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Cited by 733Acute Myeloid Leukemia ResearchGenetic Associations and EpidemiologyCancer Genomics and Diagnostics

The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index, and 2 are not checked yet.

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

Open access
Bick, Alexander G., Weinstock, Joshua S., Nandakumar, Satish K., Fulco, Charles P., Bao, Erik L., Zekavat, Seyedeh M., Szeto, Mindy D., Liao, Xiaotian, Leventhal, Matthew J., Nasser, Joseph, Chang, Kyle, Laurie, Cecelia, Burugula, Bala Bharathi, Gibson, Christopher J., Niroula, Abhishek, Lin, Amy E., Taub, Margaret A., Aguet, Francois, Ardlie, Kristin, Mitchell, Braxton D., Barnes, Kathleen C., Moscati, Arden, Fornage, Myriam, Redline, Susan, Psaty, Bruce M., Silverman, Edwin K., Weiss, Scott T., Palmer, Nicholette D., Vasan, Ramachandran S., Burchard, Esteban G., Kardia, Sharon L. R., He, Jiang, Kaplan, Robert C., Smith, Nicholas L., Arnett, Donna K., Schwartz, David A., Correa, Adolfo, de Andrade, Mariza, Guo, Xiuqing, Konkle, Barbara A., Custer, Brian, Peralta, Juan M., Gui, Hongsheng, Meyers, Deborah A., McGarvey, Stephen T., Chen, Ida Yii-Der, Shoemaker, M. Benjamin, Peyser, Patricia A., Broome, Jai G., Gogarten, Stephanie M., Wang, Fei Fei, Wong, Quenna, Montasser, May E., Daya, Michelle, Kenny, Eimear E., North, Kari E., Launer, Lenore J., Cade, Brian E., Bis, Joshua C., Cho, Michael H., Lasky-Su, Jessica, Bowden, Donald W., Cupples, L. Adrienne, Mak, Angel C. Y., Becker, Lewis C., Smith, Jennifer A., Kelly, Tanika N., Aslibekyan, Stella, Heckbert, Susan R., Tiwari, Hemant K., Yang, Ivana V., Heit, John A., Lubitz, Steven A., Johnsen, Jill M., Curran, Joanne E., Wenzel, Sally E., Weeks, Daniel E., Rao, Dabeeru C., Darbar, Dawood, Moon, Jee-Young, Tracy, Russell P., Buth, Erin J., Rafaels, Nicholas, Loos, Ruth J. F., Durda, Peter, Liu, Yongmei, Hou, Lifang, Lee, Jiwon, Kachroo, Priyadarshini, Freedman, Barry I., Levy, Daniel, Bielak, Lawrence F., Hixson, James E., Floyd, James S., Whitsel, Eric A., Ellinor, Patrick T., Irvin, Marguerite R., Fingerlin, Tasha E., Raffield, Laura M., Armasu, Sebastian M., Wheeler, Marsha M., Sabino, Ester C., Blangero, John, Williams, L. Keoki, Levy, Bruce D., Sheu, Wayne Huey-Herng, Roden, Dan M., Boerwinkle, Eric, Manson, JoAnn E., Mathias, Rasika A., Desai, Pinkal, Taylor, Kent D., Johnson, Andrew D., NHLBI Trans-Omics for Precision Medicine Consortium, Abe, Namiko, Albert, Christine, Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Arking, Dan, Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Avramopoulos, Dimitrios, Barnard, John, Barr, R. Graham, Barron-Casella, Emily, Barwick, Lucas, Beaty, Terri, Beck, Gerald, Becker, Diane, Beer, Rebecca, Beitelshees, Amber, Benjamin, Emelia, Benos, Panagiotis, Bezerra, Marcos, Bielak, Larry, Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Bunting, Karen, Bustamante, Carlos, Cardwell, Jonathan, Carey, Vincent, Carty, Cara, Casaburi, Richard, Casella, James, Castaldi, Peter, Chaffin, Mark, Chang, Christy, Chang, Yi-Cheng, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Chung, Ren-Hua, Clish, Clary, Comhair, Suzy, Cornell, Elaine, Crandall, Carolyn, Crapo, James, Curtis, Jeffrey, Damcott, Coleen, Das, Sayantan, David, Sean, Davis, Colleen, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Duan, Qing, Duggirala, Ravi, Dutcher, Susan, Eaton, Charles, Ekunwe, Lynette, Boueiz, Adel