The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis
Open accessAbstract
Epithelial barrier loss is a driver of intestinal and systemic diseases. Myosin light chain kinase (MLCK) is a key effector of barrier dysfunction and a potential therapeutic target, but enzymatic inhibition has unacceptable toxicity. Here, we show that a unique domain within the MLCK splice variant MLCK1 directs perijunctional actomyosin ring (PAMR) recruitment. Using the domain structure and multiple screens, we identify a domain-binding small molecule (divertin) that blocks MLCK1 recruitment without inhibiting enzymatic function. Divertin blocks acute, tumor necrosis factor (TNF)-induced MLCK1 recruitment as well as downstream myosin light chain (MLC) phosphorylation, barrier loss, and diarrhea in vitro and in vivo. Divertin corrects barrier dysfunction and prevents disease development and progression in experimental inflammatory bowel disease. Beyond applications of divertin in gastrointestinal disease, this general approach to enzymatic inhibition by preventing access to specific subcellular sites provides a new paradigm for safely and precisely targeting individual properties of enzymes with multiple functions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Importantly, they provided the evidence that treatment with divertin regulate paracellular transport rather than transcellular transport across the membranes.”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [191]
In the citing paper
“Further, they showed that treatment with divertin blocked acute interferon gamma–primed TNF-induced MLC phosphorylation and barrier loss in Caco-2 monolayers model system.”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [191]
In the citing paper
“Treatment with divertin also reduced the progression and severity of experimental chronic colitis of T cell transfer model (CD4+ effector T cells in immunodeficient mice) by correcting gut permeability.191”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [191]
In the citing paper
“Further, they demonstrated that treatment with divertin corrected increased intestinal permeability in IL-10–/– mice (spontaneous colitis model) without significant systemic, mucosal, or epithelial toxicity.191”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [191]
In the citing paper
“It was shown by the Turner group that a domain binding small molecule called “divertin” blocks the recruitment of MLCK1 without inhibiting enzyme function.191”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [191]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Coot : model-building tools for molecular graphics
Emsley, P., & Cowtan, K. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904019158 · Cited by 30,571
Overview of the CCP 4 suite and current developments
Winn, M. D., Ballard, C. C., Cowtan, K. D., Dodson, E. J., Emsley, P., Evans, P. R., Keegan, R. M., Krissinel, E. B., Leslie, A. G. W., McCoy, A., et al. (2011) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444910045749 · Cited by 12,353
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
ZINC − A Free Database of Commercially Available Compounds for Virtual Screening
Irwin, J. J., & Shoichet, B. K. (2005) · Journal of Chemical Information and Modeling · doi:10.1021/ci049714+ · Cited by 4,058
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Self-citationThe Immunoglobulin Superfamily: Domains For Cell Surface Recognition
Williams, A., & Barclay, A. N. (1988) · Annual Review of Immunology · doi:10.1146/annurev.iy.06.040188.002121 · Cited by 2,270
A chemical method for fast and sensitive detection of DNA synthesis in vivo
Salic, A. N., & Mitchison, T. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712168105 · Cited by 1,859
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759
The intestinal epithelial barrier: a therapeutic target?
