SLC25A51 is a mammalian mitochondrial NAD(+) transporter

Tissue-based map of the human proteome

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Using MetaboAnalyst 4.0 for Comprehensive and Integrative Metabolomics Data Analysis

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Identification and characterization of essential genes in the human genome

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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

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NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

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Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

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Gene essentiality and synthetic lethality in haploid human cells

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A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila , and Humans

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Regulation of Corepressor Function by Nuclear NADH

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Data Conversion with ProteoWizard msConvert

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Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice

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Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics

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Transporters in vitamin uptake and cellular metabolism: impacts on health and disease

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The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential

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Aryl hydrocarbon receptor (AHR) functions in infectious and sterile inflammation and NAD+-dependent metabolic adaptation

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Selenium Ameliorated Oxidized Fish Oil-Induced Lipotoxicity via the Inhibition of Mitochondrial Oxidative Stress, Remodeling of Usp4-Mediated Deubiquitination, and Stabilization of Pparα

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The redox requirement and regulation during cell proliferation

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NAD+ metabolism in acute kidney injury and chronic kidney disease transition

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Protective Effects of Nicotinamide Adenine Dinucleotide and Related Precursors in Alzheimer’s Disease: A Systematic Review of Preclinical Studies

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The best of both worlds: Chemigenetic fluorescent sensors for biological imaging

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Pathobiochemistry of Aging and Neurodegeneration: Deregulation of NAD+ Metabolism in Brain Cells

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The Role of Mitochondrial Solute Carriers SLC25 in Cancer Metabolic Reprogramming: Current Insights and Future Perspectives

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Data- and knowledge-derived functional landscape of human solute carriers

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NAD+ Degrading Enzymes, Evidence for Roles During Infection

Tan, A., & Doig, C. L. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.697359 · Cited by 23

Human peroxisomal NAD+/NADH homeostasis is regulated by two independent NAD(H) shuttle systems

Chornyi, S., Costa, C. F., IJlst, L., Fransen, M., Wanders, R. J. A., van Roermund, C. W. T., & Waterham, H. R. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.06.020 · Cited by 21

Mitochondrial NAD+ deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm

Zhang, J., Tang, Y., Zhang, S., Xie, Z., Ma, W., Liu, S., Fang, Y., Zheng, S., Huang, C., Yan, G., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00606-w · Cited by 20

The SLC25A47 locus controls gluconeogenesis and energy expenditure

Yook, J.-S., Taxin, Z. H., Yuan, B., Oikawa, S., Auger, C., Mutlu, B., Puigserver, P., Hui, S. T., & Kajimura, S. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2216810120 · Cited by 20

Molecular mechanisms of cell death by parthanatos: More questions than answers

de Moura, R. D., de Mattos, P. D., Valente, P. F., & Hoch, N. C. (2024) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2023-0357 · Cited by 17

SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure

Buonvicino, D., Ranieri, G., Pittelli, M. G., Lapucci, A., Bragliola, S., & Chiarugi, A. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100855 · Cited by 17

Disrupting Mitochondrial Electron Transfer Chain Complex I Decreases Immune Checkpoints in Murine and Human Acute Myeloid Leukemic Cells

Yolba, R. L., Marmoiton, J., Gigo, V., Marechal, X., Boët, E., Sahal, A., Alet, N., Abramovich, I., Gottlieb, E., Visentin, V., et al. (2021) · Cancers · doi:10.3390/cancers13143499 · Cited by 17

Hem25p is required for mitochondrial IPP transport in fungi

Tai, J., Guerra, R. M., Rogers, S. W., Fang, Z., Muehlbauer, L. K., Shishkova, E., Overmyer, K. A., Coon, J. J., & Pagliarini, D. J. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01250-5 · Cited by 18

Regulation of respiratory complex I assembly by FMN cofactor targeting

Curtabbi, A., Guarás, A., Cabrera-Alarcón, J. L., Rivero, M., Calvo, E., Rosa-Moreno, M., Vázquez, J., Medina, M., & Enrı́quez, J. A. (2023) · Redox Biology · doi:10.1016/j.redox.2023.103001 · Cited by 17

Emerging interactions between mitochondria and NAD+ metabolism in cardiometabolic diseases

Nasuhidehnavi, A., Zarzycka, W., Gorecki, I., Chiao, Y. A., & Lee, C. F. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.010 · Cited by 20

