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The bone marrow microenvironment at single-cell resolution
Open accessAbstract
The bone marrow microenvironment has a key role in regulating haematopoiesis, but its molecular complexity and response to stress are incompletely understood. Here we map the transcriptional landscape of mouse bone marrow vascular, perivascular and osteoblast cell populations at single-cell resolution, both at homeostasis and under conditions of stress-induced haematopoiesis. This analysis revealed previously unappreciated levels of cellular heterogeneity within the bone marrow niche and resolved cellular sources of pro-haematopoietic growth factors, chemokines and membrane-bound ligands. Our studies demonstrate a considerable transcriptional remodelling of niche elements under stress conditions, including an adipocytic skewing of perivascular cells. Among the stress-induced changes, we observed that vascular Notch delta-like ligands (encoded by Dll1 and Dll4) were downregulated. In the absence of vascular Dll4, haematopoietic stem cells prematurely induced a myeloid transcriptional program. These findings refine our understanding of the cellular architecture of the bone marrow niche, reveal a dynamic and heterogeneous molecular landscape that is highly sensitive to stress and illustrate the utility of single-cell transcriptomic data in evaluating the regulation of haematopoiesis by discrete niche populations.
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“They particularly showed that the loss of the vascular-endothelial-expressed Notch ligand DLL4 skews HSPC differentiation toward myelopoiesis.42”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [42]
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Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
Self-citationEnrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma’ayan, A. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-128 · Cited by 7,814
Massively parallel digital transcriptional profiling of single cells
Zheng, G. X. Y., Terry, J. M., Belgrader, P., Ryvkin, P., Bent, Z. W., Wilson, R., Ziraldo, S. B., Wheeler, T. D., McDermott, G. P., Zhu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14049 · Cited by 7,353
Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets.
Macosko, E. Z., Basu, A., Satija, R., Nemesh, J., Shekhar, K., Goldman, M., Tirosh, I., Bialas, A. R., Kamitaki, N., Martersteck, E. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.002 · Cited by 7,110
Self-citationA robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
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Xu, L., Zhang, W., Zhang, X. H.-F., & Chen, X. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01100 · Cited by 6
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Lucas, D., Salomonis, N., & Grimes, H. L. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0447-6 · Cited by 6
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Bosch‐Fortea, M., Marciano, D., & Gautrot, J. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.23.546233 · Cited by 6
Hesampour, F., Bernstein, C. N., & Ghia, J. (2025) · Cellular Immunology · doi:10.1016/j.cellimm.2025.104963 · Cited by 5
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de Weerd, S., Ma, X., Zohali, Z., Oudejans, L. L., Kyrloglou, E., Stuart, M. C. A., Roos, W. H., Schuringa, J. J., & Salvati, A. L. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202500667 · Cited by 5
Kanari, M., Garcia, I. J., Steffen, F. D., Krattiger, L. A., Bataclan, C., Liu, W., Simona, B. R., Deplancke, B., Naveiras, O., Ehrbar, M., et al. (2025) · Leukemia · doi:10.1038/s41375-025-02739-8 · Cited by 5
Shen, J., Hu, L., Huang, X., Mao, J., Wu, Y., Xie, Z., & Lan, Y. (2024) · Bone · doi:10.1016/j.bone.2024.117076 · Cited by 5
Feng, J., Zhang, M., Ren, H., Ren, Y., Hao, Z., Bian, S., Cui, J., Li, S., Xu, J., Daniel, M., et al. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05156-0 · Cited by 5
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Zou, W., Rohatgi, N., Pan, H., Pokhrel, N. K., Silva, M. J., & Teitelbaum, S. L. (2025) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjaf051 · Cited by 5