Odenwald, M. A., & Turner, J. R. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.169 · Cited by 1,288
Self-citationPowrie, F., Leach, M. W., Mauze, S., Menon, S., Barcomb Caddle, L., & Coffman, R. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90045-0 · Cited by 1,146
Cited by
Sorted by citations
Items 101–176 of 176
Huo, L., & Sun, Z. (2021) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12397 · Cited by 11
Arinno, A., Sukmak, P., Kulworasreth, P., Sricharunrat, T., Vaddhanaphuti, C. S., & Pongkorpsakol, P. (2025) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2025.100223 · Cited by 10
Cogswell, A. C., Jo, S., Ferguson, N., Gupta, K. H., & Barker, E. (2022) · Journal of Virology · doi:10.1128/jvi.00235-22 · Cited by 11
A new approach for inflammatory bowel disease therapy
Blander, J. M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0416-4 · Cited by 10
Huang, Y.-J., Lee, T., Pai, Y.-C., Lin, B., Turner, J. R., & Yu, L. C. (2021) · Carcinogenesis · doi:10.1093/carcin/bgab038 · Cited by 10
Self-citationHonig, G., Larkin, P. B., Heller, C. A., & Hurtado‐Lorenzo, A. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab230 · Cited by 11
Boehm, E., Droessler, L., & Amasheh, S. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100808 · Cited by 9
Tang, H., Zhou, H., Zhang, L., Tang, T., & Li, N. (2024) · Discover Oncology · doi:10.1007/s12672-024-01019-8 · Cited by 9
Camilleri, M., Magnus, Y., Carlson, P., Wang, X., Chedid, V. G., Maselli, D. B., Taylor, A. L., McKinzie, S., Nagaraj, N. K., Busciglio, I. A., et al. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00063.2022 · Cited by 9
Genetic polymorphisms of muscular fitness in young healthy men
Venckūnas, T., & Degens, H. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275179 · Cited by 11
Targeting MLCK1 uncouples immune checkpoint inhibitor-induced colitis from antitumour immunity
Xiong, L., Huang, J., Dong, Y., Han, W., Kuo, W., Xu, W., Han, Y., An, C., Zhu, R., Zhu, N., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-337780 · Cited by 8
Self-citationKang, X., Jia, M., Zhao, L., & Zhang, S. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6657141 · Cited by 8
Chihade, D. B., Smith, P., Swift, D. A., Otani, S., Zhang, W., Chen, C., Jeffers, L. A., Liang, Z., Shimazui, T., Burd, E. M., et al. (2023) · Shock · doi:10.1097/shk.0000000000002081 · Cited by 8
A Simple Method for Creating a High‐Content Microscope for Imaging Multiplexed Tissue Microarrays
Abtahi, S., Gliksman, N. R., Heneghan, J. F., Nilsen, S. P., Muhlich, J. L., Copeland, J., Rozbicki, E., Allan, C., Dudeja, P. K., & Turner, J. R. (2021) · Current Protocols · doi:10.1002/cpz1.68 · Cited by 8
Self-citationKumar, G., Agarwala, P. K., Srivatsav, A. T., Ravula, A., Ashmitha, G., Balakrishnan, S., Kapoor, S., & Narayan, R. (2024) · ACS Chemical Biology · doi:10.1021/acschembio.4c00336 · Cited by 7
Finding a mate for MLCK: improving the potential for therapeutic targeting of gut permeability
McCole, D. F. (2022) · Gut · doi:10.1136/gutjnl-2022-327599 · Cited by 7
Yin, J., Xie, X., Yao, J., Jin, X., Jiang, H., & Ji, C. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.940 · Cited by 7
Investigation of the physiological effects of uridine on Nile Tilapia (Oreochromis niloticus)
Zhou, N., Ding, F.-F., Wang, T., Dong, W.-X., Qiao, F., Du, Z., & Zhang, M. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741632 · Cited by 6
Promoting immune defensive responses of epithelial cells in airway disease
Parnham, M. J., Norris, V., & Kricker, J. A. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2025.1697194 · Cited by 6
The role of sea buckthorn in skin and mucosal health: a review from an anti-inflammatory perspective
Song, X., Sun, X., Yuan, H., Tang, Y., & Zheng, F. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1643146 · Cited by 8
Du, L., Xu, B.-Q., Xun, K., & Zhang, F. (2023) · World Journal of Emergency Medicine · doi:10.5847/wjem.j.1920-8642.2023.011 · Cited by 6
Sukmak, P., Kulworasreth, P., Treveeravoot, S., Arinno, A., Anuwongworavet, S., Wachiradejkul, W., Kulworasreth, P., Teansuk, N., Thongnak, L., Amonlerdpison, D., et al. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400230 · Cited by 6
Li, W., Qian, Y., Cai, X., He, Y., Meng, X., & Zhang, L. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118125 · Cited by 6