El, Emery, Leslie, Erzurum, Serpil, Farber, Charles, Flickinger, Matthew, Franceschini, Nora, Frazar, Chris, Fu, Mao, Fullerton, Stephanie M., Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Shanshan, Gao, Yan, Gass, Margery, Gelb, Bruce, Geng, Xiaoqi, Geraci, Mark, Germer, Soren, Gerszten, Robert, Ghosh, Auyon, Gibbs, Richard, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gong, Da-Wei, Goring, Harald, Graw, Sharon, Grine, Daniel, Gu, C. Charles, Guan, Yue, Gupta, Namrata, Haessler, Jeff, Hall, Michael, Harris, Daniel, Hawley, Nicola L., Heavner, Ben, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hobbs, Brian, Hokanson, John, Hong, Elliott, Hoth, Karin, Hsiung, Chao, Hung, Yi-Jen, Huston, Haley, Hwu, Chii Min, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Jhun, Min A., Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kang, Hyun Min, Kelly, Shannon, Kessler, Michael, Khan, Alyna, Kim, Wonji, Kinney, Greg, Kramer, Holly, Lange, Christoph, LeBoff, Meryl, Lee, Seunggeun Shawn, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Lewis, Joshua, Li, Xiaohui, Li, Yun, Lin, Henry, Lin, Honghuang, Lin, Keng Han, Lin, Xihong, Liu, Simin, Liu, Yu, Lunetta, Kathryn, Luo, James, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Margolin, Lauren, Martin, Lisa, Mathai, Susan, May, Susanne, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGoldrick, Daniel, McHugh, Caitlin, Mei, Hao, Mestroni, Luisa, Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L., Moll, Matt, Montgomery, Courtney, Musani, Solomon, Mwasongwe, Stanford, Mychaleckyj, Josyf C., Nadkarni, Girish, Naik, Rakhi, Naseri, Take, Nekhai, Sergei, Nelson, Sarah C., Neltner, Bonnie, Nickerson, Deborah, O’Connell, Jeff, O’Connor, Tim, Ochs-Balcom, Heather, Paik, David, Pankow, James, Papanicolaou, George, Parsa, Afshin, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Lawrence S., Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rasmussen-Torvik, Laura, Ratan, Aakrosh, Reed, Robert, Regan, Elizabeth, Sefuiva Reupena, Muagututi‘a, Rice, Ken, Roselli, Carolina, Ruczinski, Ingo, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Saleheen, Danish, Salimi, Shabnam, Salzberg, Steven, Sandow, Kevin, Scheller, Christopher, Schmidt, Ellen, Schwander, Karen, Sciurba, Frank, Seidman, Christine, Seidman, Jonathan, Sheehan, Vivien, Sherman, Stephanie L., Shetty, Amol, Shetty, Aniket, Silver, Brian, Smith, Josh, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Snyder, Michael, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne M., Storm, Garrett, Streeten, Elizabeth, Su, Jessica Lasky, Sung, Yun Ju, Sylvia, Jody, Szpiro, Adam, Sztalryd, Carole, Taliun, Daniel, Tang, Hua, Taylor, Matthew, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Threlkeld, Machiko, Tinker, Lesley, Tirschwell, David, Tishkoff, Sarah, Tiwari, Hemant, Tong, Catherine, Tsai, Michael, Vaidya, Dhananjay, Berg, David Van Den, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wang, Heming, Watson, Karol, Weir, Bruce, Weng, Lu-Chen, Wessel, Jennifer, Willer, Cristen, Williams, Kayleen, Wilson, Carla, Wu, Joseph, Xu, Huichun, Yanek, Lisa, Yang, Rongze, Zaghloul, Norann, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zhi, Degui, Zhou, Xiang, Zhu, Xiaofeng, Zody, Michael, Zoellner, Sebastian, Auer, Paul