The bone marrow microenvironment at single-cell resolution

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Cellular components of the hematopoietic niche and their regulation of hematopoietic stem cell function

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Inducible T‐cell co‐stimulator (ICOS) and ICOS ligand are novel players in the multiple‐myeloma microenvironment

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Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium

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CD133+ endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice

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SOXC are critical regulators of adult bone mass

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Spatial and biochemical interactions between bone marrow adipose tissue and hematopoietic stem and progenitor cells in rhesus macaques

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INTS11 regulates hematopoiesis by promoting PRC2 function

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Bone Marrow Lymphoid Niche Adaptation to Mature B Cell Neoplasms

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Single-cell transcriptomics uncovers the impacts of titanium dioxide nanoparticles on human bone marrow stromal cells

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Recent advances in “sickle and niche” research - Tribute to Dr. Paul S Frenette -

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A double-negative thymocyte-specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and β-selection

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Bone marrow fat: friend or foe in people with diabetes mellitus?

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The regulatory networks and mechanisms of bone microenvironment in tumorigenesis and metastasis

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Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche

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Non-genetic mechanisms of drug resistance in acute leukemias

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Multi-omics analysis in developmental bone biology

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Radiation-induced bone loss in mice is ameliorated by inhibition of HIF-2α in skeletal progenitor cells

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Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor

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Hematopoietic and leukemic stem cells homeostasis: the role of bone marrow niche

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Single-cell sequencing reveals that specnuezhenide protects against osteoporosis via activation of METTL3 in LEPR+ BMSCs

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Sustained lymphocyte decreases after treatment for early breast cancer

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Interactions of Hematopoietic Stem Cells with Bone Marrow Niche

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Tmem100- and Acta2-Lineage Cells Contribute to Implant Osseointegration in a Mouse Model

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Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice

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Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches

Lévesque, J.-P., SUMMERS, K. M., Millard, S. M., Bisht, K., Winkler, I. G., & Pettit, A. R. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.07.001 · Cited by 17

Leptin receptor in osteocytes promotes cortical bone consolidation in female mice

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Skeletal stem cells: a game changer of skeletal biology and regenerative medicine?

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The tissue-specific transcriptional landscape underlines the involvement of endothelial cells in health and disease

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From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells

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Recent advances of single-cell RNA sequencing technology in mesenchymal stem cell research

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Descendants of hypertrophic chondrocytes promote angiogenesis by secreting THBS4 during bone growth and injury repair

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Systematic dissection of coordinated stromal remodeling identifies Sox10+ glial cells as a therapeutic target in myelofibrosis

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Bone marrow niches for hematopoietic stem cells in homeostasis and aging

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Human bone marrow organoids: emerging progress but persisting challenges

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Molecular mechanisms for stemness maintenance of acute myeloid leukemia stem cells

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Jingui Shenqi Pills Regulate Bone‐Fat Balance in Murine Ovariectomy‐Induced Osteoporosis with Kidney Yang Deficiency

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Transcriptomic Changes of Murine Visceral Fat Exposed to Intermittent Hypoxia at Single Cell Resolution

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Identification of microenvironmental niches for hematopoietic stem cells and lymphoid progenitors—bone marrow fibroblastic reticular cells with salient features

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In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras

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Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?

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Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells

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Quo Vadis? Immunodynamics of Myeloid Cells after Myocardial Infarction

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Cellular niches for hematopoietic stem cells in bone marrow under normal and malignant conditions

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A Question of Frame: The Role of the Bone Marrow Stromal Niche in Myeloid Malignancies

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Sexual dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment via sex-specific Kdm5c/Cxcl12 signaling

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Identification of NIBAN2‐Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis

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Strategies for advanced particulate bone substitutes regulating the osteo-immune microenvironment

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New insights into Human Hematopoietic Stem and Progenitor Cells via Single-Cell Omics

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Niche Regulation of Hematopoiesis: The Environment Is “Micro,” but the Influence Is Large

Rasheed, A. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316235 · Cited by 14

Impact of mesenchymal stromal cell–derived vesicular cargo on B-cell acute lymphoblastic leukemia progression

