KRAS4A directly regulates hexokinase 1

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

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Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

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Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

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Ras signalling on the endoplasmic reticulum and the Golgi

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Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

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Video-rate nanoscopy using sCMOS camera–specific single-molecule localization algorithms

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How Driver Oncogenes Shape and Are Shaped by Alternative Splicing Mechanisms in Tumors

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Proximal Protein Interaction Landscape of RAS Paralogs

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NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane

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De novo design of Ras isoform selective binders

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ATP5J regulates microglial activation via mitochondrial dysfunction, exacerbating neuroinflammation in intracerebral hemorrhage

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S-palmitoylation: A novel player in cancer and its emerging therapeutic implications

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Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance

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Unveil Intrahepatic Cholangiocarcinoma Heterogeneity through the Lens of Omics and Multi-Omics Approaches

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Defining bone fide effectors of RAS GTPases

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RASless MEFs as a Tool to Study RAS-Dependent and RAS-Independent Functions

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The molecular mechanism of chitosan-based OEO nanoemulsion edible film in controlling Alternaria alternata and in application for apricot preservation

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Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10

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Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer

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Growth Signaling Networks Orchestrate Cancer Metabolic NetworksPreprint

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Aberrant pre-mRNA processing in cancer

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Unraveling and targeting RAS-driven metabolic signaling for therapeutic gain

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Unveiling the domain-specific and RAS isoform-specific details of BRAF kinase regulation

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The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A

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Palmitoylation in cancer: decoding its roles in signal transduction, tumor immunity, and emerging therapeutic opportunities

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Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations

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Hyperactive HRAS dysregulates energetic metabolism in fibroblasts from patients with Costello syndrome via enhanced production of reactive oxidizing species

Carpentieri, G., Leoni, C., Pietraforte, D., Cecchetti, S., Iorio, E., Belardo, A., Pietrucci, D., Nottia, M. D., Pajalunga, D., Megiorni, F., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab270 · Cited by 9

Targeted splicing therapy: new strategies for colorectal cancer

Zheng, Y., Zhong, G., He, C., & Li, M. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1222932 · Cited by 9

DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer

Ni, Y., & Zhuang, Z. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110995 · Cited by 9

Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin

Šimčíková, D., Gardáš, D., Hložková, K., Hruda, M., Žáček, P., Rob, L., & Heneberg, P. (2021) · Cancer & Metabolism · doi:10.1186/s40170-021-00277-2 · Cited by 10

Imaging the Rewired Metabolism in Lung Cancer in Relation to Immune Therapy

van Genugten, E. A. J., Weijers, J. A. M., Heskamp, S., Kneilling, M., van den Heuvel, M. M., Piet, B., Bussink, J., Hendriks, L. E. L., & Aarntzen, E. H. J. G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.786089 · Cited by 9

Differential functions of the KRAS splice variants

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ZDHHC17 participates in the pathogenesis of polycystic ovary syndrome by affecting androgen conversion to estrogen in granulosa cells

Zhao, S., Ma, R., Jueraitetibaike, K., Yao, X., Jing, J., Tang, T. F., Shi, M., Zhang, H., Ge, X., Chen, L., et al. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112076 · Cited by 8

Phlorizin ameliorates myocardial fibrosis by inhibiting pyroptosis through restraining HK1-mediated NLRP3 inflammasome activation

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K-RAS4A: Lead or Supporting Role in Cancer Biology?

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Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway

Zeng, X., Gong, G., Ganesan, K., Wen, Y., Liu, Q., Zhuo, J., Wu, J., & Chen, J. (2023) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2023.09.002 · Cited by 7

Mutant KRAS and CK2 Cooperatively Stimulate SLC16A3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression

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Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer

Mbah, N. E., Sutton, D., Hong, H. S., Singhal, R., Menjivar, R. E., Perricone, M. D., Giza, H., Sajjakulnukit, P., Myers, A. L., Nwosu, Z. C., et al. (2026) · Cancer & Metabolism · doi:10.1186/s40170-026-00428-3 · Cited by 7

