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Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells
Open accessAbstract
A sedentary lifestyle, chronic inflammation and leukocytosis increase atherosclerosis; however, it remains unclear whether regular physical activity influences leukocyte production. Here we show that voluntary running decreases hematopoietic activity in mice. Exercise protects mice and humans with atherosclerosis from chronic leukocytosis but does not compromise emergency hematopoiesis in mice. Mechanistically, exercise diminishes leptin production in adipose tissue, augmenting quiescence-promoting hematopoietic niche factors in leptin-receptor-positive stromal bone marrow cells. Induced deletion of the leptin receptor in Prrx1-creER T2; Lepr fl/fl mice reveals that leptin's effect on bone marrow niche cells regulates hematopoietic stem and progenitor cell (HSPC) proliferation and leukocyte production, as well as cardiovascular inflammation and outcomes. Whereas running wheel withdrawal quickly reverses leptin levels, the impact of exercise on leukocyte production and on the HSPC epigenome and transcriptome persists for several weeks. Together, these data show that physical activity alters HSPCs via modulation of their niche, reducing hematopoietic output of inflammatory leukocytes.
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“Instead, PA reinforces cardiorespiratory fitness, 31 inhibits inflammatory responses, 32 and improves glucose metabolism.33”
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Citations
Cites
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259
Salmon provides fast and bias-aware quantification of transcript expression
Patro, R., Duggal, G., Love, M. I., Irizarry, R. A., & Kingsford, C. (2017) · Nature Methods · doi:10.1038/nmeth.4197 · Cited by 12,700
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482
McCarthy, D. J., Chen, Y., & Smyth, G. K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks042 · Cited by 5,195
(2019) · doi:10.1161/cir.0000000000000677 · Cited by 4,501
Guidelines for assessment of bone microstructure in rodents using micro–computed tomography
Bouxsein, M., Boyd, S. K., Christiansen, B., Guldberg, R. E., Jepsen, K. J., & Müller, R. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.141 · Cited by 4,461
Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences
Soneson, C., Love, M. I., & Robinson, M. D. (2015) · F1000Research · doi:10.12688/f1000research.7563.1 · Cited by 3,929
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381
ATAC-seq: a method for assaying chromatin accessibility genome-wide
Buenrostro, J. D., Wu, B., Chang, H. Y., & Greenleaf, W. J. (2015) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb2129s109 · Cited by 3,289
Cited by
Sorted by citations
Items 101–200 of 292
Pasterkamp, G., den Ruijter, H. M., & Giannarelli, C. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316693 · Cited by 30
Role of CD40(L)-TRAF signaling in inflammation and resolution—a double-edged sword
Strohm, L., Ubbens, H., Münzel, T. F., Daiber, A., & Daub, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.995061 · Cited by 29
“They can influence molecular processes in the body and negatively affect the immune system (Frodermann et al., 2019; McAlpine et al., 2019; Tourki and Halade, 2021).”
BackgroundTime restricted feeding modifies leukocyte responsiveness and improves inflammation outcome
Ella, K., Sűdy, Á. R., Búr, Z., Koós, B., Kisiczki, Á. S., Mócsai, A., & Káldi, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.924541 · Cited by 31
“As recently reported, leptin can influence the production of CXCL12 via activation of LepR+ stromal cells of the bone marrow (60).”
BackgroundExercise rapidly alters proteomes in mice following spinal cord demyelination
Lozinski, B. M., de Almeida, L. G. N., Silva, C., Dong, Y., Brown, D., Chopra, S., Yong, V. W., & Dufour, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-86593-5 · Cited by 28
Bonaud, A., Lemos, J. P., Espéli, M., & Balabanian, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.658535 · Cited by 32
Infectious and lifestyle modifiers of immunity and host resilience
Bajpai, G., & Nahrendorf, M. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.011 · Cited by 27
Tourki, B., & Halade, G. V. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.695952 · Cited by 31
Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels
Xu, Z., Zhang, M., Li, X., Wang, Y., & Du, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073788 · Cited by 27
“Moderate exercise can reduce the risk factors of cardiovascular diseases and inhibit the development of atherosclerosis [3,13].”
