The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
Open accessAbstract
DNA and histone modifications have notable effects on gene expression 1. Being the most prevalent internal modification in mRNA, the N 6-methyladenosine (m 6 A) mRNA modification is as an important post-transcriptional mechanism of gene regulation 2-4 and has crucial roles in various normal and pathological processes 5-12. However, it is unclear how m 6 A is specifically and dynamically deposited in the transcriptome. Here we report that histone H3 trimethylation at Lys36 (H3K36me3), a marker for transcription elongation, guides m 6 A deposition globally. We show that m 6 A modifications are enriched in the vicinity of H3K36me3 peaks, and are reduced globally when cellular H3K36me3 is depleted. Mechanistically, H3K36me3 is recognized and bound directly by METTL14, a crucial component of the m 6 A methyltransferase complex (MTC), which in turn facilitates the binding of the m 6 A MTC to adjacent RNA polymerase II, thereby delivering the m 6 A MTC to actively transcribed nascent RNAs to deposit m 6 A co-transcriptionally. In mouse embryonic stem cells, phenocopying METTL14 knockdown, H3K36me3 depletion also markedly reduces m 6 A abundance transcriptome-wide and in pluripotency transcripts, resulting in increased cell stemness. Collectively, our studies reveal the important roles of H3K36me3 and METTL14 in determining specific and dynamic deposition of m 6 A in mRNA, and uncover another layer of gene expression regulation that involves crosstalk between histone modification and RNA methylation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Indeed, several reports identified specific crosstalk between m6A RNA modifications and histone modifications, including H3K36me3 (Huang et al., 2019), H3K9me2 (Li et al., 2020a), H3K9me3 (Liu et al., 2021a; 2021b), and K3K27Ac (Huang et al., 2025).”
From METTL3 uncouples chromatin accessibility from transcription during retinal development (2025) · cites this paper as Huang et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,760
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884
N6-methyladenosine-dependent regulation of messenger RNA stability
Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. (2014) · Nature · doi:10.1038/nature12730 · Cited by 4,558
Self-citationComprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Wang, X., Zhao, B. S., Roundtree, I. A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., & He, C. (2015) · Cell · doi:10.1016/j.cell.2015.05.014 · Cited by 3,483
Self-citationA METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1432 · Cited by 3,433
Self-citationEpigenetics in human disease and prospects for epigenetic therapy
Egger, G., Liang, G., Aparicio, A., & Jones, P. A. (2004) · Nature · doi:10.1038/nature02625 · Cited by 3,232
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Huang, H., Weng, H., Sun, W., Qin, X., Shi, H., Wu, H., Zhao, B. S., Mesquita, A., Liu, C., Yuan, C. L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0045-z · Cited by 2,997
Self-citation
Cited by
Sorted by citations
Items 401–500 of 694
Yuan, C., Zhang, J., Deng, C., Xia, Y., Li, B., Meng, S., Jin, X., Cheng, L., Li, H., Zhang, C., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.868830 · Cited by 10
Self-citationChallenges to mapping and defining m 6 A function in viral RNA
Horner, S. M., & Thompson, M. G. (2024) · RNA · doi:10.1261/rna.079959.124 · Cited by 10
Insight into the regulatory mechanism of m6A modification: From MAFLD to hepatocellular carcinoma