Identifying a specific small molecule to reverse intestinal barrier loss
Thomas, H. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0149-3 · Cited by 6
Tight Junctions in the Auditory System: Structure, Distribution and Function
Gao, X., Chen, C., Shi, S., Qian, F., Liu, D., & Gong, J. (2023) · Current Protein and Peptide Science · doi:10.2174/1389203724666230222102454 · Cited by 6
The epithelium takes the stage in asthma and inflammatory bowel diseases
López-Posadas, R., Bagley, D., Pardo-Pastor, C., & Zapater, E. O. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1258859 · Cited by 5
Early subclinical stages of the inflammatory bowel diseases: insights from human and animal studies
Kelly, C., Sartor, R. B., & Rawls, J. F. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00252.2024 · Cited by 6
Lin, J., Yin, L., Fan, Y., Yu, Z., Ma, X., Fu, X., Zhang, Y., Tang, S.-J., & Chen, J.-L. (2025) · iMetaOmics · doi:10.1002/imo2.49 · Cited by 4
Ferguson, N., Cogswell, A. C., & Barker, E. (2022) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2022.0007 · Cited by 4
Zhang, Y., Fu, Z., Chen, Y., Chen, J., Chen, H., Zhang, M., Pang, Y., Wang, L., Xing, S., Lin, S., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69071-2 · Cited by 4
Sukmak, P., Thongnak, L., Wachiradejkul, W., Inchai, J., Chindaduangratn, N., Kitti-udom, N., Limwattananon, T., Choksukchalalai, N., Satianrapapong, W., Hankan, S., et al. (2025) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-025-00817-x · Cited by 3
Engineering probiotics for inflammatory bowel disease: Strategies and perspectives
Ye, C., Wang, L., Gao, Y., Rui, Z., He, Q., Zhang, Y., Si, H., Pei, P., & Wang, W. (2025) · Chinese Chemical Letters · doi:10.1016/j.cclet.2025.112219 · Cited by 3
Intestinal Barrier: Mechanisms of Disruption and Strategies for Restoration in Ulcerative Colitis
Wang, M.-N., Liu, C.-G., Pan, J., Pang, X.-G., & Liu, H. (2026) · Gastrointestinal Disorders · doi:10.3390/gidisord8020024 · Cited by 3
The landscape of new therapeutic opportunities for IBD
Hurtado‐Lorenzo, A., & Swantek, J. L. (2024) · Advances in pharmacology · doi:10.1016/bs.apha.2024.10.011 · Cited by 4
The expression of intestinal Cyp2c55 is regulated by the microbiota and inflammation
Hilman, A., Sato, T., Wijatniko, B. D., Fujimura, S., Nakamura, K., Miura, H., Iwatsuki, K., Inoüe, R., & Suzuki, T. (2024) · The FASEB Journal · doi:10.1096/fj.202401807r · Cited by 4
Hu, S., Kou, Y., Liu, X., Rong, W., Han, H., & Zhang, G. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023137 · Cited by 3
Macrolides and Diseases Associated with Loss of Epithelial Barrier Integrity
Page, C. P., Gardarsson, F. R., Kricker, J. A., Guðjónsson, Þ., Norris, V., & Parnham, M. J. (2024) · Progress in inflammation research · doi:10.1007/978-3-031-42859-3_1 · Cited by 2
Enhancing intestinal epithelial microtubule stability could alleviate IBD symptoms
Yang, F., He, Z., Pan, X., Xie, S., Liang, X., Geng, L., Xu, W., & Gong, S. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02264-2 · Cited by 2
Quantification of Proliferative and Dead Cells in Enteroids
Li, H.-S., Xu, S.-F., Sheng, J.-Y., Jiang, Z., Wang, J., Ding, N., Wang, T., Odenwald, M. A., Turner, J. R., He, W., et al. (2020) · Journal of Visualized Experiments · doi:10.3791/60501 · Cited by 2
Self-citationChen, J. T.-C., Hu, X., Doppler, K., Breitkreuz-Korff, O., Otto, I. U. C., Schwabe, J., Reinhold, A., Günzel, D., Dithmer, S., Hankir, M. K., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/768267 · Cited by 2
Inter-claudin antagonism of paracellular pore function: mechanism and beyond
Wachiradejkul, W., & Pongkorpsakol, P. (2024) · Tissue Barriers · doi:10.1080/21688370.2024.2330773 · Cited by 1
Dohmen, C. G. M., Troost, F. J., Muijsenberg, A., & Sthijns, M. M. J. P. E. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117186 · Cited by 1
Joelsson, J. P., Parnham, M. J., Froment, L., Rapet, A., Hugi, A., Stucki, J. D., Hobi, N., & Kricker, J. A. (2026) · Biomedicines · doi:10.3390/biomedicines14010237 · Cited by 1
The Regulatory Role of FABP4 in Microbiome–Brain–Gut Communication Under High-Fat-Diet Conditions
Smolińska, K., Tomaszewska, E., Hułas‐Stasiak, M., Muszyński, S., Szopa, A., Serefko, A., & Dobrowolski, P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052430 · Cited by 1
