Metabolic programs of T cell tissue residency empower tumour immunity

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works

Trimmomatic: a flexible trimmer for Illumina sequence data

Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works

GSVA: gene set variation analysis for microarray and RNA-Seq data

Hänzelmann, S., Castelo, R., & Guinney, J. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-7 · Cited by 15,440 · see citing works

Fast, sensitive and accurate integration of single-cell data with Harmony

Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488 · see citing works

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

Gu, Z., Eils, R., & Schlesner, M. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw313 · Cited by 10,122 · see citing works

QuPath: Open source software for digital pathology image analysis

Bankhead, P., Loughrey, M. B., Fernández, J. A., Dombrowski, Y., McArt, D. G., Dunne, P. D., McQuaid, S., Gray, R. T., Murray, L. J., Coleman, H. G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17204-5 · Cited by 8,908 · see citing works

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

Aran, D., Looney, A. P., Liu, L., Wu, E., Fong, V., Hsu, A., Chak, S., Naikawadi, R. P., Wolters, P. J., Abate, A. R., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0276-y · Cited by 4,984 · see citing works

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

MacLean, B., Tomazela, D. M., Shulman, N., Chambers, M., Finney, G. L., Frewen, B., Kern, R., Tabb, D. L., Liebler, D. C., & MacCoss, M. J. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq054 · Cited by 4,697 · see citing works

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

Li, W., Xu, H., Xiao, T., Cong, L., Love, M. I., Zhang, F., Irizarry, R. A., Liu, J. S., Brown, M., & Liu, X. S. (2014) · Genome Biology · doi:10.1186/s13059-014-0554-4 · Cited by 2,684 · see citing works

Easy quantitative assessment of genome editing by sequence trace decomposition

Brinkman, E. K., Chen, T., Amendola, M., & van Steensel, B. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku936 · Cited by 2,390 · see citing works

Recovering Gene Interactions from Single-Cell Data Using Data Diffusion

van Dijk, D., Sharma, R., Nainys, J., Yim, K., Kathail, P., Carr, A. J., Burdziak, C., Moon, K. R., Chaffer, C. L., Pattabiraman, D., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.061 · Cited by 1,829 · see citing works

Pan-cancer single-cell landscape of tumor-infiltrating T cells

Zheng, L., Qin, S., Si, W., Wang, A., Xing, B., Gao, R., Ren, X., Wang, L., Wu, X., Zhang, J., et al. (2021) · Science · doi:10.1126/science.abe6474 · Cited by 1,402 · see citing works

SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology

Shimano, H., & Sato, R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.91 · Cited by 1,174 · see citing works

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157 · see citing works

UCell: robust and scalable single-cell gene signature scoring

Andreatta, M., & Carmona, S. J. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.06.043 · Cited by 1,104 · see citing works

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

Ma, X., Bi, E., Lu, Y., Su, P., Huang, C., Liu, L., Wang, Q., Yang, M., Kalady, M. F., Qian, J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.04.002 · Cited by 1,033 · see citing works

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

Mackay, L. K., Minnich, M., Kragten, N. A. M., Liao, Y., Nota, B., Seillet, C., Zaid, A., Man, K., Preston, S., Freestone, D., et al. (2016) · Science · doi:10.1126/science.aad2035 · Cited by 1,010 · see citing works

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

Jiang, X., Clark, R. A., Liu, L., Wagers, A. J., Fuhlbrigge, R. C., & Kupper, T. S. (2012) · Nature · doi:10.1038/nature10851 · Cited by 883 · see citing works

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Scharping, N. E., Menk, A. V., Moreci, R. S., Whetstone, R. D., Dadey, R. E., Watkins, S. C., Ferris, R. L., & Delgoffe, G. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.009 · Cited by 848 · see citing works

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

Xu, S., Chaudhary, O., Rodríguez-Morales, P., Sun, X., Chen, D., Zappasodi, R., Xu, Z. Z., Pinto, A. F. M., Williams, A. E., Schulze, I., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.003 · Cited by 815 · see citing works

Intravascular staining for discrimination of vascular and tissue leukocytes

Anderson, K. G., Mayer-Barber, K., Sung, H., Beura, L., James, B. R., Taylor, J. J., Qunaj, L., Griffith, T. S., Vezys, V., Barber, D. L., et al. (2014) · Nature Protocols · doi:10.1038/nprot.2014.005 · Cited by 812 · see citing works

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

Schenkel, J. M., Fraser, K. A., Beura, L. K., Pauken, K. E., Vezys, V., & Masopust, D. (2014) · Science · doi:10.1126/science.1254536 · Cited by 731 · see citing works

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

Pan, Y., Tian, T., Park, C. O., Lofftus, S. Y., Mei, S., Liu, X., Luo, C., O’Malley, J. T., Gehad, A. E., Teague, J. E., et al. (2017) · Nature · doi:10.1038/nature21379 · Cited by 718 · see citing works

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Scharping, N. E., Menk, A. V., Moreci, R. S., Whetstone, R. D., Dadey, R., Watkins, S. C., Ferris, R. L., & Delgoffe, G. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.009 · Cited by 705 · see citing works

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D. (2015) · Cell · doi:10.1016/j.cell.2015.03.031 · Cited by 685 · see citing works

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

Milner, J. J., Toma, C., Yu, B., Zhang, K., Omilusik, K., Phan, A. T., Wang, D., Getzler, A. J., Nguyen, T., Crotty, S., et al. (2017) · Nature · doi:10.1038/nature24993 · Cited by 677 · see citing works

A vaccine strategy that protects against genital herpes by establishing local memory T cells

Shin, H., & Iwasaki, A. (2012) · Nature · doi:10.1038/nature11522 · Cited by 646 · see citing works

