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Janus Hydrogel Microparticles with Tea Polyphenol/Melanin Nanoparticles Integration from Microfluidics for Wound Healing

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Chiral gold nanoparticle synergizes immunometabolic crosstalk and metabolism remodeling for diabetic wound healing

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Dynamic Covalent Dual Prodrug Assemblies for Endometritis Therapy via Inflammation Alleviation, Tissue Repair, and Reproductive Function Restoration

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Mechanisms of action and clinical research progress of photobiomodulation

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Ferroptosis in adipose tissue: A promising pathway for treating obesity?

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GSDME–IL-18 pyroptotic axis prevents myosteatosis by expanding tissue-resident macrophages to promote muscle regeneration

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Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

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An updated overview of lipid-regulated immunobiology in macrophages

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Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Xu, Y., Wang, Y., Jiang, S., Li, Y., Li, G., Liu, Y., Li, S., Zhou, Y., Liu, Q., Zhou, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202512278 · Cited by 4 · see citing works

A Novel Bioluminescent Biosensor Quantifying Intramolecular Interaction and Levels of Pyroptosis Effector GSDMD

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LC-MS/MS based metabolomics reveals the mechanism of skeletal muscle regeneration

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Hepatocyte‐Specific GSDMD Deficiency Aggravates Sepsis by Disrupting Non‐Canonical Secretion of Anti‐Inflammatory Factors

Qian, Y., Wang, B., Yu, C. J., Zhou, Y., Huang, W., Rong, X., Sang, Y., Song, J., Wu, H., & Kong, X. (2025) · Advanced Science · doi:10.1002/advs.202510412 · Cited by 3 · see citing works

Integrin-mediated SPP1 signaling from macrophages orchestrates extracellular matrix remodeling and chondrogenesis in heterotopic ossification

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Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation

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Advances in immune cell-based therapeutic agents for the treatment of inflammation-related diseases

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Cell Death in Skeletal Muscle Diseases: Diverse Roles and Pathological Processes

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Caspase-5c amplifies Wnt via APC cleavage to promote intestinal homeostasis

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The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke

Li, T., Yang, L., Tu, J., Hao, Y., Zhu, Z., Xiong, Y., Gao, Q., Zhou, L., Xie, G., Zhang, D., et al. (2025) · eLife · doi:10.7554/elife.105593.3 · Cited by 3 · see citing works

The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after strokePreprint

Li, T., Yang, L., Tu, J., Hao, Y., Zhu, Z., Xiong, Y., Gao, Q., Zhou, L., Xie, G., Zhang, D., et al. (2025) · eLife · doi:10.7554/elife.105593 · Cited by 3 · see citing works

Unveiling the dynamic drivers: phase separation’s pivotal role in stem cell biology and therapeutic potential

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Exosomes derived from bone marrow-derived mesenchymal stem cells of exercise-trained mice improve wound healing by inhibiting macrophage M1 polarization

Qiu, J., Zhao, Y., Chen, Y., Wang, Y., Du, J., Xu, J., Guo, L., & Liu, Y. F. (2025) · Stem Cells · doi:10.1093/stmcls/sxae081 · Cited by 2 · see citing works

Porcine decellularized splenic matrix hydrogel-based vesicle sustained-release System: A dual-regulatory biomaterial for accelerated wound healing via angiogenesis and immune remodeling

Peng, P., Fan, S., Liu, P., Huang, X., Xuan, Z., Liu, A., Wu, M., Sui, B., Ye, B., Zhang, S., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102601 · Cited by 2 · see citing works

TPPU alleviates hepatic ischemia–reperfusion injury by regulating macrophage polarization

Pan, H., Lu, J., Tian, H., Liang, H., Zhang, W., Hou, W., & Shen, Z. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117657 · Cited by 2 · see citing works

Oxidized Dextran/Carboxymethyl Chitosan Dynamic Schiff-Base Hydrogel for Sustained Hydrogen Sulfide Delivery and Burn Wound Microenvironment Remodeling

Liu, Z., Zhu, Y., Ma, Z., Ning, X., Zhou, Z., Liu, J., Xie, Y., Li, G., & Hu, P. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18030370 · Cited by 2 · see citing works

Post-translational modifications of gasdermin D: implications for pyroptosis and autoimmune diseases

Su, K., Shen, C., Wu, W., Zhou, F., & Ye, H. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116605 · Cited by 2 · see citing works

Gasdermin D unlocks metabolic pathways to enhance tissue regeneration

Shubhra, Q. T. H. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01239-6 · Cited by 2 · see citing works

