Patch repair of deep wounds by mobilized fascia
Open accessAbstract
Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism 1-5. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their surrounding extracellular jelly-like matrix, including embedded blood vessels, macrophages and peripheral nerves, to form the provisional matrix. Genetic ablation of fascia fibroblasts prevented matrix from homing into wounds and resulted in defective scars, whereas placing an impermeable film beneath the skin-preventing fascia fibroblasts from migrating upwards-led to chronic open wounds. Thus, fascia contains a specialized prefabricated kit of sentry fibroblasts, embedded within a movable sealant, that preassemble together diverse cell types and matrix components needed to heal wounds. Our findings suggest that chronic and excessive skin wounds may be attributed to the mobility of the fascia matrix.
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Fibroblasts are capable of remarkable plasticity and phenotype switching during progression and regression of fibrosis.
“Fibroblasts, in addition to displaying significant functional heterogeneity, are capable of remarkable degrees of plasticity and phenotype switching during progression and regression of fibrosis30,35,36.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [36]
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- Authors
- Correa-Gallegos, D., Jiang, D., Christ, S., Ramesh, P., Ye, H., Wannemacher, J., Kalgudde Gopal, S., Yu, Q., Aichler, M., Walch, A., Mirastschijski, U., Volz, T., & Rinkevich, Y.
- Affiliations
- Helmholtz Munich (DE)
- University of Bremen (DE)
- TUM Klinikum (DE)
- Corresponding author
- Rinkevich, Yuval
- ORCID
- Venue
- Nature
- Published
- 2019-11-27
- Volume
- 576
- Issue
- 7786
- Pages
- 287-292
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2989673368
- Cited by
- 247
- References
- 28
- Citations by year
- 2026: 32 · 2025: 38 · 2024: 27 · 2023: 54 · 2022: 37 · 2021: 39 · 2020: 19 · 2019: 1
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion, other-oa)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- wound healing, scar formation, subcutaneous fascia, chronic wounds, fate mapping, live imaging, macrophages, peripheral nerves, blood vessels
- MeSH terms
- Animals, Cell Movement, Fascia, Fibroblasts, Keloid, Mice, Inbred C57BL, Wound Healing, Biomarkers
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