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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
Open accessAbstract
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org . An analysis of single-cell transcriptomics datasets from different tissues shows that ACE2 and TMPRSS2 are co-expressed in respiratory, corneal and intestinal epithelial cell populations, and that respiratory expression of ACE2 is associated with genes involved in innate immunity.
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“Although scSeq revealed ACE2 transcripts in only a subset of OE cells, this low level of observed expression matches or exceeds that observed in respiratory cells types that are infected by CoV-2 in COVID-19 patients (39) (Fig. 3).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [39]
Experimental — accuracy not yet measuredIn the citing paper
“Probably most important for the high efficacy of SARS-CoV-2 transmission is the high co-expression of ACE2 and TMPRSS2 in nasal epithelial cells, particularly in two types of goblet cells and a subset of ciliated cells, showing the highest expression among all cells in the respiratory tree (Figure 2 A).”
From COVID-19 and the human innate immune system (2021) · cites this paper as Sungnak et al., 2020
In the citing paper
“An interesting observation of this study was the high co-expression of genes involved in early steps of antiviral immune responses in these epithelial cells, which indicated the potential for these specialized nasal cells to play an important role in the initial viral infection, spread, but potentially also, clearance.”
From COVID-19 and the human innate immune system (2021) · cites this paper as Sungnak et al., 2020
In the citing paper
“TMPRSS2 is more widely expressed than ACE2, and cells with simultaneous expression were identified in the respiratory tree, the cornea, esophagus, ileum, colon, gallbladder, and common bile duct (Sungnak et al., 2020), yet there was no evidence for simultaneous expression in immune cells.”
From COVID-19 and the human innate immune system (2021) · cites this paper as Sungnak et al., 2020
In the citing paper
“It has recently been demonstrated through single cell RNA sequencing analysis (referred to herein as scSeq) that cells from the human upper airway — including nasal RE goblet and ciliated cells —express high levels of ACE2 and TMPRSS2, suggesting that these RE cell types may serve as a viral reservoir during CoV-2 infection (39, 40).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [39]
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Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246
A novel coronavirus from patients with pneumonia in China, 2019
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001017 · Cited by 28,244
Clinical Characteristics of Coronavirus Disease 2019 in China
Eastin, C., & Eastin, T. (2020) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2020.04.004 · Cited by 24,945
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286
Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001316 · Cited by 16,575
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
Fast, sensitive and accurate integration of single-cell data with Harmony
Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488
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Hu, B., Guo, H., Zhou, P., & Shi, Z.-L. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00459-7 · Cited by 5,291
Nalbandian, A., Sehgal, K., Gupta, A., Madhavan, M. V., McGroder, C., Stevens, J. S., Cook, J. R., Nordvig, A. S., Shalev, D., Sehrawat, T. S., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01283-z · Cited by 4,862
Wiersinga, W. J., Rhodes, A., Cheng, A. C., Peacock, S. J., & Prescott, H. C. (2020) · JAMA · doi:10.1001/jama.2020.12839 · Cited by 4,609
Extrapulmonary manifestations of COVID-19
