γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works

<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data

Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works

limma powers differential expression analyses for RNA-sequencing and microarray studies

Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works

SciPy 1.0: fundamental algorithms for scientific computing in Python

Virtanen, P., Gommers, R., Oliphant, T. E., Haberland, M., Reddy, T., Cournapeau, D., Burovski, E., Peterson, P., Weckesser, W., Bright, J., et al. (2020) · Nature Methods · doi:10.1038/s41592-019-0686-2 · Cited by 38,430 · see citing works

Comprehensive Integration of Single-Cell Data

Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453 · see citing works

Integrative genomics viewer

Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390 · see citing works

SciPy 1.0: fundamental algorithms for scientific computing in Python

Virtanen, P., Gommers, R., Oliphant, T. E., Haberland, M., Reddy, T., Cournapeau, D., Burovski, E., Peterson, P., Weckesser, W., Bright, J., et al. (2019) · Apollo - University of Cambridge Repository · doi:10.17863/cam.64134 · Cited by 10,460 · see citing works

UMAP: Uniform Manifold Approximation and Projection

McInnes, L., Healy, J., Saul, N., & Großberger, L. (2018) · Journal of Open Source Software · doi:10.21105/joss.00861 · Cited by 9,826 · see citing works

UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction

McInnes, L., Healy, J., & Melville, J. (2018) · arXiv · doi:10.48550/arxiv.1802.03426 · Cited by 7,101 · see citing works

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D. T., Durham, J. N., Smith, K. N., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., et al. (2017) · Science · doi:10.1126/science.aan6733 · Cited by 6,645 · see citing works

PD-1 blockade induces responses by inhibiting adaptive immune resistance

Tumeh, P. C., Harview, C. L., Yearley, J. H., Shintaku, I. P., Taylor, E. J. M., Robert, L., Chmielowski, B., Spasic, M., Henry, G., Ciobanu, V., et al. (2014) · Nature · doi:10.1038/nature13954 · Cited by 6,609 · see citing works

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

Law, C. W., Chen, Y., Shi, W., & Smyth, G. K. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r29 · Cited by 6,155 · see citing works

The Immune Landscape of Cancer

Thorsson, V., Gibbs, D. L., Brown, S. D., Wolf, D., Bortone, D. S., Ou Yang, T.-H., Porta-Pardo, E., Gao, G. F., Plaisier, C. L., Eddy, J. A., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.023 · Cited by 5,870 · see citing works

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

Carpenter, A. E., Jones, T. R., Lamprecht, M. R., Clarke, C., Kang, I. H., Friman, O., Guertin, D. A., Chang, J. H., Lindquist, R. A., Moffat, J., et al. (2006) · Genome biology · doi:10.1186/gb-2006-7-10-r100 · Cited by 5,077 · see citing works

ilastik: interactive machine learning for (bio)image analysis

Berg, S., Kutra, D., Kroeger, T., Straehle, C., Kausler, B. X., Haubold, C., Schiegg, M., Aleš, J., Beier, T., Rudy, M., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0582-9 · Cited by 3,277 · see citing works

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

Zaretsky, J. M., Garcia-Diaz, A., Shin, D. S., Escuin-Ordinas, H., Hugo, W., Hu-Lieskovan, S., Torrejon, D. Y., Abril-Rodriguez, G., Sandoval, S., Barthly, L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1604958 · Cited by 3,237 · see citing works

Simultaneous epitope and transcriptome measurement in single cells

Stoeckius, M., Hafemeister, C., Stephenson, W., Houck-Loomis, B., Chattopadhyay, P. K., Swerdlow, H., Satija, R., & Smibert, P. (2017) · Nature Methods · doi:10.1038/nmeth.4380 · Cited by 3,098 · see citing works

Nivolumab in Patients with Metastatic DNA Mismatch Repair-Deficient or Microsatellite Instability-High Colorectal Cancer (CheckMate 142): An Open-Label, Multicentre, Phase 2 Study

Overman, M. J., McDermott, R., Leach, J. L., Lonardi, S., Lenz, H.-J., Morse, M. A., Desai, J., Hill, A., Axelson, M., Moss, R. A., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30422-9 · Cited by 2,836 · see citing works

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

Ionov, Y., Peinado, M. A., Malkhosyan, S. R., Shibata, D. K., & Perucho, M. (1993) · Nature · doi:10.1038/363558a0 · Cited by 2,691 · see citing works

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors

Haghverdi, L., Lun, A. T. L., Morgan, M. D., & Marioni, J. C. (2018) · Nature Biotechnology · doi:10.1038/nbt.4091 · Cited by 2,416 · see citing works

Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti–PD-1 Therapy

Taube, J. M., Klein, A., Brahmer, J. R., Xu, H., Pan, X., Kim, J. H., Chen, L., Pardoll, D. M., Topalian, S. L., & Anders, R. A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3271 · Cited by 2,324 · see citing works

Durable Clinical Benefit with Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal Cancer

Overman, M. J., Lonardi, S., Wong, K. Y. M., Lenz, H.-J., Gelsomino, F., Aglietta, M., Morse, M. A., Van Cutsem, E., McDermott, R., Hill, A., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.9901 · Cited by 2,079 · see citing works

Absolute quantification of somatic DNA alterations in human cancer

Carter, S. L., Cibulskis, K., Helman, E., McKenna, A., Shen, H., Zack, T. I., Laird, P. W., Onofrio, R. C., Winckler, W., Weir, B. A., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2203 · Cited by 2,003 · see citing works

CD8+ T cell states in human cancer: insights from single-cell analysis

van der Leun, A. M., Thommen, D. S., & Schumacher, T. N. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-019-0235-4 · Cited by 1,439 · see citing works

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

Chalabi, M., Fanchi, L. F., Dijkstra, K. K., Van den Berg, J. G., Aalbers, A. G., Sikorska, K., Lopez-Yurda, M., Grootscholten, C., Beets, G. L., Snaebjornsson, P., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0805-8 · Cited by 1,417 · see citing works

Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells

Groh, V., Steinle, A., Bauer, S., & Spies, T. A. (1998) · Science · doi:10.1126/science.279.5357.1737 · Cited by 1,142 · see citing works

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

Dijkstra, K. K., Cattaneo, C. M., Weeber, F., Chalabi, M., van de Haar, J., Fanchi, L. F., Slagter, M., van der Velden, D. L., Kaing, S., Kelderman, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.009 · Cited by 1,135 · see citing works

Pan-cancer whole-genome analyses of metastatic solid tumours

Priestley, P., Baber, J., Lolkema, M. P., Steeghs, N., de Bruijn, E., Shale, C., Duyvesteyn, K., Haidari, S., van Hoeck, A., Onstenk, W., et al. (2019) · Nature · doi:10.1038/s41586-019-1689-y · Cited by 1,106 · see citing works

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

Taylor, A. M., Shih, J., Ha, G., Gao, G. F., Zhang, X., Berger, A. C., Schumacher, S. E., Wang, C., Hu, H., Liu, J., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.007 · Cited by 1,027 · see citing works

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

Groh, V., Rhinehart, R. L., Secrist, H., Bauer, S., Grabstein, K. H., & Spies, T. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6879 · Cited by 1,026 · see citing works

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

Sade-Feldman, M., Jiao, Y. J., Chen, J. H., Rooney, M. S., Barzily-Rokni, M., Eliane, J.-P., Bjorgaard, S. L., Hammond, M. R., Vitzthum, H., Blackmon, S. M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01062-w · Cited by 1,005 · see citing works

Classification and characterization of microsatellite instability across 18 cancer types

Hause, R. J., Pritchard, C. C., Shendure, J., & Salipante, S. J. (2016) · Nature Medicine · doi:10.1038/nm.4191 · Cited by 982 · see citing works

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Duhen, T., Duhen, R., Montler, R., Moses, J., Moudgil, T., de Miranda, N. F., Goodall, C. P., Blair, T. C., Fox, B. A., McDermott, J. E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05072-0 · Cited by 938 · see citing works

Gene expression markers of Tumor Infiltrating Leukocytes

Danaher, P. J., Warren, S. E., Dennis, L. M., D’Amico, L., White, A. M., Disis, M. L., Geller, M. A., Odunsi, K. O., Beechem, J., & Fling, S. P. (2017) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-017-0215-8 · Cited by 791 · see citing works

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

Gettinger, S., Choi, J., Hastings, K., Truini, A., Datar, I., Sowell, R., Wurtz, A., Dong, W., Cai, G., Melnick, M. A., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0593 · Cited by 787 · see citing works

The Immune Landscape of Cancer

Thórsson, V., Gibbs, D. L., Brown, S. D., Wolf, D. M., Bortone, D. S., Yang, T.-H. O., Porta‐Pardo, E., Gao, G. F., Plaisier, C. L., Eddy, J. A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.004 · Cited by 701 · see citing works

MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices

McGinnis, C. S., Patterson, D. M., Winkler, J., Conrad, D. N., Hein, M. Y., Srivastava, V., Hu, J. L., Murrow, L. M., Weissman, J. S., Werb, Z., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0433-8 · Cited by 643 · see citing works

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Germano, G., Lamba, S., Rospo, G., Barault, L., Magrì, A., Maione, F., Russo, M., Crisafulli, G., Bartolini, A., Lerda, G., et al. (2017) · Nature · doi:10.1038/nature24673 · Cited by 627 · see citing works

Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system.

Groh, V., Porcelli, S. A., Fabbi, M., Lanier, L. L., Picker, L. J., Anderson, T., Warnke, R. A., Bhan, A. K., Strominger, J. L., & Brenner, M. B. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.4.1277 · Cited by 544 · see citing works

High Prevalence of Activated Intraepithelial Cytotoxic T Lymphocytes and Increased Neoplastic Cell Apoptosis in Colorectal Carcinomas with Microsatellite Instability

Dolcetti, R., Viel, A., Doglioni, C., Russo, A. G., Guidoboni, M., Capozzi, E., Vecchiato, N., Macrì, E., Fornasarig, M., & Boiocchi, M. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65436-3 · Cited by 480 · see citing works

γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer

Silva‐Santos, B., Mensurado, S., & Coffelt, S. B. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0153-5 · Cited by 424 · see citing works

Tumor organoid–T-cell coculture systems

Cattaneo, C. M., Dijkstra, K. K., Fanchi, L. F., Kelderman, S., Kaing, S., van Rooij, N., van den Brink, S., Schumacher, T. N., & Voest, E. E. (2020) · Nature Protocols · doi:10.1038/s41596-019-0232-9 · Cited by 410 · see citing works

Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome

Hughes, E., Hammond, C., & Cresswell, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1896 · Cited by 299 · see citing works

The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs

Velden, D. L. V. D., Hoes, L. R., van der Wijngaart, H., Henegouwen, J. M. V. B., van Werkhoven, E. D., Roepman, P., Schilsky, R. L., de Leng, W. W. J., Huitema, A. D. R., Nuijen, B., et al. (2019) · Nature · doi:10.1038/s41586-019-1600-x · Cited by 260 · see citing works

Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability–High Gastric Cancer

Kwon, M., An, M., Klempner, S. J., Lee, H., Kim, K., Sa, J. K., Cho, H. J., Hong, J. Y., Lee, T., Min, Y. W., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0219 · Cited by 238 · see citing works

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

Almeida, A. R. M., Correia, D. V., Fernandes‐Platzgummer, A., da Silva, C. L., da Silva, M. G., Anjos, D. R., & Silva‐Santos, B. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0597 · Cited by 229 · see citing works

An innate-like Vδ1 + γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

Wu, Y., Kyle‐Cezar, F., Woolf, R., Naceur‐Lombardelli, C., Owen, J., Biswas, D., Lorenc, A., Vantourout, P., Gazińska, P., Grigoriadis, A. E., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aax9364 · Cited by 199 · see citing works