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Zhang, H.-X., Cao, C., Li, X., Chen, Y., Zhang, Y., Liu, Y., Gong, Y. Y., Qiu, X., Zhou, C. L., Chen, Y., et al. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2710295 · Cited by 5
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Pendse, S., Chavan, S., Kale, V. P., & Vaidya, A. (2023) · Cell Biology International · doi:10.1002/cbin.12078 · Cited by 5
Larsen, M. C., Rondelli, C. M., Almeldin, A., Song, Y., N′jai, A. U., Alexander, D. L., Forsberg, E. C., Sheibani, N., & Jefcoate, C. R. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316884 · Cited by 5
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Hasson, M., Fernandes, L. M., Solomon, H., Pepper, T., Huffman, N., Pucha, S. A., Bariteau, J. T., Kaiser, J. M., & Patel, J. (2024) · Cells Tissues Organs · doi:10.1159/000538530 · Cited by 5
Stone, A. P., Rand, E., Thornes, G., Kay, A. G., Barnes, A. L., Hitchcock, I. S., & Genever, P. G. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03786-1 · Cited by 5
Schiavone, M. L., Crisafulli, L., Camisaschi, C., SIMONE, G. D., Liberati, F. R., Palagano, E., Rucci, N., Ficara, F., & Sobacchi, C. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03803-3 · Cited by 5
Miao, P., Yu, J., Chen, Z., Qian, S., & Chen, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-65345-1 · Cited by 5
Renou, L., Sun, W., Friedrich, C., Galant, K., Conrad, C., Consalus, A., Plantier, E., Schallmoser, K., Krisch, L. M., Barroca, V., et al. (2025) · HemaSphere · doi:10.1002/hem3.70120 · Cited by 5
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Stoilova, B., & Vyas, P. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.022 · Cited by 5
Björn, N., Falk, I. J., Lotfi, K., & Gréen, H. (2020) · Genes · doi:10.3390/genes11050549 · Cited by 5
Banjanin, B., & Schneider, R. K. (2021) · Frontiers in Genome Editing · doi:10.3389/fgeed.2020.618308 · Cited by 5
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Lim, V., Feng, X., Miao, R., Zehentmeier, S., Ewing-Crystal, N. A., Lee, M., Tumanov, A. V., Oh, J. E., Iwasaki, A., Wang, A., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202301924 · Cited by 5
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Debnath, S., & Greenblatt, M. B. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0989-7_7 · Cited by 5
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Kwang, D., Tjin, G., & Purton, L. E. (2021) · Immunological Reviews · doi:10.1111/imr.12973 · Cited by 5
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Kimura, T., Panaroni, C., Rankin, E. B., Purton, L. E., & Wu, J. Y. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4568 · Cited by 5
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Maroni, G., Panetta, D., Luongo, R., Krishnan, I., Rosa, F. L., Campani, D., Salvadori, P. A., Iozzo, P., Blasi, F., Penkov, D., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153639 · Cited by 5
A Meta-Analytic Single-Cell Atlas of Mouse Bone Marrow Hematopoietic DevelopmentPreprint
Harris, B. D., Lee, J., & Gillis, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.12.456098 · Cited by 5
Zhou, Q., Cao, C., Bao, Y., Sun, T., Adzraku, S. Y., Hao, X., Li, Y., Yuan, S., Huang, Y., Xu, K., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111760 · Cited by 4
Jann, J.-C., Schmitt, N., Streuer, A., Xu, Q., Riabov, V., Altrock, E., Weimer, N., Nowak, V., Obländer, J., Palme, I., et al. (2024) · Blood Neoplasia · doi:10.1016/j.bneo.2024.100021 · Cited by 4
Bonal, D. M., Oakes, A., Chorzalska, A. D., Pardo, M. R., Petersen, M., Clarke, M. Y., Lee, S.-H., Olszewski, A. J., Treaba, D. O., Reagan, J. L., et al. (2025) · Blood · doi:10.1182/blood.2024027125 · Cited by 4
Targeting miR-337 mitigates disuse-induced bone loss
Li, J., Ma, D., Zhang, C., Zheng, X., Hao, R., Zuo, B., Xiao, F., Li, Y., Liu, Y., Duan, Z., et al. (2025) · Cell Discovery · doi:10.1038/s41421-025-00822-z · Cited by 4
Long, J., Huang, W., Dai, Z., Kuang, Q.-X., Jiang, Y., Xiao, C., & You, F.-M. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102536 · Cited by 4
Lee, K., Hong, C.-L., Dissanayake, W. M., Kulzhanova, G., Pfeffer, A. N., Li, H., Sivakumar, S., Yin, Z., Quarato, E. R., Benoodt, L., et al. (2026) · Blood · doi:10.1182/blood.2024028031 · Cited by 5