Zhou, L., Yang, Y., Kang, L., You, J., Wang, Y., Xu, A., Tu, G., Huang, R., Zhou, Z., Li, M., et al. (2026) · Microorganisms · doi:10.3390/microorganisms14051148 · Cited by 1
Self-citationBarrier restoration as a therapeutic strategy for disorders of gut–brain interaction
Britton, T. A., & Grover, M. (2026) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(26)00081-6 · Cited by 1
Law, I. K. M., Fang, K., Pothoulakis, C., & Rankin, C. R. (2022) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2022.901404 · Cited by 1
Microbial Metabolite Regulation of Epithelial Tight Junctions and Barrier
Lee, J. S., Wang, R. X., & Colgan, S. P. (2022) · Springer eBooks · doi:10.1007/978-3-030-97204-2_8 · Cited by 2
Chánez-Paredes, S. D., Abtahi, S., Zha, J., Zuo, L., He, W., & Turner, J. R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.13.512159 · Cited by 1
Self-citationIntestinal Transport of Lipopolysaccharides
Said, H., Akiba, Y., & Kaunitz, J. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00169-9
A Microfluidic Programmable Array for Label-free Detection of Biomolecules
Dykstra, P. H. (2011) · University Libraries (University of Maryland)
Mechanisms and prevention of intestinal barrier function damage in traumatic hemorrhagic shock
Chen, F., Chu, C., & Ding, W. (2022) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v30.i12.547
Skin sensitization and food allergy
Das, M., & Geha, R. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-96018-2.00069-9
MLCK Inhibition is Synthetically Lethal to MYC-Overexpressing Cancer CellsPreprint
Sun, Z., Wu, R., Liang, X., Shi, T., Zhang, Y., Pan, Z., Zhang, W., & Luan, X. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4815527
Wang, J., Cai, L., Liu, J., Zhang, F., Zhang, G., Kang, H., Ren, G., Yan, L., Zhang, Y., Pan, Z., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.05.026
Approaches for tight junction opening
Ghante, M. H., Mishra, A., Pandey, A. K., Jain, S. K., Kulkarni, A. P., & Jain, N. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33366-8.00012-9
Mauduit, A., Nabhani, T., Morelli, L., Cherrier, F., Ahad, R. A., Nabhani, N., Singh, G., Roy, M., Dietrich, G., Turner, J. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.10.663215
Self-citationNisar, H., Prajapati, J., Mumtaz, A., Iftikhar, A., Faran, F., Mehmood, R. H., Shahid, S., & Goswami, D. (2025) · Integrative Biology · doi:10.1093/intbio/zyaf016
Skin sensitization and food allergy
Das, M., & Geha, R. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.50032-1
Treveeravoot, S., Sukmak, P., Chatkul, P., Arinno, A., Amonsiriwit, S., Supapol, P., Limwattananon, T., Choksukchalalai, N., Kitti-udom, N., Chindaduangratn, N., et al. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2585726
Tight Junction Defects in Aganglionic and Ganglionic Colon in Children With Hirschsprung Disease
Rincón-Cruz, L., Froehle, L., Abhati, S., Goldsmith, J. D., Turner, J. R., & Nandivada, P. (2025) · Laboratory Investigation · doi:10.1016/j.labinv.2025.104271
Self-citationGonzález, L., Muñoz-Fariña, O., Fernández-Guerrero, Y., García, O., Ravanal, M. C., Serrano, J., & Fernández, K. F. (2026) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2026.109086
Rouaud, F., Mutero-Maeda, A., Borgo, C., Ruzzene, M., & Citi, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.02.716052
The end of ’leaky gut’: pathway-specific mechanistic approaches to barrier restoration
Sha, Z., Bhardwaj, A., & Turner, J. R. (2026) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000001174 · Cited by 1
Self-citationArinno, A., Sukmak, P., Treveeravoot, S., Kulworasreth, P., Supapol, P., Sangsuwan, W., Teansuk, N., Wachiradejkul, W., Inchai, J., Sricharunrat, T., et al. (2026) · Biological Research · doi:10.1186/s40659-026-00696-9
Yoon, H. S., Ma, S., Kanke, M., Wu, W.-J., Hoang, U., Tan, J. A., Wilks, A., Patel, P., Chandra, S., Luo, X., et al. (2026) · Inflammation Research · doi:10.1007/s00011-026-02288-5
Chen, S., Moorthy, A., Yu, P. K., Wang, J., & Liu, D. K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.08.730759
The dietary restoration of intestinal barrier function by nutrient-sensing receptors
Arinno, A., & Pongkorpsakol, P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40306-4.00014-4
Gut microbiota from health to disease: A role for biofilms?
