The bone marrow microenvironment at single-cell resolution

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It Takes Three Receptors to Raise a B Cell

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Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation

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Awakening of Dormant Breast Cancer Cells in the Bone Marrow

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Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites

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Single-cell and spatial transcriptomics approaches of the bone marrow microenvironment

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Single‐Cell RNA ‐Sequencing Reveals the Breadth of Osteoblast Heterogeneity

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Mechanically Induced Nuclear Shuttling of β-Catenin Requires Co-transfer of Actin

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Angelica sinensis polysaccharides alleviate the oxidative burden on hematopoietic cells by restoring 5-fluorouracil-induced oxidative damage in perivascular mesenchymal progenitor cells

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Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping

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Clonal evolution dissection reveals that a high MSI2 level promotes chemoresistance in T-cell acute lymphoblastic leukemia

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Notch Signaling in the Bone Marrow Lymphopoietic Niche

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Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regeneration

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Diversity, localization, and (patho)physiology of mature lymphocyte populations in the bone marrow

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Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome

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Skeletal stem cells: origins, definitions, and functions in bone development and disease

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Modeling and countering the effects of cosmic radiation using bioengineered human tissues

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Restoring bone-fat equilibrium: Baicalin's impact on P38 MAPK pathway for treating diabetic osteoporosis

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The characterization of distinct populations of murine skeletal cells that have different roles in B lymphopoiesis

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B cell/stromal cell crosstalk in health, disease, and treatment: Follicular lymphoma as a paradigm

Lamaison, C., & Tarte, K. (2021) · Immunological Reviews · doi:10.1111/imr.12983 · Cited by 24

Turning the spotlight on bone marrow adipocytes in haematological malignancy and non‐malignant conditions

Austin, M. J., Kalampalika, F., Cawthorn, W. P., & Patel, B. G. (2023) · British Journal of Haematology · doi:10.1111/bjh.18748 · Cited by 23

Aucubin Promotes BMSCs Proliferation and Differentiation of Postmenopausal Osteoporosis Patients by Regulating Ferroptosis and BMP2 Signalling

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Imaging and spatial analysis of hematopoietic stem cell niches

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Mechanoregulation in Hematopoiesis and Hematologic Disorders

Horton, P. D., Dumbali, S. P., & Wenzel, P. L. (2020) · Current Stem Cell Reports · doi:10.1007/s40778-020-00172-4 · Cited by 23

Understanding of the crosstalk between normal residual hematopoietic stem cells and the leukemic niche in acute myeloid leukemia

Batsivari, A., Grey, W., & Bonnet, D. A. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.01.004 · Cited by 25

Mesenchymal stromal cells in the bone marrow niche consist of multi-populations with distinct transcriptional and epigenetic properties

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Identification of hematopoietic stem cells residing in the meninges of adult mice at steady state

Niu, C., Yu, J., Zou, T., Lu, Y., Deng, L., Yun, H., Si, C.-Y., Wu, X., Jiang, H., Guo, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111592 · Cited by 23

Early infiltrating NKT lymphocytes attenuate bone regeneration through secretion of CXCL2

Lin, W., Li, Q., Liu, L., Wang, Q., Zhang, D., Wang, F., Xu, R., Fan, Y., Xing, M. M. Q., Zhou, C., et al. (2024) · Science Advances · doi:10.1126/sciadv.adl6343 · Cited by 23

Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors

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PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation

Yen, Y., Chien, M., Wu, P., & Hung, S. (2021) · Communications Biology · doi:10.1038/s42003-021-02175-1 · Cited by 23

Unveiling novel insights in acute myeloid leukemia through single-cell RNA sequencing

Zhou, J., & Chng, W. J. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1365330 · Cited by 22

At the nuclear envelope of bone mechanobiology

Birks, S., & Uzer, G. (2021) · Bone · doi:10.1016/j.bone.2021.116023 · Cited by 22

Hematopoietic Stem Cells in Wound Healing Response

Urao, N., Liu, J., Takahashi, K., & Ganesh, G. (2021) · Advances in Wound Care · doi:10.1089/wound.2021.0065 · Cited by 23

Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice

Donham, C., Chicana, B. J., Robling, A. G., Mohamed, A. H., Elizaldi, S. R., Chi, M., Freeman, B., Millan, A. J., Murugesh, D. K., Hum, N. R., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179111 · Cited by 22

Metabolic crosstalk between stromal and malignant cells in the bone marrow niche

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B4GALNT3 regulates glycosylation of sclerostin and bone mass

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Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy

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Exosomes: A New Hope for Angiogenesis-Mediated Bone Regeneration