BackgroundExercise training modifies the whole blood DNA methylation profile in middle-aged and older women
Rodrigues, G. D. S., Noronha, N. Y., de Almeida, M. L., Sobrinho, A. C. D. S., Watanabe, L. M., Pinhel, M. A. D. S., de Lima, J. G. R., Zhang, R., Nonino, C. B., Alves, C. R. R., et al. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00237.2022 · Cited by 27
Su, C., Lu, Y., Wang, Z., Guo, J., Hou, Y., Wang, X., Qin, Z., Gao, J., Sun, Z., Dai, Y., et al. (2022) · Aging and Disease · doi:10.14336/ad.2022.1208 · Cited by 28
“[21], lack of exercise [22] or sleep [23] also have similar effects on bias myeloid cell hematopoietic.”
BackgroundExtrinsic and intrinsic modulators of inflammation-resolution signaling in heart failure
Rao, A., Gupta, A., Kain, V., & Halade, G. V. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00276.2023 · Cited by 27
Guo, X., & Le, Y. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.09.008 · Cited by 25
Macrophages in Atheromatous Plaque Developmental Stages
von Ehr, A., Bode, C., & Hilgendorf, I. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.865367 · Cited by 24
Clonal hematopoiesis in men living with HIV and association with subclinical atherosclerosis
Wang, S., Paşca, S., Post, W. S., Langan, S. J., Pallavajjalla, A., Haley, L. M., Gocke, C. D., Budoff, M. J., Haberlen, S., Brown, T. T., et al. (2022) · AIDS · doi:10.1097/qad.0000000000003280 · Cited by 24
Kim, Y., Lee, Y., Lee, M. N., Nah, J., Yun, N., Wu, D., & Pae, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1054875 · Cited by 22
“While voluntary exercise reduced serum leptin levels and LSK cell proliferation, leptin supplementation during exercise increased numbers of leukocytes (51).”
BackgroundPlackoska, V., Shaban, D., & Nijnik, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1041010 · Cited by 26
Mechanisms of Post-critical Illness Cardiovascular Disease
Owen, A., Patel, J. M., Parekh, D., & Bangash, M. N. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.854421 · Cited by 22
“Immobility, inactivity and sedentarism are associated with prolonged increases in bone marrow fat content, which leads to increased leptin signaling and inflammatory monocytic output (264, 265).”
BackgroundReddy, Y. N. V., Obokata, M., Jones, A. D., Lewis, G. D., Shah, S. J., Abou-Ezzedine, O. F., Fudim, M., Alhanti, B., Stevenson, L. W., Redfield, M. M., et al. (2020) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.08.008 · Cited by 23
Hematopoietic Stem Cells in Wound Healing Response
Urao, N., Liu, J., Takahashi, K., & Ganesh, G. (2021) · Advances in Wound Care · doi:10.1089/wound.2021.0065 · Cited by 23
“In line with this, exercise increases HSPC quiescence (limiting activity) but augment emergency hematopoiesis (increase reactivity).(141) For translation into clinical setting, a cellular biomarker that reflects HSPC dysregulation in human conditions should be established.”
BackgroundCHIP: a clonal odyssey of the bone marrow niche
Schleicher, W. E., Hoag, B., Dominici, M. D., DeGregori, J. V., & Pietras, E. M. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180068 · Cited by 23
“Moreover, exercise diminished adipocyte leptin production, which in turn augmented production of quies-cence-promoting factors secreted from LepR + MSCs in the BM. Notably, while exercise in this study reduced chronic leukocytosis, emergency myelopoiesis was not compromised (131).”
InfluentialThe interaction of physical activity and sleep quality with depression and anxiety in older adults
Yuan, Y., Huang, W., Hu, C., & Zhang, W. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1674459 · Cited by 26
Systemic and local regulation of hematopoietic homeostasis in health and disease
Carpenter, R. S., & Maryanovich, M. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00482-4 · Cited by 24
“Exercise also reversed inflammatory cell responses to atherosclerotic plaques in Apoe −/− mice on a Western diet 178 .”
Xu, Y., Murphy, A. J., & Fleetwood, A. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042234 · Cited by 23
Mangione, M. C., Wen, J., & Cao, D. J. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.10.011 · Cited by 20
Codella, R., Guardia, L. D., Terruzzi, I. M., Solini, A., Folli, F. B., Varoni, E. M., Carrassi, A., & Luzi, L. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.04.022 · Cited by 19
“associated with significant reduction in low-grade systemic inflammation [74], circulating leukocytes [61], and it is currently seen as a viable strategy to improve metabolic status in chronic inflammatory diseases and cardio-vascular inflammation [75,76].”