Gupta, A., Madhavan, M. V., Sehgal, K., Nair, N., Mahajan, S., Sehrawat, T. S., Bikdeli, B., Ahluwalia, N., Ausiello, J. C., Wan, E. Y., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0968-3 · Cited by 3,185
Mechanisms of SARS-CoV-2 entry into cells
Jackson, C. B., Farzan, M., Chen, B., & Choe, H. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00418-x · Cited by 3,022
Ziegler, C. G. K., Allon, S. J., Nyquist, S. K., Mbano, I. M., Miao, V. N., Tzouanas, C. N., Cao, Y., Yousif, A. S., Bals, J., Hauser, B. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.035 · Cited by 2,284
Human organoids: model systems for human biology and medicine
Kim, J., Koo, B.-K., & Knoblich, J. A. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0259-3 · Cited by 2,187
Multiorgan and Renal Tropism of SARS-CoV-2
Puelles, V. G., Lütgehetmann, M., Lindenmeyer, M. T., Sperhake, J. P., Wong, M. N., Allweiss, L., Chilla, S., Heinemann, A., Wanner, N., Liu, S., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2011400 · Cited by 1,775
Spike mutation D614G alters SARS-CoV-2 fitness
Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., et al. (2021) · Nature · doi:10.1038/s41586-020-2895-3 · Cited by 1,558
Real-time tracking of self-reported symptoms to predict potential COVID-19
Menni, C., Valdes, A. M., Freidin, M. B., Sudre, C. H., Nguyen, L. H., Drew, D. A., Ganesh, S., Varsavsky, T., Cardoso, M. J., El-Sayed Moustafa, J. S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0916-2 · Cited by 1,517
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract
Hou, Y. J., Okuda, K., Edwards, C. E., Martinez, D. R., Asakura, T., Dinnon, K. H., Kato, T., Lee, R. E., Yount, B. L., Mascenik, T. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.042 · Cited by 1,488
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
Schulte-Schrepping, J., Reusch, N., Paclik, D., Baßler, K., Schlickeiser, S., Zhang, B., Krämer, B., Krammer, T., Brumhard, S., Bonaguro, L., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.001 · Cited by 1,461
COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives
Nishiga, M., Wang, D. W., Han, Y., Lewis, D. B., & Wu, J. C. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0413-9 · Cited by 1,436
Brann, D. H., Tsukahara, T., Weinreb, C., Lipovsek, M., Van den Berge, K., Gong, B., Chance, R., Macaulay, I. C., Chou, H.-J., Fletcher, R. B., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc5801 · Cited by 1,198
Cross-tissue immune cell analysis reveals tissue-specific features in humans
Conde, C. D., Xu, C., Jarvis, L. B., Rainbow, D. B., Wells, S. B., Gomes, T., Howlett, S. K., Suchánek, O., Polański, K., King, H. W., et al. (2022) · Science · doi:10.1126/science.abl5197 · Cited by 1,246
Self-citationBourgonje, A. R., Abdulle, A. E., Timens, W., Hillebrands, J., Navis, G. J., Gordijn, S. J., Bolling, M. C., Dijkstra, G. D. H., Voors, A. A., Osterhaus, A. D. M. E., et al. (2020) · The Journal of Pathology · doi:10.1002/path.5471 · Cited by 1,160
Neuroinvasion of SARS-CoV-2 in human and mouse brain
Song, E., Zhang, C., Israelow, B., Lu-Culligan, A., Prado, A. V., Skriabine, S., Lu, P., Weizman, O.-E., Liu, F., Dai, Y., et al. (2020) · doi:10.1101/2020.06.25.169946 · Cited by 1,064
Chua, R. L., Lukassen, S., Trump, S., Hennig, B. P., Wendisch, D., Pott, F., Debnath, O., Thürmann, L., Kurth, F., Völker, M. T., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0602-4 · Cited by 1,035
The protein expression profile of ACE2 in human tissues
Hikmet, F., Méar, L., Edvinsson, Å., Micke, P., Uhlén, M., & Lindskog, C. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209610 · Cited by 1,016
Immunological considerations for COVID-19 vaccine strategies
Jeyanathan, M., Afkhami, S., Smaill, F., Miller, M. S., Lichty, B. D., & Xing, Z. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-00434-6 · Cited by 1,015