Zha, X., Gao, Z., Li, M., Xia, X., Mao, Z., & Wang, S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116966 · Cited by 9
Epitranscriptomic mechanisms of androgen signalling and prostate cancer
Patke, R., Harris, A. E., Woodcock, C. L., Thompson, R., Santos, R. M., Kumari, A. A., Allegrucci, C., Archer, N., Gudas, L. J., Robinson, B. D., et al. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101032 · Cited by 10
Campos, C. M., Lanz‐Mendoza, H., Cime‐Castillo, J., Peralta-Zaragoza, Ó., & Madrid‐Marina, V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26114964 · Cited by 10
Chen, Z., Sun, Y., Zhu, P., Zhang, L., Yang, J., & Zhang, J. (2025) · Clinical Epigenetics · doi:10.1186/s13148-025-01990-1 · Cited by 11
Self-citationPauli, C., Kienhöfer, M., Göllner, S., & Müller‐Tidow, C. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0286 · Cited by 9
Wang, Z., Zhang, M., Seery, S., Zheng, G., Wang, W., Zhao, Y., Wang, X., & Zhang, Y. (2022) · Oncology Letters · doi:10.3892/ol.2022.13370 · Cited by 9
The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine
Xiao, Z., Liu, S., Li, Z., Cui, J. J., Wang, H., Wang, Z., Ren, Q., Xia, L., Wang, Z., & Li, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.882994 · Cited by 9
Advances in detecting N6-methyladenosine modification in circRNAs
Ma, L., He, L., Kang, S., Gu, B., Gao, S., & Zuo, Z. (2022) · Methods · doi:10.1016/j.ymeth.2022.07.011 · Cited by 9
Self-citationGallego, A., Fernández-Justel, J. M., Martín-Vírgala, S., Maslon, M. M., & Gómez, M. (2022) · Genes · doi:10.3390/genes13091652 · Cited by 9
The role of RNA-modifying proteins in renal cell carcinoma
Alhammadi, M. A., Bajbouj, K., Talaat, I. M., & Hamoudi, R. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06479-y · Cited by 9
Wang, J., Wang, S., Yang, H., Wang, R., Shi, K., Liu, Y., Dou, L., & Yu, H. (2024) · Cancer Science · doi:10.1111/cas.16254 · Cited by 9
Takeda, Y., Chijimatsu, R., Vecchione, A. M., Arai, T., Kitagawa, T., Ofusa, K., Yabumoto, M., Hirotsu, T., Eguchi, H., Doki, Y., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147278 · Cited by 9
Spatial Correlation Statistics Enable Transcriptome-Wide Characterization of RNA Structure Binding
Busa, V. F., Favorov, A. V., Fertig, E. J., & Leung, A. K. L. (2020) · Cell Reports Methods · doi:10.1016/j.crmeth.2021.100088 · Cited by 9
It’s all in the combination: decoding the epigenome for cancer research and diagnostics
Furth, N., & Shema, E. (2022) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2022.101899 · Cited by 9
The Roles and Regulation of m6A Modification in Glioblastoma Stem Cells and Tumorigenesis
Li, P., Richard, H., Zhu, K., Li, L., & Huang, S. (2022) · Biomedicines · doi:10.3390/biomedicines10050969 · Cited by 9
The impact of RNA modifications on the biology of DNA virus infection
Rajendren, S., & Karijolich, J. J. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151239 · Cited by 9
Zhang, L., Yuan, M., Huang, X., Cao, Q., Huang, S., Sun, R., & Lei, L. (2022) · Reproduction · doi:10.1530/rep-22-0169 · Cited by 9
The Role of m6A Modification and m6A Regulators in Esophageal Cancer
Li, Y., Niu, C.-X., Wang, N., Huang, X., Cao, S., Cui, S., Chen, T., Huo, X., & Zhou, R. (2022) · Cancers · doi:10.3390/cancers14205139 · Cited by 9
Graille, M. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1673 · Cited by 9
Maternal tamoxifen exposure leads to abnormal primordial follicle assembly
Zhao, J., Zhang, J.-N., Sun, Y., Wang, R., Shi, D., Shen, W., & Sun, X. (2023) · Histochemistry and Cell Biology · doi:10.1007/s00418-023-02196-3 · Cited by 8