The genetic interaction map of the human solute carrier superfamily

Wolf, G., Leippe, P., Onstein, S., Goldmann, U., Frommelt, F., Teoh, S. T., Girardi, E., Wiedmer, T., & Superti‐Furga, G. (2025) · Molecular Systems Biology · doi:10.1038/s44320-025-00105-5 · Cited by 18

Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism

Peng, M.-Z., Shao, Y., Li, X., Zhang, K., Cai, Y.-N., Lin, Y., Jiang, M., Liu, Z., Su, X., Zhang, W., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04404-0 · Cited by 17

Advances of Glycometabolism Engineering in Chinese Hamster Ovary Cells

Zhang, H.-Y., Fan, Z., & Wang, T. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.774175 · Cited by 19

Dynamics of SLC25A51 reveal preference for oxidized NAD+ and substrate led transport

Goyal, S., Paspureddi, A., Lu, M., Chan, H., Lyons, S. N., Wilson, C. N., Niere, M., Ziegler, M., & Cambronne, X. A. (2023) · EMBO Reports · doi:10.15252/embr.202256596 · Cited by 16

Biomimetic Molecular Clamp Nanopores for Simultaneous Quantifications of NAD + and NADH

Liu, X., Feng, W., Yao, F., Zhang, J., Rauf, A., Chen, T., Shi, X., Qiao, X., Ma, L., Yu, S., et al. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00986 · Cited by 16

Neurotransmitters responsible for purinergic motor neurotransmission and regulation of GI motility

Sanders, K. M., & Mutafova–Yambolieva, V. N. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102829 · Cited by 16

Mitochondrial NAD + -mediated mitophagy alleviates type I interferon response to the cytosolic mitochondrial DNA

Lan, T., Shang, D., Lin, L., Wang, H., Zou, J., Hu, M., Cheng, H., & Zhou, R. (2025) · Autophagy · doi:10.1080/15548627.2025.2589909 · Cited by 15

Using mass spectrometry imaging to visualize age-related subcellular disruption

Hogan, K. A., Zeidler, J. D., Beasley, H. K., Alsaadi, A. I., Alshaheeb, A. A., Chang, Y., Tian, H., Hinton, A. O., Jr., & McReynolds, M. R. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.906606 · Cited by 16

Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants

Zlatic, S. A., Werner, E., Surapaneni, V., Lee, C. E., Gokhale, A., Singleton, K. S., Duong, D. M., Crocker, A. J., Gentile, K. L., Middleton, F. A., et al. (2023) · Human Molecular Genetics · doi:10.1093/hmg/ddad154 · Cited by 15

Ratiometric NAD + Sensors Reveal Subcellular NAD + Modulators

Chen, L., Chen, M., Luo, M., Li, Y., Liao, B., Hu, M., & Yu, Q. (2023) · ACS Sensors · doi:10.1021/acssensors.2c02565 · Cited by 17

Exercise-induced changes to the fiber type-specific redox state in human skeletal muscle are associated with aerobic capacity

Shadiow, J., Miranda, E. R., Perkins, R. K., Mazo, C. E., Lin, Z., Lewis, K. N., Mey, J. T., Solomon, T. P. J., & Haus, J. M. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00662.2022 · Cited by 11

Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary

Ren, C., Shuang, Z., Chen, Y., Deng, K., Kuang, M., Gong, Z., Zhang, K., Wang, P., Huang, P., Zhou, Z., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202400453r · Cited by 14

Access to ART treatment and gender equality

Chambers, G. M., & Fauser, B. C. J. M. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.02.011 · Cited by 14

Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice

Osborne, B., Reznick, J., Wright, L. E., Sinclair, D. A., Cooney, G. J., & Turner, N. A. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.03.088 · Cited by 16

Mitochondrial activity tunes nociceptor resilience to excitotoxicity

Yuan, L., Chandel, N. S., & Julius, D. J. (2025) · Cell · doi:10.1016/j.cell.2025.07.048 · Cited by 14

Genomic Insights into Tibetan Sheep Adaptation to Different Altitude Environments

Zhang, W., Yuan, C., An, X., Guo, T., Wei, C., Lu, Z., & Liu, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212394 · Cited by 15

Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD+

Ouyang, Y., Bott, A. J., & Rutter, J. P. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.02.001 · Cited by 13

Circ0515 reprogramming mitochondrial succinate metabolism and promotes lung adenocarcinoma progression through regulating SDHB

Yuan, Y., Wu, Y., Li, C., Huang, Z., Peng, D., Wu, Z., & Jiang, X. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07830-7 · Cited by 13

Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters

Byrne, K. L., Szeligowski, R. V., & Shen, H. (2023) · Biomolecules · doi:10.3390/biom13091314 · Cited by 12

3D culture inhibits replicative senescence of SCAPs via UQCRC2-mediated mitochondrial oxidative phosphorylation

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Regulation of immune metabolism in Th17 and Treg cells

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Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans

U-Din, M., de Mello, V. D., Tuomainen, M. H., Raiko, J. R. H., Niemi, T. S., Fromme, T., Klåvus, A., Gautier, N., Haimilahti, K., Lehtonen, M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113131 · Cited by 17

The peculiar properties of mitochondrial carriers of the SLC25 family

Kunji, E. R. S., Mavridou, V., King, M. S., Cimadamore‐Werthein, C., Baron, S. J., Jones, S. A., King, A. C., Springett, R., Chand, D., Palmer, S. M., et al. (2025) · Biochemical Journal · doi:10.1042/bcj20253171 · Cited by 15

Long non-coding RNA SLC25A21-AS1 inhibits the development of epithelial ovarian cancer by specifically inducing PTBP3 degradation

Li, S., Shen, S., Ge, W., Cen, Y., Zhang, S., Cheng, X., Wang, X., Xie, X., & Lü, W. (2023) · Biomarker Research · doi:10.1186/s40364-022-00432-x · Cited by 11

Single cell transcriptomic analysis of the canine duodenum in chronic inflammatory enteropathy and health

Manchester, A. C., Ammons, D. T., Lappin, M. R., & DOW, S. W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1397590 · Cited by 11

Polyphosphate-dependent nicotinamide adenine dinucleotide (NAD) kinase: A novel missing link in human mitochondria

Murata, K. (2021) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.97.024 · Cited by 11

AIFM2 is Required for High-Intensity Aerobic Exercise by Promoting Glucose Utilization

Nguyen, H. P., Villivalam, S. D., Jung, B. C., You, D., Lin, F., Yi, D., Pi, A., Ma, K., Jung, S., Park, S., et al. (2022) · Diabetes · doi:10.2337/db21-1114 · Cited by 11

Circadian cardiac NAD+ metabolism, from transcriptional regulation to healthy aging

Carpenter, B. J., & Dierickx, P. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00239.2022 · Cited by 11

Metabolism and Receptor Mechanisms of Niacin Action

Boronovskiy, S. E., Сергеевна, К. В., & Nartsissov, Y. R. (2024) · Cell and Tissue Biology · doi:10.1134/s1990519x23700025 · Cited by 12

SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth

Li, L., You, J., Chai, Z.-Q., Li, X., Cai, X., Wang, L., Yang, F., Zhu, L., Mi, W., Xia, X., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01455-6 · Cited by 10

SLC25A19 is required for NADH homeostasis and mitochondrial respiration

Jiang, Z. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.06.019 · Cited by 10

Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors

Chen, W., Liu, S., Yang, Y. A., Zhang, Z., & Zhao, Y. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111657 · Cited by 10

Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications

Banerjee, P., Olmsted‐Davis, E. A., Deswal, A. M., Nguyen, M. T. H., Koutroumpakis, E., Palaskas, N., Lin, S. H., Kotla, S., Reyes‐Gibby, C. C., Yeung, S. J., et al. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.13 · Cited by 10

Pseudogene Transcripts in Head and Neck Cancer: Literature Review and In Silico Analysis

Carron, J., Coletta, R. D., & Lourenço, G. J. (2021) · Genes · doi:10.3390/genes12081254 · Cited by 10

Quantitative dynamics of intracellular NMN by genetically encoded biosensor

Chen, L., Wang, P., Huang, G., Cheng, W., Liu, K., & Yu, Q. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116842 · Cited by 9

Cardiac Slc25a49 ‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

Wan, S., Qi, J., Xia, Y., Chang, F., Xu, T., Zhang, X., Shi, J., Wang, C., Cheng, Y., Zhang, D., et al. (2025) · Advanced Science · doi:10.1002/advs.202502163 · Cited by 10

Modulation of NAD metabolism by oxygen availability

Burtscher, J., Dünnwald, T., & Paglia, G. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.07.014 · Cited by 9

Biogenesis and function of the mitochondrial solute carrier (SLC25) family in yeast

Nauerz, C., Pines, O., & Herrmann, J. M. (2025) · Biological Chemistry · doi:10.1515/hsz-2025-0152 · Cited by 9

Aging of stallion spermatozoa stored in vitro is delayed at 22°C using a 67 m m glucose–10 m m pyruvate‐based media