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

Teijaro, J. R., Turner, D., Pham, Q., Wherry, E. J., Lefrançois, L., & Farber, D. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102243 · Cited by 641 · see citing works

Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation

Mackay, L. K., Stock, A. T., Ma, J., Jones, C. M., Kent, S., Mueller, S. N., Heath, W., Carbone, F., & Gebhardt, T. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1202288109 · Cited by 638 · see citing works

CD8+CD103+ Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients

Djenidi, F., Adam, J., Goubar, A., Durgeau, A., Meurice, G., de Montpréville, V., Validire, P., Besse, B., & Mami-Chouaib, F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402711 · Cited by 622 · see citing works

Tissue-Resident T Cells and Other Resident Leukocytes

Masopust, D., & Soerens, A. G. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053214 · Cited by 608 · see citing works

CD8+ T cell metabolism in infection and cancer

Reina-Campos, M., Scharping, N. E., & Goldrath, A. W. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00537-8 · Cited by 574 · see citing works

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

Kidani, Y., Elsaesser, H., Hock, M. B., Vergnes, L., Williams, K. J., Argus, J. P., Marbois, B. N., Komisopoulou, E., Wilson, E. B., Osborne, T. F., et al. (2013) · Nature Immunology · doi:10.1038/ni.2570 · Cited by 552 · see citing works

Lung‐resident memory CD8 T cells (TRM) are indispensable for optimal cross‐protection against pulmonary virus infection

Wu, T., Hu, Y., Lee, Y.-T., Bouchard, K. R., Benechet, A. P., Khanna, K., & Cauley, L. S. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.0313180 · Cited by 537 · see citing works

Skin-resident memory CD8 + T cells trigger a state of tissue-wide pathogen alert

Ariotti, S., Hogenbirk, M. A., Dijkgraaf, F. E., Visser, L. L., Hoekstra, M. E., Song, J., Jacobs, H., Haanen, J. B. A. G., & Schumacher, T. N. (2014) · Science · doi:10.1126/science.1254803 · Cited by 534 · see citing works

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer

Ganesan, A.-P., Clarke, J., Wood, O., Garrido-Martin, E. M., Chee, S. J., Mellows, T., Samaniego-Castruita, D., Singh, D., Seumois, G., Alzetani, A., et al. (2017) · Nature Immunology · doi:10.1038/ni.3775 · Cited by 528 · see citing works

Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

Wei, J., Long, L., Zheng, W., Dhungana, Y., Lim, S. A., Guy, C. S., Wang, Y., Wang, Y., Qian, C., Xu, B., et al. (2019) · Nature · doi:10.1038/s41586-019-1821-z · Cited by 442 · see citing works

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

Fernandez-Ruiz, D., Ng, W. Y., Holz, L. E., Ma, J. Z., Zaid, A., Wong, Y. C., Lau, L. S., Mollard, V., Cozijnsen, A., Collins, N., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.011 · Cited by 438 · see citing works

A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells

Iijima, N., & Iwasaki, A. (2014) · Science · doi:10.1126/science.1257530 · Cited by 420 · see citing works

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses

Menk, A. V., Scharping, N. E., Rivadeneira, D. B., Calderon, M. J., Watson, M. J., Dunstane, D., Watkins, S. C., & Delgoffe, G. M. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20171068 · Cited by 313 · see citing works

Induction of resident memory T cells enhances the efficacy of cancer vaccine

Nizard, M., Roussel, H., Diniz, M. O., Karaki, S., Tran, T., Voron, T., Dransart, E., Sandoval, F., Riquet, M., Rance, B., et al. (2017) · Nature Communications · doi:10.1038/ncomms15221 · Cited by 308 · see citing works

Resident memory T cells in the skin mediate durable immunity to melanoma

Malik, B. T., Byrne, K. T., Vella, J. L., Zhang, P., Shabaneh, T. B., Steinberg, S. M., Molodtsov, A. K., Bowers, J. S., Angeles, C. V., Paulos, C. M., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aam6346 · Cited by 278 · see citing works

Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses

Boland, B. S., He, Z., Tsai, M. S., Olvera, J. G., Omilusik, K. D., Duong, H. G., Kim, E. S., Limary, A. E., Jin, W., Milner, J. J., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb4432 · Cited by 274 · see citing works

Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection

van Konijnenburg, D. P. H., Reis, B. S., Pedicord, V. A., Farache, J., Victora, G. D., & Mucida, D. (2017) · Cell · doi:10.1016/j.cell.2017.08.046 · Cited by 273 · see citing works

Biological Insights into TCRγδ+ and TCRαβ+ Intraepithelial Lymphocytes Provided by Serial Analysis of Gene Expression (SAGE)

Shires, J., Theodoridis, E., & Hayday, A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00192-3 · Cited by 271 · see citing works

Tissue-resident memory T cells in breast cancer control and immunotherapy responses

Byrne, A., Savas, P., Sant, S., Li, R., Virassamy, B., Luen, S., Beavis, P., Mackay, L. K., Neeson, P., & Loi, S. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0333-y · Cited by 253 · see citing works

Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

Crowl, J. T., Heeg, M., Ferry, A., Milner, J. J., Omilusik, K. D., Toma, C., He, Z., Chang, J. T., & Goldrath, A. W. (2022) · Nature Immunology · doi:10.1038/s41590-022-01229-8 · Cited by 253 · see citing works

Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation

Yu, B., Zhang, K., Milner, J. J., Toma, C., Chen, R., Scott-Browne, J. P., Pereira, R. M., Crotty, S., Chang, J. T., Pipkin, M. E., et al. (2017) · Nature Immunology · doi:10.1038/ni.3706 · Cited by 248 · see citing works

