The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Biomimetic 3D-printed scaffolds for spinal cord injury repair
Open accessAbstract
Current methods for bioprinting functional tissue lack appropriate biofabrication techniques to build complex 3D microarchitectures essential for guiding cell growth and promoting tissue maturation1. 3D printing of central nervous system (CNS) structures has not been accomplished, possibly owing to the complexity of CNS architecture. Here, we report the use of a microscale continuous projection printing method (μCPP) to create a complex CNS structure for regenerative medicine applications in the spinal cord. μCPP can print 3D biomimetic hydrogel scaffolds tailored to the dimensions of the rodent spinal cord in 1.6 s and is scalable to human spinal cord sizes and lesion geometries. We tested the ability of µCPP 3D-printed scaffolds loaded with neural progenitor cells (NPCs) to support axon regeneration and form new ‘neural relays’ across sites of complete spinal cord injury in vivo in rodents1,2. We find that injured host axons regenerate into 3D biomimetic scaffolds and synapse onto NPCs implanted into the device and that implanted NPCs in turn extend axons out of the scaffold and into the host spinal cord below the injury to restore synaptic transmission and significantly improve functional outcomes. Thus, 3D biomimetic scaffolds offer a means of enhancing CNS regeneration through precision medicine. Fast scalable 3D bioprinting generates biocompatible and biomimetic scaffolds to precisely fit the geometries of spinal cord lesions, promote axonal regeneration, and support stem cell grafts to promote recovery from spinal cord injury in rodents.
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Cites
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Cited by
Spinal cord injury: molecular mechanisms and therapeutic interventions
Hu, X., Xu, W., Ren, Y., Wang, Z., He, X., Huang, R., Ma, B., Zhao, J., Zhu, R., & Cheng, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01477-6 · Cited by 770
Photopolymerizable Biomaterials and Light-Based 3D Printing Strategies for Biomedical Applications
Yu, C., Schimelman, J., Wang, P., Miller, K. L., Ma, X., You, S., Guan, J., Sun, B., Zhu, W., & Chen, S. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00810 · Cited by 579
Self-citationProjection micro stereolithography based 3D printing and its applications
Ge, Q., Li, Z., Wang, Z., Kowsari, K., Zhang, W., He, X., Zhou, J., & Fang, N. X. (2020) · International Journal of Extreme Manufacturing · doi:10.1088/2631-7990/ab8d9a · Cited by 444
Fan, L., Liu, C., Chen, X., Zheng, L., Zou, Y., Wen, H., Guan, P., Lu, F., Luo, Y., Tan, G., et al. (2022) · Advanced Science · doi:10.1002/advs.202105586 · Cited by 401
Design Challenges in Polymeric Scaffolds for Tissue Engineering
Echeverria Molina, M. I., Malollari, K. G., & Komvopoulos, K. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.617141 · Cited by 397
Metadata
- Authors
- Koffler, J., Zhu, W., Qu, X., Platoshyn, O., Dulin, J. N., Brock, J., Graham, L., Lu, P., Sakamoto, J., Marsala, M., Chen, S., & Tuszynski, M. H.
- Venue
- Nature Medicine
- Published
- 2019-01-14
- Volume
- 25
- Issue
- 2
- Pages
- 263-269
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2908359749
- Cited by
- 708
- References
- 35
- FWCI
- 28.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Koffler, J., Zhu, W., Qu, X., Platoshyn, O., Dulin, J. N., Brock, J., Graham, L., Lu, P., Sakamoto, J., Marsala, M., Chen, S., & Tuszynski, M. H. (2019). Biomimetic 3D-printed scaffolds for spinal cord injury repair. Nature Medicine. https://doi.org/10.1038/s41591-018-0296-z
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