The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
Open accessAbstract
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org . An analysis of single-cell transcriptomics datasets from different tissues shows that ACE2 and TMPRSS2 are co-expressed in respiratory, corneal and intestinal epithelial cell populations, and that respiratory expression of ACE2 is associated with genes involved in innate immunity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Although scSeq revealed ACE2 transcripts in only a subset of OE cells, this low level of observed expression matches or exceeds that observed in respiratory cells types that are infected by CoV-2 in COVID-19 patients (39) (Fig. 3).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [39]
Experimental — accuracy not yet measuredIn the citing paper
“Probably most important for the high efficacy of SARS-CoV-2 transmission is the high co-expression of ACE2 and TMPRSS2 in nasal epithelial cells, particularly in two types of goblet cells and a subset of ciliated cells, showing the highest expression among all cells in the respiratory tree (Figure 2 A).”
From COVID-19 and the human innate immune system (2021) · cites this paper as Sungnak et al., 2020
In the citing paper
“An interesting observation of this study was the high co-expression of genes involved in early steps of antiviral immune responses in these epithelial cells, which indicated the potential for these specialized nasal cells to play an important role in the initial viral infection, spread, but potentially also, clearance.”
From COVID-19 and the human innate immune system (2021) · cites this paper as Sungnak et al., 2020
In the citing paper
“TMPRSS2 is more widely expressed than ACE2, and cells with simultaneous expression were identified in the respiratory tree, the cornea, esophagus, ileum, colon, gallbladder, and common bile duct (Sungnak et al., 2020), yet there was no evidence for simultaneous expression in immune cells.”
From COVID-19 and the human innate immune system (2021) · cites this paper as Sungnak et al., 2020
In the citing paper
“It has recently been demonstrated through single cell RNA sequencing analysis (referred to herein as scSeq) that cells from the human upper airway — including nasal RE goblet and ciliated cells —express high levels of ACE2 and TMPRSS2, suggesting that these RE cell types may serve as a viral reservoir during CoV-2 infection (39, 40).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246
A novel coronavirus from patients with pneumonia in China, 2019
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001017 · Cited by 28,244
Clinical Characteristics of Coronavirus Disease 2019 in China
Eastin, C., & Eastin, T. (2020) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2020.04.004 · Cited by 24,945
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286
Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001316 · Cited by 16,575
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
Fast, sensitive and accurate integration of single-cell data with Harmony
Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488
Cited by
Sorted by citations
Items 801–900 of 1,000
Amati, F., Vancheri, C., Latini, A., Colona, V. L., Grelli, S., D’Apice, M. R., Balestrieri, E., Passarelli, C., Minutolo, A., Loddo, S., et al. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05143 · Cited by 31
López‐Cortés, A., Guevara‐Ramírez, P., Kyriakidis, N. C., Barba‐Ostria, C., Cáceres, Á. L., Guerrero, S. X., Ortiz‐Prado, E., Munteanu, C. R., Tejera, E., Cevallos-Robalino, D., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.598925 · Cited by 30
Issa, H., Eid, A. H., Berry, B., Takhviji, V., Khosravi, A., Mantash, S., Nehme, R., Hallal, R., Karaki, H., Dhayni, K., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.620990 · Cited by 30
Campos-Ferreira, D. S., Visani, V., Córdula, C., Nascimento, G. A., Montenegro, L. M. L., Schindler, H. C., & Cavalcanti, I. M. F. (2021) · Biochemical Engineering Journal · doi:10.1016/j.bej.2021.108200 · Cited by 30
Ahmad, S., Wen, Y., & Irudayaraj, J. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.11.014 · Cited by 30
Mucosal Antibody Response to SARS-CoV-2 in Paediatric and Adult Patients: A Longitudinal Study
Chan, R. W. Y., Chan, K. C. C., Lui, G. C.-Y., Tsun, J. G., Chan, K. Y. Y., Yip, J. S. K., Liu, S., Yu, M. W., Ng, R. W. Y., Chong, K. K. L., et al. (2022) · Pathogens · doi:10.3390/pathogens11040397 · Cited by 31
Xie, J., Tian, S., Liu, J., Cao, R., Yue, P., Cai, X., Shang, Q., Yang, M. H., Han, L., & Zhang, D. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106189 · Cited by 30
Translational feasibility and efficacy of nasal photodynamic disinfection of SARS-CoV-2
Pires, L., Wilson, B. C., Bremner, R., Lang, A. L. S., Larouche, J., McDonald, R. R., Pearson, J. D., Trcka, D., Wrana, J. L., Wu, J. S., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-18513-0 · Cited by 30
Non-permissive SARS-CoV-2 infection in human neurospheres
Pedrosa, C. D. S. G., Goto‐Silva, L., Temerozo, J. R., Souza, L. R. Q., Vitória, G., Ornelas, I. M., Karmirian, K., Mendes, M. A., Gomes, I. C., Sacramento, C. Q., et al. (2021) · Stem Cell Research · doi:10.1016/j.scr.2021.102436 · Cited by 31
Pulmonary macrophages and SARS-Cov2 infection
Bain, C. C., Lucas, C. D., & Rossi, A. G. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.01.001 · Cited by 31
Can ACE2 expression explain SARS‐CoV‐2 infection of the respiratory epithelia in COVID‐19?