Lange, M., Babczyk, P., & Tobiasch, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105204 · Cited by 22

Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression

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Of vascular defense, hemostasis, cancer, and platelet biology: an evolutionary perspective

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Towards single cell encapsulation for precision biology and medicine

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The emerging Janus face of SVEP1 in development and disease

Elenbaas, J. S., Jung, I., Coler-Reilly, A. L. G., Lee, P. C., Alisio, A. E., & Stitziel, N. O. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.08.002 · Cited by 21

Stem cell heterogeneity, plasticity, and regulation

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Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization

Bisht, K., McGirr, C., Lee, S.-Y., Tseng, H., Fleming, W., Alexander, K. A., Matsumoto, T., Barbier, V., Sims, N. A., Müller‐Newen, G., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01413-z · Cited by 22

Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration

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Hematopoietic Progenitors and the Bone Marrow Niche Shape the Inflammatory Response and Contribute to Chronic Disease

Xu, Y., Murphy, A. J., & Fleetwood, A. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042234 · Cited by 23

Epithelial–immune crosstalk in health and disease

Rosenblum, D., & Naik, S. (2022) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2022.101910 · Cited by 21

Recent updates on the biological basis of heterogeneity in bone marrow stromal cells/skeletal stem cells.

Arora, D., & Robey, P. G. (2022) · PubMed Central · doi:10.12336/biomatertransl.2022.01.002 · Cited by 20

Single-cell methods in myeloproliferative neoplasms: old questions, new technologies

O’Sullivan, J., Mead, A. J., & Psaila, B. (2022) · Blood · doi:10.1182/blood.2021014668 · Cited by 24

Single-cell RNA sequencing identifies Fgf23-expressing osteocytes in response to 1,25-dihydroxyvitamin D3 treatment

Hanai, A., Kawabata, A., Nakajima, K., Masuda, K., Urakawa, I., Abe, M., Yamazaki, Y., & Fukumoto, S. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1102751 · Cited by 20

Age-associated declining of the regeneration potential of skeletal stem/progenitor cells

Mancinelli, L., & Intini, G. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1087254 · Cited by 20

MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism

Chu, T. L., Chen, P., Yu, A. X., Kong, M., Tan, Z., Tsang, K. Y., Zhou, Z., & Cheah, K. S. E. (2023) · eLife · doi:10.7554/elife.82142 · Cited by 20

Three-dimensional morphologic and molecular atlases of nasal vasculature

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WHIM Syndrome-linked CXCR4 mutations drive osteoporosis

Anginot, A., Nguyen, J., Nader, Z. A., Rondeau, V., Bonaud, A., Kalogeraki, M., Boutin, A., Lemos, J. P., Bisio, V., Koenen, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37791-4 · Cited by 20

The initial age‐associated decline in early T‐cell progenitors reflects fewer pre‐thymic progenitors and altered signals in the bone marrow and thymus microenvironments

Srinivasan, J., Vasudev, A., Shasha, C., Selden, H. J., Perez, E., LaFleur, B., Sinari, S. A., Krueger, A., Richie, E. R., & Ehrlich, L. I. R. (2023) · Aging Cell · doi:10.1111/acel.13870 · Cited by 23

Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models

Cao, J., Jin, L., Yan, Z., Wang, X., Li, Y., Wang, Z., Liu, Y.-W., Li, H.-M., Guan, Z., He, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-44312-w · Cited by 20

Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program

Gao, L., Lee, H. J., Goodman, J. H., & Ding, L. (2024) · Cell · doi:10.1016/j.cell.2024.03.032 · Cited by 20

The bone marrow stromal niche: a therapeutic target of hematological myeloid malignancies

Behrmann, L., Wellbrock, J., & Fiedler, W. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1744850 · Cited by 20

A Microfluidic Platform Equipped With Magnetic Nano Films for Organizing Bio-Particle Arrays and Long-Term Studies

Abedini‐Nassab, R., & Mahdaviyan, N. (2020) · IEEE Sensors Journal · doi:10.1109/jsen.2020.2992551 · Cited by 20

Cellular senescence mediates the detrimental effect of prenatal dexamethasone exposure on postnatal long bone growth in mouse offspring

Su, J., Chai, Y., Ji, Z., Xie, Y., Yu, B., & Zhang, X. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01790-9 · Cited by 20

Time for revival of the red blood cell count and red cell mass in the differential diagnosis between essential thrombocythemia and polycythemia vera?