L., Kooperberg, Charles, Laurie, Cathy C., Blackwell, Thomas W., Smith, Albert V., Zhao, Hongyu, Lange, Ethan, Lange, Leslie, Rich, Stephen S., Rotter, Jerome I., Wilson, James G., Scheet, Paul, Kitzman, Jacob O., Lander, Eric S., Engreitz, Jesse M., Ebert, Benjamin L., Reiner, Alexander P., Jaiswal, Siddhartha, Abecasis, Gonçalo, Sankaran, Vijay G., Kathiresan, Sekar, Natarajan, Pradeep·2020·Nature
DOI 10.1038/s41586-020-2819-2PMC PMC7944936
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Abstract

Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown 1. The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating haematopoietic stem cell populations has recently been associated with both haematological cancer 2-4 and coronary heart disease 5-this phenomenon is termed clonal haematopoiesis of indeterminate potential (CHIP)6. Simultaneous analyses of germline and somatic whole-genome sequences provide the opportunity to identify root causes of CHIP. Here we analyse high-coverage whole-genome sequences from 97,691 participants of diverse ancestries in the National Heart, Lung, and Blood Institute Trans-omics for Precision Medicine (TOPMed) programme, and identify 4,229 individuals with CHIP. We identify associations with blood cell, lipid and inflammatory traits that are specific to different CHIP driver genes. Association of a genome-wide set of germline genetic variants enabled the identification of three genetic loci associated with CHIP status, including one locus at TET2 that was specific to individuals of African ancestry. In silico-informed in vitro evaluation of the TET2 germline locus enabled the identification of a causal variant that disrupts a TET2 distal enhancer, resulting in increased self-renewal of haematopoietic stem cells. Overall, we observe that germline genetic variation shapes haematopoietic stem cell function, leading to CHIP through mechanisms that are specific to clonal haematopoiesis as well as shared mechanisms that lead to somatic mutations across tissues.

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Authors
Bick, A. G., Weinstock, J. S., Nandakumar, S. K., Fulco, C. P., Bao, E. L., Zekavat, S. M., Szeto, M. D., Liao, X., Leventhal, M. J., Nasser, J., Chang, K., Laurie, C., Burugula, B. B., Gibson, C. J., Niroula, A., Lin, A. E., Taub, M. A., Aguet, F., Ardlie, K., Mitchell, B. D., Barnes, K. C., Moscati, A., Fornage, M., Redline, S., Psaty, B. M., Silverman, E. K., Weiss, S. T., Palmer, N. D., Vasan, R. S., Burchard, E. G., Kardia, S. L. R., He, J., Kaplan, R. C., Smith, N. L., Arnett, D. K., Schwartz, D. A., Correa, A., de Andrade, M., Guo, X., Konkle, B. A., Custer, B., Peralta, J. M., Gui, H., Meyers, D. A., McGarvey, S. T., Chen, I. Y.-D., Shoemaker, M. B., Peyser, P. A., Broome, J. G., Gogarten, S. M., Wang, F. F., Wong, Q., Montasser, M. E., Daya, M., Kenny, E. E., North, K. E., Launer, L. J., Cade, B. E., Bis, J. C., Cho, M. H., Lasky-Su, J., Bowden, D. W., Cupples, L. A., Mak, A. C. Y., Becker, L. C., Smith, J. A., Kelly, T. N., Aslibekyan, S., Heckbert, S. R., Tiwari, H. K., Yang, I. V., Heit, J. A., Lubitz, S. A., Johnsen, J. M., Curran, J. E., Wenzel, S. E., Weeks, D. E., Rao, D. C., Darbar, D., Moon, J.