Vδ1 T Lymphocytes from B-CLL Patients Recognize ULBP3 Expressed on Leukemic B Cells and Up-Regulated by Trans -Retinoic Acid

Poggi, A. D., Venturino, C., Catellani, S., Clavio, M., Miglino, M., Gobbi, M., Steinle, A., Ghia, P., Stella, S., Caligaris‐Cappio, F., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2417 · Cited by 189 · see citing works

Immunoselective Pressure and Human Leukocyte Antigen Class I Antigen Machinery Defects in Microsatellite Unstable Colorectal Cancers

Kloor, M., Becker, C., Benner, A., Woerner, S. M., Gebert, J. F., Ferrone, S., & Doeberitz, M. V. K. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0044 · Cited by 178 · see citing works

Control of self‐reactive cytotoxic T lymphocytes expressing γδ T cell receptors by natural killer inhibitory receptors

Halary, F. A., Peyrat, M., Champagne, É., López‐Botet, M., Moretta, A., Moretta, L., Vié, H., Fournié, J., & Bonneville, M. (1997) · European Journal of Immunology · doi:10.1002/eji.1830271111 · Cited by 157 · see citing works

Human intestinal Vdelta1+ lymphocytes recognize tumor cells of epithelial origin.

Maeurer, M. J., Martin, D., Walter, W., Liu, K., Zitvogel, L., Halusczcak, K., Rabinowich, H., Duquesnoy, R., Storkus, W. J., & Lotze, M. T. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1681 · Cited by 155 · see citing works

A 40-Marker Panel for High Dimensional Characterization of Cancer Immune Microenvironments by Imaging Mass Cytometry

Ijsselsteijn, M. E., van der Breggen, R., Sarasqueta, A. F., Koning, F., & de Miranda, N. F. C. C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02534 · Cited by 155 · see citing works

A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma

Cader, F. Z., Hu, X. S., Goh, W. L., Wienand, K., Ouyang, J., Mandato, E., Redd, R. A., Lawton, L. N., Chen, P.-H., Weirather, J. L., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1006-1 · Cited by 144 · see citing works

Immunohistochemistry for PMS2 and MSH6 alone can replace a four antibody panel for mismatch repair deficiency screening in colorectal adenocarcinoma

Hall, G., Clarkson, A., Shi, A., Langford, E., Leung, H., Eckstein, R. P., & Gill, A. J. (2010) · Pathology · doi:10.3109/00313025.2010.493871 · Cited by 143 · see citing works

NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high antitumor activity against colorectal cancer

Mikulak, J., Oriolo, F., Bruni, E., Roberto, A., Colombo, F., VILLA, A. M., Bosticardo, M., Bortolomai, I., Presti, E. L., Meraviglia, S., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.125884 · Cited by 141 · see citing works

MSIseq: Software for Assessing Microsatellite Instability from Catalogs of Somatic Mutations

Huang, M. N., McPherson, J. R., Cutcutache, I., Teh, B. T., Tan, P. B. O., & Rozen, S. (2015) · Scientific Reports · doi:10.1038/srep13321 · Cited by 135 · see citing works

Selection for β2-microglobulin mutation in mismatch repair-defective colorectal carcinomas

Bicknell, D., Kaklamanis, L., Hampson, R., Bodmer, W. F., & Karran, P. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70795-1 · Cited by 132 · see citing works

Cytosplore: Interactive Immune Cell Phenotyping for Large Single‐Cell Datasets

Höllt, T., Pezzotti, N., van Unen, V., Koning, F., Eisemann, E., Lelieveldt, B. P. F., & Vilanova, A. (2016) · Computer Graphics Forum · doi:10.1111/cgf.12893 · Cited by 122 · see citing works

High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity

Vries, N. L. D., van Unen, V., Ijsselsteijn, M. E., Abdelaal, T., van der Breggen, R., Sarasqueta, A. F., Mahfouz, A. E., Peeters, K. C. M. J., Höllt, T., Lelieveldt, B. P. F., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318672 · Cited by 121 · see citing works

A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

Wu, Y., Biswas, D., Usaite, I., Angelova, M., Boeing, S., Karasaki, T., Veeriah, S., Czyzewska-Khan, J., Morton, C., Joseph, M., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00376-z · Cited by 118 · see citing works

HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression

Dierssen, J. W. F., de Miranda, N. F. C. C., Ferrone, S., van Puijenbroek, M., Cornelisse, C. J., Fleuren, G. J., van Wezel, T., & Morreau, H. M. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-33 · Cited by 112 · see citing works

Majority of B2M -Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High

Middha, S., Yaeger, R. D., Shia, J., Stadler, Z. K., King, S., Guercio, S., Paroder, V., Bates, ‬. D. B., Rana, S., Diaz, L. A., et al. (2019) · JCO Precision Oncology · doi:10.1200/po.18.00321 · Cited by 111 · see citing works

Ex vivo expanded human circulating Vδ1 γδT cells exhibit favorable therapeutic potential for colon cancer

Wu, D., Wu, P., Wu, X., Ye, J., Wang, Z., Zhao, S., Ni, C., Hu, G., Xu, J., Han, Y., et al. (2015) · OncoImmunology · doi:10.4161/2162402x.2014.992749 · Cited by 103 · see citing works

ImaCytE: Visual Exploration of Cellular Micro-Environments for Imaging Mass Cytometry Data

Somarakis, A., van Unen, V., Koning, F., Lelieveldt, B. P. F., & Höllt, T. (2019) · IEEE Transactions on Visualization and Computer Graphics · doi:10.1109/tvcg.2019.2931299 · Cited by 92 · see citing works

CD4 T Cell–Dependent Rejection of Beta-2 Microglobulin Null Mismatch Repair–Deficient Tumors

Germano, G., Lu, S., Rospo, G., Lamba, S., Rousseau, B., Fanelli, S., Stenech, D., Le, D. T., Hays, J. L., Totaro, M. G., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0987 · Cited by 83 · see citing works