Immune modulatory effects of statins

Zeiser, R. (2018) · Immunology · doi:10.1111/imm.12902 · Cited by 248 · see citing works

Early precursors and molecular determinants of tissue-resident memory CD8 + T lymphocytes revealed by single-cell RNA sequencing

Kurd, N. S., He, Z., Louis, T. L., Milner, J. J., Omilusik, K. D., Jin, W., Tsai, M. S., Widjaja, C. E., Kanbar, J. N., Olvera, J. G., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz6894 · Cited by 209 · see citing works

Tissue-Resident Memory T Cells in Cancer Immunosurveillance

Park, S. L., Gebhardt, T., & Mackay, L. K. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.06.002 · Cited by 190 · see citing works

Functional T cells are capable of supernumerary cell division and longevity

Soerens, A. G., Künzli, M., Quarnstrom, C. F., Scott, M. C., Swanson, L., Locquiao, J., Ghoneim, H. E., Zehn, D., Youngblood, B., Vezys, V., et al. (2023) · Nature · doi:10.1038/s41586-022-05626-9 · Cited by 177 · see citing works

Attributes of γδ intraepithelial lymphocytes as suggested by their transcriptional profile

Fahrer, A. M., Konigshofer, Y., Kerr, E. M., Ghandour, G., Mack, D. H., Davis, M. M., & Chien, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171320798 · Cited by 168 · see citing works

γδ T cells regulate the intestinal response to nutrient sensing

Sullivan, Z. A., Khoury-Hanold, W., Lim, J., Smillie, C. S., Biton, M., Reis, B. S., Zwick, R. K., Pope, S. D., Israni-Winger, K., Parsa, R., et al. (2021) · Science · doi:10.1126/science.aba8310 · Cited by 167 · see citing works

HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity

Ye, Q., Lau, R., Mathews, I. T., Birkholz, E. A., Watrous, J. D., Azimi, C. S., Pogliano, J., Jain, M., & Corbett, K. D. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.12.009 · Cited by 159 · see citing works

In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions

Huang, H., Zhou, P., Wei, J., Long, L., Shi, H., Dhungana, Y., Chapman, N. M., Fu, G., Saravia, J., Raynor, J. L., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.021 · Cited by 156 · see citing works

Transcriptional programming of tissue-resident memory CD8+ T cells

Milner, J., & Goldrath, A. W. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.03.017 · Cited by 124 · see citing works

Organ-specific isoform selection of fatty acid–binding proteins in tissue-resident lymphocytes

Frizzell, H., Fonseca, R., Christo, S., Evrard, M., Cruz-Gomez, S., Zanluqui, N., von Scheidt, B., Freestone, D., Park, S. L., McWilliam, H., et al. (2020) · Science immunology · doi:10.1126/sciimmunol.aay9283 · Cited by 122 · see citing works

Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo

McCausland, M. M., & Crotty, S. (2007) · Journal of Virological Methods · doi:10.1016/j.jviromet.2007.08.025 · Cited by 119 · see citing works

Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target

Pauls, S. D., & Marshall, A. J. (2017) · European Journal of Immunology · doi:10.1002/eji.201646795 · Cited by 118 · see citing works

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

Milner, J. J., Nguyen, H., Omilusik, K. D., Reina‐Campos, M., Tsai, M. S., Toma, C., Delpoux, A., Boland, B. S., Hedrick, S. Μ., Chang, J. T., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008571117 · Cited by 117 · see citing works

Expansible residence decentralizes immune homeostasis

Wijeyesinghe, S. P., Beura, L., Pierson, M. J., Stolley, J., Adam, O. A., Ruscher, R., Steinert, E. M., Rosato, P. C., Vezys, V., & Masopust, D. (2021) · Nature · doi:10.1038/s41586-021-03351-3 · Cited by 113 · see citing works

The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation

Trindade, B. C., Ceglia, S., Berthelette, A., Raso, F., Howley, K., Muppidi, J. R., & Reboldi, A. (2021) · Immunity · doi:10.1016/j.immuni.2021.09.004 · Cited by 79 · see citing works

Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes

Konjar, Š., Frising, U. C., Ferreira, C., Hinterleitner, R., Mayassi, T., Zhang, Q., Blankenhaus, B., Haberman, N., Loo, Y., Guedes, J., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aan2543 · Cited by 75 · see citing works

Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics

O’Connor, A., Quizon, P. M., Albright, J., Lin, F. T., & Bennett, B. J. (2014) · Mammalian Genome · doi:10.1007/s00335-014-9540-0 · Cited by 67 · see citing works

Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA

Passi, S., Stancato, A., Aleo, E., Dmitrieva, A., & Littarru, G. P. (2003) · BioFactors · doi:10.1002/biof.5520180213 · Cited by 57 · see citing works

The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice

Lanterna, C., Musumeci, A., Raccosta, L., Corna, G., Moresco, M. A., Maggioni, D., Fontana, R., Doglioni, C., Bordignon, C., Traversari, C., et al. (2016) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-016-1884-8 · Cited by 48 · see citing works

Functional Analysis of Immune Signature Genes in Th1* Memory Cells Links ISOC1 and Pyrimidine Metabolism to IFN-γ and IL-17 Production

Kushnareva, Y., Mathews, I. T., Andreyev, A. Y., Altay, G., Arlehamn, C. S. L., Vijayanand, P., Nilsson, R., Jain, M., Sette, A., Peters, B., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000672 · Cited by 23 · see citing works

Conditional Deletion of PTEN in Peripheral T Cells Augments TCR-Mediated Activation but Does Not Abrogate CD28 Dependency or Prevent Anergy Induction