Buret, A. G., & Allain, T. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40306-4.00011-9
The interplay of gut microbiota and energy homeostasis in obesity-related diseases
Ruan, J., & Kao, C. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40306-4.00009-0
Epithelial brush border as a gatekeeper for gut barrier integrity and microbiota eubiosis
Pai, Y.-C., Li, Y.-H., & Yu, L. C.-H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40306-4.00013-2
Hu, D., Wang, Z., Xue, Y., Li, X., Li, Y., Liu, S., Gao, L., Liu, H., & Yan, H. (2026) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbag021
Xiong, L., Huang, J., Liu, Q., Xia, H., Zhu, N., Xiang, W., Xu, W., Dong, Y., Zhu, R., Han, Y., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101857
Self-citationXu, J., Shi, T., Qian, D., Cheng, K., Xu, P., 陈学年, Wang, C., Ru, N., Li, T., Ma, N., et al. (2026) · 中国科学通报:英文版 · doi:10.1016/j.scib.2026.09.052
Alternative splicing fine-tunes modular protein interfaces to control protein localization
Kjer-Hansen, P., Pazaky, K., Kavanagh, D., King, H. A., O’Connell, S. M., Rodriguez, G. S., Grootveld, A. K., Vieira, H. G. S., Berry, S. M., Fernández-Chamorro, J., et al. (2026) · Nature Structural & Molecular Biology · doi:10.1038/s41594-026-01875-8
Colitis-associated colorectal carcinogenesis: molecular mechanisms and therapeutic potential
Lu, Y., Wang, X., Yin, C., Wang, J., Guo, S., Wang, Z., Zhou, J., Cui, M., Cheng, X., Zhang, L., et al. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00623-0
Metadata
- Authors
- Graham, W. V., He, W., Marchiando, A. M., Zha, J., Singh, G., Li, H.-S., Biswas, A., Ong, M. L. D. M., Jiang, Z.-H., Choi, W., Zuccola, H., Wang, Y., Griffith, J., Wu, J., Rosenberg, H. J., Wang, Y., Snapper, S. B., Ostrov, D., Meredith, S. C., Miller, L. W., & Turner, J. R.
- Affiliations
- University of Chicago (US)
- Soochow University (CN)
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Vertex Pharmaceuticals (United States) (US)
- University of Florida (US)
- University of Illinois Chicago (US)
- Corresponding author
- Turner, Jerrold R.
- ORCID
- Venue
- Nature Medicine
- Published
- 2019-04
- Volume
- 25
- Issue
- 4
- Pages
- 690-700
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC6461392
- OpenAlex
- W2933961522
- Cited by
- 176
- References
- 56
- Citations by year
- 2026: 22 · 2025: 20 · 2024: 37 · 2023: 17 · 2022: 26 · 2021: 23 · 2020: 21 · 2019: 9
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Figshare (submittedVersion, cc-by)
- University of Illinois Chicago
- Funders
- Crohn's and Colitis Foundation (310801)
- National Institute on Aging (R01AG048793)
- National Heart, Lung, and Blood Institute (T32HL007237)
- National Cancer Institute (P30CA014599)
- National Institute of General Medical Sciences (R01GM081030)
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK094954, R24DK099803, R01DK068271, P30DK034854, R01DK061931)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- myosin light chain kinase, epithelial barrier dysfunction, small molecule inhibitors, myosin light chain phosphorylation, inflammatory bowel disease, diarrhea, mucosal homeostasis
- MeSH terms
- Protein Domains, Actomyosin, Animals, Chronic Disease, Homeostasis, Humans, Inflammation, Intestinal Mucosa, Jejunum, Myosin-Light-Chain Kinase, Phosphorylation, Tumor Necrosis Factor-alpha, Inflammatory Bowel Diseases, Caco-2 Cells, Myosin Light Chains, Tight Junctions, Intracellular Space, Mice, Small Molecule Libraries
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review