Unscrambling cancer genomes via integrated analysis of structural variation and copy number

Shale, C., Cameron, D., Baber, J., Wong, M., Cowley, M. J., Papenfuss, A. T., Cuppen, E. P. J. G., & Priestley, P. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100112 · Cited by 83 · see citing works

Extensive expansion of primary human gamma delta T cells generates cytotoxic effector memory cells that can be labeled with Feraheme for cellular MRI

Siegers, G. M., Ribot, E. J., Keating, A., & Foster, P. J. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1353-y · Cited by 56 · see citing works

Semi‐automated background removal limits data loss and normalizes imaging mass cytometry data

Ijsselsteijn, M. E., Somarakis, A., Lelieveldt, B. P. F., Höllt, T., & de Miranda, N. F. C. C. (2021) · Cytometry Part A · doi:10.1002/cyto.a.24480 · Cited by 46 · see citing works

Revisiting immune escape in colorectal cancer in the era of immunotherapy

Ijsselsteijn, M. E., Petitprez, F., Lacroix, L., Ruano, D., van der Breggen, R., Julié, C., Morreau, H., Sautès‐Fridman, C., Fridman, W. H., & de Miranda, N. F. C. C. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0421-x · Cited by 42 · see citing works

Apoptosis Induced via Gamma Delta T Cell Antigen Receptor “Blocking” Antibodies: A Cautionary Tale

Dutta, I., Postovit, L.-M. M., & Siegers, G. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00776 · Cited by 17 · see citing works

T cells in health and disease

Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,060 · see citing works

γδ T cells: origin and fate, subsets, diseases and immunotherapy

Hu, Y., Hu, Q., Li, Y., Lu, L., Xiang, Z., Yin, Z., Kabelitz, D., & Wu, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01653-8 · Cited by 395 · see citing works

Tertiary lymphoid structures and B cells: An intratumoral immunity cycle

Fridman, W. H., Meylan, M., Pupier, G., Calvez, A., Hernández-Verdín, I., & Sautès‐Fridman, C. (2023) · Immunity · doi:10.1016/j.immuni.2023.08.009 · Cited by 331 · see citing works

Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell

Zhu, X., Li, K., Liu, G., Wu, R., Zhang, Y., Wang, S., Xu, M., Lu, L., & Li, P. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2249143 · Cited by 220 · see citing works

Beyond the blood: expanding CAR T cell therapy to solid tumors

Uslu, U., & June, C. H. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02446-2 · Cited by 170 · see citing works

Tumour mutational burden: clinical utility, challenges and emerging improvements

Budczies, J., Kazdal, D. N., Menzel, M., Beck, S., Kluck, K., Altbürger, C., Schwab, C., Allgäuer, M., Ahadova, A., Kloor, M., et al. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00932-9 · Cited by 175 · see citing works

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition

Glaviano, A., Lau, H., Carter, L. M., Lee, E. H. C., Lam, H. Y., Okina, E., Tan, D. J. J., Tan, W., Ang, H. L., Carbone, D., et al. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01634-6 · Cited by 162 · see citing works

Gamma delta T-cell-based immune checkpoint therapy: attractive candidate for antitumor treatment

Gao, Z., Bai, Y., Lin, A., Jiang, A., Zhou, C., Cheng, Q., Liu, Z., Chen, X., Zhang, J., & Luo, P. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01722-0 · Cited by 138 · see citing works

CD8+ T cells maintain killing of MHC-I-negative tumor cells through the NKG2D–NKG2DL axis

Lerner, E., Woroniecka, K. I., D’Anniballe, V. M., Wilkinson, D. S., Mohan, A. A., Lorrey, S., Polania, J. W., Wachsmuth, L. P., Hoyt-Miggelbrink, A. M., Jackson, J. D., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00600-4 · Cited by 137 · see citing works

Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial

Verschoor, Y. L., van de Haar, J., van den Berg, J. G., van Sandick, J. W., Kodach, L. L., van Dieren, J. M., Balduzzi, S., Grootscholten, C., Ijsselsteijn, M. E., Veenhof, A. A. F. A., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02758-x · Cited by 130 · see citing works

Roles of exosomes in immunotherapy for solid cancers

Lyu, C., Sun, H., Sun, Z., Liu, Y., & Wang, Q. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06494-z · Cited by 118 · see citing works

Innate lymphoid cells and innate-like T cells in cancer — at the crossroads of innate and adaptive immunity

Ruf, B., Greten, T. F., & Korangy, F. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00562-w · Cited by 118 · see citing works

Cancer cell-intrinsic mechanisms driving acquired immune tolerance

Ghorani, E., Swanton, C., & Quezada, S. A. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.004 · Cited by 108 · see citing works

Cancer immunotherapy by γδ T cells

Hayday, A., Déchanet‐Merville, J., Rossjohn, J., & Silva‐Santos, B. (2024) · Science · doi:10.1126/science.abq7248 · Cited by 107 · see citing works

The immune microenvironment of colorectal cancer

Kennel, K. B., & Greten, F. R. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00872-1 · Cited by 100 · see citing works

T Cells in Colorectal Cancer: Unravelling the Function of Different T Cell Subsets in the Tumor Microenvironment

Zheng, Z., Wieder, T., Mauerer, B., Schäfer, L., Kesselring, R., & Braumüller, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411673 · Cited by 105 · see citing works

Sequential immunotherapy and targeted therapy for metastatic BRAF V600 mutated melanoma: 4-year survival and biomarkers evaluation from the phase II SECOMBIT trial

Ascierto, P. A., Casula, M., Bulgarelli, J., Pisano, M., Piccinini, C., Piccin, L., Cossu, A., Mandalà, M., Ferrucci, P. F., Guidoboni, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44475-6 · Cited by 98 · see citing works

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

Ghasemi, A., Martínez-Usatorre, A., Li, L., Hicham, M., Guichard, A., Marcone, R., Fournier, N., Torchia, B., Bedoya, D. M., Davanture, S., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00668-y · Cited by 96 · see citing works