Locke, F. L., Zha, Y., Zheng, Y., Driessens, G., & Gajewski, T. F. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202018 · Cited by 16 · see citing works

Advances in molecular pathology and therapy of non-small cell lung cancer

Huang, Q., Li, Y., Huang, Y., Wu, J., Bao, W., Xue, C., Li, X., Dong, S., Dong, Z., & Hu, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02243-6 · Cited by 197 · see citing works

Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity

Zhou, L., Lian, G., Zhou, T., Cai, Z., Yang, S., Li, W., Cheng, L., Ye, Y., He, M., Lu, J., et al. (2025) · Nature Cancer · doi:10.1038/s43018-025-00937-y · Cited by 146 · see citing works

Lysine lactylation in the regulation of tumor biology

Yang, Z., Zheng, Y., & Gao, Q. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.01.011 · Cited by 109 · see citing works

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted

Reina‐Campos, M., Monell, A., Ferry, A., Luna, V., Cheung, K. P., Galletti, G., Scharping, N. E., Takehara, K. K., Quon, S., Challita, P. P., et al. (2025) · Nature · doi:10.1038/s41586-024-08466-x · Cited by 108 · see citing works

CD8+ T cell-based cancer immunotherapy

Chen, Y., Yu, D., Qian, H., Shi, Y., & Tao, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05134-6 · Cited by 108 · see citing works

A new era of cancer immunotherapy: combining revolutionary technologies for enhanced CAR-M therapy

Li, N., Geng, S., Dong, Z., Jin, Y., Ying, H., Li, H., & Shi, L. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02032-9 · Cited by 104 · see citing works

Nutrients: Signal 4 in T cell immunity

Raynor, J. L., & Chi, H. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20221839 · Cited by 94 · see citing works

Nanomaterial-enabled metabolic reprogramming strategies for boosting antitumor immunity

Ma, M., Zhang, Y., Pu, K., & Tang, W. (2024) · Chemical Society Reviews · doi:10.1039/d4cs00679h · Cited by 97 · see citing works

Resident memory T cells and cancer

Gavil, N. V., Cheng, K., & Masopust, D. (2024) · Immunity · doi:10.1016/j.immuni.2024.06.017 · Cited by 94 · see citing works

Epigenetic regulation of tumor immunity

Pang, L., Zhou, F., Liu, Y., Ali, H. A., Khan, F., Heimberger, A. B., & Chen, P. (2024) · Journal of Clinical Investigation · doi:10.1172/jci178540 · Cited by 74 · see citing works

The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling

Huang, M., Yu, X., Wang, Q., Jiang, Z., Li, X., Chen, W., & Song, C. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01455-z · Cited by 70 · see citing works

Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome

Venkatraman, K., Lee, C. T., García, G. C., Mahapatra, A., Milshteyn, D., Perkins, G. A., Keun-young Kim, A., Pasolli, H. A., Phan, S., Lippincott‐Schwartz, J., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2023114054 · Cited by 67 · see citing works

A Bioactive Injectable Hydrogel Regulates Tumor Metastasis and Wound Healing for Melanoma via NIR‐Light Triggered Hyperthermia

Liu, X., Shen, M., Bing, T., Zhang, X., Li, Y., Cai, Q., Yang, X., & Yu, Y. (2024) · Advanced Science · doi:10.1002/advs.202402208 · Cited by 65 · see citing works

CRISPR–Cas9 applications in T cells and adoptive T cell therapies

Chen, X., Zhong, S., Zhan, Y., & Zhang, X. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00561-1 · Cited by 56 · see citing works

Tumor microenvironment-responsive nanoplatforms for enhanced cancer immunotherapy: Advances and synergistic strategies

Wu, J., Xue, X., & Qu, H. (2025) · Nano TransMed · doi:10.1016/j.ntm.2025.100092 · Cited by 45 · see citing works

Altered cancer metabolism and implications for next-generation CAR T-cell therapies

Ramapriyan, R., Vykunta, V. S., Vandecandelaere, G., Richardson, L. G., Sun, J. M., Curry, W. T., & Choi, B. D. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108667 · Cited by 43 · see citing works

Metabolic rewiring and communication in cancer immunity

Chapman, N. M., & Chi, H. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.02.001 · Cited by 43 · see citing works

Setting the curve: the biophysical properties of lipids in mitochondrial form and function

Venkatraman, K., Lee, C. T., & Budin, I. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100643 · Cited by 32 · see citing works

Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway

Brown, E., Temple, E. R., Jeanfavre, S., Ávila-Pacheco, J., Taylor, N., Liu, K., Nguyen, P. N. U., Mohamed, A. M., Ung, P., Walker, R. A., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.05.007 · Cited by 35 · see citing works

Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment

Green, W. D., Gomez, A., Plotkin, A. L., Pratt, B. M., Merritt, E. F., Mullins, G. N., Kren, N. P., Modliszewski, J. L., Zhabotynsky, V., Woodcock, M. G., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.030 · Cited by 31 · see citing works

Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy

Zou, D., Li, X. C., & Chen, W. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01321-7 · Cited by 30 · see citing works

Targeting metabolic pathways to counter cancer immunotherapy resistance

Agarwala, Y., Brauns, T. A., Sluder, A. E., Poznansky, M. C., & Gemechu, Y. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.05.006 · Cited by 32 · see citing works

The cellular composition of the tumor microenvironment is an important marker for predicting therapeutic efficacy in breast cancer

Dou, T., Li, J., Zhang, Y., Pei, W., Zhang, B., Wang, B., Wang, Y., & Jia, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1368687 · Cited by 27 · see citing works

Targeting the mevalonate pathway potentiates NUAK1 inhibition-induced immunogenic cell death and antitumor immunity

Gui, L., Chen, K., Yan, J., Chen, P., Gao, W., & Ma, B. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101913 · Cited by 27 · see citing works

CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation

Raynor, J. L., Collins, N., Shi, H., Guy, C. S., Saravia, J., Lim, S. A., Chapman, N. M., Zhou, P., Wang, Y., Sun, Y., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.09.013 · Cited by 25 · see citing works

CD8+ T-cell exhaustion: Impediment to triple-negative breast cancer (TNBC) immunotherapy.