Pan-immune-inflammatory value and systemic immune-inflammatory index in relation to osteoradionecrosis of the jaws: a single institutional experience over 15 years

Li, C., Gong, Z., Jumatai, S., Fang, C., Pataer, P., & Zhao, H. (2025) · Odontology · doi:10.1007/s10266-025-01101-9 · Cited by 2 · see citing works

Deciphering Periodontitis: Host Mechanisms, Predictive Biomarkers, and Systemic Drivers for Precision PreventionPreprint

Zong, C., Zong, C., Li, T., Nguyen, A., Ginsberg, S., Feng, M., Wang, M., & Lee, C. K. (2025) · Research Square · doi:10.21203/rs.3.rs-7715539/v1 · Cited by 2 · see citing works

Macrophage duality in liver diseases: heterogeneity, plasticity, and the quest for precision therapeutics

Chen, L., Chen, Y., Zhao, M., Yang, X., Sutte, K., Lu, M., Chen, J., Zheng, X., Yang, D., & Liu, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1814879 · Cited by 1 · see citing works

Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulation

Ma, C., Jia, Z., Jiang, T., Cai, Q., Yang, J., Gan, L., Qian, K., Pan, Z., Ye, Q., Dai, M., et al. (2025) · eLife · doi:10.7554/elife.107938.3 · Cited by 1 · see citing works

Immune and metabolic mechanisms underlying fishmeal replacement with Tenebrio molitor in enhancing Pseudobagrus ussuriensis resistance to Aeromonas veronii

Cao, Y., Hu, R., Yang, C., Miao, H., Gao, J., Liu, Y., Dong, X., Wang, X., & Liu, Q. (2026) · Aquaculture Reports · doi:10.1016/j.aqrep.2025.103323 · Cited by 1 · see citing works

Atomic‐Precision NiCo Dual‐Atom Nanozybiotic for Drug‐Resistant Infections and Tissue Repair

Wang, M., Lu, W., Zhu, X., Xiao, J., JIANG, X. J., Zhu, H., & Gan, D. (2026) · Advanced Functional Materials · doi:10.1002/adfm.202530602 · Cited by 1 · see citing works

Targeting methionine-induced pyroptosis enhances anti-tumor immunity

Lei, M., Zhu, W., Wang, C., Zhang, F., Li, M., Zhang, Y., Qu, J., Luo, Z., Li, J., Li, Z.-X., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3149-4 · Cited by 1 · see citing works

The eicosanoid-cell death axis: A mechanistic review of crosstalk in health and disease

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Triggering Receptor Expressed on Myeloid Cells 2+ Macrophages Promote Pancreatic Regeneration Through Cholesterol–Metabolism Reprogramming and Hedgehog Signaling Activation Following Acute Pancreatitis

Song, P.-L., Peng, Q., Jin, X., Li, B., Wang, R., Jiang, J., Shen, J., Ni, J.-B., Chen, C.-Y., Ge, X., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101819 · Cited by 1 · see citing works

Regulated cell death programs shaping cancer therapy

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Osteocyte-specific gasdermin D deletion accelerates osteoarthritis via promoting subchondral inflammation and remodeling

Ogawa, Y., Ebata, T., Tokuhiro, T., Chen, L., Suzuki, R., Fujie, Y., Nakajo, M., Endo, T., Alhasan, H., Hamasaki, M., et al. (2026) · Bone Research · doi:10.1038/s41413-026-00566-w · Cited by 2 · see citing works

Zinc accumulation in macrophages exacerbates metabolic dysfunction-associated steatotic liver disease progression

Zhou, J., Wang, X., Liu, W., Yu, Y., Wang, S., Yao, Z., Song, Z., Shi, W., Zheng, W., Xie, E., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02816-z · Cited by 1 · see citing works

Metformin Inhibited GSDME to Suppress M2 Macrophage Pyroptosis and Maintain M2 Phenotype to Mitigate Cisplatin-Induced Intestinal Inflammation

Jiang, K., He, Q., Wang, C., Yang, W., Zhou, C., Li, J., Li, J., Cui, Y., Shi, J., Wei, Z., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12112526 · Cited by 1 · see citing works

The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after strokePreprint

Li, T., Yang, L., Tu, J., Hao, Y., Zhu, Z., Xiong, Y., Gao, Q., Zhou, L., Xie, G., Zhang, D., et al. (2025) · eLife · doi:10.7554/elife.105593.1

The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after strokePreprint

Li, T., Yang, L., Tu, J., Hao, Y., Zhu, Z., Xiong, Y., Gao, Q., Zhou, L., Xie, G., Zhang, D., et al. (2025) · eLife · doi:10.7554/elife.105593.2

