Cited by 138Mast cells and histamineEpigenetics and DNA MethylationAsthma and respiratory diseases

Dnmt3a restrains mast cell inflammatory responses

Open access
Leoni, Cristina, Montagner, Sara, Rinaldi, Andrea, Bertoni, Francesco, Polletti, Sara, Balestrieri, Chiara, Monticelli, Silvia·2017·Proceedings of the National Academy of Sciences

Abstract

Significance Methylation of genomic DNA is an epigenetic modification at the interface between genetic information and environmental stimuli underlying many phenotypic variations in the human population as well as the pathogenesis of complex diseases. Accordingly, mutations in the de novo DNA methyltransferase enzyme DNMT3A have been identified in a number of diseases, including mast cell-related disorders. However, the role of DNA methylation and DNMT3A in regulating mast cell physiology still needs to be elucidated. Here, we found that Dnmt3a plays a critical role in modulating mast cell responsiveness to acute and chronic stimulation, potentially implicating DNA methylation-mediated processes in all types of mast cell-related diseases.

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Crossref · 10.1073/pnas.1616420114

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  • Enhanced mast cell activity was seen in a mouse model of allergy.

    “enhanced mast cell activity was also seen in a mouse model of allergy 94”

    From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [94]

  • Mast cells from mice that lacked Dnmt3a produced higher levels of IL-6, TNF-alpha, and IL-13 in response to stimulation with IgE in vitro.

    “one study found that mast cells from mice that lacked Dnmt3a produced higher levels of IL-6, TNF-alpha, and IL-13 in response to stimulation with IgE in vitro”

    From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [94]

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Authors
Leoni, C., Montagner, S., Rinaldi, A., Bertoni, F., Polletti, S., Balestrieri, C., & Monticelli, S.
Affiliations
  • University of Bern (CH)
  • Institute for Research in Biomedicine (CH)
  • Institute of Oncology Research (CH)
  • European Institute of Oncology (IT)
Venue
Proceedings of the National Academy of Sciences
Published
2017-02-06
Volume
114
Issue
8
Pages
E1490-E1499
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2587262629
Cited by
138
References
72
Citations by year
2026: 2 · 2025: 17 · 2024: 17 · 2023: 17 · 2022: 19 · 2021: 16 · 2020: 20 · 2019: 13 · 2018: 11 · 2017: 6
FWCI
6.19
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Swiss National Science Foundation (156875, 164489)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords
DNMT3A, DNA methylation, mast cells, epigenetic regulation, de novo DNA methyltransferases
MeSH terms
DNA (Cytosine-5-)-Methyltransferase 1, Decitabine, DNA Methyltransferase 3A, Animals, Azacitidine, Cells, Cultured, Dermatitis, Contact, Disease Models, Animal, DNA (Cytosine-5-)-Methyltransferases, Enzyme-Linked Immunosorbent Assay, Female, Fluorescent Antibody Technique, Immunoglobulin E, Interleukin-3, Mast Cells, Mutation, Oxazolone, Passive Cutaneous Anaphylaxis, Down-Regulation, Cell Degranulation, Mice, Knockout, DNA Methylation, ras GTPase-Activating Proteins, RNA Interference, Mastocytosis, Systemic, RNA, Small Interfering, Epigenesis, Genetic, Cell Proliferation, Mice

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