Feng, D., Pu, D.-Q., Ren, J., Liu, M., Zhang, Z., Liu, Z., & Li, J.-W. (2024) · Biochimica et biophysica acta. Reviews on cancer · doi:10.1016/j.bbcan.2024.189193 · Cited by 28 · see citing works

Resistance to immunotherapy in non-small cell lung cancer: Unraveling causes, developing effective strategies, and exploring potential breakthroughs

Dong, S., Li, X., Huang, Q., Li, Y., Li, J., Zhu, X., Xue, C., Chen, R., Zeng, Y., Wu, J., et al. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101215 · Cited by 24 · see citing works

Squalene Epoxidase: Its Regulations and Links with Cancers

Zhang, L., Cao, Z., Hong, Y., He, H. H., Chen, L., Yu, Z., & Gao, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073874 · Cited by 22 · see citing works

Metabolic landscape of disseminated cancer dormancy

Drápela, S., Garcia, B. M., Gomes, A. P., & Correia, A. L. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.10.005 · Cited by 22 · see citing works

Mitochondrial Transfer Between Cancer and T Cells: Implications for Immune Evasion

Chun, S., An, J. Y., & Kim, M. S. (2025) · Antioxidants · doi:10.3390/antiox14081008 · Cited by 21 · see citing works

Mitochondria and lysosomes in T cell immunometabolism

Norton, E. G., Chapman, N. M., & Chi, H. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.07.014 · Cited by 21 · see citing works

Tissue-Resident T Cells in Clinical Response and Immune-Related Adverse Events of Immune Checkpoint Blockade

Zhao, Y., & Wucherpfennig, K. W. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3296 · Cited by 21 · see citing works

PCK1 as a target for cancer therapy: from metabolic reprogramming to immune microenvironment remodeling

Liu, N., Zhu, X., Wu, C., Liu, Y.-Y., Chen, M., & Gu, J.-H. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02240-8 · Cited by 20 · see citing works

Fatty Acid Oxidation Promotes Apoptotic Resistance and Proinflammatory Phenotype of CD4+ Tissue-resident Memory T cells in Crohn’s Disease

Liang, G., Huang, J., Chen, J., Wen, X., Li, R., Xie, H., Zhang, Z., Chen, Z., Chen, Y., Xian, Z., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.02.014 · Cited by 19 · see citing works

T cell cholesterol transport links intestinal immune responses to dietary lipid absorption

Gao, Y., Kennelly, J. P., Xu, X., Whang, E. C., Ferrari, A., Bedard, A. H., Mack, J. J., Nguyen, A., Srikanth, S., Weston, T. A., et al. (2025) · Science · doi:10.1126/science.adt4169 · Cited by 18 · see citing works

T cell adaptation in chronic infections and tumors

Luxenburger, H., Thimme, R., & Hofmann, M. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01405-y · Cited by 20 · see citing works

Homologous-magnetic dual-targeted metal-organic framework to improve the Anti-hepatocellular carcinoma efficacy of PD-1 inhibitor

Guo, H., Li, X., Mao, D., Wang, H., Wei, L., Qu, D., Qin, X., Li, X., Liu, Y., & Chen, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02469-6 · Cited by 20 · see citing works

Cholesterol sensing and metabolic adaptation in tissue immunity

Dang, E. V., & Reboldi, A. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.09.013 · Cited by 16 · see citing works

The XCL1–XCR1 axis supports intestinal tissue residency and antitumor immunity

Ferry, A., Mempel, K. M., Monell, A., Reina‐Campos, M., Scharping, N. E., Heeg, M., Takehara, K. K., Schokrpur, S., Kuo, N., Saddawi‐Konefka, R., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20240776 · Cited by 17 · see citing works

Tissue-resident memory CD103+CD8+ T cells in colorectal cancer: its implication as a prognostic and predictive liver metastasis biomarker

Liu, S., Wang, P., Wang, P., Zhao, Z., Zhang, X., Pan, Y., & Pan, J. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03709-2 · Cited by 18 · see citing works

Tissue‐resident memory T cells in diseases and therapeutic strategies

Xie, D., Lu, G., Mai, G., Guo, Q., & Xu, G. (2025) · MedComm · doi:10.1002/mco2.70053 · Cited by 18 · see citing works

Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms

Luo, L., Lechuga‐Vieco, A. V., Sattentau, C., Borsa, M., & Simon, A. K. (2025) · EMBO Reports · doi:10.1038/s44319-025-00536-z · Cited by 14 · see citing works

Tissue‐Resident Memory CD8+ T Cells: Differentiation, Phenotypic Heterogeneity, Biological Function, Disease, and Therapy

Xu, L., Ye, L., & Huang, Q. (2025) · MedComm · doi:10.1002/mco2.70132 · Cited by 15 · see citing works

Roles of tissue-resident immune cells in immunotherapy of non-small cell lung cancer

Tang, R., Wang, H., & Tang, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1332814 · Cited by 12 · see citing works

Tissue-resident memory T cells: decoding intra-organ diversity with a gut perspective

Murakami, M. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00333-6 · Cited by 13 · see citing works

Integrative systems biology reveals NKG2A-biased immune responses correlate with protection in infectious disease, autoimmune disease, and cancer

