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Prime genome editing in rice and wheat
Abstract
Prime editors, which are CRISPR-Cas9 nickase (H840A)-reverse transcriptase fusions programmed with prime editing guide RNAs (pegRNAs), can edit bases in mammalian cells without donor DNA or double-strand breaks. We adapted prime editors for use in plants through codon, promoter, and editing-condition optimization. The resulting suite of plant prime editors enable point mutations, insertions and deletions in rice and wheat protoplasts. Regenerated prime-edited rice plants were obtained at frequencies of up to 21.8%.
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“Prime editing allows for all types of desired base substitutions, small insertions up to 44 bp and deletions up to 88 bp at selected target sites with the use of CRSIPR/Cas9 nickase-reverse transcriptase fusions (Anzalone et al., 2019;Lin et al., 2020).”
From Genetic resources and precise gene editing for targeted improvement of barley abiotic stress tolerance (2023) · cites this paper as Lin et al., 2020
In the citing paper
“Plant prime-editing systems have been used in rice and wheat, but not in barley (Lin et al., 2020;Xu et al., 2020).”
From Genetic resources and precise gene editing for targeted improvement of barley abiotic stress tolerance (2023) · cites this paper as Lin et al., 2020
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Efficient prime editors for heritable multiplex precision genome editing in soybean
Su, F., Dong, Y., Guo, R., Xie, H., ZHANG, Y., Liu, J., Cao, X., Xie, H., Zhou, M., Sun, X., et al. (2026) · Nature Plants · doi:10.1038/s41477-026-02315-7 · Cited by 3
Contribution of Biotechnological Approaches to Micronutrient Improvements in Legumes
Younas, A., Yousaf, Z., Rashid, M., Riaz, N., Aftab, A., Shahid, M. J., Yasin, H., Shahzadi, Z., Maqbool, Z., Feroz, A., et al. (2023) · Springer eBooks · doi:10.1007/978-3-031-33957-8_6 · Cited by 3
Genome-Editing Advances for Disease Resistance in Plants
Shivani, Chauhan, H., & Singh, K. (2024) · Springer eBooks · doi:10.1007/978-981-99-8874-7_12 · Cited by 3
Prime-editing methods and pegRNA design programs
Mikhaylova, E. V., Кулуев, Б. Р., Геращенков, Г. А., Chemeris, D. A., Гарафутдинов, Р. Р., Kuluev, A. R., Baymiev, A. K., Baymiev, A. K., & Chemeris, A. V. (2024) · Molecular Biology · doi:10.31857/s0026898424010023 · Cited by 3
Genome Editing Technologies towards Tomato Improvement: Recent Advances and Future Perspectives
Priya, S. S., Joshi, R. K., & Mishra, R. (2024) · Journal of Experimental Biology and Agricultural Sciences · doi:10.18006/2024.12(4).537.556 · Cited by 4
Genes Affecting Cotton Fiber Length: A Systematic Review and Meta-Analysis
Jiao, J., Chang, S., Wang, F., et al. (2025) · Plants · doi:10.3390/plants14081203 · Cited by 3
Wang, Y., Wang, H., Jian, Y.-Z., Luo, Z., Shao, H., & Zhang, W. (2021) · Human Gene Therapy · doi:10.1089/hum.2021.283 · Cited by 3
Self-citationReforming cotton genes: from elucidation of DNA structure to genome editing
Mubarik, M. S., Majeed, S., Khan, S. H., Du, X., Frelichowski, J., Hinze, L. L., & Azhar, M. T. (2021) · TURKISH JOURNAL OF AGRICULTURE AND FORESTRY · doi:10.3906/tar-2012-64 · Cited by 3
Application of CRISPR-Cas-Based Genome Editing for Precision Breeding in Wheat
Wang, W., & Akhunov, E. (2022) · Springer eBooks · doi:10.1007/978-3-030-90673-3_29 · Cited by 3
Cisgenic Crops: Major Strategies to Create Cisgenic Plants Based on Genome Editing
Cabrera‐Ponce, J. L., Barraza, A., & Álvarez-Venegas, R. (2022) · Concepts and strategies in plant sciences · doi:10.1007/978-3-031-06628-3_11 · Cited by 3
Metadata
- Authors
- Lin, Q., Zong, Y., Xue, C., Wang, S., Jin, S., Zhu, Z., Wang, Y., Anzalone, A. V., Raguram, A., Doman, J. L., Liu, D. R., & Gao, C.
- Affiliations
- Chinese Academy of Sciences (CN)
- Broad Institute (US)
- Corresponding author
- Gao, Caixia
- ORCID
- Venue
- Nature Biotechnology
- Published
- 2020-03-16
- Volume
- 38
- Issue
- 5
- Pages
- 582-585
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W3012016445
- Semantic Scholar
- 8cfc62e789552485d639d0542c1caaaf730db03d
- Cited by
- 873
- References
- 23
- Citations by year
- 2026: 105 · 2025: 118 · 2024: 106 · 2023: 135 · 2022: 146 · 2021: 175 · 2020: 86
- FWCI
- 44.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Human Genome Research Institute (RM1HG009490)
- National Institute of General Medical Sciences (R35GM118062)
- National Institute of Allergy and Infectious Diseases (U01AI142756)
- National Institute of Biomedical Imaging and Bioengineering (R01EB022376)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Genetic and Mutation Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Transgenic Plants and Applications
- Keywords
- prime editing, CRISPR/Cas9 nickase, reverse transcriptase, pegRNA, plant genome editing, rice, wheat, protoplast transformation, point mutations, indels, codon optimization, promoter optimization, plant regeneration
- MeSH terms
- Gene Editing, Deoxyribonuclease I, Oryza, Triticum, Genome, Plant, CRISPR-Cas Systems
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