolkit for experimental and clinical medicine

Yang, Y., & Huang, Y. (2019) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12061 · Cited by 8

Gene Editing of Human Embryos with CRISPR/Cas9: Great Promise Coupled with Important Caveats

Schenkwein, D., & Ylä‐Herttuala, S. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.02.007 · Cited by 9

Editing the Reactive Genome: Towards a Postgenomic Ethics of Germline Editing

Güttinger, S. (2019) · Journal of Applied Philosophy · doi:10.1111/japp.12367 · Cited by 11

Gene conversion following CRISPR/Cas9 DNA cleavage: an overlooked effect

Burgio, G. (2020) · Gene Therapy · doi:10.1038/s41434-020-0154-8 · Cited by 8

Applications of CRISPR technologies to the development of gene and cell therapy

Park, C.-S., Habib, O., Lee, Y.-S., & Hur, J. K. (2024) · BMB Reports · doi:10.5483/bmbrep.2023-0221 · Cited by 9

Epigenetic mechanisms and next-gen editing platforms in hematology: From molecular basis to therapeutic frontiers

Huang, M., Ewadi, A., Servatian, N., Noormohamadi, H., Aminov, Z., Muzammil, K., Esfahani, M. A., Abak, N., & Samarkhazan, H. S. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104916 · Cited by 8

CRISPR-Based Gene Editing Techniques in Pediatric Neurologic Disorders

Chrzanowski, S. M., & Batra, R. (2022) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2024.01.021 · Cited by 7

Germline Modification and Policymaking: The Relationship between Mitochondrial Replacement and Gene Editing

Cussins, J., & Lowthorp, L. (2018) · The New Bioethics · doi:10.1080/20502877.2018.1443409 · Cited by 6

#CRISPRfacts, Gene Editing, and Joking in the Twittersphere

Lowthorp, L. (2018) · Journal of American Folklore · doi:10.5406/jamerfolk.131.522.0482 · Cited by 6

Cas9 in Human Embryos: On Target but No Repair

Hoffmann, E. R., & Roig, I. (2020) · Cell · doi:10.1016/j.cell.2020.11.022 · Cited by 6

Retained chromosomal integrity following CRISPR-Cas9-based mutational correction in human embryos

Bekaert, B., Boel, A., Witte, L. D., Vandenberghe, W., Popovic, M., Stamatiadis, P., Cosemans, G., Tordeurs, L., Loore, A. M. D., Lopes, S. M. C. D. S., et al. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.06.013 · Cited by 6

Efficient SNP editing in haploid human pluripotent stem cells

Safier, L. Z., Zuccaro, M. V., & Egli, D. (2020) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-020-01723-8 · Cited by 6

Genome Editing: Promoting Responsible Research

Hirsch, F., Lemaitre, C., Chneiweiss, H., & Montoliu, L. (2019) · Pharmaceutical Medicine · doi:10.1007/s40290-019-00276-1 · Cited by 5

Editing the human genome: where ART and science intersect

Hershlag, A., & Bristow, S. L. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1219-0 · Cited by 4

Prospects and modalities for the treatment of genetic ocular anomalies

Gregory, C. Y., Wang, X., & Gregory-Evans, K. (2019) · Human Genetics · doi:10.1007/s00439-018-01968-5 · Cited by 4

Development of zygotic and germline gene drives in micePreprint

Pfitzner, C., Hughes, J. N., White, M. A., Scherer, M., Piltz, S. G., & Thomas, P. (2020) · bioRxiv · doi:10.1101/2020.06.21.162594 · Cited by 5

Highly efficient ssODN‐mediated homology‐directed repair of DSBs generated by CRISPR/Cas9 in human 3PN zygotes

Tang, L., Zeng, Y., Zhou, X. W., Du, H., Li, C., Liu, J., & Zhang, P. (2018) · Molecular Reproduction and Development · doi:10.1002/mrd.22983 · Cited by 3

Untangling the Promises of Human Genome Editing

Drabiak, K. (2018) · The Journal of Law Medicine & Ethics · doi:10.1177/1073110518822001 · Cited by 6

Outlook on the Security and Potential Improvements of CRISPR–Cas9

Zha, M.-J., Cai, C., & He, P. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00708-z · Cited by 3

Editing the Genome Ex Vivo Stem Cell Therapy

Fan, Y., & Chan, J. K. Y. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0148-2 · Cited by 3

Fearful old world? A commentary on the Second International Summit on human genome editing

Greenfield, A. (2019) · Mammalian Genome · doi:10.1007/s00335-018-9791-2 · Cited by 4

A rocky road for the maturation of embryo-editing methods

Marx, V. (2019) · Nature Methods · doi:10.1038/s41592-018-0307-5 · Cited by 2

Human germline editing: Insights to future clinical treatment of diseases

Li, Y., Kang, X., Pang, J. K. S., Soh, B.-S., Yu, Y., & Fan, Y. (2018) · Protein & Cell · doi:10.1007/s13238-018-0594-8 · Cited by 2

Genome-Editing – Gentherapie 2.0 oder nur eine Wunschvorstellung?