Chen, D. G., Xie, J., Choi, J., Ng, R. H., Zhang, R., Li, S., Edmark, R., Zheng, H., Solomon, B. D., Campbell, K. M., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113872 · Cited by 11 · see citing works

Spatial omics technology potentially promotes the progress of tumor immunotherapy

Lan, Z., Yang, Y., Li, L., Wang, C., Sun, Z., Wang, Q., & Liu, Y. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03075-5 · Cited by 11 · see citing works

Preoperative C‑reactive protein‑albumin‑lymphocyte index predicts survival outcomes in patients with stage I‑III colorectal cancer: A retrospective cohort study

Li, J., Hu, X., & Zhang, S. (2025) · Oncology Letters · doi:10.3892/ol.2025.15281 · Cited by 11 · see citing works

743 Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function

Scharping, N. E., Ge, X., Matias, M. I., Jiang, F., Cafferata, A., Heeg, M., Monell, A., Galletti, G., Cheung, K. P., Rock, A. E., et al. (2025) · Cell · doi:10.1016/j.cell.2026.02.019 · Cited by 12 · see citing works

Nanomaterial-Enhanced Immunotherapy: Advancing T-Cell-Based Treatments for Bladder Cancer

Chen, J., Fu, Y., Zhang, Z., Zhao, J., Zuo, J., Ye, X., Xiong, Q., Nie, Z., Dong, H., Shi, H., et al. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s557690 · Cited by 10 · see citing works

Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression

Bataclan, M., Leoni, C., Moro, S. G., Pecoraro, M., Wong, E. H., Heissmeyer, V., & Monticelli, S. (2024) · Life Science Alliance · doi:10.26508/lsa.202402784 · Cited by 10 · see citing works

Tissue-resident memory cells in antitumoral immunity and cancer immunotherapy

Min, D., Fiedler, J., & Anandasabapathy, N. (2024) · Current Opinion in Immunology · doi:10.1016/j.coi.2024.102499 · Cited by 10 · see citing works

Immune Memory: A New Frontier in Treating Recurrent Inflammatory Skin Diseases

Yin, H., Chen, J., & Li, C. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09039-0 · Cited by 10 · see citing works

Tissue‐resident memory T cells in immunotherapy and immune‐related adverse events by immune checkpoint inhibitor

Xiong, H., & Shen, Z. (2024) · International Journal of Cancer · doi:10.1002/ijc.34940 · Cited by 9 · see citing works

Intestinal tissue-resident memory T cells: Characteristics, spatial heterogeneity, age-related dynamics, and roles in disease regulation

Yan, R., Jia, D., Qi, Y., Wang, Q., & Chen, S. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.03.021 · Cited by 9 · see citing works

The signature of the small intestinal epithelial and immune cells in health and diseases

Gao, X., Yang, C., Feng, Z., Liu, P., & Liu, Z. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003615 · Cited by 9 · see citing works

Metabolic regulation of tissue-resident immune cells: Molecular mechanisms and therapeutic implications

Chen, Z.-X., Xiao, F., Zhu, X., Zhou, W., Rui, K., Lu, L., & Tian, J. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156349 · Cited by 9 · see citing works

Immunological memory to vaccines

Crotty, S. (2026) · Immunity · doi:10.1016/j.immuni.2026.02.019 · Cited by 9 · see citing works

Near‐Infrared‐II Nanomaterials for Activatable Photodiagnosis and Phototherapy

Jiang, W., Lin, L., Wu, P., Lin, H., & Sui, J. H. (2024) · Chemistry - A European Journal · doi:10.1002/chem.202400816 · Cited by 9 · see citing works

Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells

Bendre, S. V., Wang, Y., Hajyousif, B., K C, R., Bhogale, S. G., Pradeep, D., Krawczynska, N., Schane, C. P., Weisser, E., Singh, A., et al. (2026) · Science Advances · doi:10.1126/sciadv.adx5490 · Cited by 8 · see citing works

Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4 + T cells

Kiuchi, M., Nemoto, M., Yagyu, H., Aoki, A., Iwamura, C., Sugimoto, H., Masuo, Y., Morita, H., Ma, S., Okuno, Y., et al. (2025) · Science · doi:10.1126/science.adp0714 · Cited by 8 · see citing works

Spatial organization of tissue-resident memory T cells.

Burn, T. N., & Mackay, L. K. (2026) · Immunity · doi:10.1016/j.immuni.2026.03.009 · Cited by 13 · see citing works

Nutritional competition within tumor microenvironment dictates anti-tumor immunity

Fei, Y., Cao, X., & Liu, J. (2023) · National Science Review · doi:10.1093/nsr/nwad277 · Cited by 8 · see citing works

Cholesterol: The driving force behind the remodeling of tumor microenvironment in colorectal cancer

Wang, K., Zhang, Y., Si, C., Cao, Y., Shao, P., Zhang, P., Wang, N., Su, G., Qian, J., & Liu, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39425 · Cited by 7 · see citing works

SREBP2 as a central player in cancer progression: potential for targeted therapeutics

Chen, R., Chen, T., Li, X., Yu, J., Lin, M., Wen, S., Zhang, M., Chen, J., Yi, B., Zhong, H., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1535691 · Cited by 6 · see citing works

The roles of tissue-resident memory T cells (TRMs) in diseases and vaccine development: A comprehensive review

Wei, H., Wang, Y., Jiang, S., Zhang, X., & Zhang, J. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.127605 · Cited by 6 · see citing works

Tissue-Resident Memory T Cells in Cancer Metastasis Control

Montgomery, T., Master, A. P., Jin, Z., Shi, Q., Lai, Q., Desai, R., Zhang, W., Maharjan, C. K., & Kolb, R. H. (2025) · Cells · doi:10.3390/cells14161297 · Cited by 6 · see citing works

