Cited by 880CRISPR and Genetic EngineeringPlant Genetic and Mutation StudiesTransgenic Plants and Applications

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Prime genome editing in rice and wheat

Lin, Qiupeng, Zong, Yuan, Xue, Chenxiao, Wang, Shengxing, Jin, Shuai, Zhu, Zixu, Wang, Yanpeng, Anzalone, Andrew V., Raguram, Aditya, Doman, Jordan L., Liu, David R., Gao, Caixia·2020·Nature Biotechnology

DOI 10.1038/s41587-020-0455-x

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Abstract

Prime editors, which are CRISPR-Cas9 nickase (H840A)-reverse transcriptase fusions programmed with prime editing guide RNAs (pegRNAs), can edit bases in mammalian cells without donor DNA or double-strand breaks. We adapted prime editors for use in plants through codon, promoter, and editing-condition optimization. The resulting suite of plant prime editors enable point mutations, insertions and deletions in rice and wheat protoplasts. Regenerated prime-edited rice plants were obtained at frequencies of up to 21.8%.

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Authors: Lin, Q., Zong, Y., Xue, C., Wang, S., Jin, S., Zhu, Z., Wang, Y., Anzalone, A. V., Raguram, A., Doman, J. L., Liu, D. R., & Gao, C.
Affiliations: Chinese Academy of Sciences (CN)
Broad Institute (US)
Corresponding author: Gao, Caixia
ORCID: Lin, Qiupeng
Zong, Yuan
Wang, Shengxing
Jin, Shuai
Zhu, Zixu
Wang, Yanpeng
Anzalone, Andrew V.
Raguram, Aditya
Doman, Jordan L.
Liu, David R.
Gao, Caixia
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2020-03-16
Volume: 38
Issue: 5
Pages: 582-585
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/s41587-020-0455-x
OpenAlex: W3012016445
Semantic Scholar: 8cfc62e789552485d639d0542c1caaaf730db03d
Cited by: 873
References: 23
Citations by year: 2026: 105 · 2025: 118 · 2024: 106 · 2023: 135 · 2022: 146 · 2021: 175 · 2020: 86
FWCI: 44.86
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Human Genome Research Institute (RM1HG009490)
National Institute of General Medical Sciences (R35GM118062)
National Institute of Allergy and Infectious Diseases (U01AI142756)
National Institute of Biomedical Imaging and Bioengineering (R01EB022376)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Genetic and Mutation Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Transgenic Plants and Applications
Keywords: prime editing, CRISPR/Cas9 nickase, reverse transcriptase, pegRNA, plant genome editing, rice, wheat, protoplast transformation, point mutations, indels, codon optimization, promoter optimization, plant regeneration
MeSH terms: Gene Editing, Deoxyribonuclease I, Oryza, Triticum, Genome, Plant, CRISPR-Cas Systems

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Prime genome editing in rice and wheat

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