Nawijn, M. C., & Timens, W. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209841 · Cited by 30
More than loss of taste and smell: burning watering eyes in coronavirus disease 2019
Rokohl, A. C., Loreck, N., Matos, P. A. W., Zwingelberg, S. B., Augustin, M., Dewald, F., Grajewski, R. S., Klein, F., Lehmann, C., & Heindl, L. M. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.08.018 · Cited by 29
Koca, C., Civas, M., Sahin, S. M., Ergönül, Ö., & Akan, Ö. B. (2021) · IEEE Transactions on Molecular Biological and Multi-Scale Communications · doi:10.1109/tmbmc.2021.3071748 · Cited by 29
Pardhan, S., Vaughan, M., Zhang, J., Smith, L., & Chichger, H. (2020) · BMJ Open Ophthalmology · doi:10.1136/bmjophth-2020-000632 · Cited by 31
Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS‐CoV‐2
dos Anjos, F., Simões, J. L. B., Assmann, C. E., Carvalho, F. B., & Bagatini, M. D. (2020) · Journal of Immunology Research · doi:10.1155/2020/8632048 · Cited by 32
Potential impacts of COVID-19 on reproductive health: Scientific findings and social dimension
Hashem, N. M., Abdelnour, S. A., Alhimaidi, A. R., & Swelum, A. A. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.12.012 · Cited by 29
Dysregulation of COVID-19 related gene expression in the COPD lung
Studygroup, T. M. I., Watson, A., Öberg, L., Angermann, B., Spalluto, C. M., Hühn, M. H., Burke, H., Cellura, D., Freeman, A. T., Muthas, D., et al. (2021) · Respiratory Research · doi:10.1186/s12931-021-01755-3 · Cited by 29
Orlando, G., Chiavaroli, A., Adorisio, S., Delfino, D. V., Brunetti, L., Recinella, L., Leone, S., Zengin, G., Acquaviva, A., Angelini, P., et al. (2021) · Molecules · doi:10.3390/molecules26154422 · Cited by 29
Differences and similarities between the upper and lower airway: focusing on innate immunity
Cho, H., Ha, J., Lee, S. N., Kim, C., Wang, D.-Y., & Yoon, J. (2021) · Rhinology Journal · doi:10.4193/rhin21.046 · Cited by 29
Noël, S., Servel, N., Hatton, A., Golec, A., Rodrat, M., Ng, D. R. S., Li, H., Pranke, I. M., Hinzpeter, A., Edelman, A., et al. (2021) · The Journal of Physiology · doi:10.1113/jp282143 · Cited by 29
Redefining intestinal immunity with single-cell transcriptomics
James, K. R., Elmentaite, R., Teichmann, S. A., & Hold, G. L. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00470-y · Cited by 30
IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis
Cioccarelli, C., Sánchez‐Rodríguez, R., Angioni, R., Venegas, F. C., Bertoldi, N., Munari, F., Cattelan, A. M., Molon, B., & Viola, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.781352 · Cited by 30
Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients
Baxter, A. L., Schwartz, K., Johnson, R. W., Kuchinski, A.-M., Swartout, K. M., Rao, A. S. R. S., Gibson, R. W., Cherian, E., Giller, T., Boomer, H., et al. (2022) · Ear Nose & Throat Journal · doi:10.1177/01455613221123737 · Cited by 30
Castrejón-Jiménez, N. S., García‐Pérez, B. E., Rodríguez, N. E. R., Vega-Sánchez, V., Juárez, V. M. M., & Hernández-González, J. C. (2022) · Biosensors · doi:10.3390/bios12090728 · Cited by 31
Ugalde, A. P., Bretones, G., Rodríguez, D., Quesada, V., Llorente, F. R., Fernández‐Delgado, R., Jiménez‐Clavero, M. Á., Vázquez, J., Calvo, E., Tamargo‐Gómez, I., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2022110727 · Cited by 29
Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections
Joseph, J. (2022) · Immuno · doi:10.3390/immuno2040036 · Cited by 31