Pacritinib inhibits glucose consumption in squamous cell lung cancer cells by targeting FLT3

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Metabolic targeting of malignant tumors: a need for systemic approach

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Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors

Babu, V. S., Mallipatna, A. C., Dudeja, G., Shetty, R., Nair, A. P., Tun, S. B. B., Ho, C. E. H., Chaurasia, S. S., Bhattacharya, S. S., Verma, N. K., et al. (2023) · Translational research · doi:10.1016/j.trsl.2023.07.001 · Cited by 7

MCL1 modulates mTORC1 signaling to promote bioenergetics and tumorigenesis

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Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis

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The Non-canonical Role of Metabolic Enzymes in Immune Cells and Its Impact on Diseases

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Pancreatic cancer epigenetics: adaptive metabolism reprograms starving primary tumors for widespread metastatic outgrowth

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The moonlighting functions of glycolytic enzymes in tumorigenesis

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Non-targeted metabonomics reveals the effect of linalyl alcohol on Brochothrix thermophile and its potential application

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Drugging Ras trafficking—are there new roads to travel?

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A Biochemical View on Intermittent Fasting’s Effects on Human Physiology—Not Always a Beneficial Strategy

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Negative correlation between acetyl-CoA acyltransferase 2 and cetuximab resistance in colorectal cancer

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Metabolic signatures in pancreatic ductal adenocarcinoma: diagnostic and therapeutic implications

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RAS: Circuitry and therapeutic targeting

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IMPACT OF HEAVY METALS ON HEXOKINASE ISOFORMS: AN IN SILICO STUDY

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Isoform‐specific functions of Ras in T‐cell development and differentiation

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Photocatalytic proximity labeling for the identification of G-quadruplex DNA-interacting proteins

Abdelhady, A. M., Sato, S., Masuzawa, T., Deguchi, K., Oba, M., Sato, T., Mase, N., Yamanaka, T., Osman, J. A., Kato, M., et al. (2026) · Communications Chemistry · doi:10.1038/s42004-026-02170-9 · Cited by 3

Depletion-dependent activity-based protein profiling using SWATH/DIA-MS detects serine hydrolase lipid remodeling in lung adenocarcinoma progression

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Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass

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The connection between innervation and metabolic rearrangements in pancreatic cancer through serine

Dong, M.-M., Cao, L., Cui, R., & Xie, Y.-J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.992927 · Cited by 4

The RAS Signaling Network and Cancer

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The role of chromatin modulator DPY30 in glucose metabolism of colorectal cancer cells

Mao, X., Yang, S., Zhang, Y., Yang, H., Yan, D., & Zhang, L. (2024) · Translational Cancer Research · doi:10.21037/tcr-24-366 · Cited by 4

RAS GTPases and Interleaflet Coupling in the Plasma MembranePreprint

Liu, J., Arora, N., & Zhou, Y. (2023) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041414 · Cited by 5

Metabolic permissiveness: how tissue context shapes cancerPreprint

Moschandrea, C., & Frezza, C. (2026) · Genes & Development · doi:10.1101/gad.353516.125 · Cited by 4

Systematic and precise interventions for KRAS-mutant cancers

Liang, J., Wu, J., Zhang, Y., Wang, H., Zheng, Y., & He, Q. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00763-7 · Cited by 4

Bridging metabolic reprogramming and targeted therapy: the critical role of S-palmitoylation in cancer

Sun, Y., Tang, W. P., Xia, Y., Xia, M., Liu, G., Zhang, W., Chen, Y., & Zhong, J. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1802109 · Cited by 3

Oncogenic KRAS Drives Metabolic Vulnerabilities by Directly Regulating Metabolic Enzymes in Cancer

Zhang, L. (2020) · Global Medical Genetics · doi:10.1055/s-0040-1712456 · Cited by 3

On the Relevance of Soft Tissue Sarcomas Metabolic Landscape Mapping

Esperança‐Martins, M., Duarte, I. F., Rodrigues, M., do Brito, J. S., Lopéz‐Presa, D., Costa, L., Fernandes, I., & Dias, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911430 · Cited by 3

Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors

Tripathi, P., Kumari, R., & Pathak, R. (2024) · International review of cytology · doi:10.1016/bs.ircmb.2023.11.004 · Cited by 3

Cross-Species Comparison of the Pan-RAF Inhibitor LY3009120’s Anti-Tumor Effects in Equine, Canine, and Human Malignant Melanoma Cell Lines

Yu, G., Packeiser, E., Wendt, S., Sekora, A., Cavalleri, J. V., Pratscher, B., Alammar, M., Hühns, M., Brenig, B., Junghanß, C., et al. (2024) · Genes · doi:10.3390/genes15020202 · Cited by 5

Kirsten rat sarcoma inhibitors in clinical development against nonsmall cell lung cancer

Li, Y., Hu, L., & Xu, C. S. (2021) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000808 · Cited by 3

S-palmitoylation in ferroptosis: molecular mechanisms, modulators, and interplay with autophagy

Wang, L., Wang, C., & He, H. (2026) · APOPTOSIS · doi:10.1007/s10495-025-02227-5 · Cited by 2

KRAS4A and KRAS4B in liquid biopsy of metastatic lung adenocarcinoma patients treated with Pembrolizumab or chemotherapy plus Pembrolizumab

Chiari, R., Palladino, S., Emili, R., Lisa, M. D., Sarti, D., Catalano, V., Magnani, M., Graziano, F., & Ruzzo, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-48304-0 · Cited by 2

The essential role of glucose metabolism in chemoresistance of colorectal cancer - a mini review

Huong, P. T., Lap, N. T., Anh, D. T. M., Bac, N. X., Hiên, M. V., Ha, P. T. T., & Phuong, V. T. (2023) · Tạp chí Nghiên cứu Dược và Thông tin Thuốc · doi:10.59882/1859-364x/155 · Cited by 2

Comprehensive analysis of glycometabolism-related genes reveals PLOD2 as a prognostic biomarker and therapeutic target in gastric cancer

Ye, W., Zhang, X., Tang, Z., Hu, Y., Zheng, Y., & Yuan, Y. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03878-z · Cited by 2

Warburg and pasteur phenotypes modulate cancer behavior and therapy

Karaca, C., Tokatli, A., Tokatli, A., Karadag, A., & Calibasi‐Kocal, G. (2021) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000001236 · Cited by 2

USP30-mediated Deubiquitination of Hexokinase 2 controls the metabolic fate of glucose and tumor progression

Zhang, H., Li, X., Liao, W., Qin, X., Jiang, Y., Yang, H., Zeng, H., Li, Y., Xie, W., Zhang, Y., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08459-w · Cited by 1

Bioengineered systems to exploit tumor microenvironment metabolism

Sanganoo, C., Caturegli, I., Mattes, Z. F., Ryan, J., Wong, W. W., & Grinstaff, M. W. (2026) · Trends in cancer · doi:10.1016/j.trecan.2026.04.003 · Cited by 1

KRAS4A promotes oligomerization of hexokinase 1 on mitochondria

Nuevo‐Tapioles, C., Qin, Z., Bazley, A., Branco, C., Hamilton, G., Kong, X., Rothenberg, E., & Philips, M. R. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117392 · Cited by 1

Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF Regulation

Trebino, T., Markusic, B., Nan, H., Banerjee, S., & Wang, Z. (2023) · doi:10.1101/2023.04.24.538112 · Cited by 1

Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF Regulation

(2023) · doi:10.7554/elife.88836.2 · Cited by 1

BCL-xL antagonizes the deleterious effects of KRAS on mitochondrial scaffoldingPreprint

Belaid, N., Basseville, A., André‐Grégoire, G., Fétiveau, A., Maillet, L., Guillonneau, F., Leduc, M., Guette, C., Désaubry, L., Gavard, J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.13.488211

Understanding the Interplay Between the Tumor Immune Microenvironment and Genetic Alterations in Thoracic Malignancies

Pasello, G., Felley‐Bosco, E., & Remon, J. (2022) · Frontiers research topics · doi:10.3389/978-2-88974-818-1

G-proteins | Ras Family

Quilliam, L. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00115-8

Coupling Glucose Phosphorylation to Oxygen in Brain Mitochondria: Would It Be a Redox Set Point?

