Immune-evasive human islet-like organoids ameliorate diabetes

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314

Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets.

Macosko, E. Z., Basu, A., Satija, R., Nemesh, J., Shekhar, K., Goldman, M., Tirosh, I., Bialas, A. R., Kamitaki, N., Martersteck, E. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.002 · Cited by 7,110

Differential analysis of gene regulation at transcript resolution with RNA-seq

Trapnell, C., Hendrickson, D. G., Sauvageau, M., Goff, L., Rinn, J. L., & Pachter, L. (2013) · Nature Biotechnology · doi:10.1038/nbt.2450 · Cited by 3,492

ATAC-seq: a method for assaying chromatin accessibility genome-wide

Buenrostro, J. D., Wu, B., Chang, H. Y., & Greenleaf, W. J. (2015) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb2129s109 · Cited by 3,289

Vascularized and functional human liver from an iPSC-derived organ bud transplant

Takebe, T., Sekine, K., Enomura, M., Koike, H., Kimura, M., Ogaeri, T., Zhang, R.-R., Ueno, Y., Zheng, Y.-W., Koike, N., et al. (2013) · Nature · doi:10.1038/nature12271 · Cited by 2,170

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Huang, S.-M. A., Mishina, Y., Liu, S.-M., Cheung, A. K., Stegmeier, F., Michaud, G., Charlat, O., Wiellette, E., Zhang, Y., Wiessner, S., et al. (2009) · Nature · doi:10.1038/nature08356 · Cited by 2,077

Generation of Functional Human Pancreatic β Cells In Vitro

Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025

Advancement of Nanomaterials- and Biomaterials-Based Technologies for Wound Healing and Tissue Regenerative Applications

Banerjee, D., Vydiam, K., Vangala, V., & Mukherjee, S. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00075 · Cited by 29

Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells

Jin, W., & Jiang, W. (2022) · Cell Regeneration · doi:10.1186/s13619-022-00125-8 · Cited by 35

Challenges with Cell-based Therapies for Type 1 Diabetes Mellitus

Siwakoti, P., Rennie, C., Huang, Y., Li, J. J., Tuch, B. E., McClements, L., & Xu, X. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10482-1 · Cited by 26

Innervation of the pancreas in development and disease

Agerskov, R. H., & Nyeng, P. (2024) · Development · doi:10.1242/dev.202254 · Cited by 24

Unlocking the potential of iPSC-derived immune cells: engineering iNK and iT cells for cutting-edge immunotherapy

Fang, M., Allen, A. G., Luo, C., & Finn, J. D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1457629 · Cited by 26

The Interface of Gene Editing with Regenerative Medicine

Farag, V., Devey, E. A., & Leong, K. W. (2024) · Engineering · doi:10.1016/j.eng.2024.10.019 · Cited by 30

Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I

Santini-González, J., Castro-Gutiérrez, R., Becker, M. W., Rancourt, C., Russ, H. A., & Phelps, E. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.989815 · Cited by 26

Mechanisms and therapeutic strategies of immune checkpoint molecules and regulators in type 1 diabetes

Ding, J., Yang, K., Lin, K.-L., Cao, Y.-K., & Zou, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1090842 · Cited by 25

Differentiation of stem cell-derived pancreatic progenitors into insulin-secreting islet clusters in a multiwell-based static 3D culture system

Liang, S., Zhao, J., Baker, R. K., Tran, E., Zhan, L., & Kieffer, T. J. (2023) · Cell Reports Methods · doi:10.1016/j.crmeth.2023.100466 · Cited by 27

The Immune Depth Presentation Convolutional Neural Network Used for Oil and Gas Pipeline Fault Diagnosis

Xu, J., & Yu, X. Y. (2024) · IEEE Access · doi:10.1109/access.2024.3358208 · Cited by 22

Drug conjugates crosslinked bioresponsive hydrogel for combination therapy of diabetic wound

Zheng, M., Song, W., Huang, P., Huang, Y., Lin, H., Zhang, M., He, H., & Wu, J. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.046 · Cited by 25