Shaikh, S., Zhao, X., Wagner, R. T., Pan, X., Hlady, R. A., Wang, L., Ho, T. H., & Robertson, K. D. (2025) · Epigenetics · doi:10.1080/15592294.2025.2456418 · Cited by 8
Yang, L., Ma, M., Gao, Y., & Liu, J. (2025) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2025.102311 · Cited by 8
Self-citationm6A Profile Dynamics Indicates Regulation of Oyster Development by m6A-RNA Epitranscriptomes
Franc, L. L., Petton, B., Favrel, P., & Rivière, G. (2022) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2022.12.002 · Cited by 8
SETD2 controls m6A modification of transcriptome and regulates the molecular oncogenesis of glioma
Kumari, S., Singh, M., Kumar, S., & Muthuswamy, S. (2023) · Medical Oncology · doi:10.1007/s12032-023-02121-7 · Cited by 8
Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis
Lu, P., Xu, J., Shen, X., Sun, J., Liu, M., Niu, N., Wang, Q., & Xue, J. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113703 · Cited by 8
Zhao, Q., Yang, S., Hao, S., Chen, Z., Tang, L., Wu, Z., Wu, J., Xu, M., Ma, Z., Li, Z., et al. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29769 · Cited by 8
Self-citationZhang, L., Chen, S., Zhu, J., Meng, J., & Liu, H. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-03787-w · Cited by 8
Function of m6A and its regulation of domesticated animals’ complex traits
Mi, S., Shi, Y., Dari, G., & Yu, Y. (2022) · Journal of Animal Science · doi:10.1093/jas/skac034 · Cited by 8
The Effects of Moxibustion on Learning and Memory and m6A RNA Methylation in APP/PS1 Mice
Huang, Q., Li, C., Zhang, N., Zhang, Q., Li, H., Shen, Y., Xie, L., Yu, S., & Wu, Q. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2998301 · Cited by 8
Self-citationFeng, L., Du, R., Chang, B., Li, M., Tian, J., & Wang, S. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.08.018 · Cited by 8
Li, Z., Li, M., Wu, X., & Wang, J. (2022) · Horticulture Research · doi:10.1093/hr/uhac230 · Cited by 8
Self-citationYTHDF1 and YTHDC1 m 6 A reader proteins regulate HTLV-1 tax and hbz activity
King, E. M., Midkiff, A., McClain, K., Kim, S., & Panfil, A. R. (2025) · Journal of Virology · doi:10.1128/jvi.02063-24 · Cited by 9
The role of YTHDF2 in anti-tumor immunity
Zhang, L., Chen, C., Feng, J., Zhang, H., Nguyen, L. X. T., & Chen, Z. (2025) · Cell investigation. · doi:10.1016/j.clnves.2025.100008 · Cited by 7
Self-citationYang, L., Li, D., Guo, W., Song, J., Liu, C., Liu, H., Li, C., & Gu, X. (2025) · Molecular Plant · doi:10.1016/j.molp.2025.05.016 · Cited by 7
Self-citationTargeting intracellular mRNA m6A-modifiers in advancing immunotherapeutics
Kumar, S., & Sinha, M. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.06.030 · Cited by 7
Nascent RNA at the crossroad of transcription and replication
Zhu, M., Zhang, Y., Guo, T., & Ren, J. (2025) · Trends in Genetics · doi:10.1016/j.tig.2025.05.010 · Cited by 8
METTL16-dependent GPX4 m6A modification links ferroptosis to NSCLC TKIs resistance
Zeng, Y., Wang, Q., Qiao, D., Dai, B., Wu, Y., Wang, M., Fan, Z., & Chen, J. (2025) · BMC Cancer · doi:10.1186/s12885-025-14729-1 · Cited by 7
Self-citationTargeting epigenetic methylation: emerging diagnosis and therapeutic strategies in cancer
Zhu, Y., Liu, K., & Zhu, H. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00760-w · Cited by 8
m6A RNA Methylation in Plants: From Molecular Insights to Applications
Song, P., Cai, Z., & Jia, G. (2026) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-070225-033859 · Cited by 7
RNA Modifications in the Central Nervous System
Wang, D. O. (2020) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190686307.013.23 · Cited by 6
Histone Methyltransferase SETD2 Is Required for Porcine Early Embryonic Development