COVID-19 Therapeutic Potential of Natural Products
Low, Z., Lani, R., Tiong, V., Poh, C. L., AbuBakar, S., & Hassandarvish, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119589 · Cited by 29
Nasal delivery as a strategy for the prevention and treatment of COVID-19
Sonvico, F., Colombo, G., Quarta, E., Guareschi, F., Banella, S., Buttini, F., & Scherließ, R. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2263363 · Cited by 29
Can SARS-CoV-2 infect the eye? An overview of the receptor status in ocular tissue
Schnichels, S., Rohrbach, J. M., Bayyoud, T., Thaler, S., Ziemssen, F., & Hurst, J. (2020) · Der Ophthalmologe · doi:10.1007/s00347-020-01281-5 · Cited by 28
Nakagawara, K., Masaki, K., Uwamino, Y., Kabata, H., Uchida, S., Uno, S., Asakura, T., Funakoshi, T., Kanzaki, S., Ishii, M., et al. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.07.034 · Cited by 28
Emerging Human Coronavirus Infections (SARS, MERS, and COVID-19): Where They Are Leading Us
Kumar, V. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1800688 · Cited by 29
Razeghian‐Jahromi, I., Zibaeenezhad, M. J., Lu, Z., Elyaspour, Z., Razmkhah, M., & Lionetti, V. (2020) · Heart Failure Reviews · doi:10.1007/s10741-020-10016-2 · Cited by 29
Nakase, H., Matsumoto, T., Matsuura, M., Iijima, H., Matsuoka, K., Ohmiya, N., Ishihara, S., Hirai, F., 我妻康平, Yokoyama, Y., et al. (2020) · Digestion · doi:10.1159/000510502 · Cited by 28
Ebrahimi, N., Aslani, S., Babaie, F., Hemmatzadeh, M., Hosseinzadeh, R., Joneidi, Z., Tourzani, Z. M., Pakravan, N., & Mohammadi, H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107082 · Cited by 28
Marinova, E., Dabov, S. D., & Zdravkov, Y. (2020) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2020.1838323 · Cited by 28
Impact of Gastrointestinal Symptoms in COVID-19: a Molecular Approach
Sonkar, C., Kashyap, D., Varshney, N., Baral, B., & Jha, H. C. (2020) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-020-00619-z · Cited by 28
COVID-19: The Emerging Immunopathological Determinants for Recovery or Death
Ahmad, T., Chaudhuri, R., Joshi, M. C., Almatroudi, A., Rahmani, A. H., & Ali, S. M. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.588409 · Cited by 30
Spiking dependence of SARS‐CoV‐2 pathogenicity on TMPRSS2
Abbasi, A. Z., Kiyani, D. A., Hamid, S. M., Saalim, M., Fahim, A., & Jalal, N. (2021) · Journal of Medical Virology · doi:10.1002/jmv.26911 · Cited by 29
The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations
Barrantes, F. J. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100251 · Cited by 29
Jakieła, B., Rebane, A., Soja, J., Bazan‐Socha, S., Laanesoo, A., Plutecka, H., Surmiak, M., Sanak, M., Sładek, K., & Bochenek, G. (2021) · Scientific Reports · doi:10.1038/s41598-021-92252-6 · Cited by 30
Regulation of the Expression of SARS-CoV-2 Receptor Angiotensin-Converting Enzyme 2 in Nasal Mucosa
Takabayashi, T., Yoshida, K., Imoto, Y., Schleimer, R. P., & Fujieda, S. (2021) · American Journal of Rhinology and Allergy · doi:10.1177/19458924211027798 · Cited by 28
Uberti, F., Ruga, S., Farghali, M., Galla, R., & Molinari, C. G. (2021) · Journal of Dietary Supplements · doi:10.1080/19390211.2021.1966152 · Cited by 28
Tryptophan‐Kynurenine Pathway in COVID‐19‐Dependent Musculoskeletal Pathology: A Minireview