-Y., Tracy, R. P., Buth, E. J., Rafaels, N., Loos, R. J. F., Durda, P., Liu, Y., Hou, L., Lee, J., Kachroo, P., Freedman, B. I., Levy, D., Bielak, L. F., Hixson, J. E., Floyd, J. S., Whitsel, E. A., Ellinor, P. T., Irvin, M. R., Fingerlin, T. E., Raffield, L. M., Armasu, S. M., Wheeler, M. M., Sabino, E. C., Blangero, J., Williams, L. K., Levy, B. D., Sheu, W. H.-H., Roden, D. M., Boerwinkle, E., Manson, J. E., Mathias, R. A., Desai, P., Taylor, K. D., Johnson, A. D., NHLBI Trans-Omics for Precision Medicine Consortium, Abe, N., Albert, C., Almasy, L., Alonso, A., Ament, S., Anderson, P., Anugu, P., Applebaum-Bowden, D., Arking, D., Ashley-Koch, A., Aslibekyan, S., Assimes, T., Avramopoulos, D., Barnard, J., Barr, R. G., Barron-Casella, E., Barwick, L., Beaty, T., Beck, G., Becker, D., Beer, R., Beitelshees, A., Benjamin, E., Benos, P., Bezerra, M., Bielak, L., Bowler, R., Brody, J., Broeckel, U., Bunting, K., Bustamante, C., Cardwell, J., Carey, V., Carty, C., Casaburi, R., Casella, J., Castaldi, P., Chaffin, M., Chang, C., Chang, Y.-C., Chasman, D., Chavan, S., Chen, B.-J., Chen, W.-M., Choi, S. H., Chuang, L.-M., Chung, M., Chung, R.-H., Clish, C., Comhair, S., Cornell, E., Crandall, C., Crapo, J., Curtis, J., Damcott, C., Das, S., David, S., Davis, C., DeBaun, M., Deka, R., DeMeo, D., Devine, S., Duan, Q., Duggirala, R., Dutcher, S., Eaton, C., Ekunwe, L., Boueiz, A. E., Emery, L., Erzurum, S., Farber, C., Flickinger, M., Franceschini, N., Frazar, C., Fu, M., Fullerton, S. M., Fulton, L., Gabriel, S., Gan, W., Gao, S., Gao, Y., Gass, M., Gelb, B., Geng, X., Geraci, M., Germer, S., Gerszten, R., Ghosh, A., Gibbs, R., Gignoux, C., Gladwin, M., Glahn, D., Gong, D.-W., Goring, H., Graw, S., Grine, D., Gu, C. C., Guan, Y., Gupta, N., Haessler, J., Hall, M., Harris, D., Hawley, N. L., Heavner, B., Hernandez, R., Herrington, D., Hersh, C., Hidalgo, B., Hobbs, B., Hokanson, J., Hong, E., Hoth, K., Hsiung, C., Hung, Y.-J., Huston, H., Hwu, C. M., Jackson, R., Jain, D., Jaquish, C., Jhun, M. A., Johnson, C., Johnston, R., Jones, K., Kang, H. M., Kelly, S., Kessler, M., Khan, A., Kim, W., Kinney, G., Kramer, H., Lange, C., LeBoff, M., Lee, S. S., Lee, W.-J., LeFaive, J., Levine, D., Lewis, J., Li, X., Li, Y., Lin, H., Lin, H., Lin, K. H., Lin, X., Liu, S., Liu, Y., Lunetta, K., Luo, J., Mahaney, M., Make, B., Manichaikul, A., Margolin, L., Martin, L., Mathai, S., May, S., McArdle, P., McDonald, M.-L., McFarland, S., McGoldrick, D., McHugh, C., Mei, H., Mestroni, L., Mikulla, J., Min, N., Minear, M., Minster, R. L., Moll, M., Montgomery, C., Musani, S., Mwasongwe, S., Mychaleckyj, J. C., Nadkarni, G., Naik, R., Naseri, T., Nekhai, S., Nelson, S. C., Neltner, B., Nickerson, D., O’Connell, J., O’Connor, T., Ochs-Balcom, H., Paik, D., Pankow, J., Papanicolaou, G., Parsa, A., Perez, M., Perry, J., Peters, U., Peyser, P., Phillips, L. S., Pollin, T., Post, W., Becker, J. P., Boorgula, M. P., Preuss, M., Qasba, P., Qiao, D., Qin, Z., Rasmussen-Torvik, L., Ratan, A., Reed, R., Regan, E., Sefuiva