BackgroundThe Role of Biomarkers in Atherothrombotic Stroke—A Systematic Review
Andone, S. R., Bajkó, Z., Moțățăianu, A., Mosora, O., & Bălașa, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169032 · Cited by 19
“The same study also showed that mice with leptin receptor deletion had a reduction of infarct inflammation and the size of atherosclerotic plaques [58].”
BackgroundWang, H., Zhang, W., Cai, Y., Guo, Q., Pan, L., Chu, G., Chen, J., Yuan, Z., & Li, B. (2023) · Journal of Orthopaedic Research® · doi:10.1002/jor.25596 · Cited by 18
“62 Mechanical loading reduces inflammatory responses to stimulate self ‐ recovery from tendon injuries.”
BackgroundExercise protects against cardiovascular disease by modulating immune cell supply
Fernández-Ruíz, I. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0311-1 · Cited by 18
Kaastrup, K., & Grønbæk, K. (2021) · HemaSphere · doi:10.1097/hs9.0000000000000615 · Cited by 18
One genome, many cell states: epigenetic control of innate immunity
Fraschilla, I. R., Amatullah, H., & Jeffrey, K. L. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102173 · Cited by 19
Marcos‐Garcés, V., Bertolín‐Boronat, C., Merenciano-Gonzalez, H., Mas, M. L. M., Alberola, J. I. C., López, L., Rubio, A. P., Pérez-Solé, N., Ríos‐Navarro, C., de Dios, E., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262210964 · Cited by 20
“Post-AMI inflammation, although necessary and beneficial to some extent [128], can be modulated by exercise training [129].”
Fotopoulou, F., Rodriguez-Correa, E., Dussiau, C., & Milsom, M. D. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104698 · Cited by 17
Gao, C., Liu, Y., Jiang, C., Liu, L., Li, J., Li, D., Guo, X., Wang, Z., Yang, Y., Liu, L., et al. (2020) · Nutrients · doi:10.3390/nu12092770 · Cited by 19
“Regular physical exercise is generally deemed to play a protective effect on human against inflammation [1].”
BackgroundLow‐Dose Tamoxifen Induces Significant Bone Formation in Mice
Xie, Z., McGrath, C., Sankaran, J. S., Styner, M., Little, S. E., Dudakovic, A., van Wijnen, A. J., Rubin, J. E., & Sen, B. (2020) · JBMR Plus · doi:10.1002/jbm4.10450 · Cited by 16
“For investigation of bone metabolism, different promoters that drive osteogenic gene expression in bone, combined with the Cre-loxP system, have been used to study the roles of bonespecific genes during bone development including Col1,((27)) Col2, Osx,((31)) and Prrx1, which is specifically expressed in MSC which driv…”
Preclinical techniques to investigate exercise training in vascular pathophysiology
Sangha, G. S., Goergen, C. J., Prior, S. J., Ranadive, S. M., & Clyne, A. M. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00719.2020 · Cited by 17
Trained immunity in cardiovascular disease
Riksen, N. P., Netea, M. G., Ait‐Oufella, H., Chavakis, T., & Hajishengallis, G. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf982 · Cited by 21
Vanhie, J. J., Kim, W., Orloff, L. E., Ngu, M., Collao, N., & Lisio, M. D. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1054463 · Cited by 16
“Previous reports from our lab and others indicate exercise impacts hematopoiesis via paracrine actions in the HSC niche (Emmons et al., 2016; Wen et al., 2016; Szatmári et al., 2017; Frodermann et al., 2019).”
BackgroundResultInfluentialThe treatment of chronic anemia in heart failure: a global approach
Bianchi, V. E., & von Haehling, S. (2023) · Clinical Research in Cardiology · doi:10.1007/s00392-023-02275-4 · Cited by 19
“Physical exercise reduces inflammation [282] and oxidative stress [283] and improves oxygen transport.”