Metabolic determinants of cancer immunotherapy outcomes identified by plasma profiling

Suissa, D., Fidelle, M., Reich, E., Pham, T.-N., Thomas, S., Björk, J. R., Liu, P., Zhao, L., Kitaoka, K., Piard, E., et al. (2026) · Nature Medicine · doi:10.1038/s41591-026-04481-9 · Cited by 7 · see citing works

Capecitabine mitigates cardiac allograft rejection via inhibition of TYMS-Mediated Th1 differentiation in mice

Kong, D., Wang, Z.-L., Wang, H., Yang, R., Zhang, W., Cao, L., Nian, Y., Ren, J., Lu, J., Chen, T., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112955 · Cited by 6 · see citing works

Metabolic control of innate-like T cells

Riffelmacher, T., & Kronenberg, M. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01219-5 · Cited by 6 · see citing works

Cristae formation is a mechanical buckling event controlled by the inner membrane lipidomePreprint

Venkatraman, K., Lee, C. T., García, G. C., Mahapatra, A., Milshteyn, D., Perkins, G. A., Keun-young Kim, A., Pasolli, H. A., Phan, S., Lippincott‐Schwartz, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.13.532310 · Cited by 6 · see citing works

T cells of patients with systemic sclerosis or Sjögren’s disease display an aberrant metabolic state and memory phenotype in blood and lungs

Ehlers, C., Biermann, H., Thiele, T., Schupp, J. C., Villa, M., Jänke, C., Risser, L. M., Witte, T., Kalinke, U., Seeliger, B., et al. (2025) · Lara D. Veeken · doi:10.1093/rheumatology/keaf198 · Cited by 6 · see citing works

Inhibition of Cholesterol Synthesis in T Cells Protects the Liver Against Steatosis, Inflammation, and Oxidative Stress in Metabolic Dysfunction‐Associated Steatohepatitis

Lin, H., Qi, J.-W., Lin, S.-W., Lin, M.-C., Chen, Z., Guo, Y., Zhang, X., Wang, Q.-L., Cai, T., Yang, W., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202500115r · Cited by 5 · see citing works

Brevilin A suppresses lipid metabolism reprogramming in colorectal adenoma-to-adenocarcinoma sequence via the NR1D1/APOH signaling axis

Tang, C., Wu, Y., Jin, Y., Li, J., Zeng, C., Liao, P., & Long, S. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157386 · Cited by 5 · see citing works

YDJC restrains Th1 cell differentiation by blocking SREBP2-mediated cholesterol biosynthesis to alleviate mucosal inflammation in inflammatory bowel disease

Ai, L., Kang, D., Feng, Z., Lian, H., Gao, X., Wu, X., Gao, H., Li, X., Kou, F., Lin, J., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01361-z · Cited by 6 · see citing works

GPR25 promotes the formation of lung and liver tissue-resident memory CD8 T cells

Feng, H., Park, S., Shin, J. W., Castañeda-Castro, F. E., Hernandez, J. R., Schmiedel, B. J., Liu, C.-L., Jackson, M. R., Ottensmeier, C. H., & Vijayanand, P. (2025) · Science immunology · doi:10.1126/sciimmunol.adu2089 · Cited by 4 · see citing works

Cholesterol metabolism in immune cells: From mechanisms to therapeutic opportunities

Yin, M., Liang, T., Zhang, Y., Wang, G., Yang, W., & Xu, C. (2026) · Immunity · doi:10.1016/j.immuni.2026.05.007 · Cited by 4 · see citing works

Reference-guided computational framework identifies microenvironment metabolic subtypes and targets using pan-cancer single-cell datasets

Tang, K., Han, Y., Sun, D., Dong, X., Han, T., Wei, H., Shao, W., Hu, J., Liu, Z., Zhang, L., et al. (2025) · Genome Medicine · doi:10.1186/s13073-025-01572-z · Cited by 4 · see citing works

Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis

Brown, E., Nguyen, P. N. U., & Xavier, R. J. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.07.012 · Cited by 4 · see citing works

Finding a needle in a haystack: functional screening for novel targets in cancer immunology and immunotherapies

Du, Y., Yang, Y., Zheng, B., Zhang, Q., Zhou, S., & Zhao, L. (2025) · Oncogene · doi:10.1038/s41388-025-03273-8 · Cited by 4 · see citing works

The role of tumor microenvironment in regulating tumor cell dormancy

Xiao, Y., Xue, H., Hua, G., Shao, C., & Pan, Y. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124126 · Cited by 3 · see citing works

Spatial transcriptomics uncovers unique tumor microenvironments in folliculotropic versus classic mycosis fungoides

Williams, M., Joffe, D., Mandel, J. L., Schepps, S., Wallace, M., Portocarrero, C. P., Abinader, O., Mitra, R., Mishra, A., & Nikbakht, N. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.11.013 · Cited by 3 · see citing works

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility

Trang, B. K., Sharma, P. K., Cook, L. E., Mount, Z., Thomas, R. M., Kulkarni, N. N., Cabrera, E. C., Rachimi, S., Pahl, M. C., Pippin, J. A., et al. (2025) · Genome biology · doi:10.1186/s13059-025-03880-4 · Cited by 3 · see citing works

Transcription factor collaboration enables precise T cell state engineeringPreprint

Savage, R. E., Amador, C. D. M., Hock, C., Zhang, R., Kuo, H., Gao, A., Horlbeck, M. A., Gersbach, C. A., & Buenrostro, J. D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.20.718569 · Cited by 4 · see citing works