Vyavahare, S. S., Kumar, S., Cantu, N., Kolhe, R. B., Bollag, W. B., McGee‐Lawrence, M. E., Hill, W., Hamrick, M. W., Isales, C. M., & Fulzele, S. (2021) · Mediators of Inflammation · doi:10.1155/2021/2911578 · Cited by 29
Yang, M., Park, M.-J., Lee, J., Oh, B., Kang, K. W., Kim, Y., Lee, S., Lim, J., Jung, T.-Y., Park, J., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.010 · Cited by 30
Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulation
Lobo, C. S., Rodrigues‐Santos, P., Pereira, D., Núñez, J. G., Trêpa, J., Sousa, D. L., Lourenço, J. V., Coelho, M. F., de Almeida, L. P., da Cunha, J. S., et al. (2022) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-022-00202-6 · Cited by 28
Robbins, J. A., Tait, D. R., Huang, Q., Dubey, S. A., Crumley, T. M., Côté, J., Luk, J. A. M., Sachs, J. R., Rutkowski, K. T., Park, H., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104138 · Cited by 28
Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)
Khongthaw, B., Dulta, K., Chauhan, P. K., Kumar, V., & Ighalo, J. O. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01061-4 · Cited by 29
Valyaeva, A. A., Zharikova, A. A., & Sheval, E. V. (2022) · Cell Biology International · doi:10.1002/cbin.11928 · Cited by 30
Pushkaran, A. C., Prajeesh Nath, E. N., Melge, A. R., Puthiyedath, R., & Mohan, C. G. (2021) · RSC Advances · doi:10.1039/d0ra10458b · Cited by 28
Zhu, H., Zhang, H., Zhou, N., Ding, J., Jiang, J., Liu, T., Liu, Z., Wang, F., Zhang, Q., Zhang, Z., et al. (2021) · Advanced Science · doi:10.1002/advs.202100965 · Cited by 29
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
Yang, X., Zheng, X., Zhu, Y., Zhao, X., Liu, J., Xun, J., Yuan, S., Chen, J., Pan, H., Yang, J., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01754-y · Cited by 27
Potential Immunotherapeutic Targets for Hypoxia Due to COVI-Flu
Leyfman, Y., Erick, T. K., Reddy, S., Galwankar, S., Nanayakkara, P. W. B., Somma, S. D., Sharma, P., Stawicki, S. P., & Chaudry, I. H. (2020) · Shock · doi:10.1097/shk.0000000000001627 · Cited by 28
Membrane remodeling by SARS-CoV-2 – double-enveloped viral replication
Mohan, J., & Wollert, T. (2021) · Faculty Reviews · doi:10.12703/r/10-17 · Cited by 27
Nishibata, Y., Koshimoto, S., Ogaki, K., Ishikawa, E., Wada, K., Yoshinari, M., Tamura, Y., Uozumi, R., Masuda, S., Tomaru, U., et al. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153381 · Cited by 27
Overview of COVID-19 and neurological complications
Hosseini, N., Nadjafi, S., & Ashtari, B. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0116 · Cited by 29
Potential biomarkers for the early prediction of SARS-COV-2 disease outcome
Mariappan, V., Manoharan, P. S., Ranganadin, P., Lokesh, S., Rao, S. R., & Pillai, A. B. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105057 · Cited by 27
Intranasal Corticosteroids Are Associated with Better Outcomes in Coronavirus Disease 2019
Strauss, R. A., Jawhari, N., Attaway, A. H., Hu, B., Jehi, L. E., Milinovich, A., Ortega, V. E., & Zein, J. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.08.007 · Cited by 27
Modeling Within-Host Dynamics of SARS-CoV-2 Infection: A Case Study in Ferrets
Vaidya, N. K., Bloomquist, A., & Perelson, A. S. (2021) · Viruses · doi:10.3390/v13081635 · Cited by 27
Paull, J. R., Luscombe, C. A., Castellarnau, A., Heery, G. P., Bobardt, M. D., & Gallay, P. A. (2021) · Viruses · doi:10.3390/v13081656 · Cited by 27
What Happens to the Immune System after Vaccination or Recovery from COVID-19?