Shao, W., Ning, W., Liu, C., Zou, Y., Yao, Y., Kang, J., & Cao, Z. (2022) · Animals · doi:10.3390/ani12172226 · Cited by 8
Zou, J., Shen, Y., Zou, J., Yu, J., Jiang, Y., Huang, Y., & Jiang, Q. (2023) · Foods · doi:10.3390/foods12061159 · Cited by 7
Regulation of m6A Methylome in Cancer: Mechanisms, Implications, and Therapeutic Strategies
Bhattarai, P. Y., Kim, G., Bhandari, D., Shrestha, P., & Choi, H. S. (2023) · Cells · doi:10.3390/cells13010066 · Cited by 7
N6-Methyladenosine RNA Modification in Normal and Malignant Hematopoiesis
Weng, H., Huang, H., & Chen, J. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-7471-9_7 · Cited by 7
Self-citationN6-methyladenosine-dependent signaling in colorectal cancer: Functions and clinical potential
Liu, S., Liu, M., Li, Y., & Song, Q. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104360 · Cited by 9
Liu, X., Wang, H. X., Yuan, M., Zhang, T., Wang, Q., Chen, N., Zhou, X., He, M., Ji, Z., & Shen, H. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140988 · Cited by 7
Methyltransferases in the Pathogenesis of Keratinocyte Cancers
Ko, E. K., & Capell, B. C. (2021) · Cancers · doi:10.3390/cancers13143402 · Cited by 7
Functional interplay within the epitranscriptome: Reality or fiction?
Worpenberg, L., Paolantoni, C., & Roignant, J. (2021) · BioEssays · doi:10.1002/bies.202100174 · Cited by 7
Leseva, M. N., Buttari, B., Saso, L., & Dimitrova, P. A. (2023) · Biomolecules · doi:10.3390/biom13071060 · Cited by 7
Wang, P., Feng, M., Han, G., Yin, R., Li, Y., Yao, S., Lu, P., Wang, Y., & Zhang, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.710964 · Cited by 7
Pan, Z., Tan, C., Rao, L., Zhang, H., Zheng, Y., Liang, H., Ji, L., & Mao, Z. (2020) · Angewandte Chemie · doi:10.1002/ange.202008624 · Cited by 7
Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolismPreprint
Dierks, D., Shachar, R., Nir, R., García-Campos, M. A., Uzonyi, A., Wiener, D., Toth, U., Rossmanith, W., Lasman, L., Slobodin, B., et al. (2024) · eLife · doi:10.7554/elife.100448 · Cited by 7
Chang, K.-J., Shiau, L.-Y., Lin, S.-C., Cheong, H.-P., Wang, C., Ma, C., Liang, Y., Yang, Y., Ko, P., Hsu, C.-H., et al. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00965-x · Cited by 6
Sang, H., Liu, J., Chen, X., & Zeng, Y. (2025) · BMC Cancer · doi:10.1186/s12885-025-14041-y · Cited by 6
Self-citationWang, H., Wan, M., Li, W., Zhang, Y., Pang, Y., Wen, L., Cai, Y., Shen, C., Wang, Q., Li, D., et al. (2025) · Environment International · doi:10.1016/j.envint.2025.109703 · Cited by 6
Self-citationSynergistic function of RNA modifications in Arabidopsis and rice
Ma, A., Wang, S., He, X., Qu, Y., Xie, S., Gao, J., Peng, Y., Shen, L., Pu, W., & He, C. (2025) · aBIOTECH · doi:10.1007/s42994-025-00248-x · Cited by 6
Self-citationMapping the Binding Energy of Layered Crystals to Macroscopic Observables
Gudarzi, M. M., & Aboutalebi, S. H. (2022) · Advanced Science · doi:10.1002/advs.202204001 · Cited by 6
Targeted Profiling of Epitranscriptomic Reader, Writer, and Eraser Proteins Regulated by H3K36me3
Yin, J., Qi, T. F., Li, L., & Wang, Y. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c01552 · Cited by 6
The histone methyltransferase SETD2 regulates HIV expression and latency
Bussey-Sutton, C. R., Ward, A., Fox, J. A., Turner, A. W., Peterson, J. J., Emery, A., Longoria, A. R., Gomez-Martinez, I., Jones, C. D., Hepperla, A. J., et al. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012281 · Cited by 7
Impact of high-fat diet on ovarian epigenetics: Insights from altered intestinal butyric acid levels