Neoadjuvant immunotherapy for dMMR and pMMR colorectal cancers: therapeutic strategies and putative biomarkers of response

Williams, C. J. M., Peddle, A. M., Kasi, P. M., Seligmann, J. F., Roxburgh, C. S. D., Middleton, G., & Tejpar, S. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00943-6 · Cited by 95 · see citing works

Oral administration of garlic-derived nanoparticles improves cancer immunotherapy by inducing intestinal IFNγ-producing γδ T cells

Xu, J., Yu, Y., Zhang, Y., Dai, H., Yang, Q., Wang, B., Ma, Q., Chen, Y., Xu, F., Shi, X., et al. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01722-1 · Cited by 90 · see citing works

Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function

Rancan, C., Arias-Badia, M., Dogra, P., Chen, B., Aran, D., Yang, H., Luong, D., Ilano, A., Li, J., Chang, H., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01448-7 · Cited by 88 · see citing works

Immune escape and resistance to immunotherapy in mismatch repair deficient tumors

Mestrallet, G., Brown, M., Bozkus, C. C., & Bhardwaj, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1210164 · Cited by 85 · see citing works

Intraepithelial Lymphocytes of the Intestine

Lockhart, A. A. K., Mucida, D., & Bilate, A. M. B. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090222-100246 · Cited by 88 · see citing works

Precision cancer medicine: Concepts, current practice, and future developments

Edsjö, A., Holmquist, L., Geoerger, B., Nowak, F., Gomon, G., Alix‐Panabières, C., Staaf, J., Ploeger, C., Lassen, U., Tourneau, C. L., et al. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13709 · Cited by 86 · see citing works

Immune evasion in cell-based immunotherapy: unraveling challenges and novel strategies

Li, Y.-R., Halladay, T., & Yang, L. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-00998-8 · Cited by 80 · see citing works

γδ T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors

Harmon, C., Zaborowski, A. M., Moore, H., Louis, P. S., Slattery, K., Duquette, D., Scanlan, J., Kane, H., Kunkemoeller, B. H., McIntyre, C., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00589-w · Cited by 75 · see citing works

T Cell Based Immunotherapy for Cancer: Approaches and Strategies

Want, M. Y., Bashir, Z., & Najar, R. A. (2023) · Vaccines · doi:10.3390/vaccines11040835 · Cited by 74 · see citing works

Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges

Pang, Z., Lu, M., Zhang, Y., Gao, Y., Bai, J. J., Gu, J., Xie, L., & Wu, W. (2023) · Biomarker Research · doi:10.1186/s40364-023-00534-0 · Cited by 68 · see citing works

Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment

Cao, M., Deng, Y., Hao, Q., Yan, H., Wang, Q., Dong, C., Wu, J., He, Y., Huang, L., Xia, X., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02226-7 · Cited by 71 · see citing works

Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells

Picco, G., Rao, Y., Saedi, A. A., Lee, Y., Vieira, S. F., Bhosle, S. G., May, K., Herranz, C., Walker, S. J., Shenje≠, R., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0052 · Cited by 68 · see citing works

PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy

Davies, D., Kamdar, S., Woolf, R., Zlatareva, I., Iannitto, M. L., Morton, C., Haque, Y., Martin, H., Biswas, D., Ndagire, S., et al. (2024) · Nature Cancer · doi:10.1038/s43018-023-00690-0 · Cited by 64 · see citing works

IGSF8 is an innate immune checkpoint and cancer immunotherapy target

Li, Y., Wu, X., Sheng, C., Liu, H., Liu, H., Tang, Y., Liu, C., Ding, Q., Xie, B., Xiao, X., et al. (2024) · Cell · doi:10.1016/j.cell.2024.03.039 · Cited by 62 · see citing works

Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms

Li, F., Yang, Z., Savage, T. M., Vincent, R. L., Santos, K. D. L., Ahn, A., Rouanne, M., Mariuzza, D. L., Danino, T., & Arpaia, N. (2024) · Science Immunology · doi:10.1126/sciimmunol.adn9879 · Cited by 59 · see citing works

Engineering innate immune cells for cancer immunotherapy

Tarannum, M., Ding, X., Barisa, M., Hu, S., Anderson, J., Romee, R., & Zhang, J. (2025) · Nature Biotechnology · doi:10.1038/s41587-025-02629-5 · Cited by 63 · see citing works

Efficient and accurate KIR and HLA genotyping with massively parallel sequencing dataPreprint

Song, L., Bai, G., Liu, X. S., Li, B., & Li, H. (2023) · Genome Research · doi:10.1101/gr.277585.122 · Cited by 51 · see citing works

Immunotherapy of MSI Cancer: Facts and Hopes

Wilbur, H. C., Le, D. T., & Agarwal, P. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1935 · Cited by 52 · see citing works

Immunotherapy for Colorectal Cancer with High Microsatellite Instability: The Ongoing Search for Biomarkers

Ros, J., Baraibar, I., Gonzalez, N. S., Rodríguez-Castells, M., Salvà, F., Tabernero, J. M., & Élez, E. (2023) · Cancers · doi:10.3390/cancers15174245 · Cited by 53 · see citing works

γδ T cells as critical anti-tumor immune effectors

Arias-Badia, M., Chang, R., & Fong, L. H. (2024) · Nature Cancer · doi:10.1038/s43018-024-00798-x · Cited by 51 · see citing works

Unlocking the potential of allogeneic Vδ2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering

Lee, D., Dunn, Z. S., Guo, W., Rosenthal, C. J., Penn, N. E., Yu, Y., Zhou, K., Li, Z., Ma, F., Li, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42619-2 · Cited by 49 · see citing works

The complex role of immune cells in antigen presentation and regulation of T-cell responses in hepatocellular carcinoma: progress, challenges, and future directions

Ning, J., Wang, Y., & Tao, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1483834 · Cited by 47 · see citing works

Genomic instability as a driver and suppressor of anti-tumor immunity

Requesens, M., Foijer, F., Nijman, H. W., & de Bruyn, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1462496 · Cited by 44 · see citing works