Tiyo, B. T., Schmitz, G. J. H., Ortega, M. M., da Silva, L. T., de Almeida, A., Oshiro, T. M., & Duarte, A. J. D. S. (2021) · Life · doi:10.3390/life11111152 · Cited by 28
Immuno-Endocrinology of COVID-19: The Key Role of Sex Hormones
Tramontana, F., Battisti, S., Napoli, N., & Strollo, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.726696 · Cited by 29
Nguyen, T. H., Turek, I., Meehan-Andrews, T., Zacharias, A., & Irving, H. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263968 · Cited by 27
Urinary angiotensin-converting enzyme 2 and metabolomics in COVID-19-mediated kidney injury
Vergara, A., Wang, K., Colombo, D., Gheblawi, M., Rasmuson, J., Mandal, R., Nonno, F. D., Chiu, B., Scholey, J. W., Soler, M. J., et al. (2022) · Clinical Kidney Journal · doi:10.1093/ckj/sfac215 · Cited by 27
Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2
Guo, X., Cao, J., Cai, J.-P., Wu, J., Huang, J., Asthana, P., Wong, S. K. K., Ye, Z.-W., Gurung, S., Zhang, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35590-x · Cited by 25
Long COVID Definition, Symptoms, Risk Factors, Epidemiology and Autoimmunity: A Narrative Review
Kozłowski, P., Leszczyńska, A., & Ciepiela, O. (2024) · American Journal of Medicine Open · doi:10.1016/j.ajmo.2024.100068 · Cited by 27
Noce, A., Albanese, M., Marrone, G., Lauro, M. D., Zaitseva, A. P., Palazzetti, D., Guerriero, C., Paolino, A., Pizzenti, G., Daniele, F. D., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14040336 · Cited by 28
Nakayama, T., Lee, I. T., Jiang, S., Matter, M. S., Yan, C. H., Overdevest, J. B., Wu, C.-T., Goltsev, Y., Shih, L., Liao, S. C., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100421 · Cited by 28
Reshaping the healthcare world by AI-integrated wearable sensors following COVID-19
Khan, B., Khalid, R. T., Wara, K. U., Masrur, M. A., Khan, S., Khan, W. U., Amara, U., & Abdullah, S. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.159478 · Cited by 28
Consideration of Pannexin 1 channels in COVID-19 pathology and treatment
Swayne, L. A., Johnstone, S. R., Ng, C. S., Sanchez‐Arias, J. C., Good, M. E., Peñuela, S., Lohman, A. W., Wolpe, A. G., Laubach, V. E., Koval, M. H., et al. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00146.2020 · Cited by 27
Oral Corticosteroid Relieves Post-COVID-19 Anosmia in a 35-Year-Old Patient
Touisserkani, S. K., & Ayatollahi, A. (2020) · Case Reports in Otolaryngology · doi:10.1155/2020/5892047 · Cited by 26
No Small Matter: A Perspective on Nanotechnology-Enabled Solutions to Fight COVID-19
Jones, G. W., Monopoli, M. P., Campagnolo, L., Pietroiusti, A., Tran, L., & Fadeel, B. (2020) · Nanomedicine · doi:10.2217/nnm-2020-0286 · Cited by 28
El-Betany, A., Behiry, E. M., Gumbleton, M., & Harding, K. G. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594295 · Cited by 26
Admin, A., Batchu, S. N., Kaur, H., Yerra, V. G., Advani, S. L., Kabir, G., Liu, Y., Klein, T., & Advani, A. (2020) · Diabetes · doi:10.2337/db20-0765 · Cited by 26
Zhao, Y., Liu, Y., Yi, F., Zhang, J., Xu, Z., Liu, Y., & Tao, Y. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107406 · Cited by 26
Choi, H. M., Moon, S. Y., Yang, H.-I., & Kim, K. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041737 · Cited by 28
DNA methylation architecture of the ACE2 gene in nasal cells of children
Cárdenas, A., Rifas‐Shiman, S. L., Sordillo, J. E., DeMeo, D. L., Baccarelli, A., Hivert, M., Gold, D. R., & Oken, E. (2021) · Scientific Reports · doi:10.1038/s41598-021-86494-7 · Cited by 26