Qi, J., Xia, C., Zhang, Y., Ding, R., Zhang, Y., Cao, W., Duan, C., Yao, Z., Qin, H., Ye, Y., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33170 · Cited by 6
Self-citationLeitner, M., Murigneux, V., Etebari, K., & Sassan Asgari, B. (2025) · BMC Microbiology · doi:10.1186/s12866-025-03898-5 · Cited by 6
The importance of physiological and disease contexts in capturing mRNA modifications
Penning, A., Jeschke, J., & Fuks, F. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01548-y · Cited by 6
The old and the new: DNA and RNA methylation in normal and malignant hematopoiesis
Guirguis, A. A., Liddicoat, B., & Dawson, M. A. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.09.193 · Cited by 6
Integrative analyses of transcriptome data reveal the mechanisms of post-transcriptional regulation
Wang, J. (2021) · Briefings in Functional Genomics · doi:10.1093/bfgp/elab004 · Cited by 6
Research progress of m6A regulation during animal growth and development
Yu, H., Raza, S. H. A., Zhang, W., Yang, X., Almohaimeed, H. M., Alshanwani, A. R., Assiri, R., Aggad, W. S., & Zan, L. (2022) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2022.101851 · Cited by 6
Hong, W., Zhao, Y., Weng, Y., & Cheng, C. (2023) · iScience · doi:10.1016/j.isci.2023.106250 · Cited by 6
N6‐ Methyladenosine defines a new checkpoint in γδ T cell development
Zhao, J., Ding, C., & Li, H. (2023) · BioEssays · doi:10.1002/bies.202300002 · Cited by 6
The role of m6A mRNA modification in normal and malignant hematopoiesis
Ma, Z., Sugimura, R., & Lui, K. O. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad061 · Cited by 6
RNA Metabolism Governs Immune Function and Response
Yoshinaga, M., & Takeuchi, O. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-9781-7_10 · Cited by 6
Aska, E.-M., Đermadi, D., & Kauppi, L. (2020) · iScience · doi:10.1016/j.isci.2020.101452 · Cited by 6
The Impacts of Non-coding RNAs and N6-Methyladenosine on Cancer: Past, Present and Future
Xu, Z.-Y., Ji, G., Cui, Y., & Cui, X. (2021) · Current Cancer Drug Targets · doi:10.2174/1568009621999210120193636 · Cited by 6
Zhang, T., Zhang, S., Zhang, S.-Y., & Ma, Q. (2022) · Methods · doi:10.1016/j.ymeth.2022.03.008 · Cited by 6
Min, L., Huo, F., Zhu, Z., Din, L., Zhang, L., Xu, Y., Xing, X., Zhang, P., & Wang, Q. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111649 · Cited by 5
Niu, J., Fu, J., Feng, H., Han, J., Chen, Z., Yang, G., & Yuan, G. (2025) · Development · doi:10.1242/dev.204352 · Cited by 5
Self-citationLee, H., Chen, L., & Jin, Y. (2025) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2025.1607661 · Cited by 5
Molecular mechanisms and crop improvement potential of RNA N6-methyladenosine in plants
Fu, D., Wang, H., & Jiang, B. (2025) · aBIOTECH · doi:10.1007/s42994-025-00228-1 · Cited by 5
Martinelli, A. W., Wu, C.-P., Vornbäumen, T., Coates, H. W., Jordon, L., Wit, N., Sia, J. J., Speak, A. O., & Nathan, J. A. (2025) · Science Advances · doi:10.1126/sciadv.adw9095 · Cited by 5
Yang, J., Yang, Y., Zhang, X., Yan, C., Jiang, L., Zhang, D., & Jiang, W. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116414 · Cited by 5
Self-citationBao, X., Jiang, Q., Chen, W., Li, H., Li, X., Zuo, X., Lin, Z., Huang, Y., Li, L., Yang, A., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1206 · Cited by 5
Self-citationKansal, R., Sharma, V., Potraje, P., & Datta, M. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07805-y · Cited by 9
Kdm4a is an activity downregulated barrier to generate engrams for memory separation
Guo, X., Hong, P., Xiong, S., Yan, Y., Xie, H. B., & Guan, J. (2024) · Nature Communications · doi:10.1038/s41467-024-50218-y · Cited by 7