Human Organoids and Their Application in Tumor Models, Disease Modeling, and Tissue Engineering

Song, S., Liu, Z., Wang, Y., & Gong, B. (2025) · Medicine Bulletin · doi:10.1002/mdb2.70001 · Cited by 25

Isolation of mouse pancreatic islet Procr+ progenitors and long-term expansion of islet organoids in vitro

Wang, J., Wang, D., Chen, X., Yuan, S., Bai, L., Liu, C., & Zeng, Y. A. (2022) · Nature Protocols · doi:10.1038/s41596-022-00683-w · Cited by 22

Immunoprotection Strategies in β‐Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation

Grimus, S., Sarangova, V., Welzel, P. B., Ludwig, B., Seißler, J., Kemter, E., Wolf, E., & Ali, A. (2024) · Advanced Science · doi:10.1002/advs.202401385 · Cited by 22

Tissue Engineering Strategies for Improving Beta Cell Transplantation Outcome

Abadpour, S., Wang, C., Niemi, E. M., & Scholz, H. (2021) · Current Transplantation Reports · doi:10.1007/s40472-021-00333-2 · Cited by 21

Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research’s Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases

Cefalu, W. T., Andersen, D. K., Arreaza-Rubín, G., Pin, C. L., Sato, S. M., Verchere, C. B., Woo, M., & Rosenblum, N. D. (2021) · Diabetes · doi:10.2337/db21-0777 · Cited by 20

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

Wang, C. J., Petersone, L., Edner, N. M., Heuts, F. W. H., Ovcinnikovs, V., Ntavli, E., Kogimtzis, A., Fabri, A., Elfaki, Y., Houghton, L. P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34477-1 · Cited by 21

Microphysiological Constructs and Systems: Biofabrication Tactics, Biomimetic Evaluation Approaches, and Biomedical Applications

Zhang, S., Xu, G., Wu, J., Liu, X., Fan, Y. Z., Chen, J., Wallace, G. G., & Gu, Q. (2023) · Small Methods · doi:10.1002/smtd.202300685 · Cited by 26

Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice

Muralidharan, C., Huang, F., Enriquez, J. R., Wang, J. E., Nelson, J. B., Nargis, T., May, S. C., Chakraborty, A., Figatner, K. T., Navitskaya, S., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci176136 · Cited by 21

Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of type 1 diabetes

Rao, C., Cater, D. T., Roy, S., Xu, Z., Oliveira, A. G. D., Evans‐Molina, C., Piganelli, J. D., Eizirik, D. L., Mirmira, R. G., & Sims, E. K. (2024) · Diabetologia · doi:10.1007/s00125-024-06313-2 · Cited by 22

Selective HLA knockdown and PD-L1 expression prevent allogeneic CAR-NK cell rejection and enhance safety and anti-tumor responses in xenograft mice

Liu, F., Tarannum, M., Zhao, Y., Zhang, Y. J., Ham, J. D., Lei, K., Qiang, Y., Deng, X., Nguyen, M., Dinh, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63863-8 · Cited by 23

N6-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis

Ma, X.-J., Cao, J., Zhou, Z.-Y., Lu, Y.-K., Li, Q. H., Jin, Y., Chen, G., Wang, W.-Y., Ge, W., Chen, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31698-2 · Cited by 18

Islet allografts expressing a PD-L1 and IDO fusion protein evade immune rejection and reverse preexisting diabetes in immunocompetent mice without systemic immunosuppression

Paul, P. K., Das, R., Drow, T., Nylen, E. A., de Souza, A. H., Wang, Z., Wood, M. W., Davis, D. B., Bjorling, D. E., & Galipeau, J. (2022) · American Journal of Transplantation · doi:10.1111/ajt.17162 · Cited by 19

Bioengineering and vascularization strategies for islet organoids: advancing toward diabetes therapy

Yang, J., Yan, Y., Yin, X., Liu, X., Reshetov, I. V., Karalkin, P. A., Li, Q., & Huang, R. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155786 · Cited by 22

Revolutionizing pancreatic islet organoid transplants: Improving engraftment and exploring future frontiers