Antitumor Immune Responses in B2M -Deficient Cancers

Torrejon, D. Y., Galvez, M., Abril-Rodríguez, G., Campbell, K. M., Medina, E., Vega-Crespo, A., Kalbasi, A. K., Comı́n-Anduix, B., & Ribas, A. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0139 · Cited by 41 · see citing works

Association of Clostridium butyricum Therapy Using the Live Bacterial Product CBM588 with the Survival of Patients with Lung Cancer Receiving Chemoimmunotherapy Combinations

Tomita, Y., Sakata, S., Imamura, K., Iyama, S., Jodai, T., Saruwatari, K., Hamada, S., Akaike, K., Anai, M., Fukusima, K., et al. (2023) · Cancers · doi:10.3390/cancers16010047 · Cited by 42 · see citing works

γδ T cell antigen receptor polyspecificity enables T cell responses to a broad range of immune challenges

Guo, J., Chowdhury, R. R., Mallajosyula, V. V. A., Xie, J., Dubey, M., Liu, Y., Li, J., Wei, Y.-L., Palanski, B. A., Wang, C., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315592121 · Cited by 39 · see citing works

Current and emerging concepts for systemic treatment of metastatic colorectal cancer

Steup, C., Kennel, K. B., Neurath, M. F., Fichtner-Feigl, S., & Greten, F. R. (2025) · Gut · doi:10.1136/gutjnl-2025-335412 · Cited by 39 · see citing works

The role of B2M in cancer immunotherapy resistance: function, resistance mechanism, and reversal strategies

Han, X., Zhang, J., Li, W., Huang, X., Wang, X., Wang, B., Gao, L., & Chen, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1512509 · Cited by 39 · see citing works

Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer

Marteau, V., Nemati, N., Handler, K., Raju, D., Kirchmair, A., Rieder, D., Soto, E. K., Fotakis, G., de Lange, G., Carollo, S., et al. (2026) · Cancer Cell · doi:10.1016/j.ccell.2025.12.003 · Cited by 37 · see citing works

Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient

Lien, S. C., Ly, D., Yang, S. Y. C., Wang, B. X., Clouthier, D., Paul, M. S., Gadalla, R., Noamani, B., Garcia-Batres, C. R., Boross-Harmer, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45449-y · Cited by 36 · see citing works

Generating and using real-world data: A worthwhile uphill battle

Verkerk, K., & Voest, E. E. (2024) · Cell · doi:10.1016/j.cell.2024.02.012 · Cited by 39 · see citing works

Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy Efficacy

Reinstein, Z. Z., Zhang, Y., Ospina, O. E., Nichols, M. D., Chu, V. A., Pulido, A. D. M., Prieto, K., Nguyen, J. V., Yin, R., Moran Segura, C., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0798 · Cited by 33 · see citing works

Dysfunctional tumor-infiltrating Vδ1 + T lymphocytes in microsatellite-stable colorectal cancer

Stary, V., Pandey, R. V., List, J., Kleißl, L., Deckert, F., Kabiljo, J., Laengle, J., Gerakopoulos, V., Oehler, R., Watzke, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51025-1 · Cited by 33 · see citing works

IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR+HER2− breast cancer via CX3CR1+ macrophages

Petroni, G., Galassi, C., Gouin, K. H., Chen, H., Buqué, A., Bloy, N., Yamazaki, T., Sato, A., Beltrán‐Visiedo, M., Campia, G., et al. (2025) · Nature Cancer · doi:10.1038/s43018-025-01007-z · Cited by 33 · see citing works

EBV-induced T-cell responses in EBV-specific and nonspecific cancers

Zhang, Q., & Xu, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1250946 · Cited by 31 · see citing works

β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Suzuki, T., Kilbey, A., Casa-Rodríguez, N., Lawlor, A., Γεωργακοπούλου, Α., Hayman, H., Swe, K. L. Y., Nordin, A., Cantù, C., Vantourout, P., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0644 · Cited by 31 · see citing works

Therapeutic avenues for γδ T cells in cancer

Costa, G. P., Mensurado, S., & Silva‐Santos, B. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-007955 · Cited by 31 · see citing works

γδ T cells and the PD-1/PD-L1 axis: a love–hate relationship in the tumor microenvironment

Liu, J., Wu, M., Yang, Y., Wang, Z., He, S., Tian, X., & Wang, H. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05327-z · Cited by 31 · see citing works

TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma

Yakou, M. H., Ghilas, S., Tran, K., Liao, Y., Afshar‐Sterle, S., Kumari, A. N., Schmid, K., Dijkstra, C., Inguanti, C., Ostrouska, S., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.adf2163 · Cited by 30 · see citing works

DNA repair-dependent immunogenic liabilities in colorectal cancer: opportunities from errors

Amodio, V., Vitiello, P. P., Bardelli, A., & Germano, G. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02848-8 · Cited by 32 · see citing works

Therapeutic targeting of mismatch repair-deficient cancers

Johannet, P. M., Rousseau, B., Aghajanian, C. A., Foote, M. B., & Diaz, L. A. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01054-6 · Cited by 34 · see citing works

Coengineering specificity, safety, and function into T cells for cancer immunotherapy

Attianese, G. M. P. G., Ash, S., & Irving, M. B. (2023) · Immunological Reviews · doi:10.1111/imr.13252 · Cited by 29 · see citing works

Identification of driver genes in lupus nephritis based on comprehensive bioinformatics and machine learning

Wang, Z., Hu, D., Pei, G., Zeng, R., & Yao, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1288699 · Cited by 27 · see citing works

Recent highlights of cancer immunotherapy

Fan, X. (2023) · Holistic Integrative Oncology · doi:10.1007/s44178-023-00057-6 · Cited by 27 · see citing works

Subclonal immune evasion in non-small cell lung cancer

Dijkstra, K. K., Vendramin, R., Karagianni, D., Witsen, M., Gálvez‐Cancino, F., Hill, M. S., Foster, K. A., Barbè, V., Angelova, M., Hynds, R. E., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.06.012 · Cited by 30 · see citing works