Eastman, R. T., Roth, J. S., Brimacombe, K. R., Simeonov, A. M., Shen, M., Patnaik, S., & Hall, M. D. (2020) · ACS Central Science · doi:10.1021/acscentsci.0c00489 · Cited by 963
Considering how biological sex impacts immune responses and COVID-19 outcomes
Scully, E. P., Haverfield, J., Ursin, R. L., Tannenbaum, C., & Klein, S. L. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0348-8 · Cited by 954
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
Hou, Y. J., Chiba, S., Halfmann, P., Ehre, C., Kuroda, M., Dinnon, K. H., Leist, S. R., Schäfer, A., Nakajima, N., Takahashi, K., et al. (2020) · Science · doi:10.1126/science.abe8499 · Cited by 900
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
Ren, X., Wen, W., Fan, X., Hou, W., Su, B., Cai, P., Li, J., Liu, Y., Tang, F., Zhang, F., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.053 · Cited by 865
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
Delorey, T. M., Ziegler, C. G. K., Heimberg, G., Normand, R., Yang, Y., Segerstolpe, Å., Abbondanza, D., Fleming, S. J., Subramanian, A., Montoro, D. T., et al. (2021) · Nature · doi:10.1038/s41586-021-03570-8 · Cited by 827
SARS-CoV-2 infection of the oral cavity and saliva
Huang, N., Pérez, P., Kato, T., Mikami, Y., Okuda, K., Gilmore, R. C., Conde, C. D., Gasmi, B., Stein, S. R., Beach, M. E., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01296-8 · Cited by 806
Self-citationSingle-cell multi-omics analysis of the immune response in COVID-19
Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID-19 BioResource Collaboration, Stephenson, E., Reynolds, G., Botting, R. A., Calero-Nieto, F. J., Morgan, M. D., Tuong, Z. K., Bach, K., Sungnak, W., Worlock, K. B., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01329-2 · Cited by 742
Self-citationCOVID-19 and the human innate immune system
Schultze, J. L., & Aschenbrenner, A. C. (2021) · Cell · doi:10.1016/j.cell.2021.02.029 · Cited by 714
“In absence of cell-type-specific expression maps of SARSCoV-2 viral entry-associated genes, the Human Cell Atlas (HCA) Lung Biological Network investigated the prevalence of ACE2 and TMPRSS2 in the body by analyzing their expression in single-cell RNA sequencing data (scRNA-seq) from multiple tissues from healthy huma…”
BackgroundInfluentialCircuits between infected macrophages and T cells in SARS-CoV-2 pneumonia
Grant, R. A., Morales‐Nebreda, L., Markov, N. S., Swaminathan, S., Querrey, M., Rios-Guzman, E., Abbott, D. A., Donnelly, H. K., Donayre, A., Goldberg, I. A., et al. (2021) · Nature · doi:10.1038/s41586-020-03148-w · Cited by 718
A molecular single-cell lung atlas of lethal COVID-19
Melms, J. C., Biermann, J., Huang, H., Wang, Y., Nair, A., Tagore, S., Katsyv, I., Rendeiro, A. F., Amin, A. D., Schapiro, D., et al. (2021) · Nature · doi:10.1038/s41586-021-03569-1 · Cited by 685
Intranasal drug delivery: opportunities and toxicologic challenges during drug development
Keller, L.-A., Merkel, O. M., & Popp, A. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00891-5 · Cited by 636
Immunity, endothelial injury and complement-induced coagulopathy in COVID-19
Perico, L., Benigni, A., Casiraghi, F., Ng, L. F. P., Rénia, L., & Remuzzi, G. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00357-4 · Cited by 616
The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System
Daryabor, G., Atashzar, M. R., Kabelitz, D., Meri, S., & Kalantar, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01582 · Cited by 617
Regulation of immune responses by the airway epithelial cell landscape
Hewitt, R. J., & Lloyd, C. M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-020-00477-9 · Cited by 627
Sardu, C., Gambardella, J., Morelli, M. B., Wang, X., Marfella, R., & Santulli, G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051417 · Cited by 610