Disrupting cholesterol homeostasis in T cells boosts antitumour responses

Kennewick, K. T., & Bensinger, S. J. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01240-x · Cited by 2 · see citing works

Obesity rewires CD8+ T cell iron metabolism in adipose tissue to fuel metabolic inflammation

Dai, J., Zeng, Z., Wang, L., Yuan, W., Rocha, K. C. E., Park, J., An, G., Wang, K., Song, J., Xiang, Q., et al. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156438 · Cited by 2 · see citing works

Near infrared enhanced palladium loaded siraitia grosvenorii carbon dots amplify mitophagy for acute lung injury immunotherapy

Zhang, J., Duan, K., Liu, Q., Chen, S., Zheng, H., Liu, Y., Qian, J., Yin, M., Liu, J., Li, J., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.02.040 · Cited by 2 · see citing works

Memory T cell aging and rejuvenation

Adamo, S., Rurik, J. G., Gustafson, C. E., & Buggert, M. (2026) · Immunity · doi:10.1016/j.immuni.2026.02.018 · Cited by 3 · see citing works

Distinct tissue niches contribute to prostate tissue-resident memory CD8+ T cell differentiation and heterogeneity

Takehara, K. K., Monell, A., Luna, V., Melisso, B., Mempel, K. M., Cheung, K. P., Zane, N., Challita, P. P., Ferry, A., Xu, E. C., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.03.003 · Cited by 2 · see citing works

A mitochondrial ferroptosis-related gene signature predicts prognosis and immune landscape in colon cancer

Wang, H. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1614012 · Cited by 2 · see citing works

ZFP1 is a biomarker related to poor prognosis and immunity in gastric cancer

Yao, J., Ma, F., Shi, D., & Da, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-72387-y · Cited by 2 · see citing works

Crosstalk between the RNA-binding proteins Regnase-1 and -3 shapes mast cell survival and cytokine expressionPreprint

Bataclan, M., Leoni, C., Moro, S. G., Pecoraro, M., Wong, E. H., Heissmeyer, V., & Monticelli, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.24.577016 · Cited by 2 · see citing works

CIMT 2024: Report on the 21st Annual Meeting of the Association for Cancer Immunotherapy

Ahrberg, Y., Dallmann, J., Freitag, J., Hassan, A., Jung, C., Kiefer, J., Muralidharan, A. M., Peter, M., & Beck, J. D. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2381925 · Cited by 2 · see citing works

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibilityPreprint

Trang, B. K., Sharma, P. K., Cook, L. E., Mount, Z., Thomas, R. M., Kulkarni, N. N., Cabrera, E. C., Rachimi, S., Pahl, M. C., Pippin, J. A., et al. (2024) · medRxiv · doi:10.1101/2024.08.12.24311676 · Cited by 2 · see citing works

Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolismPreprint

Carroll, D. D., Cira, K., Archer, J., Shapiro, J. W., Pen, U.-Y., Tieri, D. A., Leonor, L., Roofchayee, N. D., Yee, S. S., Wahab, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.31.697156 · Cited by 2 · see citing works

Chronic Graft-versus-host Disease, Part 1: How Preclinical Models Shape Our Understanding of Biology and Pave the Way for Future Therapeutic Interventions

Hartigan, C. R., McDonald-Hyman, C. S., Pavletic, S. Z., & Blazar, B. R. (2025) · Transplantation · doi:10.1097/tp.0000000000005444 · Cited by 1 · see citing works

SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2

Zhang, Y., Shao, Y., Li, X., Zhou, D., Zhou, J., Yan, Q., Gao, W., & Yang, L. (2026) · Communications Biology · doi:10.1038/s42003-026-09678-9 · Cited by 1 · see citing works

Molecular Targets for Cancer Immunotherapy: Focusing on (Immune and Tumor) Cell-Derived Metabolites

Quintans, R. D. T., de Freitas, Â. A., de Souza, M. M., Dias-Lopes, G., & Silva, R. C. M. C. (2026) · Applied Sciences · doi:10.3390/app16052461 · Cited by 1 · see citing works

Convergent hub pathways targeted by IAV, SARS-CoV-2, and RSV in type II alveolar epithelial cells: molecular mechanisms and therapeutic implications

Zhang, K., Zhu, S., Zhang, M., Hu, H., Qin, S., Li, H., Zhao, P., & Xu, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1781447 · Cited by 1 · see citing works

Spatial instruction of tissue immunity

Reina‐Campos, M. (2026) · ImmunoHorizons · doi:10.1093/immhor/vlaf082 · Cited by 1 · see citing works

1416 Common metabolic adaptations empower CD8 T cell tissue residency and antitumor immunity

Campos, M. R., Heeg, M., Kennewick, K. T., Mathews, I. T., Galletti, G., Luna, V., Nguyen, Q., Huang, H., Milner, J. J., Hu, K. H., et al. (2023) · Regular and Young Investigator Award Abstracts · doi:10.1136/jitc-2023-sitc2023.1416

Metabolic Regulation of Tissue-Resident Memory CD8+ T cells

Vardam-Kaur, T., Sun, J., & da Silva, H. B. (2021) · Current opinion in pharmacology (Print) · doi:10.1016/j.coph.2021.02.004 · Cited by 11 · see citing works

Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells

Pan, Y., & Kupper, T. S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01347 · Cited by 100 · see citing works

Dynamic Metabolic State of Tissue Resident CD8 T Cells

Konjar, Š., & Veldhoen, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01683 · Cited by 50 · see citing works

Metabolic regulation of tissue-resident immune cells: Molecular mechanisms and therapeutic implications

Chen, Z.-X., Xiao, F., Zhu, X., Zhou, W., Rui, K., Lu, L., & Tian, J. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156349 · Cited by 9 · see citing works