Self-citationm6A methylation regulators and ncRNAs in osteosarcoma: Potential therapeutic strategies
Shi, C., Chen, L., Huang, K., Yang, G., Shi, T., Li, J., & Zheng, H. (2024) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2024.10.003 · Cited by 5
Zhao, S.-S., Yuan, C., Liu, J., Wu, Q., & Zhou, X. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05809-3 · Cited by 5
Self-citationKuklinkova, R., Benova, N., & Anene, C. A. (2026) · RNA · doi:10.1261/rna.080681.125 · Cited by 5
The role of the m6A/m demethylase FTO in memory is both task and sex-dependent in mice
Leonetti, A. M., Galluzzo, I. R., McLean, T. A. B., Stefanelli, G., Ramnaraign, F. O., Holm, S., Winston, S. M., Reeves, I. L., Brimble, M. A., & Walters, B. J. (2024) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2024.107903 · Cited by 5
Regulatory roles of RNA methylation in vascular lesions in ocular and cardiopulmonary diseases
Liu, S., Cao, Y., & Zhang, Y. (2024) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2024.2370267 · Cited by 5
Zhao, Y., Li, J., Dian, M., Bie, Y., Peng, Z., Zhou, Y., Zhou, B., Hao, W.-C., & Wang, X.-C. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02266-y · Cited by 6
Self-citationTuning up gene transcription via direct crosstalk of DNA and RNA methylation
Deng, X., & Fan, G. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.01.030 · Cited by 5
Self-citationTaguchi, Y., Dharshini, S. A. P., & Gromiha, M. M. (2020) · Applied Sciences · doi:10.3390/app11010213 · Cited by 5
Cellular and molecular functions of SETD2 in the central nervous system
Mitchell, B., Thor, S., & Piper, M. (2023) · Journal of Cell Science · doi:10.1242/jcs.261406 · Cited by 5
Clapes, T., & Trompouki, E. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000585 · Cited by 5
Nsd2 Represses Endogenous Retrovirus MERVL in Embryonic Stem Cells
Gao, T., Chen, F., Zhang, W., Zhao, X., Hu, X., & Lu, X. (2021) · Stem Cells International · doi:10.1155/2021/6663960 · Cited by 5
Yang, Y., Fry, J., Yum, C., Wang, R., Wu, S., Narayan, S., Liu, Q., Zhang, X., Oo, H. Z., Xie, N., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci195840 · Cited by 4
Hou, X., Yang, Y., Wang, C., Huang, Z., Zhang, M., Yang, J., Li, N., Yang, H., Yang, L., & Wu, K. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31402 · Cited by 4
Self-citationMechanistic insights into stem cell fate regulation via RNA methylation
Sun, Y., & Li, J. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102717 · Cited by 4
Environmental Exposure, Epitranscriptomic Perturbations, and Human Diseases
Wei, S., Tao, H., Duan, Z., & Wang, Y. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c00907 · Cited by 5
LAMC1 is a Novel Prognostic Factor and a Potential Therapeutic Target in Gastric Cancer
Xi, D., Jia, Q., Liu, X., Zhang, L., Xu, B., Ma, Z., Ma, Y., Yu, Y., Zhang, F., & Chen, H. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s353289 · Cited by 4
Ensinck, I., Maman, A., Albihlal, W. S., Lassandro, M., Salzano, G., Sideri, T., Howell, S. A., Calvani, E., Patel, H., Bushkin, G., et al. (2023) · eLife · doi:10.7554/elife.87860.3 · Cited by 4
Metadata
- Authors
- Huang, H., Weng, H., Zhou, K., Wu, T., Zhao, B. S., Sun, M., Chen, Z., Deng, X., Xiao, G., Auer, F., Klemm, L., Wu, H., Zuo, Z., Qin, X., Dong, Y., Zhou, Y., Qin, H., Tao, S., Du, J., Liu, J., Lu, Z., Yin, H., Mesquita, A., Yuan, C. L., Hu, Y.-C., Sun, W., Su, R., Dong, L., Shen, C., Li, C., Qing, Y., Jiang, X., Wu, X., Sun, M., Guan, J.-L., Qu, L., Wei, M., Müschen, M., Huang, G., He, C., Yang, J., & Chen, J.