Abraham, N., Kolipaka, T., Pandey, G., Negi, M., Srinivasarao, D. A., & Srivastava, S. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122545 · Cited by 20

A novel injectable sodium alginate/chitosan/sulfated bacterial cellulose hydrogel as biohybrid artificial pancreas for real-time glycaemic regulation

Zhao, X., Xue, W., Ding, W., Qiao, Y., Chu, X., Qiu, Y., Tang, M., Sun, D., & Fu, X. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123323 · Cited by 19

Mini‐organs forum: how to advance organoid technology to organ transplant community

Berishvili, E., Casiraghi, F., Amarelli, C., Scholz, H., Piemonti, L., Berney, T., & Montserrat, N. (2021) · Transplant International · doi:10.1111/tri.13988 · Cited by 20

Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice

Ghoneim, M. A., Gabr, M. M., Refaie, A. F., El-Halawani, S. M., Al-issawi, M. M., Elbassiouny, B. L., Kader, M. A. A. E., Ismail, A. M., Zidan, M. F., Karras, M. S., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03048-y · Cited by 19

Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases

Liu, Y., Li, N., & Zhu, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044027 · Cited by 22

Pathogenesis of diabetic complications: Exploring hypoxic niche formation and HIF-1α activation

Bi, J., Zhou, W., & Tang, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116202 · Cited by 19

A 3D-printed microdevice encapsulates vascularized islets composed of iPSC-derived β-like cells and microvascular fragments for type 1 diabetes treatment

Chen, S., Wang, W., Shen, L., Liu, H., Luo, J. C., Ren, Y., Cui, S., Ye, Y., Shi, G., Cheng, F., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122947 · Cited by 19

Stem Cells as a Source of Pancreatic Cells for Production of 3D Bioprinted Bionic Pancreas in the Treatment of Type 1 Diabetes

Wszola, M., Nitarska, D., Cywoniuk, P., Gomółka, M., & Klak, M. (2021) · Cells · doi:10.3390/cells10061544 · Cited by 20

Current status and future prospects of patient-derived induced pluripotent stem cells

Wang, Z., Zheng, J., Pan, R., & Chen, Y. (2021) · Human Cell · doi:10.1007/s13577-021-00592-2 · Cited by 20

The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy

Wang, X., Gao, M., Wang, Y., & Zhang, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.927324 · Cited by 20

Stem cell-based multi-tissue platforms to model human autoimmune diabetes

Leavens, K. F., Alvarez‐Dominguez, J. R., Vo, L. T., Russ, H. A., & Parent, A. V. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101610 · Cited by 18

The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes

Inoue, R., Nishiyama, K., Li, J., Miyashita, D., Ono, M., Terauchi, Y., & Shirakawa, J. (2021) · Cells · doi:10.3390/cells10071589 · Cited by 20

Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes

Bluestone, J. A., & Tang, Q. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.09.008 · Cited by 16

The functional importance of the cellular and extracellular composition of the islets of Langerhans

Wieland, F. C., van Blitterswijk, C., van Apeldoorn, A. A., & LaPointe, V. L. S. (2021) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2021.100048 · Cited by 18

Porous microcarriers with pancreatic β cell aggregates loading for diabetic care

Li, J., Zhang, H., Sun, L., Fan, L., Fu, X., Liu, X., Liu, D., Wei, Q., Zhao, Y., Pandol, S. J., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.135174 · Cited by 16

Stem Cell-Derived Islets for Type 2 Diabetes

Salib, A., Cayabyab, F., & Yoshihara, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095099 · Cited by 16

Emerging molecular technologies for light-mediated modulation of pancreatic beta-cell function

Chen, Z., Truskinovsky, L. F., & Tzanakakis, E. S. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101552 · Cited by 15

Biomimetic cell culture for cell adhesive propagation for tissue engineering strategies

Luo, Q., Shang, K., Zhu, J. F., Wu, Z., Cao, T., Ahmed, A. A. Q., Huang, C., & Xiao, L. J. (2023) · Materials Horizons · doi:10.1039/d3mh00849e · Cited by 18

Unleashing the potential of adipose organoids: A revolutionary approach to combat obesity-related metabolic diseases

Liu, X.-R., Yang, J., Yan, Y., Li, Q.-F., & Huang, R.-L. (2024) · Theranostics · doi:10.7150/thno.93919 · Cited by 13

Challenges in Beta Cell Replacement for Type 1 Diabetes

Lemos, J. R. N., & Skyler, J. S. (2024) · Hormone Research in Paediatrics · doi:10.1159/000542206 · Cited by 18

Is hypoimmunogenic stem cell therapy safe in times of pandemics?