Reupena, M., Rice, K., Roselli, C., Ruczinski, I., Russell, P., Ruuska, S., Ryan, K., Saleheen, D., Salimi, S., Salzberg, S., Sandow, K., Scheller, C., Schmidt, E., Schwander, K., Sciurba, F., Seidman, C., Seidman, J., Sheehan, V., Sherman, S. L., Shetty, A., Shetty, A., Silver, B., Smith, J., Smith, T., Smoller, S., Snively, B., Snyder, M., Sofer, T., Sotoodehnia, N., Stilp, A. M., Storm, G., Streeten, E., Su, J. L., Sung, Y. J., Sylvia, J., Szpiro, A., Sztalryd, C., Taliun, D., Tang, H., Taylor, M., Taylor, S., Telen, M., Thornton, T. A., Threlkeld, M., Tinker, L., Tirschwell, D., Tishkoff, S., Tiwari, H., Tong, C., Tsai, M., Vaidya, D., Berg, D. V. D., VandeHaar, P., Vrieze, S., Walker, T., Wallace, R., Walts, A., Wang, H., Watson, K., Weir, B., Weng, L.-C., Wessel, J., Willer, C., Williams, K., Wilson, C., Wu, J., Xu, H., Yanek, L., Yang, R., Zaghloul, N., Zhang, Y., Zhao, S. X., Zhao, W., Zhi, D., Zhou, X., Zhu, X., Zody, M., Zoellner, S., Auer, P. L., Kooperberg, C., Laurie, C. C., Blackwell, T. W., Smith, A. V., Zhao, H., Lange, E., Lange, L., Rich, S. S., Rotter, J. I., Wilson, J. G., Scheet, P., Kitzman, J. O., Lander, E. S., Engreitz, J. M., Ebert, B. L., Reiner, A. P., Jaiswal, S., Abecasis, G., Sankaran, V. G., Kathiresan, S., & Natarajan, P.
Affiliations
  • Broad Institute (US)
  • University of Michigan (US)
  • University of Colorado Anschutz (US)
  • The University of Texas MD Anderson Cancer Center (US)
  • University of Washington (US)
  • Dana-Farber Cancer Institute (US)
  • Brigham and Women's Hospital (US)
  • Johns Hopkins University (US)
  • University of Maryland, Baltimore (US)
  • Icahn School of Medicine at Mount Sinai (US)
  • Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (US)
  • Kaiser Permanente Washington Health Research Institute (US)
  • Wake Forest University Health Sciences (US)
  • Boston University (US)
  • University of California, San Francisco (US)
  • Tulane University (US)
  • Albert Einstein College of Medicine (US)
  • United States Department of Veterans Affairs (US)
  • University of Kentucky (US)
  • University of Mississippi Medical Center (US)
  • Mayo Clinic (US)
  • The Lundquist Institute (US)
  • The University of Texas Rio Grande Valley (US)
  • Henry Ford Health (US)
  • University of Arizona (US)
  • Brown University (US)
  • Vanderbilt University Medical Center (US)
  • University of North Carolina at Chapel Hill (US)
  • National Institutes of Health (US)
  • University of Alabama at Birmingham (US)
  • University of Pittsburgh (US)
  • Washington University in St. Louis (US)
  • University of Illinois Chicago (US)
  • University of Vermont (US)
  • Duke Medical Center (US)
  • Northwestern University (US)
  • The University of Texas Health Science Center at Houston (US)
  • National Jewish Health (US)
  • Taichung Veterans General Hospital (TW)
  • Baylor College of Medicine (US)
  • Weill Cornell Medicine (US)
  • New York Genome Center (US)
  • Children's Hospital of Philadelphia (US)
  • University of Mississippi (US)
  • Cleveland Clinic (US)
  • Columbia University (US)
  • Emmes (United States) (US)
  • Medical College of Wisconsin (US)
  • Stanford University (US)
  • Washington State University (US)
  • University of California, Los Angeles (US)
  • National Taiwan University Hospital (TW)
  • University of Virginia (US)
  • National Health Research Institutes (TW)
  • University of Chicago (US)
  • Vanderbilt University (US)
  • University of Cincinnati (US)
  • Fred Hutch Cancer Center (US)