Development and validation of prediction model for older adults with cognitive frailty
Huang, J., Zeng, X., Ning, H., Peng, R., Guo, Y., Hu, M., & Feng, H. (2024) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02647-w · Cited by 17
Resolving inflammatory links between myocardial infarction and vascular dementia
Thorp, E. B., Flanagan, M. E., Popko, B., & DeBerge, M. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101600 · Cited by 17
Elevated highly sensitive C-reactive protein in fibromyalgia associates with symptom severity
Zetterman, T., Markkula, R., & Kalso, E. A. (2022) · Rheumatology Advances in Practice · doi:10.1093/rap/rkac053 · Cited by 17
Guardia, L. D., Pellino, V. C., Filipas, L., Bonato, M., Gallo, G., Lovecchio, N., Vandoni, M., & Codella, R. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.11.007 · Cited by 14
Halade, G. V., Upadhyay, G., Marimuthu, M., Xuan, W., & Kain, V. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.02.004 · Cited by 14
Chen, J., Hua, S., Huang, L., Zhang, X., Yao, W., & Xue, Z. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111140 · Cited by 14
Exercise lowers leptin and leukocytosis
Bird, L. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0253-1 · Cited by 14
Niche Regulation of Hematopoiesis: The Environment Is “Micro,” but the Influence Is Large
Rasheed, A. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316235 · Cited by 14
Bone Marrow Niche in Cardiometabolic Disease: Mechanisms and Therapeutic Potential
Kohutek, Z. A., Caslin, H. L., Fehrenbach, D. J., Heimlich, J. B., Brown, J. D., Madhur, M. S., Ferrell, P. B., & Doran, A. C. (2025) · Circulation Research · doi:10.1161/circresaha.124.323778 · Cited by 18
Proteome atlas for mechanistic discovery and risk prediction of diabetic retinopathy
Yang, S., Xin, Z., Xiong, R., Zhu, Z., Li, H., Chen, Y., Zhong, Z., Du, L. Z., Zhu, Z., Shang, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64634-1 · Cited by 17
Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis
Gerhardt, T., Huynh, P., & McAlpine, C. S. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae167 · Cited by 14
Does Physical Activity Have an Impact on Recurrence Dynamics in Early Breast Cancer Patients?
Biganzoli, E. M., Desmedt, C., & Demicheli, R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040831 · Cited by 13
“A recent experimental study also suggested a new mechanism in which exercise reduces inflammatory cell production via the reduction of leptin levels and instruction of the hematopoietic progenitor cells [15].”
BackgroundInflammation reprogramming and immunomodulation: Next-generation treatments for atherosclerosis
Choudhury, R. P., Hargreaves, R., Chai, J., & Fisher, E. A. A. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102288 · Cited by 12
“Data are emerging on further specific neural intercon-nections in relation to immune function, 144 which are of particular relevance to sleep, 145 physical exercise, 146 circadian rhythm, 147 and psychological stress.”
Liu, S., Meng, X., Li, G., Gokulnath, P., Wang, J., & Xiao, J. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2304148 · Cited by 13
Zhao, B., Wan, J., Zhou, H., Yang, J., & Wan, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1669796 · Cited by 14
The immunology of exercise: Mechanisms, mediators, and therapeutic opportunities
Phelps, C. M., & Meisel, M. (2026) · Immunity · doi:10.1016/j.immuni.2026.04.016 · Cited by 12
Wang, Z., Sim, H., Liu, W., Kim, J.-C., Lee, J., Kook, S., & Kim, S. H. (2023) · Aging and Disease · doi:10.14336/ad.2023.0713 · Cited by 11
Exercise-induced adaptive response of different immune organs during ageing
Zhou, H., Han, X., Chunxiu, H., Wu, H., Hu, Y., Chen, C., & Tao, J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102573 · Cited by 11
Zhang, Y., Ma, R.-W., Bhandari, S., Xie, J., Zhang, X., Xie, C. L., Duan, H., Meng, J., Wu, Q., Liu, K., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-91125-6 · Cited by 11
“For example, increasing physical activity, improving dietary habits, and strengthening health education could reduce inflammation and control weight in high-risk subgroups 26 .”
Joo, Y. B., Lee, K. B., Sul, B., Lee, H., Lim, S. H., & Park, Y. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02765-2 · Cited by 11
Wu, M., Pang, Y., Chen, M., Li, L., Yan, L., Ning, J., Liu, Q., Zhang, Y., Jiang, T., Kang, A., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158598 · Cited by 11
Yang, W., Xu, S., Zhou, M., & Chan, P. (2024) · Aging · doi:10.18632/aging.205954 · Cited by 10
“LEPR mediates the actions of leptin, a hormone involved in regulating energy balance [39], but also implicated in inflammation and immunity [40].”