Advances in gasdermin activation, regulation, and targeted drug development

Luo, T., & Guo, Y. R. (2025) · Acta Materia Medica · doi:10.15212/amm-2025-0014

Toward Pan-Age Sepsis Detection: Leveraging Pediatric Transcriptome Data to Enhance Diagnostic Model Generalizability in Heterogeneous Populations

Nan, C., Zhang, N., Wu, H., Chen, Y., Huang, P., Zheng, C., Jin, N., Wang, S., Zhang, X., Zheng, X., et al. (2025) · Fundamental Research · doi:10.1016/j.fmre.2025.04.016

Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulationPreprint

Ma, C., Jia, Z., Jiang, T., Cai, Q., Yang, J., Gan, L., Qian, K., Pan, Z., Ye, Q., Dai, M., et al. (2025) · eLife · doi:10.7554/elife.107938

Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulationPreprint

Ma, C., Jia, Z., Jiang, T., Cai, Q., Yang, J., Gan, L., Qian, K., Pan, Z., Ye, Q., Dai, M., et al. (2025) · eLife · doi:10.7554/elife.107938.1

Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulationPreprint

Ma, C., Jia, Z., Jiang, T., Cai, Q., Yang, J., Gan, L., Qian, K., Pan, Z., Ye, Q., Dai, M., et al. (2025) · eLife · doi:10.7554/elife.107938.2

Advancing tumor immunotherapy through rationally engineered inorganic nanomaterials

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O-GlcNAcylation-regulated classical programmed cell death in diseases: molecular crosstalk and therapeutic opportunities

Liu, R., Wei, J., Luo, Z., Gao, X., Zhang, H., & Kong, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1658769

Liquid-liquid phase separation in physiological and pathophysiological bone turnover

Xia, Y., Xu, W., Yang, X., Huang, X., Xie, H., Yeung, K., Xie, Z., & Lan, Y. (2025) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjaf178

Wetting-mediated extracellular phase separation drives long-range cell adhesionPreprint

Wang, A., Yang, D., Zhang, H., Paunov, V. N., Tian, S., Dong, L., Tanaka, H., Yuan, J., & Wang, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.23.700778

Comprehensive Analysis of Immune-Related Mitochondrial Genes in Ischemic Stroke Through Integrated Bioinformatics and Validation

Li, C., You, R., Meng, X., Long, H., Zheng, C., & Zhan, Z. (2026) · Biomedicines · doi:10.3390/biomedicines14020375

Cell death mechanisms in heat stroke and sepsis: ZBP1 and caspase-11 as molecular sensors driving the MLKL/GSDMD death execution axis

Qin, X.-J., Luo, C.-S., Li, Q.-Q., Zhong, B.-C., Wei, Q.-T., Chun-hui, Z., & Yang, K. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1778368

The human and murine immune systems: regulated by dichotomous molecules

Silva, R. C. M. C. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116329

Extracellular and intracellular ATP regulate hematopoietic stem/progenitor cells

Brzeźniakiewicz‐Janus, K., Kakar, S. S., Abdelbaset-Ismail, A., Ratajczak, J., Konopko, A., Kucia, M., Ulrich, H., & Ratajczak, M. Z. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30250-3.00028-x

Perivascular mesenchymal cells instruct ST2+ reparative macrophages to promote endovascular injury-induced neointimal hyperplasia in mice

Ping, Y., Qin, Z., Huang, X., Sun, Q., Yao, T., Li, S., Tian, X., Xia, X., Diao, B., Zhao, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68587-x

IRGM1-IRF7 Axis Controls Macrophage Chemotaxis to Orchestrate Skeletal Muscle Regeneration

Wang, J., Ge, X., Zhang, Z., Wang, Z., Qiao, Z., Weng, Y., Weng, Y., Yao, X., Zhang, Y., Zhang, X., et al. (2026) · Inflammation · doi:10.1007/s10753-026-02496-5

Cannabinoid type 2 receptor regulates skeletal muscle regeneration by NLRP3-GSDMD mediated macrophage pyroptosis after injury

Li, X., Yuan, H., Mu, S., Pan, J., Zhang, F., Du, S., Liu, J., Qu, A., Sun, Y., Wang, L., et al. (2026) · Cell Death Discovery · doi:10.1038/s41420-026-03077-z

Agonal cell resuscitation strategy to promote tissue repair

Huang, Z., Wang, Q., Chen, Y., Zhu, J., Xu, J., Yang, Y., Wang, Y., Yang, K., Yan, H., Li, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71653-z

Gasdermin E: a missing link in muscle regeneration

Krishna, S., & Rafael‐Fortney, J. A. (2026) · Journal of Clinical Investigation · doi:10.1172/jci205442

Macrophages with ITIH4 overexpression attenuate inflammatory responses and regulate intestinal epithelial cells.