Intraperitoneal infusion of NKG2D CAR-NK cells induces endogenous CD8+ T cell activation in patients with advanced colorectal cancer

Li, B., Zhu, X., Ge, J., Zhang, H., Gao, Y., Bao, X., Dai, X., Du, Z., Tu, X., Zhou, T., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.05.026 · Cited by 26 · see citing works

The Interface of Gene Editing with Regenerative Medicine

Farag, V. E., Devey, E., & Leong, K. W. (2024) · Engineering · doi:10.1016/j.eng.2024.10.019 · Cited by 21 · see citing works

Local γδ T cells: translating promise to practice in cancer immunotherapy

Zlatareva, I., & Wu, Y. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02303-0 · Cited by 24 · see citing works

The single cell immunogenomic landscape after neoadjuvant immunotherapy combined chemotherapy in esophageal squamous cell carcinoma

Wang, Z., Zhao, Y., Wo, Y., Peng, Y., Hu, W., Wu, Z., Liu, P., Shang, Y., Liu, C., Chen, X., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216951 · Cited by 23 · see citing works

Tumor-Infiltrating Immune Cells in Colorectal Cancer

Ferkel, S. A. M., Holman, E. A., Sojwal, R. S., Rubin, S. J. S., & Rogalla, S. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101091 · Cited by 22 · see citing works

Uncovering the mysteries of human gamma delta T cells: from origins to novel therapeutics

Biały, S., & Bogunia‐Kubik, K. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1543454 · Cited by 22 · see citing works

Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential

Yu, X., Song, L., Cen, L., Cao, B., Tao, R., Shen, Y., Abate‐Daga, D., Rodrı́guez, P. C., Conejo-Garcia, J. R., & Wang, X. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101764 · Cited by 21 · see citing works

Leveraging immune resistance archetypes in solid cancer to inform next-generation anticancer therapies

Anderson, K. G., Braun, D. A., Buqué, A., Gitto, S. B., Guerriero, J. L., Horton, B. L., Keenan, B. P., Kim, T. S., Overacre-Delgoffe, A. E., Ruella, M., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006533 · Cited by 21 · see citing works

Image‐based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno‐oncology Biomarker Working Group on Breast Cancer

Jahangir, C. A., Page, D. B., Broeckx, G., Gonzalez, C. A., Burke, C., Murphy, C. L., Reis-Filho, J. S., Ly, A., Harms, P. W., Gupta, R., et al. (2024) · The Journal of Pathology · doi:10.1002/path.6238 · Cited by 21 · see citing works

Multimodal profiling of chordoma immunity reveals distinct immune contextures

van Oost, S., Meijer, D. M., Ijsselsteijn, M. E., Roelands, J. P., van den Akker, B. E., van der Breggen, R., Bruijn, I. H. B., van der Ploeg, M., Wijers‐Koster, P. M., Polak, S. B., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-008138 · Cited by 21 · see citing works

Systematic analysis of human colorectal cancer scRNA-seq revealed limited pro-tumoral IL-17 production potential in gamma delta T cells

Ran, R., Trapečar, M., & Brubaker, D. K. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101072 · Cited by 20 · see citing works

Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma

Paczkowska, J., Tang, M., Wright, K., Song, L., Luu, K., Shanmugam, V., Welsh, E. L., Weirather, J. L., Besson, N. R., Olszewski, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54512-7 · Cited by 20 · see citing works

Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer

Blanco-Domínguez, R., Barros, L., Carreira, M., van der Ploeg, M., Condeço, C., Marsères, G., Ferreira, C., Costa, C., Ferreira, C. M., Déchanet‐Merville, J., et al. (2025) · Nature Cancer · doi:10.1038/s43018-025-00948-9 · Cited by 20 · see citing works

Unveiling the functional roles of patient‐derived tumour organoids in assessing the tumour microenvironment and immunotherapy

Chen, D., Xu, L., Xuan, M., Chu, Q., & Xue, C. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1802 · Cited by 20 · see citing works

Disrupting the balance between activating and inhibitory receptors of γδT cells for effective cancer immunotherapy

Beringer, D. X., Straetemans, T., Minguet, S., Riillo, C., Lynch, L., Sebestyén, Z., & Kuball, J. H. E. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00830-x · Cited by 18 · see citing works

Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape

Fallarino, F., & Blank, C. U. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01222-w · Cited by 19 · see citing works

Perioperative chemoimmunotherapy induces strong immune responses and long-term survival in patients with HLA class I-deficient non-small cell lung cancer

Molina-Alejandre, M., Perea, F., Calvo, V., Martínez-Toledo, C., Nadal, E., Sierra‐Rodero, B., Casarrubios, M., Casal‐Rubio, J., Martínez‐Martí, A., Insa, A., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009762 · Cited by 20 · see citing works

ADI-270: an armored allogeneic gamma delta T cell therapy designed to target CD70-expressing solid and hematologic malignancies

Nishimoto, K. P., Lamture, G., Chanthery, Y. H., Teague, A., Verma, Y., Au, M., Smith‐Boeck, M., Salum, M., Murthy, P., Gundurao, S. R. Y., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-011704 · Cited by 17 · see citing works

Isolation and expansion of pure and functional γδ T cells

Verkerk, T., Pappot, A. T., Jorritsma, T., King, L. A., Duurland, M. C., Spaapen, R. M., & van Ham, S. M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1336870 · Cited by 17 · see citing works

Advances in the application of colorectal cancer organoids in precision medicine

Zhang, Y., Meng, R., Sha, D., Gao, H., Wang, S., Zhou, J., Wang, X., Li, F., Li, X., & Song, W. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1506606 · Cited by 17 · see citing works

Genetic immune escape in cancer: timing and implications for treatment

Martínez-Jiménez, F., & Chowell, D. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.11.002 · Cited by 17 · see citing works