BackgroundSequestration of Inflammation in Parkinson’s Disease via Stem Cell Therapy
Gordon, J., Lockard, G., Monsour, M., Alayli, A., Choudhary, H., & Borlongan, C. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710138 · Cited by 10
“In mouse models, exercise is implicated in stem cell driven antiinflammatory effects through changes to the epigenome and transcriptome of hematopoietic stem and progenitor cells, diminishing the proliferative yield of inflammatory immune cells [139].”
BackgroundZheng, X., Jiang, M., Ren, X., Han, L., Yang, P., Jia, Y., Sun, L., Wang, R., Shi, M., Zhu, Z., et al. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae070 · Cited by 9
Association of blood cadmium and physical activity with mortality: A prospective cohort study
Chen, Y., Zhen, C., Zeng, L., Feng, H., Wang, J., Ai, Q. Y. H., Ai, S., Zhang, J., Liang, Y. Y., Xue, H., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117541 · Cited by 9
Zhang, Z., Cao, F., Liang, D., Pan, M., Lu, W. W., Lyu, H., Xie, Y., Zhang, L., & Tang, P. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.04.018 · Cited by 10
How Does Lifestyle Affect Hematopoiesis and the Bone Marrow Microenvironment?
Vanhie, J. J., & Lisio, M. D. (2022) · Toxicologic Pathology · doi:10.1177/01926233221123523 · Cited by 9
Zeng, H., Chen, N., Chen, F., Zhong, X., Yang, L., Lu, Y., Chen, M., Shen, M., Wang, S., Chen, S., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01959-2 · Cited by 8
Duan, T., Cao, Z., Wang, X., Min, J., Sun, T., Hong, L., & Xu, C. (2024) · The British Journal of Psychiatry · doi:10.1192/bjp.2024.227 · Cited by 8
“8,9 Limited epidemiological studies have indicated a lack of statistically significant interaction between diet and physical activity in the general population, thus supporting the notion that combining a high-quality diet with high levels of physical activity was independently associated with a…”
Lankila, H., Kekäläinen, T., Hietavala, E., & Laakkonen, E. K. (2025) · Scientific Reports · doi:10.1038/s41598-025-85134-8 · Cited by 9
“Previous research suggests that exercise 11 , weight loss 12 and whole grain diet 13 can reduce systemic levels of proinflammatory cytokines.”
Exercise in atherosclerosis: its beneficial effects and underlying mechanism
Yin, M.-T., & Guo, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1598794 · Cited by 10
Solimando, A. G., Melaccio, A., Vacca, A., & Ria, R. (2022) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2021.166 · Cited by 9
Lifestyle, caries, and apical periodontitis: Results from a university‐based cross‐sectional study
Gaeta, C., Malvicini, G., Lascio, D. D., Martignoni, M., Ragucci, G., Grandini, S., & Marruganti, C. (2024) · International Endodontic Journal · doi:10.1111/iej.14165 · Cited by 8
“The negative impact of unhealthy lifestyles on overall health is often attributed to the onset of low-grade systemic inflammation (LGSI) and the overproduction of reactive oxygen species, leading to oxidative stress (Esposito et al., 2004; Frodermann et al., 2019).”
The role of adipose tissue-derived hydrogen sulfide in inhibiting atherosclerosis
Tian, Z., Deng, N.-H., Zhou, Z., Ren, Z., Xiong, W., & Jiang, Z. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.07.001 · Cited by 8
Burns, S. S., & Kapur, R. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.06.021 · Cited by 9
“In addition, exercise alleviates CV inflammation by modulating hematopoiesis (Frodermann et al., 2019).”
BackgroundGallo, G., Autore, C., Volterrani, M., Barbato, E., & Volpe, M. (2025) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-025-00707-y · Cited by 9
“Moreover, other preclinical studies have shown that ET can modulate the immune system increasing. serum and cardiac interleukin-10, cardiac myeloid derived suppressor cells and leptin receptor and reducing cardiac and circulating leukocytes and cytokine production [75, 76].”