Matheus, F., Raveh, T. B., Oro, A. E., Wernig, M., & Drukker, M. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.02.014 · Cited by 15

Construction of engineered 3D islet micro-tissue using porcine decellularized ECM for the treatment of diabetes

Wang, X., Jin, L., Liu, W., Stingelin, L., Zhang, P., & Tan, Z. (2023) · Biomaterials Science · doi:10.1039/d3bm00346a · Cited by 15

Tryptophan metabolism promotes immune evasion in human pancreatic β cells

Rachdi, L., Zhou, Z., Berthault, C., Lourenço, C., Fouque, A., Domet, T., Armanet, M., You, S., Peakman, M., Mallone, R., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104740 · Cited by 15

Challenges and opportunities in the islet transplantation microenvironment: a comprehensive summary of inflammatory cytokine, immune cells, and vascular endothelial cells

Chen, Q., Liu, L., Zhao, X., Liang, J., & Li, S.-W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1293762 · Cited by 17

Advancements and Challenges in Immune Protection Strategies for Islet Transplantation

Wang, X., Zeng, Z., Li, D., Wang, K., Zhang, W., Yu, Y., & Wang, X. (2025) · Journal of Diabetes · doi:10.1111/1753-0407.70048 · Cited by 18

Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization of organoids

Lee, H., Im, J. S., Choi, D. B., & Woo, D. (2021) · Organoid · doi:10.51335/organoid.2021.1.e11 · Cited by 17

The World of Organoids: Gastrointestinal Disease Modelling in the Age of 3R and One Health with Specific Relevance to Dogs and Cats

Csukovich, G., Pratscher, B., & Burgener, I. A. (2022) · Animals · doi:10.3390/ani12182461 · Cited by 17

Immune-evasive beta cells in type 1 diabetes: innovations in genetic engineering, biomaterials, and computational modeling

Karaoğlu, İ. C., Duymaz, D., Rashid, M. M., & Kızılel, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1618086 · Cited by 15

Organoids as predictive platforms: advancing disease modeling, therapeutic innovation, and drug delivery systems

Huang, T. H., Huang, W. T., & Bian, Q. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114222 · Cited by 14

Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment

Heaton, E. S., & Jin, S. (2022) · Translational research · doi:10.1016/j.trsl.2022.06.014 · Cited by 15

Nutritional assessment models for diabetes and aging

Wen, Y., Liu, Y., Huang, Q., Farag, M. A., Li, X., Wan, X., & Zhao, C. (2022) · Food Frontiers · doi:10.1002/fft2.168 · Cited by 14

Bioengineering toolkits for potentiating organoid therapeutics

Park, S., & Cho, S. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115238 · Cited by 18

Recent progress in modeling and treating diabetes using stem cell-derived islets

Maestas, M. M., Bui, M. H., & Millman, J. R. (2024) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szae059 · Cited by 14

Single-Cell Sequencing: High-Resolution Analysis of Cellular Heterogeneity in Autoimmune Diseases

Tang, X., Zhang, Y., Zhang, H., Zhang, N., Dai, Z., Cheng, Q., & Li, Y. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-09001-6 · Cited by 15

A multimodal cross-species comparison of pancreas development

Yang, K., Spitzer, H., Sterr, M., Hrovatin, K., Sean de la, O., Zhang, X., Setyono, E. S. A., Ud‐Dean, M., Walzthoeni, T., Flisikowski, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64774-4 · Cited by 16