Radiotherapy in combination with PD-1 and TIGIT blockade mediate antitumor abscopal effects and immune memory via CD8+ T cells

Wang, C., Han, L., Zhang, J., Ji, Q., Guo, X., Li, Y., Li, S., He, J., He, F., Dai, W., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217935 · Cited by 16 · see citing works

The role of γδ T cells in the immunopathogenesis of inflammatory diseases: from basic biology to therapeutic targeting

Bernal‐Alferes, B., Gómez-Mosqueira, R., Ortega-Tapia, G. T., Burgos‐Vargas, R., Garcı́a-Latorre, E., Domínguez‐López, M. L., & Romero‐López, J. P. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad046 · Cited by 16 · see citing works

γδ T cells: Major advances in basic and clinical research in tumor immunotherapy

Zhao, Y., Dong, P., He, W., Zhang, J., & Chen, H. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002781 · Cited by 16 · see citing works

Genetic and immune landscape evolution in MMR‐ deficient colorectal cancer

Challoner, B. R., Woolston, A., Lau, D. K., Buzzetti, M., Fong, C., Barber, L. J., Anandappa, G., Crux, R., Assiotis, I., Fenwick, K., et al. (2023) · The Journal of Pathology · doi:10.1002/path.6228 · Cited by 19 · see citing works

Ex vivo modeling of precision immuno-oncology responses in lung cancer

Alsaed, B., Smolander, J., Laitinen, H. K., Lin, L., Bobik, N., Lahtinen, L., Räsänen, M., Jansouz, S., Peltonen, K., Jokinen, E., et al. (2024) · Science Advances · doi:10.1126/sciadv.adq6830 · Cited by 15 · see citing works

CAR-γδ T Cells Targeting Claudin18.2 Show Superior Cytotoxicity Against Solid Tumor Compared to Traditional CAR-αβ T Cells

Zhao, Y., Li, Y., Wang, S., Han, J., Lu, M., Xu, Y., Qiao, W., Cai, M., Yi, X., Hu, Y., et al. (2025) · Cancers · doi:10.3390/cancers17060998 · Cited by 15 · see citing works

Intratumoral heterogeneity and immunotherapy resistance: clinical implications

Keenan, B. P., Yadav, M., Ansstas, G., Fabrizio, D. A., Murugesan, K., Montesion, M., Niyogi, D. G., Mellman, I., & Melero, I. (2025) · Annals of Oncology · doi:10.1016/j.annonc.2025.10.1239 · Cited by 18 · see citing works

Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid

Zhang, Y., Xiang, Z., Xu, Y., Cheung, L. S., Wang, X., Wang, M., Wong, H. H. W., Zhu, Z., Zhang, W., Gao, Y., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02295-8 · Cited by 14 · see citing works

Assessment of cancer cell‐expressed HLA class I molecules and their immunopathological implications

Kubo, T., Asano, S., Sasaki, K., Murata, K., Kanaseki, T., Tsukahara, T., Hirohashi, Y., & Torigoe, T. (2024) · HLA · doi:10.1111/tan.15472 · Cited by 14 · see citing works

Single-cell transcriptomic analysis of the immune microenvironment in pediatric acute leukemia

Yuan, J., Zhang, J., Zhao, B., Liu, F., Liu, T., Duan, Y.-J., Chen, Y., Chen, X., Zou, Y., Li, Z., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217018 · Cited by 13 · see citing works

Mapping intratumor heterogeneity across layers for advancing immunotherapy

Marine, J., Bartok, O., Sagie, S., Vitiello, P. P., Bardelli, A., Weller, C., Chang, T., Tonelli, C., Spranger, S., Ruppin, E., et al. (2026) · Cell · doi:10.1016/j.cell.2026.03.025 · Cited by 13 · see citing works

Organoids as an Enabler of Precision Immuno-Oncology

Zhao, J., Fong, A. S. W., Seow, S. V., & Toh, H. C. (2023) · Cells · doi:10.3390/cells12081165 · Cited by 13 · see citing works

Strategies to overcome low MHC-I expression in paediatric and adult tumours

Guillaume, J., Perzolli, A., & Boes, M. L. (2023) · Immunotherapy Advances · doi:10.1093/immadv/ltad028 · Cited by 12 · see citing works

Improved overall survival in patients with high-grade serous ovarian cancer is associated with CD16a+ immunologic neighborhoods containing NK cells, T cells and macrophages

Nersesian, S., Arseneau, R. J., Mejia, J. P., Lee, S. N., Westhaver, L. P., Griffiths, N. W., Grantham, S. R., Meunier, L., Communal, L., Mukherjee, A., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1307873 · Cited by 13 · see citing works

From backstage to the spotlight: γδT cells in cancer

Wiesheu, R., & Coffelt, S. B. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.08.017 · Cited by 13 · see citing works

CAR-γδ T cells: a new paradigm of programmable innate immune sentinels and their systemic applications in cancer and beyond

Fang, X., Yan, S., He, L., & Deng, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1735763 · Cited by 12 · see citing works

γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defectsPreprint

Vries, N. L. D., van de Haar, J., Veninga, V., Chalabi, M., Ijsselsteijn, M. E., van der Ploeg, M., van den Bulk, J., Ruano, D., Haanen, J. B. A. G., Schumacher, T. N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.14.464229 · Cited by 3 · see citing works

To-day's Drugs

(1962) · BMJ · doi:10.1136/bmj.2.5319.1608

733MO γδT cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

van de Haar, J., van de Haar, J., Veninga, V., Chalabi, M., Ijsselsteijn, M. E., van der Ploeg, M., van den Bulk, J., Ruano, D., van den Berg, J. G., Schumacher, T. N., et al. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.07.859 · Cited by 313 · see citing works

γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors

Silva‐Santos, B., & Mensurado, S. (2023) · Nature Immunology · doi:10.1038/s41590-023-01429-w · Cited by 11 · see citing works

γδ T cells mediate immunotherapy responses when cancers lack MHC class I

Bordon, Y. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00842-4 · Cited by 4 · see citing works