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Wang, J. C., Sanchez, D., Arul, S., Gülsuyu, B., Gopinadhan, A., Mukhtar, T., Kim, J., Andrews, J. P., Williams, M. A. C., Jung, Y., et al. (2026) · Cell · doi:10.1016/j.cell.2026.07.007 · Cited by 4
Frangi, G., Guicheteau, M., Jacquot, F., Pyka, G., Kerckhofs, G., Feyeux, M., Véziers, J., Guihard, P. J., Halgand, B., Sourice, S., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.921073 · Cited by 4
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Deng, Z., Ma, L.-Y., Chen, Q., & Liu, Y. (2023) · BioEssays · doi:10.1002/bies.202200121 · Cited by 4
Bone marrow microenvironment: roles and therapeutic implications in obesity-associated cancer
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Nelson, T., Tommasini, S. M., & Fretz, J. A. (2024) · Bone · doi:10.1016/j.bone.2024.117198 · Cited by 4
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Yu, X., Zheng, G., Xu, L., Guo, W., Chen, G., Zhu, Y., Li, T., Rao, M., Wang, L., Rong, C., et al. (2024) · Molecular Omics · doi:10.1039/d4mo00111g · Cited by 4
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Chai, R. C. C., Lundberg, M., Freudenthal, B., Smith, J. T., Boughton, A. P., Zhang, Y., Flynn, K. A., Frysz, M., Corr, A. P., Khoo, W. H., et al. (2026) · Nature Genetics · doi:10.1038/s41588-026-02640-9 · Cited by 4
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Zhou, B. O., Huang, H., Ding, Z., Luo, K., Chen, Y., Han, Y., Pang, W., Tang, W., Chen, L., Jin, W., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05597-w · Cited by 4
Mughal, T. I., Pemmaraju, N., Psaila, B., Radich, J. P., Bose, P., Lion, T., Kiladjian, J., Rampal, R. K., Jain, T., Verstovsek, S., et al. (2020) · Hematological Oncology · doi:10.1002/hon.2771 · Cited by 4
Matthews, E., Lanham, S., White, K., Kyriazi, M. E., Alexaki, K., El-Sagheer, A. H., Brown, T. P., Kanaras, A. G., West, J. J., MacArthur, B. D., et al. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314231169375 · Cited by 4
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Park, E., Evans, M. A., & Walsh, K. X. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.39 · Cited by 4
Zupan, J., Tang, D., Oreffo, R. O. C., Redl, H. R., & Marolt, D. (2020) · Springer eBooks · doi:10.1007/978-3-319-37076-7_7-1 · Cited by 4
Tay, J., Barbier, V., Helwani, F., Price, G. R., Lévesque, J.-P., & Winkler, I. G. (2021) · Stem Cells · doi:10.1002/stem.3438 · Cited by 4
Leimkühler, N. B., Costa, I. G., & Schneider, R. K. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.09.006 · Cited by 4
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Vinchi, F., Mendelson, A., Yazdanbakhsh, K., & An, X. (2019) · HemaSphere · doi:10.1097/hs9.0000000000000299 · Cited by 4
Caplan, A. I. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231194250 · Cited by 4
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Redmond, D., & Rafii, S. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01242-5 · Cited by 4
Xu, Z., Liu, F., Ding, Y., Pan, T., Wu, Y.-H., Liu, J., Bado, I., Zhang, W., Wu, L., Gao, Y., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4846389 · Cited by 4
Borda, M., Sierra, R., Cantero, M. J., Gómez Bustillo, S., Fiore, E. J., Giardelli, G., Martino Garcet, M., Rebottaro, M. L., Bayo Fina, J. M., Schiavone, M., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03896-w · Cited by 3
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Weldon, K. C., Longaker, M. T., & Ambrosi, T. H. (2025) · Stem Cells · doi:10.1093/stmcls/sxaf006 · Cited by 3
Liu, J., Chen, J., Chen, S., Huang, Y., Xu, K., Cai, D., Liao, X., You, R., Xu, X., Wang, X., et al. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102461 · Cited by 3
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Xu, Z., Liu, F., Ding, Y., Pan, T., Wu, Y.-H., Han, Y., Liu, J., Bado, I., Zhang, W., Wu, L., et al. (2026) · Cell · doi:10.1016/j.cell.2026.04.009 · Cited by 5
Xu, C., Lv, X., Yang, S., Lv, Y., Zheng, Y., Wang, Y.-X., Hui, Y., Sun, G. Y., Zhao, X., Ma, L.-Y., et al. (2026) · Blood · doi:10.1182/blood.2025031474 · Cited by 3