Neonatal islets from human PD-L1 transgenic pigs reduce immune cell activation and cellular rejection in humanized nonobese diabetic-scid IL2rγnull mice

Lei, Y., Buerck, L. W., Honarpisheh, M. M., Zhang, Y., Schwinzer, R., Petersen, B., & Seißler, J. (2023) · American Journal of Transplantation · doi:10.1016/j.ajt.2023.08.026 · Cited by 14

Pluripotent Stem Cell-Derived Hepatocytes Inhibit T Cell Proliferation In Vitro through Tryptophan Starvation

Romano, M., Elgueta, R., McCluskey, D., Ortega‐Prieto, A. M., Stolarczyk, É., Dazzi, F., Lucendo‐Villarin, B., Meseguer-Ripolles, J., Williams, J. H., Fanelli, G., et al. (2021) · Cells · doi:10.3390/cells11010024 · Cited by 13

Human A2-CAR T Cells Reject HLA-A2+ Human Islets Transplanted into Mice Without Inducing Graft Versus Host Disease

Ellis, C., Mojibian, M., Ida, S., Fung, V. C. W., Skovsø, S., McIver, E., O’Dwyer, S. M., Webber, T. D., Braam, M., Saber, N., et al. (2023) · Transplantation · doi:10.1097/tp.0000000000004709 · Cited by 5

The extra-islet pancreas supports autoimmunity in human type 1 diabetes

Barlow, G. L., Schürch, C. M., Bhate, S. S., Phillips, D. J., Young, A., Dong, S., Martinez, H., Kaber, G., Nagy, N., Ramachandran, S., et al. (2025) · eLife · doi:10.7554/elife.100535.3 · Cited by 13

Nanotechnology in Immunotherapy for Type 1 Diabetes: Promising Innovations and Future Advances

Nigam, S., Bishop, J. O., Hayat, H., Quadri, T., Hayat, H., & Wang, P. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030644 · Cited by 13

Advances in targeting glycogen synthase kinase 3β for diabetes therapy

Wang, F., Li, Y., Bai, L., Xiao, W., Zhong, L., & Shi, J. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.109051 · Cited by 14

Stem Cell-Derived β Cells: A Versatile Research Platform to Interrogate the Genetic Basis of β Cell Dysfunction

Bartolomé, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010501 · Cited by 15

From stem cells to pancreatic β-cells: strategies, applications, and potential treatments for diabetes

Feng, X., Zhang, H., Yang, S., Cui, D., Wu, Y., Qi, X., & Su, Z. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-04999-x · Cited by 13

Immune Evasion in Stem Cell-Based Diabetes Therapy—Current Strategies and Their Application in Clinical Trials

Mu-u-min, R., Diané, A., Allouch, A., & Al-Siddiqi, H. (2025) · Biomedicines · doi:10.3390/biomedicines13020383 · Cited by 14

Stem-cell-derived beta cells mature metabolically upon murine engraftment

Vähäkangas, E., Saarimäki‐Vire, J., Montaser, H., Lithovius, V., Eurola, S., Ibrahim, H., Kuuluvainen, E., Balboa, D., Katajisto, P., Barsby, T., et al. (2025) · Diabetologia · doi:10.1007/s00125-025-06474-8 · Cited by 13

Optimizing Generation of Stem Cell-Derived Islet Cells

Verhoeff, K. K., Cuesta‐Gomez, N., Jasra, I. T., Marfil‐Garza, B. A., Dadheech, N., & Shapiro, A. M. J. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10391-3 · Cited by 11

Cell Heterogeneity and Paracrine Interactions in Human Islet Function: A Perspective Focused in β-Cell Regeneration Strategies

Bru-Tarí, E., Oropeza, D., & Herrera, P. L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.619150 · Cited by 12

β cell replacement therapy for the cure of diabetes

Lee, J., & Yoon, K. (2022) · Journal of Diabetes Investigation · doi:10.1111/jdi.13884 · Cited by 15

Non-invasive quantification of stem cell-derived islet graft size and composition