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Skull and vertebral bone marrow in central nervous system inflammation

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Orchiectomy Sensitizes Cortical Bone in Male Mice to the Harmful Effects of Kynurenine

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Ruxolitinib improves hematopoietic regeneration by restoring mesenchymal stromal cell function in acute graft-versus-host disease

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The hematopoietic microenvironment: a network of niches for the development of all blood cell lineages

Hernández-Barrientos, D., Pelayo, R., & Mayani, H. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad075 · Cited by 13

Emerging Insights into Molecular Mechanisms of Inflammation in Myelodysplastic Syndromes

Vallelonga, V., Gandolfi, F., Ficara, F., Porta, M. G. D., & Ghisletti, S. (2023) · Biomedicines · doi:10.3390/biomedicines11102613 · Cited by 15

Desperately seeking a home marrow niche for T-cell acute lymphoblastic leukaemia

Calvo, J., Fahy, L., Uzan, B., & Pflumio, F. (2019) · Advances in Biological Regulation · doi:10.1016/j.jbior.2019.100640 · Cited by 13

Molecular interactome between HSCs and their niches

Méndez‐Ferrer, S. (2019) · Blood · doi:10.1182/blood.2019002615 · Cited by 13

Transcriptomic Profiling of Dental Pulp Pericytes: An RNAseq Approach

Yianni, V., & Sharpe, P. T. (2020) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2020.00006 · Cited by 13

Editorial: Advances in Osteoimmunology

Blin‐Wakkach, C., & de Vries, T. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02595 · Cited by 13

Hematopoietic Stem Cells and RegenerationPreprint

Biermann, M., & Reya, T. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040774 · Cited by 14

Distinct stromal cell populations define the B-cell acute lymphoblastic leukemia microenvironment

Blanco, M. N. F., Kazybay, B., Belderbos, M. E., Heidenreich, O. T., & Vormoor, J. H. (2025) · Leukemia · doi:10.1038/s41375-025-02734-z · Cited by 12

Modeling of skeletal development and diseases using human pluripotent stem cells

Hojo, H., Tani, S., & Ohba, S. (2024) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjae178 · Cited by 12

Periarteriolar niches become inflamed in aging bone marrow, remodeling the stromal microenvironment and depleting lymphoid progenitors

Du, L., Freitas-Cortez, M. A., Zhang, J., Xue, Y., Veettil, R. T., Zhao, Z., & Morrison, S. J. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2412317122 · Cited by 13

Mechanical signatures and models of the bone marrow niche

Rogkoti, T., Donnelly, H., Dalby, M. J., & Salmerón‐Sánchez, M. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00305-6 · Cited by 15

Notch in the niche: new insights into the role of Notch signaling in the bone marrow

Vanderbeck, A., & Maillard, I. P. (2019) · Haematologica · doi:10.3324/haematol.2019.230854 · Cited by 12

Cytochrome P4501B1 in bone marrow is co-expressed with key markers of mesenchymal stem cells. BMS2 cell line models PAH disruption of bone marrow niche development functions

Larsen, M. C., Almeldin, A., Tong, T., Rondelli, C. M., Maguire, M., Jaskula‐Sztul, R., & Jefcoate, C. R. E. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115111 · Cited by 13

Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches

Pievani, A., Savoldelli, R., Poelchen, J., Mattioli, E., Anselmi, G., Girardot, A., Utikal, J. S., Bourdely, P., Serafini, M., & Guermonprez, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.631279 · Cited by 15

Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis

Rios‐Arce, N. D., Murugesh, D. K., Hum, N. R., Sebastian, A., Jbeily, E. H., Christiansen, B., & Loots, G. G. (2022) · JBMR Plus · doi:10.1002/jbm4.10625 · Cited by 12

Osteogenic differentiation: a universal cell program of heterogeneous mesenchymal cells or a similar extracellular matrix mineralizing phenotype?