Arizkane, K., Geistlich, K., Moindrot, L., Risson, E., Jeanpierre, S., Barral, L., Bobard, A., Menegazzi, G., Voeltzel, T., Maguer‐Satta, V., et al. (2022) · Journal of Visualized Experiments · doi:10.3791/64736-v · Cited by 3
Zhou, W., Lin, J., Hay, D. C., Yao, X., & Ouyang, H. (2024) · Medical Review · doi:10.1515/mr-2024-0056 · Cited by 3
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Qiu, C., Li, Y., Gong, Y., Sherman, W., Tian, D., Lin, W., Pan, Z., Afolabi, B., Thumbigere‐Math, V., Su, K.-J., et al. (2026) · Bone Research · doi:10.1038/s41413-026-00520-w · Cited by 3
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Yogo, T., Becker, H., Kimura, T., Iwano, S., Kuchimaru, T., Miyawaki, A., Yokomizo, T., Suda, T., Iwama, A., & Yamazaki, S. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115241 · Cited by 3
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Atria, P. J., & Castillo, A. B. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1233920 · Cited by 3
Blumenberg, L. M., & Ruggles, K. V. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.13.905323 · Cited by 3
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Tian, Y., Li, X., Chen, Y., Gan, D., Deng, D., Jing, L., Li, F., Zhang, W., Wu, R., Liu, F., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202510486 · Cited by 2
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Self-citationWang, Z., Huang, C., Liu, S., Xiao, P., Lu, Z., Xu, Y., & Tian, Y. (2025) · Communications Biology · doi:10.1038/s42003-025-08985-x · Cited by 2
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Metadata
- Authors
- Tikhonova, A. N., Dolgalev, I., Hu, H., Sivaraj, K. K., Hoxha, E., Cuesta-Domínguez, Á., Pinho, S., Akhmetzyanova, I., Gao, J., Witkowski, M., Guillamot, M., Gutkin, M. C., Zhang, Y., Marier, C., Diefenbach, C., Kousteni, S., Heguy, A., Zhong, H., Fooksman, D. R., Butler, J. M., Economides, A., Frenette, P. S., Adams, R. H., Satija, R., Tsirigos, A., & Aifantis, I.
- Affiliations
- NYU Langone Health (US)
- University of Münster (DE)
- Albert Einstein College of Medicine (US)
- Regeneron (United States) (US)
- Hackensack University Medical Center (US)
- Columbia University (US)
- New York Genome Center (US)
- Corresponding author
- Tikhonova, Anastasia N.
- Tsirigos, Aristotelis
- Aifantis, Iannis
- ORCID
- Tikhonova, Anastasia N.
- Dolgalev, Igor
- Hu, Hai
- Sivaraj, Kishor K.
- Pinho, Sandra
- Akhmetzyanova, Ilseyar
- Gao, Jie
- Witkowski, Matthew
- Gutkin, Michael C.
- Zhang, Yutong
- Diefenbach, Catherine
- Kousteni, Stavroula
- Heguy, Adriana
- Fooksman, David R.
- Butler, Jason M.
- Economides, Aris
- Frenette, Paul S.
- Adams, Ralf H.
- Satija, Rahul
- Tsirigos, Aristotelis
- Aifantis, Iannis
- Venue
- Nature
- Published
- 2019-04-10
- Volume
- 569
- Issue
- 7755
- Pages
- 222-228
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC6607432
- OpenAlex
- W2936664461
- Cited by
- 936
- References
- 73
- Citations by year
- 2026: 89 · 2025: 106 · 2024: 113 · 2023: 153 · 2022: 129 · 2021: 153 · 2020: 137 · 2019: 56
- FWCI
- 83.83
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-07-12)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- NYU Langone Medical Center
- Nature
- National Institutes of Health (1dp2hg009623-01)
- National Heart, Lung, and Blood Institute (R01HL130937, R01HL069438)
- National Human Genome Research Institute (DP2-HG-009623)
- National Cancer Institute (R01CA194923, R01CA202027, R01CA202025, R01CA169784, R01CA105129)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK112976, R01DK056638, U01DK116312)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- bone marrow microenvironment, hematopoiesis, hematopoietic stem cells, single-cell transcriptomics, perivascular cells, osteoblasts, vascular cells, DLL4, DLL1, Notch signaling, myeloid differentiation, chemokines, growth factors, cellular heterogeneity
- MeSH terms
- RNA-Seq, Animals, Bone Marrow, Calcium-Binding Proteins, Cell Differentiation, Endothelium, Vascular, Female, Gene Expression Regulation, Hematopoiesis, Hematopoietic Stem Cells, Male, Osteoblasts, Stress, Physiological, Adipocytes, Cell Lineage, Myeloid Cells, Adaptor Proteins, Signal Transducing, Mice, Receptors, Notch, Stem Cell Niche, Single-Cell Analysis, Transcriptome, Cellular Microenvironment
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