- Affiliations
- City of Hope (US)
- Sun Yat-sen University (CN)
- Howard Hughes Medical Institute (US)
- Cincinnati Children's Hospital Medical Center (US)
- Sun Yat-sen University Cancer Center (CN)
- University of Cincinnati (US)
- China Medical University (CN)
- City Of Hope National Medical Center (US)
- Corresponding author
- Huang, Gang
- He, Chuan
- Yang, Jianhua
- Chen, Jianjun
- ORCID
- Huang, Huilin
- Weng, Hengyou
- Zhou, Keren
- Wu, Tong
- Zhao, Boxuan Simen
- Sun, Mingli
- Chen, Zhenhua
- Deng, Xiaolan
- Xiao, Gang
- Auer, Franziska
- Wu, Huizhe
- Zuo, Zhixiang
- Qin, Xi
- Dong, Yunzhu
- Qin, Hanjun
- Tao, Shu
- Du, Juan
- Liu, Jun
- Lu, Zhike
- Yin, Hang
- Hu, Yueh-Chiang
- Sun, Wenju
- Su, Rui
- Dong, Lei
- Shen, Chao
- Li, Chenying
- Qing, Ying
- Jiang, Xi
- Wu, Xiwei
- Sun, Miao
- Guan, Jun-Lin
- Wei, Minjie
- Müschen, Markus
- Huang, Gang
- He, Chuan
- Yang, Jianhua
- Chen, Jianjun
- Venue
- Nature
- Published
- 2019-03
- Volume
- 567
- Issue
- 7748
- Pages
- 414-419
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC6438714
- OpenAlex
- W2921763102
- Cited by
- 677
- References
- 33
- Citations by year
- 2026: 48 · 2025: 93 · 2024: 99 · 2023: 114 · 2022: 103 · 2021: 114 · 2020: 76 · 2019: 30
- FWCI
- 27.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Human Genome Research Institute (RM1HG008935)
- National Cancer Institute (R01CA214965, R21CA187276, R01CA243386, R01CA163493, R01CA236399, R01CA178454, R01CA213138, R01CA182528, R01CA172558, U10CA180827, R01CA139032, R01CA137060, R01CA157644, R35CA197628, P30CA033572, R01CA211066, R01CA211614)
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK120282)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- H3K36me3, N6-methyladenosine, m6A RNA methylation, METTL14, m6A methyltransferase complex, RNA polymerase II, nascent RNA, pluripotency, mouse embryonic stem cells, gene expression regulation
- MeSH terms
- Adenosine, Animals, Cell Differentiation, Cell Line, Histones, Humans, Lysine, Methylation, Methyltransferases, RNA Polymerase II, RNA, Messenger, Transcription, Genetic, Mice, Embryonic Stem Cells, Transcriptome, Transcription Elongation, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