  • Indiana University School of Medicine (US)
  • Harvard University (US)
  • Yale University (US)
  • McGill University (CA)
  • Atrium Health Wake Forest Baptist (US)
  • University of Iowa (US)
  • Tri-Service General Hospital (TW)
  • Bloodworks Northwest (US)
  • The Ohio State University Wexner Medical Center (US)
  • Emory University (US)
  • Loyola University Chicago (US)
  • University of Wisconsin–Milwaukee (US)
  • Oklahoma Medical Research Foundation (US)
  • Howard University (US)
  • Stanford Cardiovascular Institute (US)
  • University of Minnesota (US)
  • UMass Memorial Medical Center (US)
  • Duke University (US)
  • University of Pennsylvania (US)
  • University of Southern California (US)
  • Indiana University Indianapolis (US)
  • Case Western Reserve University (US)
  • Beth Israel Deaconess Medical Center (US)
  • Stanford Medicine (US)
  • Regeneron (United States) (US)
Corresponding author
  • Kathiresan, Sekar
  • Natarajan, Pradeep
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2020-10-14
Volume
586
Issue
7831
Pages
763-768
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/s41586-020-2819-2
PMC
PMC7944936
OpenAlex
W3093370683
Cited by
733
References
54
Citations by year
2026: 101 · 2025: 142 · 2024: 149 · 2023: 115 · 2022: 124 · 2021: 97 · 2020: 5
FWCI
54.00
Type
journal article
Language
en
Update notices
correction (2021-03-11)
Open access
Licence
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley) (submittedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • American Heart Association (18SFRN34250007)
  • National Institutes of Health (1r01hl120393-01a1, 5p50hl118006-05, DP5OD029586, 5k01hl135405-04, UL1TR001863, 5r01hl113323-05)
  • National Institute on Aging (K01AG059898)
  • National Heart, Lung, and Blood Institute (R03HL154284, R01-HL120393, K01-HL135405, R01HL148050, R01HL143818, K01HL136700, R35HL135818, HHSN268201800001C, R01-HL113323, P50-HL-118006, P01HL132825, UG3HL151865, U01HL130114, DP2HL157540, F30HL149180, R01HL149836, U01HL089856, R01HL091357, R01HL138737, U01HL137162, R01HL117626, K08HL141601, R01HL055673, UH3HL151865, T32HL129982, R01HL133040, R01HL148565, R01HL139731)
  • National Human Genome Research Institute (UM1HG008895, R01HG009974)
  • National Cancer Institute (R35CA253125)
  • National Institute of General Medical Sciences (U54GM115428)
  • National Institute of Allergy and Infectious Diseases (R01AI132476)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Keywords
clonal hematopoiesis of indeterminate potential, germline genetic variants, somatic mutations, hematopoietic stem cells, TET2, distal enhancers, aging, coronary artery disease, hematologic cancer, genetic susceptibility, TOPMed, African ancestry
MeSH terms
Cell Self Renewal, Tripartite Motif Proteins, Whole Genome Sequencing, Clonal Hematopoiesis, Adult, Africa, Aged, Aged, 80 and over, Black or African American, DNA-Binding Proteins, Female, Hematopoietic Stem Cells, Humans, Male, Middle Aged, Phenotype, Proto-Oncogene Proteins, United States, Genome, Human, Germ-Line Mutation, Genetic Predisposition to Disease, alpha Karyopherins, Black People, Intracellular Signaling Peptides and Proteins, Dioxygenases, National Heart, Lung, and Blood Institute (U.S.), Precision Medicine

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