Yuan, C., Zhou, T., Xx, C., Xie, S., Lu, X., & Liu, F. (2026) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwag054 · Cited by 7
Dietary restriction and/or exercise training impairs spermatogenesis in normal rats
Li, Y., Zhang, L., Zheng, X., Qian, J., Li, Y., Xie, C., Zhang, X., Zhou, Y., & Huang, H. (2020) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2020-0477 · Cited by 7
Exercising immune cells: The immunomodulatory role of exercise on atrial fibrillation
Miguel‐dos‐Santos, R., Moreira, J. B. N., Loennechen, J. P., Wisløff, U., & Mesquita, T. (2021) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2021.07.008 · Cited by 8
Yao, P., Zhong, Y., & Wei, Z. (2025) · BMC Cancer · doi:10.1186/s12885-025-13578-2 · Cited by 6
Wang, Y., Zhu, W., Zhang, T., Liu, Q., Zou, M., Xie, Y., Wang, M., Wang, T. S., Pang, Y., Jing, T., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138273 · Cited by 6
Broderick, C. A., Stewart, M. C. W., Thomson, K., Sellers, C., Fenton, C., Cowie, J., Wei, X., St-Jean, C., Charteris, K., Nundy, M., et al. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103201 · Cited by 6
Cheng, G., Liu, Y., Xing, Y., Shi, Z., Farag, M. A., Jin, S., & Xia, B. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.01.007 · Cited by 6
Li, J., Peng, X., Huang, C., Huang, J., Si, J., Xiang, L., Dong, J., & 向光大 (2026) · Metabolism · doi:10.1016/j.metabol.2026.156620 · Cited by 6
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Gerhardt, T., Jacob, W., Gaebel, L., Heiser, M., Wolfram, C., Huynh, P., Nakao, T., dos Santos, B. G., Toh, P., Douglas, A., et al. (2026) · Nature · doi:10.1038/s41586-026-10634-0 · Cited by 10
“CH mutations are profoundly atherogenic 7,8,28,29 and sleep and exercise influence atherosclerosis in non-CH Ldlr −/− mice 24,25 (Extended Data Fig.”
Hematopoietic Stem Cells as an Integrative Hub Linking Lifestyle to Cardiovascular Health
Chen, X., Liu, C., Wang, J., & Du, C. (2024) · Cells · doi:10.3390/cells13080712 · Cited by 6
“Here, we focus on the salutary effects of a healthy diet pattern and physical exercise on BM HSC homeostasis as well as their causal links with cardiovascular health.”
BackgroundTrained immunity: A link between risk factors and cardiovascular disease
Chen, M., Kang, X., Zhang, Y., & Liu, Y. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16472 · Cited by 8
“Moreover, the epigenetic alterations in myeloid HSPCs induced by voluntary exercise persist for weeks even after cessation of exercise (Frodermann et al., 2019).”
Rentz, T., Wanschel, A. C. B. A., Moi, L. D. C., Lorza‐Gil, E., de Souza, J. C., dos Santos, R. R., & Oliveira, H. C. F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.599379 · Cited by 7
Habitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness
Cho, J. M., Vu, K., Park, S., Zhu, E., Li, Y.-R., Zhao, P., Yokota, T., Yang, L., Lu, R., Xiang, Y. K., et al. (2025) · Circulation Research · doi:10.1161/circresaha.124.325656 · Cited by 5
“5 Thus, elucidating the autonomic system underlying vascular dysfunction represents an emerging therapeutic target.”
Exercise pills for cardiometabolic health cannot mimic the exercise milieu
Plaza‐Florido, A., Lindholm, M. E., Carrera‐Bastos, P., Santos‐Lozano, A., Valenzuela, P. L., Fiuza‐Luces, C., Radom‐Aizik, S., & Lucı́a, A. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.07.005 · Cited by 5
Abohashem, S., Aldosoky, W., Abbasi, T. A., Dar, T. A., Rollings, R. C., Tung, B., Hammad, B., Saeed, F. U., Ali, A., Takx, R. A. P., et al. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156427 · Cited by 5
Liu, J.-C., Yang, R., Feng, Z.-F., Liu, B.-Q., Yu, L., Chen, Y.-H., Li, D.-R., Zheng, W.-R., Liu, N., Gao, S., et al. (2025) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaf365 · Cited by 5
Lechner, K., Kia, S., von Korn, P., Dinges, S. M.-T., Mueller, S., Tjønna, A. E., Wisløff, U., Craenenbroeck, E. M. V., Pieske, B. M., Adams, V., et al. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1329633 · Cited by 5