Galina, A. (2023) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-19-8342-9_6

Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF RegulationPreprint

Trebino, T. E., Markusic, B., Nan, H., Banerjee, S., & Wang, Z. (2023) · eLife · doi:10.7554/elife.88836.1

Reviewer #2 (Public Review): Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF Regulation

Trebino, T., Markusic, B., Nan, H., et al. (2023) · eLife · doi:10.7554/elife.88836.2.sa0

eLife Assessment: Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF Regulation

Dötsch, V. (2023) · eLife · doi:10.7554/elife.88836.2.sa2

Author Response: Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF Regulation

Trebino, T., Markusic, B., Nan, H., Banerjee, S., & Wang, Z. (2023) · eLife · doi:10.7554/elife.88836.2.sa3

Reviewer #1 (Public Review): Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF Regulation

Trebino, T., Markusic, B., Nan, H., et al. (2023) · eLife · doi:10.7554/elife.88836.2.sa1

Impact of metabolic rewiring by KRAS mutations on plasma lipidome profiling in patients with advanced solid tumorsPreprint

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2-Deoxy-D-Glucose: A Glycolysis Inhibitor in the Treatment of Cancer

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Loss of Golga7 Suppresses Oncogenic Nras ‐Driven Leukemogenesis without Detectable Toxicity in Adult Mice

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Cancer‐Type‐Specific DNA Methylation Is a Source of Vulnerability in Liver Cancer Cells

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Metabolic enzymes co-opted in oncogenic signalling

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Palmitoylation-dependent activation of NADK promotes NADP + synthesis and tumorigenesisPreprint

Chen, L., Zhang, W., Zhu, Y., Xing, X., Yao, Y., Pei, H., Chen, Y., Qin, W., & Zhang, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.24.666230

Hypoxia-induced metastatic heterogeneity in pancreatic cancer

Gunasekaran, P. M., Wang, Q., Guseva, P., Chang, Y., Chauhan, R., Kley, A., Xu, M., Lee, G., Marshall, G., Roy, S. G., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76143-w

eIF2B Selectively Anchors and Activates Mutant KRASPreprint

Kim, H., Diao, S., Cho, K., Lee, H.-R., Liu, J., Egea, P. F., Pantsar, T., Kurki, M., Ghaddar, N., Wang, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.10.686860

Alternative splicing of KRAS exon 4 promotes tumor progression via enhanced KRAS4A oncogenic activity

Cho, N., Kwon, E., Kim, S.-E., & Kim, K. K. (2025) · Animal Cells and Systems · doi:10.1080/19768354.2025.2598971

Additional file 1 of Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin

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Palmitoylation remodeling dictates HCC heterogeneity: implications for subtype-specific prognostication and targeting the YAP-RhoA axis

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DHHC7 palmitoylates KRAS4A and promotes mutant KRAS-driven pancreatic cancersPreprint

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Posttranslational modifications of RAS: few pockets but many bumps

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Alternative Splicing in Cyclin‐Dependent Kinase 4/6 Inhibitor Resistance in Estrogen Receptor‐Positive Breast Cancer

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KRAS signaling networks, mutational heterogeneity, and emerging therapeutic strategies for cancer treatment

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ENOPH1 orchestrates KRASG12D/G13D-driven glycolytic reprogramming and colorectal cancer progression through modulating the TGF-β/SMAD pathway

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Co-targeting KRAS and BCL-2 induces pyroptosis and antitumor tertiary lymphoid structuresPreprint

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Abstract A13: KRAS4A directly regulates hexokinase 1

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Isoform-Specific KRAS–Hexokinase 1 Interaction Affects Metabolism

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Oncogenic KRAS Drives Metabolic Vulnerabilities by Directly Regulating Metabolic Enzymes in Cancer

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KRAS4A promotes oligomerization of hexokinase 1 on mitochondria

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Abstract IA009: Differential Biology of KRAS Splice Variants

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