Robinson, T. E., Moakes, R. J. A., & Grover, L. M. (2021) · Frontiers in Medical Technology · doi:10.3389/fmedt.2021.687681 · Cited by 26
Recent advance of ACE2 and microbiota dysfunction in COVID-19 pathogenesis
Yu, Z., Yang, Z., Wang, Y., Zhou, F., Li, S., Li, C., Li, L., Zhang, W., & Li, X. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07548 · Cited by 26
Comprehensive Consensus Analysis of SARS-CoV-2 Drug Repurposing Campaigns
Mslati, H., Gentile, F., Perez, C. F., & Cherkasov, A. R. (2021) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.1c00384 · Cited by 29
Immune response to SARS‐CoV‐2 in children: A review of the current knowledge
Filippatos, F., Tatsi, E., & Michos, A. G. (2021) · Pediatric Investigation · doi:10.1002/ped4.12283 · Cited by 26
Age-Related Susceptibility of Ferrets to SARS-CoV-2 Infection
Martins, M., Fernandes, M. H. V., Joshi, L. R., & Diel, D. G. (2021) · Journal of Virology · doi:10.1128/jvi.01455-21 · Cited by 26
Bezerra, B. B., da Silva, G. P. D., Coelho, S. V. A., Corrêa, I. A., de Souza, M. R. M., Macedo, K. V. G., Matos, B. M., Tanuri, A., Matassoli, F. L., da Costa, L. J., et al. (2022) · Antiviral Research · doi:10.1016/j.antiviral.2022.105373 · Cited by 26
Low molecular weight cytotoxic components (DAMPs) form the post-COVID-19 syndrome
Klimova, E. M., Божков, А. И., Lavinska, O. V., Drozdova, L. A., & Kurhuzova, N. I. (2022) · Immunobiology · doi:10.1016/j.imbio.2022.152316 · Cited by 26
Mitsui, Y., Suzuki, T., Kuniyoshi, K., Inamo, J., Yamaguchi, K., Komuro, M., Watanabe, J., Edamoto, M., Li, S., Kouno, T., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.013 · Cited by 27
Fang, L., Xu, J., Zhao, Y., Fan, J., Shen, J., Liu, W., & Cao, G. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1228128 · Cited by 26
Tonsils are major sites of persistence of SARS-CoV-2 in children
de Lima, T. M., Júnior, R. B. M., Miura, C. S., de Souza, M. G. M., Cassiano, M. H. A., Rodrigues, T. S., Veras, F. P., Sousa, J. F., Gomes, R., de Almeida, G. M., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.01347-23 · Cited by 26
Stelzer‐Braid, S., Walker, G. J., Aggarwal, A., Isaacs, S. R., Yeang, M., Naing, Z., Stella, A. O., Turville, S. G., & Rawlinson, W. D. (2020) · Pathology · doi:10.1016/j.pathol.2020.09.012 · Cited by 26
Korath, A. D. J., Janda, J., Untersmayr, E., Sokołowska, M., Feleszko, W., Agache, I. O., Seida, A. A., Hartmann, K., Jensen‐Jarolim, E., & Pali‐Schöll, I. (2021) · Allergy · doi:10.1111/all.14991 · Cited by 27
Pathophysiology of the COVID-19 – entry to the CNS through the nose
Ylikoski, J. S., Markkanen, M., & Mäkitie, A. A. (2020) · Acta Oto-Laryngologica · doi:10.1080/00016489.2020.1773533 · Cited by 27
Conde, C. D., Xu, C., Jarvis, L., Gomes, T., Howlett, S., Rainbow, D., Suchanek, O., King, H., Mamanova, L., Polanski, K., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.28.441762 · Cited by 27
Self-citationAttenuation of SARS-CoV-2 infection by losartan in human kidney organoids
Rahmani, W., Chung, H., Sinha, S., Bui-Marinos, M. P., Arora, R., Jaffer, A., Corcoran, J. A., Biernaskie, J., & Chun, J. (2022) · iScience · doi:10.1016/j.isci.2022.103818 · Cited by 25
Rowbotham, S. P., Pessina, P., de Alba, C. G., Jensen, J., Nguyen, Y., Yoon, J. H., Li, J., Wong, I. G., Fahey, C., Moye, A. L., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.10.011 · Cited by 27
Emerging Therapeutic Modalities against COVID-19
Malik, S., Gupta, A., Zhong, X., Rasmussen, T. P., Manautou, J. E., & Bahal, R. (2020) · Pharmaceuticals · doi:10.3390/ph13080188 · Cited by 27
