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SLC25A51 is a mammalian mitochondrial NAD(+) transporter
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Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been identified in yeast and plants 1,2, but their existence in mammals remains controversial 3-5. Here we demonstrate that mammalian mitochondria can take up intact NAD+, and identify SLC25A51 (also known as MCART1)-an essential 6,7 mitochondrial protein of previously unknown function-as a mammalian mitochondrial NAD+ transporter. Loss of SLC25A51 decreases mitochondrial-but not whole-cell-NAD+ content, impairs mitochondrial respiration, and blocks the uptake of NAD+ into isolated mitochondria. Conversely, overexpression of SLC25A51 or SLC25A52 (a nearly identical paralogue of SLC25A51) increases mitochondrial NAD+ levels and restores NAD+ uptake into yeast mitochondria lacking endogenous NAD+ transporters. Together, these findings identify SLC25A51 as a mammalian transporter capable of importing NAD+ into mitochondria.
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“Notably, while NAD+ itself can be imported into mitochondria through SLC25A51–MCART1 (98, 99, 100), NADH is not efficiently transported.”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [100]
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Do, D. V., Tulsian, N. K., Tan, W. K. Y., Li, Z., Cheng, L. Y., Autio, M. I., Tan, W. L. W., Tiang, Z., Perrin, A., Ching, J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.24.465637
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Li, S., Shen, S., Ge, W., Cen, Y., Zhang, S., Cheng, X., Wang, X., Xie, X., & Lu, W. (2023) · Figshare · doi:10.6084/m9.figshare.22602263
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Dubey, S., Yu, G., Aboul-Hosn, R., Tse, C., Nathanson, D. A., Lai, A., Vossel, K. A., & Rodríguez, F. J. (2026) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdag088
Bostwick-Galaviz, A. M., & Usherwood, E. J. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag035
Meyer‐Ficca, M. L., & Chini, C. C. S. (2026) · Advances in Nutrition · doi:10.1016/j.advnut.2026.100646
“SelO”ective NAD+ hydrolysis regulates mitochondrial NAD+ and homeostasis
Zhang, Q. F., Tan, T. C. M., & Sorrentino, V. (2026) · Cell chemical biology · doi:10.1016/j.chembiol.2026.04.012
Wang, X., Li, Y., Tan, J., Sun, X., Zhou, Q., Xu, R., Song, X., Cui, Y., & Zhang, Z. (2026) · Antioxidants and Redox Signaling · doi:10.1177/15230864261455714
Morciano, G., Gorgoglione, R., Porcelli, V., Ahmed, A., Scarcia, P., Vozza, A., Lasorsa, F. M., Fiermonte, G., & Palmieri, L. (2026) · Biomolecules · doi:10.3390/biom16060842 · Cited by 1
Rong, C., Chen, R., Lou, H., Xia, Y., & Duan, S. (2026) · Human Cell · doi:10.1007/s13577-026-01428-7
Li, H., Liu, X., Li, W., Schreiber, A. C., Park, S., Hamouda, A. M., Gasvoda, K. L., Terzic, A., Elder, B. D., & Lu, L. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124478
SelO-mediated NAD+ hydrolysis safeguards mitochondrial homeostasis
Yao, T., Sl, W., & Zhou, F. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00509-1
He, Y., Liu, C., Li, B., Hong, S., Tang, J., Huang, G., Yang, L. T., Chen, M., Zhang, S., Xiao, Y., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3316-5
Wang, S., Sun, P., Zhang, Y., Zhang, J. B., Shen, X., & Yang, H. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.08.022
Ouyang, X., Deng, X., Qizhao, W., Chu, M., Wei, X., Wang, M., Xiang, C., Zhang, P., Sun, Z., Shen, S., et al. (2026) · Cancer Gene Therapy · doi:10.1038/s41417-026-01071-2
Nicotinamide Mononucleotide Adenylyltransferase 1 and NAD+ Homeostasis in Neuroprotection and Aging
Sun, Y., Li, B., & Qian, Z. (2026) · Metabolites · doi:10.3390/metabo16080597
Mitochondrial NAD+ determines the metabolic capacity for liver regeneration
Luukkonen, P. K. (2026) · Journal of Hepatology · doi:10.1016/j.jhep.2026.08.003
Metadata
- Authors
- Luongo, T. S., Eller, J. M., Lu, M.-J., Niere, M., Raith, F., Perry, C., Bornstein, M. R., Oliphint, P., Wang, L., McReynolds, M. R., Migaud, M. E., Rabinowitz, J. D., Johnson, F. B., Johnsson, K., Ziegler, M., Cambronne, X. A., & Baur, J. A.
- Affiliations
- University of Pennsylvania (US)
- The University of Texas at Austin (US)
- University of Bergen (NO)
- Heidelberg University (DE)
- Princeton University (US)
- USA Mitchell Cancer Institute (US)
- Max Planck Institute for Medical Research (DE)
- Corresponding author
- Cambronne, Xiaolu A.
- Baur, Joseph A.
- ORCID
- Venue
- Nature
- Published
- 2020-09-09
- Volume
- 588
- Issue
- 7836
- Pages
- 174-179
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7718333
- OpenAlex
- W3084174900
- Cited by
- 308
- References
- 44
- Citations by year
- 2026: 39 · 2025: 60 · 2024: 56 · 2023: 56 · 2022: 48 · 2021: 46 · 2020: 3
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Institutes of Health (TL1TR001880)
- National Heart, Lung, and Blood Institute (F32HL145923)
- National Institute of General Medical Sciences (DP2GM126897)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK019525, R01DK098656)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (T32AR053461)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial respiration, yeast mitochondria
- MeSH terms
- Animals, Biological Transport, Cell Line, Genetic Complementation Test, Humans, Mitochondria, NAD, Saccharomyces cerevisiae, Cell Respiration, Mitochondrial Proteins, Organic Cation Transport Proteins, Saccharomyces cerevisiae Proteins, Nucleotide Transport Proteins, Mice
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