Hasselbalch, H. C. (2019) · Haematologica · doi:10.3324/haematol.2019.229039 · Cited by 20

Mesenchymal stromal cells, metabolism, and mitochondrial transfer in bone marrow normal and malignant hematopoiesis

Singh, A. K., Prasad, P., & Cancelas, J. A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1325291 · Cited by 21

Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation

Heil, J., Olsavszky, V., Busch, K., Klapproth, K., Torre, C. D. L., Sticht, C., Sandorski, K., Hoffmann, J., Schönhaber, H., Zierow, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27161-3 · Cited by 19

Reduced Bone Mass in Collagen Prolyl 4‐Hydroxylase P4ha1 +/− ; P4ha2 −/− Compound Mutant Mice

Tolonen, J., Salo, A. M., Finnilä, M., Aro, E., Karjalainen, E., Ronkainen, V., Drushinin, K., Merceron, C., Izzi, V., Schipani, E., et al. (2022) · JBMR Plus · doi:10.1002/jbm4.10630 · Cited by 21

Toward Marrow Adipocytes: Adipogenic Trajectory of the Bone Marrow Stromal Cell Lineage

Matsushita, Y., Ono, W., & Ono, N. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.882297 · Cited by 19

A mechanosensitive vascular niche for Drosophila hematopoiesis

Tian, Y., Morin-Poulard, I., Liu, X., Vanzo, N. F., & Crozatier, M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2217862120 · Cited by 20

Tumor-derived interleukin-1α and leukemia inhibitory factor promote extramedullary hematopoiesis

Barisas, D. A. G., Kim, M., Subramanian, M., Kabir, A. U., Krchma, K., Wu, J., Zinselmeyer, B. H., Stewart, C. L., & Choi, K. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3001746 · Cited by 19

The emerging studies on mesenchymal progenitors in the long bone

Shen, F., Huang, X., He, G., & Shi, Y. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01039-x · Cited by 19

Transforming the Niche: The Emerging Role of Extracellular Vesicles in Acute Myeloid Leukaemia Progression

Mendes, M., Monteiro, A. C., Neto, E., Barrias, C. C., Simões, M. S., Duarte, D., & Caires, H. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084430 · Cited by 19

In Vitro Cell Surface Marker Expression on Mesenchymal Stem Cell Cultures does not Reflect Their Ex Vivo Phenotype

Cao, Y., Boss, A. L., Bolam, S. M., Munro, J. T., Crawford, H., Dalbeth, N., Poulsen, R. C., & Matthews, B. G. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10743-1 · Cited by 19

PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging

Xie, L., Cheng, Y., Hu, B., Chen, X., An, Y., Xia, Z., Cai, G., Li, C., & Peng, H. (2024) · Bone Research · doi:10.1038/s41413-024-00337-5 · Cited by 19

Transcriptional Profiles and Stromal Changes Reveal Bone Marrow Adaptation to Early Breast Cancer in Association with Deregulated Circulating microRNAs

Chiodoni, C., Cancila, V., Renzi, T. A., Perrone, M., Tomirotti, A., Sangaletti, S., Botti, L., Dugo, M., Milani, M., Bongiovanni, L., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1425 · Cited by 19

Single-cell sequencing in hematology

Brierley, C. K., & Mead, A. J. (2019) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000613 · Cited by 19

Bone regeneration via skeletal cell lineage plasticity: All hands mobilized for emergencies

Matsushita, Y., Ono, W., & Ono, N. (2020) · BioEssays · doi:10.1002/bies.202000202 · Cited by 19

Bone Marrow Niches and Tumour Cells: Lights and Shadows of a Mutual Relationship

Granata, V., Crisafulli, L., Nastasi, C., Ficara, F., & Sobacchi, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.884024 · Cited by 19

The bone marrow hematopoietic niche and its adaptation to infection

Gomes, A. C., Saraiva, M., & Gomes, M. S. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.05.014 · Cited by 18

Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging

Pham, J., Isquith, J. M., Balaian, L., Nandi, S. P., Engstrom, C., Mack, K., van der Werf, I. M., Chang, P. C., Stoudemire, J., Ladel, L., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.07.013 · Cited by 18

Inhibition of longevity regulator PAPP‐A modulates tissue homeostasis via restraint of mesenchymal stromal cells

Mohrin, M., Liu, J., Zavala‐Solorio, J., Bhargava, S., Trumble, J. M., Brito, A., Hu, D. Z., Brooks, D. J., Κούκος, Γ., Alabdulaaly, L., et al. (2021) · Aging Cell · doi:10.1111/acel.13313 · Cited by 20

Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3+ NK Cell Subset with a Bcl11b-Regulated T Cell Signature

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Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis

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