The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Fully implantable and bioresorbable cardiac pacemakers without leads or batteries
Open accessAbstract
Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology. A biodegradable pacemaker without external leads improves the safety of temporary cardiac pacing.
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Metadata
- Authors
- Choi, Y. S., Yin, R. T., Pfenniger, A., Koo, J., Avila, R., Benjamin Lee, K., Chen, S. W., Lee, G., Li, G., Qiao, Y., Murillo-Berlioz, A., Kiss, A., Han, S., Lee, S. M., Li, C., Xie, Z., Chen, Y.-Y., Burrell, A., Geist, B., Jeong, H., Kim, J., Yoon, H.-J., Banks, A., Kang, S.-K., Zhang, Z. J., Haney, C. R., Sahakian, A. V., Johnson, D., Efimova, T., Huang, Y., Trachiotis, G. D., Knight, B. P., Arora, R. K., Efimov, I. R., & Rogers, J. A.
- Venue
- Nature Biotechnology
- Published
- 2021-06-28
- Volume
- 39
- Issue
- 10
- Pages
- 1228-1238
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W3175547357
- Cited by
- 361
- References
- 40
- FWCI
- 34.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Choi, Y. S., Yin, R. T., Pfenniger, A., Koo, J., Avila, R., Benjamin Lee, K., Chen, S. W., Lee, G., Li, G., Qiao, Y., Murillo-Berlioz, A., Kiss, A., Han, S., Lee, S. M., Li, C., Xie, Z., Chen, Y.-Y., Burrell, A., Geist, B., . . . Rogers, J. A. (2021). Fully implantable and bioresorbable cardiac pacemakers without leads or batteries. Nature Biotechnology. https://doi.org/10.1038/s41587-021-00948-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