Li, J., Zhao, Z.-Q., Fei, J., Zhang, R., Pan, L.-Y., Xiang, Y., Hong, L., & Zhan, Z.-Y. (2026) · Inflammation Research · doi:10.1007/s00011-026-02247-0

A cell-death protein has an unexpected role in intestinal repair

Yisimayi, A., & Lieberman, J. (2026) · Nature · doi:10.1038/d41586-026-00810-7

Ferrous lactate-loaded hydrogels induce iron-dependent non-canonical ferroptosis in Cutibacterium acnes: a novel therapeutic strategy for acne vulgaris

Wang, R., Mo, H., Hu, L., Lee, J., Yao, L., Peng, S., Zhang, M., Zhou, W., Li, H., & Zhang, J. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103174

Long noncoding RNA#61 synergizes with viral PA-X to augment pyroptosis and attenuate the virulence of highly pathogenic H5N1 influenza virus in mice

Chen, X., Zheng, X., Zhang, L., Cai, X., Hong, X., Hou, S., Ma, X., Hu, Z., Gu, M., Wang, X., et al. (2026) · Journal of Virology · doi:10.1128/jvi.02214-25

Polystyrene nanoplastics promote tumor lung metastasis by inducing sodium overload in macrophages in an NMDAR-dependent way

Li, L., Li, Z. M., Ji, N., Chen, Y., Zhang, X., Li, Z. M., Huang, Q., Wang, X., Gao, Y., Chen, T., et al. (2026) · Nanotoxicology · doi:10.1080/17435390.2026.2669645

Asiaticoside alleviates mesothelial cell senescence and peritoneal fibrosis by targeting macrophage-mesothelial communication in single-cell peritoneal landscape

You, Y., Wang, F., Zhou, Z., Chen, X., Yu, M., Meng, X., Jia, J., Shan, Y., & Sheng, M. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158339

Salidroside suppresses hyperglycemia-induced M1 macrophage polarization to accelerate diabetic wound healing by restraining mTOR pathway

Jiang, T., Zhang, L., Ruan, C., Wang, J., Liu, J., Kasim, V., & Wu, S. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116953

The lncRNA Brip1os Orchestrates IFN-γ–Mediated Inflammatory-Myogenic Crosstalk to Promote Muscle RegenerationPreprint

Luo, Y., Zhang, J., Chen, W.-C., Chen, W.-X., Zhang, Z., Hou, Y., Li, P., Zhong, X., Xiao, Z.-D., He, J. S., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9886579/v1

Deep-penetrating tetrahedral framework nucleic acid nanogel spray restores miRNA-223 to potentiate macrophage-driven angiogenesis for deep tissue pressure injuries

Su, X., Shi, S., Xu, K., Dong, Z., Liu, S., Lu, W., Wang, K., Wang, J., Li, Y., Cun, W., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124422

Gasdermin D unlocks metabolic pathways to enhance tissue regeneration

Shubhra, Q. T. H. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01239-6 · Cited by 2 · see citing works

GSDME–IL-18 pyroptotic axis prevents myosteatosis by expanding tissue-resident macrophages to promote muscle regeneration

Cao, Q., Liu, J., Huang, G., Wang, S.-Y., Lu, G.-D., Huang, Y., Chen, Y.-T., Zhang, Z., Fu, J., Sun, S., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci198076 · Cited by 6 · see citing works

Abstract Tue010: A Non-Pyroptotic Nuclear Role of Gasdermin D in Skeletal Muscle Regeneration

Xu, Y., Wang, J., Zhang, Z., Chen, P., Alizai, U., Sathish, K., Sollenberger, W., Zhang, Q., Pawlik, T. M., & Hua Zhu, C. (2026) · Circulation Research · doi:10.1161/res.139.suppl_1.tue010

Gasdermin D–mediated pyroptosis suppresses liver regeneration after 70% partial hepatectomy

Lv, X., Chen, J., He, J., Hou, L., Ren, Y., Shen, X., Wang, Y., Ji, T., & Cai, X. (2022) · Hepatology Communications · doi:10.1002/hep4.1973 · Cited by 22 · see citing works

Gasdermin E: a missing link in muscle regeneration

Krishna, S., & Rafael‐Fortney, J. A. (2026) · Journal of Clinical Investigation · doi:10.1172/jci205442