Rayhan, M. A., Islam, M. K., Khatun, M. A., Islam, D., & Rahman, M. N. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13458 · Cited by 5
Lehti, M., Valkeinen, H., Sipilä, S., Perhonen, M. A., Rottensteiner, M., Pullinen, T., Pietiläinen, R., Nyman, K., Vehkaoja, A. T., Kainulainen, H., et al. (2020) · PubMed Central · Cited by 5
Vanhie, J. J., Kim, W., Goode, C., Collao, N., Tate, A., & Lisio, M. D. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00899.2024 · Cited by 4
Vanhie, J. J., Orloff, L. E., TATE, A., Goode, C., Collao, N., PISANKO, A., Power, K. A., & Lisio, M. D. (2024) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003572 · Cited by 4
Hematopoietic stem and progenitor cells fine-tuning the “sweet” of trained immunity
Li, J., Wang, H., & Xia, S. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf043 · Cited by 4
Oneda, E., Noventa, S., Libertini, M., Cherri, S., Manno, A., Meriggi, F. A., Martinetti, M., & Zaniboni, A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1648004 · Cited by 4
Silva, R. V. D. C., Torres, L. C., da Fonte, E. J. A., Mello, M. J. G., Lima, J. T. D. O., & da Matta, M. C. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2021.111677 · Cited by 4
Ge, Z., Zhang, Z., & Ding, S. (2022) · European Journal of Inflammation · doi:10.1177/1721727x221134942 · Cited by 4
“However, in this context, the reduction in the number of inflammatory leukocytes does not weaken the immunity of the mice, but enhances the anti-infection ability of the mice.(46) This provides strong 8 European Journal of Inflammation”
BackgroundChen, X., Zhou, M., Wang, J., Liu, M., Zhu, C., Wu, C., Dong, M., Liu, Y., Ai, S., Feng, H., et al. (2024) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2024.08.005 · Cited by 4
Metadata
- Authors
- Frodermann, V., Rohde, D., Courties, G., Severe, N., Schloss, M. J., Amatullah, H., McAlpine, C. S., Cremer, S., Hoyer, F. F., Ji, F., van Koeverden, I. D., Herisson, F., Honold, L., Masson, G. S., Zhang, S., Grune, J., Iwamoto, Y., Schmidt, S. P., Wojtkiewicz, G. R., Lee, I.-H., Gustafsson, K., Pasterkamp, G., de Jager, S. C. A., Sadreyev, R. I., MacFadyen, J., Libby, P., Ridker, P., Scadden, D. T., Naxerova, K., Jeffrey, K. L., Swirski, F. K., & Nahrendorf, M.
- Affiliations
- Harvard University (US)
- University Medical Center Utrecht (NL)
- Brigham and Women's Hospital (US)
- Corresponding author
- Nahrendorf, Matthias
- ORCID
- Frodermann, Vanessa
- Rohde, David
- Courties, Gabriel
- Schloss, Maximilian J.
- Amatullah, Hajera
- McAlpine, Cameron S.
- Cremer, Sebastian
- Hoyer, Friedrich F.
- Ji, Fei
- Zhang, Shuang
- Grune, Jana
- Iwamoto, Yoshiko
- Wojtkiewicz, Gregory R.
- Lee, I-Hsiu
- Gustafsson, Karin
- Pasterkamp, Gerard
- de Jager, Saskia C. A.
- Sadreyev, Ruslan I.
- Libby, Peter
- Ridker, Paul
- Scadden, David T.
- Naxerova, Kamila
- Jeffrey, Kate L.
- Nahrendorf, Matthias
- Venue
- Nature Medicine
- Published
- 2019-11
- Volume
- 25
- Issue
- 11
- Pages
- 1761-1771
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC6858591
- OpenAlex
- W2982848656
- Cited by
- 292
- References
- 79
- Citations by year
- 2026: 39 · 2025: 51 · 2024: 42 · 2023: 32 · 2022: 51 · 2021: 47 · 2020: 26 · 2019: 3
- FWCI
- 22.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (HL139598)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- physical activity, voluntary running, hematopoietic stem and progenitor cells, leukocytosis, atherosclerosis, cardiovascular inflammation, leptin, leptin receptor, bone marrow microenvironment, adipose tissue, emergency hematopoiesis, PRRX1, epigenome, transcriptome
- MeSH terms
- Epigenome, Adipose Tissue, Animals, Cardiovascular Diseases, Hematopoiesis, Hematopoietic Stem Cells, Humans, Inflammation, Leukocytes, Leukocytosis, Physical Conditioning, Animal, Exercise, Homeodomain Proteins, Atherosclerosis, Mice, Receptors, Leptin, Sedentary Behavior, Transcriptome
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