Cited by 231T-cell and B-cell ImmunologyAdvanced Proteomics Techniques and ApplicationsPI3K/AKT/mTOR signaling in cancer

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Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

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Howden, Andrew J. M., Hukelmann, Jens L., Brenes, Alejandro, Spinelli, Laura, Sinclair, Linda V., Lamond, Angus I., Cantrell, Doreen A.·2019·Nature Immunology

DOI 10.1038/s41590-019-0495-xPMC PMC6859072

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Abstract

Quantitative mass spectrometry reveals how CD4+ and CD8+ T cells restructure proteomes in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis of copy numbers per cell of >9,000 proteins provides new understanding of T cell phenotypes, exposing the metabolic and protein synthesis machinery and environmental sensors that shape T cell fate. We reveal that lymphocyte environment sensing is controlled by immune activation, and that CD4+ and CD8+ T cells differ in their intrinsic nutrient transport and biosynthetic capacity. Our data also reveal shared and divergent outcomes of mTORC1 inhibition in naïve versus effector T cells: mTORC1 inhibition impaired cell cycle progression in activated naïve cells, but not effector cells, whereas metabolism was consistently impacted in both populations. This study provides a comprehensive map of naïve and effector T cell proteomes, and a resource for exploring and understanding T cell phenotypes and cell context effects of mTORC1.

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Authors: Howden, A. J. M., Hukelmann, J. L., Brenes, A., Spinelli, L., Sinclair, L. V., Lamond, A. I., & Cantrell, D. A.
Affiliations: University of Dundee (GB)
Corresponding author: Lamond, Angus I.
Cantrell, Doreen A.
ORCID: Howden, Andrew J. M.
Hukelmann, Jens L.
Brenes, Alejandro
Spinelli, Laura
Sinclair, Linda V.
Lamond, Angus I.
Cantrell, Doreen A.
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2019-10-07
Volume: 20
Issue: 11
Pages: 1542-1554
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/s41590-019-0495-x
PMC: PMC6859072
OpenAlex: W2977451996
Cited by: 231
References: 49
Citations by year: 2026: 19 · 2025: 34 · 2024: 42 · 2023: 34 · 2022: 34 · 2021: 37 · 2020: 29 · 2019: 2
FWCI: 10.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Discovery Research Portal (University of Dundee) (submittedVersion, other-oa)
Funders: Wellcome Trust (205023/Z/16/Z, 105024/Z/14/Z, 202950/Z/16/Z)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: T cell proteome, CD4+ T cells, CD8+ T cells, mTORC1, T cell differentiation, naive T cells, effector T cells, protein copy number, nutrient sensing, T cell metabolism, cell cycle progression, immune activation, quantitative mass spectrometry
MeSH terms: Mechanistic Target of Rapamycin Complex 1, Animals, Cell Differentiation, Cells, Cultured, Female, Gene Expression Regulation, Male, Mice, Transgenic, Mass Spectrometry, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Gene Dosage, Sirolimus, Proteome, Gene Expression Profiling, Proteomics, Mice, Cell Cycle Checkpoints

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Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

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