Alnefaie, A., & Albogami, S. M. (2020) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2020.08.024 · Cited by 25
Chan, E. Y. Y., Shahzada, T. S., Sham, T. S. T., Dubois, C., Huang, Z., Liu, S., Ho, J., Hung, K. K. C., Kwok, K. O., Kayano, R., et al. (2020) · British Medical Bulletin · doi:10.1093/bmb/ldaa030 · Cited by 27
Potential Role of Xylitol Plus Grapefruit Seed Extract Nasal Spray Solution in COVID-19: Case Series
Go, C. C., Pandav, K. B., Sanchez‐Gonzalez, M. A., & Ferrer, G. (2020) · Cureus · doi:10.7759/cureus.11315 · Cited by 26
Signorini, C., Pignatti, P., & Coccini, T. (2021) · Life · doi:10.3390/life11030182 · Cited by 25
Verhoef, P. A., Kannan, S., Sturgill, J., Tucker, E. W., Morris, P. E., Miller, A. C., Sexton, T. R., Koyner, J. L., Hejal, R. B., Brakenridge, S. C., et al. (2021) · Critical Care Explorations · doi:10.1097/cce.0000000000000374 · Cited by 25
Schepler, H., Wang, X., Neufurth, M., Wang, S., Schröder, H. C., & Müller, W. E. G. (2021) · Theranostics · doi:10.7150/thno.59535 · Cited by 26
Metadata
- Authors
- HCA Lung Biological Network, Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., Sampaziotis, F., Worlock, K. B., Yoshida, M., & Barnes, J. L.
- Affiliations
- Wellcome Sanger Institute (GB)
- Centre National de la Recherche Scientifique (FR)
- University Medical Center Groningen (NL)
- Max Delbrück Center (DE)
- Harvard University (US)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- University College London (GB)
- Corresponding author
- Sungnak, Waradon
- ORCID
- Venue
- Nature Medicine
- Published
- 2020-04-23
- Volume
- 26
- Issue
- 5
- Pages
- 681-687
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC8637938
- OpenAlex
- W3011483298
- Cited by
- 2,501
- References
- 59
- Citations by year
- 2026: 53 · 2025: 105 · 2024: 140 · 2023: 265 · 2022: 454 · 2021: 814 · 2020: 664
- FWCI
- 71.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature Medicine (publishedVersion, other-oa)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- PubMed Central (acceptedVersion)
- arXiv (Cornell University) (submittedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, public-domain)
- Apollo (University of Cambridge) (submittedVersion)
- HAL (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Site cant be reached (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Apollo
- Funders
- U.S. Department of Defense (W81XWH1910416)
- Howard Hughes Medical Institute
- U.S. Department of Veterans Affairs
- Bill and Melinda Gates Foundation
- Richard and Susan Smith Family Foundation
- Massachusetts General Hospital
- Yale University
- Vanderbilt University
- Massachusetts Institute of Technology
- Memorial Sloan-Kettering Cancer Center
- Northwestern University
- School of Medicine, Boston University
- Arizona State University
- Helsingin Yliopisto
- University of Washington
- Deutsches Zentrum für Infektionsforschung
- Wellcome Trust (211276/Z/18/Z, 211276/D/18/Z, 108082/A/15/Z, #MR/R006237/1, WT206194, 107931/Z/15/Z, GINOP-2.3.2-15-2016-00026, WT211276/Z/18/Z)
- Deutsches Zentrum für Herz-Kreislaufforschung
- European Bioinformatics Institute
- National Jewish Health
- Vanderbilt University Medical Center
- European Molecular Biology Laboratory
- Broad Institute
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Manton Foundation
- University of Alberta
- Cancer Research UK
- National Institute for Health and Care Research (PB-PG-1215-20037, CL-2017-14-001)