Lobov, A. A., & Malashicheva, A. (2022) · Biological Communications · doi:10.21638/spbu03.2022.104 · Cited by 12

Hypercluster: a flexible tool for parallelized unsupervised clustering optimization

Blumenberg, L. M., & Ruggles, K. V. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-03774-1 · Cited by 12

Multi-walled carbon nanotubes reversing the bone formation of bone marrow stromal cells by activating M2 macrophage polarization

Lin, R., Ge, K., Fan, D., Li, J., Zhou, G., Zhang, K., Huang, Y., Ma, L., & Zhang, J. (2023) · Regenerative Biomaterials · doi:10.1093/rb/rbad042 · Cited by 11

Engineered hematopoietic and immune cells derived from human pluripotent stem cells

Chang, Y., Hummel, S. N., Jung, J., Jin, G., Deng, Q., & Bao, X. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.08.006 · Cited by 11

Regulation of immune cell development, differentiation and function by stromal Notch ligands

Schneider, M., Allman, A., & Maillard, I. P. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102256 · Cited by 11

Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection

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Macrophage heterogeneity in bone metastasis

Guo, J., Ma, R., & Qian, B. (2024) · Journal of bone oncology · doi:10.1016/j.jbo.2024.100598 · Cited by 11

Remote coupling of electrical and mechanical cues by diurnal photothermal irradiation synergistically promotes bone regeneration

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Identification of LRP1+CD13+ human periosteal stem cells that require LRP1 for bone repair

Jeong, Y., Deveza, L. R., Ortinau, L. C., Lei, K. N., Dawson, J. R., & Park, D. (2024) · JCI Insight · doi:10.1172/jci.insight.173831 · Cited by 11

Emerging insights into epigenetics and hematopoietic stem cell trafficking in age-related hematological malignancies

Xinyi, Y., Vladimirovich, R. I., Beeraka, N. M., Satyavathi, A., Kamble, D., Nikolenko, V. N., Lakshmi, A. N., Basappa, B., Padmanabha Reddy, Y., Fan, R., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04008-4 · Cited by 11

Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections

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Lymphoma B cells remodel bone marrow stromal cells into extracellular matrix–producing cancer-associated fibroblasts

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Aberrant EZHIP expression drives tumorigenesis in osteosarcoma

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The RANK/RANKL axis controls vascular dynamics in the bone marrow

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From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy

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The long and winding road: homeostatic and disordered haematopoietic microenvironmental niches: a narrative review.

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Intrathymic somatotropic circuitry: consequences upon thymus involution

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Single‐Cell Transcriptomics of Bone Marrow Stromal Cells in Diversity Outbred Mice: A Model for Population‐Level scRNA ‐Seq Studies

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Mapping Cell Atlases at the Single‐Cell Level

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Ptip safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis

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Navigating the biophysical landscape: how physical cues steer the journey of bone metastatic tumor cells

Ouyang, P., Cheng, B., He, X., Lou, J., Li, X., Guo, H., & Xu, F. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.07.003 · Cited by 11

Studying immune to non-immune cell cross-talk using single-cell technologies

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High-content image analysis to study phenotypic heterogeneity in endothelial cell monolayers

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Insights into osteoarthritis development from single-cell RNA sequencing of subchondral bone

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Rodent incisor as a model to study mesenchymal stem cells in tissue homeostasis and repair

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Mesenchymal stromal cells in tumor microenvironment remodeling of BCR-ABL negative myeloproliferative diseases

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CSF-1 and Notch signaling cooperate in macrophage instruction and tissue repair during peripheral limb ischemia

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The evolving hematopoietic niche during development

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Exosomes derived from mucoperiosteum Krt14 + Ctsk + cells promote bone regeneration by coupling enhanced osteogenesis and angiogenesis

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Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs

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Single-cell and spatial transcriptomics approaches of the bone marrow microenvironment

Al-Sabah, J., Baccin, C., & Haas, S. F. (2019) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000602 · Cited by 28

Genome-Wide Transcriptomic Profiling Reveals Dynamic Functional Remodeling of the Bone Marrow Microenvironment during Postnatal Development, Aging, and Inflammation

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Combined Single-Cell and Spatial Transcriptomics to Deconvolute the Hematopoietic Stem Cell Niche

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Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization

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Heterogeneity of the bone marrow niche

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