Lithovius, V., Lahdenpohja, S., Ibrahim, H., Saarimäki‐Vire, J., Uusitalo, L., Montaser, H., Mikkola, K., Yim, C., Keller, T., Rajander, J., et al. (2024) · Diabetologia · doi:10.1007/s00125-024-06194-5 · Cited by 10

The Role of Biophysical Factors in Organ Development: Insights from Current Organoid Models

Wyle, Y., Lu, N., Hepfer, J., Sayal, R., Martinez, T., & Wang, A. (2024) · Bioengineering · doi:10.3390/bioengineering11060619 · Cited by 13

A perfect islet: reviewing recent protocol developments and proposing strategies for stem cell derived functional pancreatic islets

Sali, S., Azzam, L., Jaro, T., Ali, A. A. G., Mardini, A., Al-Dajani, O., Khattak, S., Butler, A. E., Azeez, J. M., & Nandakumar, M. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04293-7 · Cited by 14

Unveiling a novel type 1 diabetes endotype: Opportunities for intervention

Fiorina, P., & Pozzilli, P. (2022) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3536 · Cited by 11

Leverage biomaterials to modulate immunity for type 1 diabetes

Jing, Z., Li, Y., Ma, Y., Zhang, X., Liang, X., & Zhang, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.997287 · Cited by 11

Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement

Goode, R. A., Hum, J. M., & Kalwat, M. A. (2022) · Endocrinology · doi:10.1210/endocr/bqac193 · Cited by 12

Bioengineering Platelets Presenting PD‐L1, Galectin‐9 and BTLA to Ameliorate Type 1 Diabetes

Ma, Y., Meng, F., Lin, Z., Chen, Y., Lan, T., Yang, Z., Diao, R., Zhang, X., Chen, Q., Zhang, C., et al. (2025) · Advanced Science · doi:10.1002/advs.202501139 · Cited by 13

Islet Transplantation: Microencapsulation, Nanoencapsulation, and Hypoimmune Engineering

Lee, K., Vargas, A. A., Bottino, R., & Wang, Y. (2025) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.70016 · Cited by 12

From the dish to humans: A stem cell recipe for success

Russ, H. A., Shilleh, A. H., & Sussel, L. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.01.002 · Cited by 10

Pancreatic β-cell remodeling in health and aging: Lessons from rodents and humans

Darwish, R., Alcibahy, Y., Dhawan, S., Butler, A. E., & Moin, A. S. M. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102815 · Cited by 11

The Role of Alpha Cells in the Self-Assembly of Bioengineered Islets

Wieland, F. C., Sthijns, M. M. J. P. E., Geuens, T., van Blitterswijk, C., & LaPointe, V. L. S. (2020) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0080 · Cited by 9

Diabetic Retinopathy and Insulin Insufficiency: Beta Cell Replacement as a Strategy to Prevent Blindness

Ipp, E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.734360 · Cited by 10

100 years post-insulin: immunotherapy as the next frontier in type 1 diabetes

Pearson, J. A., McKinney, E. F., & Walker, L. S. K. (2021) · Immunotherapy Advances · doi:10.1093/immadv/ltab024 · Cited by 9

Engineering islets from stem cells: The optimal solution for the treatment of diabetes

Du, S., Li, Y., Geng, Z., Zhang, Q., Buhler, L. H., Gonelle-Gispert, C., & Wang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.869514 · Cited by 9

A novel insulin delivery system by β cells encapsulated in microcapsules

Luo, Z., Dong, Y., Yu, M., Fu, X., Qiu, Y., Sun, X., & Chu, X. (2023) · Frontiers in Chemistry · doi:10.3389/fchem.2022.1104979 · Cited by 9

The application of organoid models in research into metabolic diseases

Song, Y., Lu, S., Gao, F., Wei, T., & Ma, W. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15390 · Cited by 9

Convergence of human pluripotent stem cell, organoid, and genome editing technologies

Wang, L., Ye, Z., & Jang, Y.-Y. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370220985808 · Cited by 10

Stem Cell Based Models in Congenital Hyperinsulinism – Perspective on Practicalities and Possibilities

Lithovius, V., & Otonkoski, T. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.837450 · Cited by 8

Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoidsPreprint

Jun, Y., Nguyen-Ngoc, K.-V., Sai, S., Bender, R., Gong, W., Kravets, V., Zhu, H., Hatch, C. J., Schlichting, M., Gaetani, R., et al. (2022) · bioRxiv · doi:10.1101/2022.10.28.513298 · Cited by 42

The extra-islet pancreas supports autoimmunity in human type 1 diabetesPreprint

Barlow, G. L., Schürch, C. M., Bhate, S. S., Phillips, D. J., Young, A., Dong, S., Martinez, H. A., Kaber, G., Nagy, N., Ramachandran, S., et al. (2024) · eLife · doi:10.7554/elife.100535 · Cited by 12

A Cure for Type 1 Diabetes: Are We There Yet?

Schaaf, C., & Sussel, L. (2025) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2024.0498 · Cited by 10

iPSC modification strategies to induce immune tolerance

Hong, Z., Zhao, Y. F., Pahlavan, S., Wang, X., Han, S., Wang, K., & Wang, K. (2025) · Life Medicine · doi:10.1093/lifemedi/lnaf016 · Cited by 9

Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy

Shang, K., Suzuki, T., Kato, H., Toyoda, T., Tai, Y., & Komatsu, H. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00984.2024 · Cited by 14

FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction

Tacto, C., Tahbaz, M., Salib, A., Wang, S., Cayabyab, F., Choi, J., Kim, K. A., Hamba, Y., Perez, H. D., Gershon, P. D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60188-4 · Cited by 9

Direct Differentiation of Human Adult Adipose Tissue into Multilineage Functional Organoids

Huang, R., Yang, J., Yan, Y., Liu, X., Yin, X., Liu, C., Liu, X., Aimaier, R., Ji, Q., Li, G., et al. (2025) · Engineering · doi:10.1016/j.eng.2025.06.031 · Cited by 9

Gene editing strategies to address current challenges in stem cell-derived β cell therapy for type 1 Diabetes

Han, J., Lim, D., & Yang, K. (2025) · Journal of Tissue Engineering · doi:10.1177/20417314251373039 · Cited by 8

A narrative review of organoids for investigating organ aging: opportunities and challenges

Sun, X., Sun, F., Zhang, Y., Qu, J. T., Zhang, W., & Liu, G. (2023) · Journal of Bio-X Research · doi:10.1097/jbr.0000000000000139 · Cited by 8

LINC MIR503HG Controls SC‐β Cell Differentiation and Insulin Production by Targeting CDH1 and HES1

Xu, Y., Mao, S., Fan, H., Wan, J., Wang, L., Zhang, M., Zhu, S., Yuan, J., Lu, Y., Wang, Z., et al. (2024) · Advanced Science · doi:10.1002/advs.202305631 · Cited by 7

Type 1 diabetes mellitus: another step closer to pancreatic β-cell transplantation

Morris, A. W. J. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00417-6

Generation and long-term expansion of human pancreatic islet organoids in vitroPreprint

Song, W., Liu, C., Wang, S. Y., Wang, D., Xu, Y., Yuan, S., Chang, J., Zhang, B. Y., Xu, H. M., Fu, H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.15.718643

Generation of hypoimmunogenic gastric insulin-secreting organoidsPreprint

Dattoli, A. A., Brown, M. E., Pearson, B., Feinstein, Z., Lan, Y., Polavarapu, V., Zhou, M., Nachman, R., Kelemen, Y., Rafii, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.08.736836

Immune Protection of Stem Cell-Derived Islet Cell Therapy for Treating Diabetes

Tahbaz, M., & Yoshihara, E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.716625 · Cited by 43

Brown Adipose Tissue as a Unique Niche for Islet Organoid Transplantation: Insights From In Vivo Imaging

Sun, A., Hayat, H., Kenyon, E., Quadri, T., Amos, D., Perkins, K., Nigam, S., Tarleton, D., Mallett, C. L., Deng, C. X., et al. (2024) · Transplantation Direct · doi:10.1097/txd.0000000000001658 · Cited by 7