Fehse, B., Grünewald, J., & Petri, K. (2023) · Springer eBooks · doi:10.1007/978-3-662-67908-1_7 · Cited by 2

High-Level Correction of the Sickle Mutation is Amplified in Vivo During Erythroid DifferentiationPreprint

Magis, W., DeWitt, M. A., Wyman, S. K., Vu, J. T., Heo, S., Shao, S. J., Hennig, F., Romero, Z. G., Fernandez, B. C., Said, S., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3985189 · Cited by 2

CRISPR/CAS9-Mediated Gene Editing in Human Gametes: A Review

Kumari, E., Banu, N., Marbaniang, K., Momin, F. J., & Hynniewta, B. C. (2025) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/3413 · Cited by 1

CRISPR-based genome editing in human embryos: a review of efficiency, safety, and ethical implications

Yin, J., Wen, H., Zeng, J., Sun, Y., Chen, X., Jin, L. G., Song, Y., & Xia, S. (2026) · Biology of Reproduction · doi:10.1093/biolre/ioag056 · Cited by 1

Human embryo editing: 10 years of breakthroughs and challenges

Zhou, Y., Xie, D., Ding, C., Wu, W., Cao, T., Liu, Q., Keefe, D. L., 周灿权, & Huang, J. (2026) · Protein & Cell · doi:10.1093/procel/pwag030 · Cited by 1

Highly efficient base editing at PCSK9 and normal human embryo development

Jerabek, S., Jung, C., Kappy, M. D., Zhao, Q., Sung, J., Wang, N., Kim, E., Kim, J., Kulmann, M. I. R., King, M. B., et al. (2026) · Nature · doi:10.1038/s41586-026-11118-x · Cited by 1

The BRCA1 coiled-coil domain is dispensable for suppression of tandem duplications and tolerance of FANCM loss

Nilavar, N. M., Marín-González, A., Menghi, F., Nguyen, D., Willis, N. A., Wientjens, E., Xia, B., Jonkers, J., Liu, E. T., & Scully, R. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00913-x · Cited by 2

La comunicación de la edición genética: CRISPR, Entre el optimismo y las falsas expectativas

Montoliu, L. (2018) · Mètode: Revista de difusió de la investigació de la Universitat de Valencia · doi:10.7203/metode.9.11288 · Cited by 1

The Changing Face of Biological Research and the Growing Role of Biosecurity

Dunaway, N., & Berger, K. M. (2021) · Advanced sciences and technologies for security applications · doi:10.1007/978-3-030-69464-7_6 · Cited by 2

CRISPR-CAS9, BIOSSEGURANÇA E BIOÉTICA Uma Análise Jusfilosófica-Ambiental da Engenharia Genética

Reis, É. V. B., & Naves, B. T. D. O. (2019) · Veredas do Direito Direito Ambiental e Desenvolvimento Sustentável · doi:10.18623/rvd.v16i34.1490 · Cited by 9

Crossing the germline: CRISPR-Cas9 and our responsibility as reproductive endocrinology and infertility physicians

Kaser, D. J., & Franasiak, J. M. (2017) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-017-1075-3 · Cited by 1

Defective BRCA1-mediated DNA end resection drives tandem duplication formation and FANCM synthetic lethalityPreprint

Nilavar, N. M., Marín-González, A., Menghi, F., Nguyen, D., Willis, N. A., Wientjens, E., Xia, B., Jonkers, J., Liu, E. T., & Scully, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.20.706968 · Cited by 1

Did CRISPR really fix a genetic mutation in these human embryos?

Callaway, E. (2018) · Nature · doi:10.1038/d41586-018-05915-2

Who? What? How? Why? If You Don’t Ask You’ll Never Know …

Dabrock, P. (2018) · Technikzukünfte, Wissenschaft und Gesellschaft · doi:10.1007/978-3-658-22660-2_11 · Cited by 1

Delivery Methods for Treatment of Genetic Disorders

Gupta, K., & Selden, N. R. W. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813997-4.00022-0

At the heart of gene edits in human embryos

Winblad, N., & Lanner, F. (2017) · Nature · doi:10.1038/nature23533 · Cited by 11

Gene Editing of Human Embryos with CRISPR/Cas9: Great Promise Coupled with Important Caveats

Schenkwein, D., & Ylä‐Herttuala, S. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.02.007 · Cited by 9

Precision editing in the human embryo

Aschheim, K. (2017) · Nature Biotechnology · doi:10.1038/nbt.3965 · Cited by 1

Retained chromosomal integrity following CRISPR-Cas9-based mutational correction in human embryos

Bekaert, B., Boel, A., Witte, L. D., Vandenberghe, W., Popovic, M., Stamatiadis, P., Cosemans, G., Tordeurs, L., Loore, A. M. D., Lopes, S. M. C. D. S., et al. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.06.013 · Cited by 6

On the Origins of Homology Directed Repair in Mammalian Cells

Sansbury, B. M., & Kmiec, E. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073348 · Cited by 6