Becerro‐Rey, L., Martín‐Cano, F. E., Ortega‐Ferrusola, C., Rodríguez‐Martínez, H., Gaitskell‐Phillips, G., da Silva‐Álvarez, E., Silva‐Rodríguez, A., Gil, M. C., & Peña, F. J. (2023) · Andrology · doi:10.1111/andr.13565 · Cited by 9

Transcriptomic Analysis of Long Noncoding RNA and mRNA Expression Profiles in the Amygdala of Rats with Bone Cancer Pain-Depression Comorbidity

Wu, S., Chen, X., Huang, F., Lin, M., Chen, P., Wan, H., Gao, F., Zheng, T., & Zheng, X. (2021) · Life · doi:10.3390/life11080834 · Cited by 9

Learning from Yeast about Mitochondrial Carriers

Mentel, M., Chovančíková, P., Zeman, I., & Polčic, P. (2021) · Microorganisms · doi:10.3390/microorganisms9102044 · Cited by 9

Synthesis of Mixed Dinucleotides by Mechanochemistry

Hayat, F., Makarov, M. V., Belfleur, L., & Migaud, M. E. (2022) · Molecules · doi:10.3390/molecules27103229 · Cited by 9

PARP1 mediated PARylation contributes to myogenic progression and glucocorticoid transcriptional response

Tan, A., Younis, A. Z., Evans, A., Creighton, J. V., Coveny, C., Boocock, D. J., Sale, C., Lavery, G. G., Coutts, A. S., & Doig, C. L. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01420-2 · Cited by 10

Targeting mitophagy for neurological disorders treatment: advances in drugs and non-drug approaches

Yang, X., Zhang, Y., Luo, J.-X., Zhu, T., Zhao, R., Mu, B., & Lu, M. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02636-w · Cited by 9

β-Nicotinamide mononucleotide blocks UVB-induced collagen reduction via regulation of ROS/MAPK/AP-1 and stimulation of mitochondrial proline biosynthesis

Zhang, Y., Ai, C., Huang, F.-Z., Zhao, J.-L., Ling, Y., Chen, W.-J., Li, Z.-Z., Wang, Y., Gao, F., Li, S., et al. (2025) · Photochemical and Photobiological Sciences · doi:10.1007/s43630-025-00692-0 · Cited by 9

Targeting SARM1 as a novel neuroprotective therapy in neurotropic viral infections

He, S., Zhu, Y., Wang, X., Zhang, G., Hou, K., Xia, X., Jiang, Z., Gong, X., & Zhao, P. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03423-5 · Cited by 8

Histidine triad nucleotide-binding protein 2 attenuates metabolic dysfunction-associated steatotic liver disease through NAD+-dependent sirtuin-3 activation

Wang, Q., Guo, Y., Chen, S., Liu, Z., Wang, X., Huang, H., Shen, Q., Yang, L., Li, M., Li, Y., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01445-w · Cited by 8

Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis

Flickinger, K. M., Fritz, C. M., Huggler, K. S., Wade, G., Chang, G. R., Fox, K. C., Simcox, J., & Cantor, J. R. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01272-3 · Cited by 9

Aspartate availability drives differential engagement of the malate-aspartate shuttle

Brunner, J. S., Bridgeman, A. E., Jackson, B. T., Chakraborty, S., Fagoaga-Eugui, M., Paras, K. I., Xie, A., Arnold, P. K., Losner, J., & Finley, L. W. S. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.02.004 · Cited by 8

The role of protein acetylation in regulating mitochondrial fusion and fission

Uddin, G. M., Abbas, R., & Shutt, T. E. (2021) · Biochemical Society Transactions · doi:10.1042/bst20210798 · Cited by 8

Unlocking mitochondrial drug targets: The importance of mitochondrial transport proteins

Hoogstraten, C. A., Schirris, T. J. J., & Rüssel, F. G. M. (2024) · Acta Physiologica · doi:10.1111/apha.14150 · Cited by 7

N4-acetylcytidine modification of LINC02802 promotes non-small cell lung cancer progression by modulating mitochondrial NAD+/NADH ratio

Yuan, Y., Zhang, D., Wang, J., Tang, L., Duan, Y., Duan, L., & Jiang, X. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.116639 · Cited by 7

Effects of aging and anti-aging dietary restriction on regulators of the [NADPH]/[NADP+] in different neural cell types and brain regions

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Hepatocyte mitochondrial NAD+ content is limiting for liver regeneration

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