- British Heart Foundation (SP/19/1/34461, PG/16/47/32156)
- Cystic Fibrosis Trust (VIA 028)
- Academy of Medical Sciences (SGL019\1071)
- Imperial College London (H2020)
- University College London
- Newcastle University
- European Commission (2018-342, GINOP‐2.3.2‐15‐2016‐00037, 874656, GINOP-2.3.2-15-2016-00006, H2020)
- Rosetrees Trust
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC/T2T0419, NC/N001540/1)
- National Research Foundation
- Deutsche Forschungsgemeinschaft (347286815, DK043351, EXC2151/1, EXC 2151, 329123747, 390873048)
- Agence Nationale de la Recherche (ANR‐10‐INBS‐09‐03, ANR- 10-INBS-09, ANR‐19, ANR-19-CE14, ANR-19-CE14-0027, ANR-10, 10-INBS-09, -15-IDEX-01, ANR‐15‐IDEX‐01)
- Fondation Leducq
- Rijksuniversiteit Groningen
- University of New South Wales
- National Natural Science Foundation of China (31871370)
- Catholic University of Korea
- Cancerfonden (2019-)
- Fondation pour la Recherche Médicale (DEQ20180339158)
- National Research Foundation of Korea
- Karolinska Institutet
- National Science and Technology Development Agency
- Kungliga Tekniska Högskolan
- Vetenskapsrådet (2018-)
- Thailand Research Fund
- Centre National de la Recherche Scientifique
- Universitair Medisch Centrum Groningen
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Medizinischen Hochschule Hannover
- Rheinische Friedrich-Wilhelms-Universität Bonn
- Stockholms Universitet
- Science for Life Laboratory
- Conseil Départemental des Alpes Maritimes (2016-294DGADSH-CV)
- Deutsches Zentrum für Lungenforschung
- National Centre for the Replacement Refinement and Reduction of Animals in Research (NC/N001540/1)
- Ministerie van Economische Zaken en Klimaat
- Berlin Institute of Health
- National Institutes of Health (1r56hl135124-01, H2020, AG‐049665, DK 043351, AI135964)
- Directorate for Biological Sciences
- School of Medicine, Duke University
- School of Medicine, Stanford University
- University of California, San Diego
- Harvard Stem Cell Institute
- Feinberg School of Medicine
- Medical School, University of Michigan
- Horizon 2020 Framework Programme (874656, GINOP-2.3.2)
- Klarman Cell Observatory, Broad Institute
- Medical Research Council (MC_PC_17230, MR/R015635/1, MR/P009581/1, MC_PC_12009, MR/R006237/1, MR/K017047/1, MR/S005579/1)
- Engineering and Physical Sciences Research Council (TS/H001220/1)
- Biotechnology and Biological Sciences Research Council (BB/T004460/1, BB/V01126X/1)
- National Health and Medical Research Council
- Faculty of Medical Sciences, Newcastle University
- European Regional Development Fund (GINOP‐2.3.2‐15‐2016‐00006, H2020, GINOP-2.3.2-15-2016-00037, GINOP-2.3.2-15-2016-00026)
- NIHR Newcastle Biomedical Research Centre
- Helmholtz Zentrum München
- NIHR Cambridge Biomedical Research Centre
- National Institute on Aging (P01AG049665)
- National Heart, Lung, and Blood Institute (HL135124, R01HL146557, U01HL148856, R56 HL135124, K08HL130595, K08HL146943, HL148856, U01HL145567, R01HL145372, R01HL127349)
- National Institute of Allergy and Infectious Diseases (U24AI118672, U19AI135964)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK043351)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24HD000836)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- SARS-CoV-2, viral entry factors, ACE2, TMPRSS2, nasal epithelial cells, innate immunity, respiratory epithelium, corneal epithelium, intestinal epithelium, tissue tropism, COVID-19 pandemic, single-cell transcriptomics, gene co-expression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