Pellegrini, L., Albecka, A., Mallery, D. L., Kellner, M. J., Paul, D., Carter, A. P., James, L. C., & Lancaster, M. A. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.10.001 · Cited by 562
Radzikowska, U., Ding, M., Tan, G., Zhakparov, D., Peng, Y., Wawrzyniak, P., Wang, M., Li, S., Morita, H., Altunbulakli, C., et al. (2020) · Allergy · doi:10.1111/all.14429 · Cited by 555
SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity
Ozono, S., Zhang, Y., Ode, H., Sano, K., Tan, T. S., Imai, K., Miyoshi, K., Kishigami, S., Ueno, T., Iwatani, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21118-2 · Cited by 522
More Than Smell—COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis
Parma, V., Ohla, K., Veldhuizen, M. G., Niv, M. Y., Kelly, C. E., Bakke, A. J., Cooper, K. W., Bouysset, C., Pirastu, N., Dibattista, M., et al. (2020) · Chemical Senses · doi:10.1093/chemse/bjaa041 · Cited by 518
The aging lung: Physiology, disease, and immunity
Schneider, J. L., Rowe, J. H., Garcia-de-Alba, C., Kim, C. F., Sharpe, A. H., & Haigis, M. C. (2021) · Cell · doi:10.1016/j.cell.2021.03.005 · Cited by 500
A single-cell atlas of the human healthy airways
Deprez, M., Zaragosi, L.-E., Truchi, M., Garcia, S. R., Arguel, M.-J., Lebrigand, K., Paquet, A., Pee’r, D., Marquette, C.-H., Leroy, S., et al. (2019) · doi:10.1101/2019.12.21.884759 · Cited by 493
Self-citationWang, S., Qiu, Z., Hou, Y., Deng, X., Xu, W., Zheng, T., Wu, P., Xie, S., Bian, W., Zhang, C., et al. (2021) · Cell Research · doi:10.1038/s41422-020-00460-y · Cited by 497
A perspective on potential antibody-dependent enhancement of SARS-CoV-2
Arvin, A. M., Fink, K., Schmid, M. A., Cathcart, A., Spreafico, R., Havenar-Daughton, C., Lanzavecchia, A., Corti, D., & Virgin, H. W. (2020) · Nature · doi:10.1038/s41586-020-2538-8 · Cited by 485
Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past
Shah, V. K., Firmal, P., Alam, A., Ganguly, D., & Chattopadhyay, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01949 · Cited by 476
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COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City
Borczuk, A. C., Salvatore, S. P., Seshan, S. V., Patel, S. S., Bussel, J. B., Mostyka, M., Elsoukkary, S., He, B., Del Vecchio, C., Fortarezza, F., et al. (2020) · Modern Pathology · doi:10.1038/s41379-020-00661-1 · Cited by 452
Global pandemics interconnected — obesity, impaired metabolic health and COVID-19
Stefan, N., Birkenfeld, A. L., & Schulze, M. B. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00462-1 · Cited by 452
Si, L., Bai, H., Rodas, M., Cao, W., Oh, C. Y., Jiang, A., Moller, R., Hoagland, D., Oishi, K., Horiuchi, S., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00718-9 · Cited by 440
“ACE2 plays a central role in lung physiology and pathophysiology 19 , in addition to serving as the main receptor for SARS-CoV-2 that mediates its infection 20,21 .”
Chan, J. M., Quintanal-Villalonga, À., Gao, V. R., Xie, Y., Allaj, V., Chaudhary, O., Masilionis, I., Egger, J. V., Chow, A. T., Walle, T., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.09.008 · Cited by 464
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Kwee, T. C., & Kwee, R. M. (2020) · Radiographics · doi:10.1148/rg.2020200159 · Cited by 451
Katsura, H., Sontake, V., Tata, A., Kobayashi, Y., Edwards, C. E., Heaton, B. E., Konkimalla, A., Asakura, T., Mikami, Y., Fritch, E. J., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.10.005 · Cited by 416
Smith, J. C., Sausville, E. L., Girish, V., Yuan, M. L., Vasudevan, A., John, K. M., & Sheltzer, J. M. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.05.012 · Cited by 431
Zhao, H., Lu, L., Peng, Z., Chen, L.-L., Meng, X., Zhang, C., Ip, J. D., Chan, W.-M., Chu, A. W.-H., Chan, K.-H., et al. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2021.2023329 · Cited by 413
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses
Wang, R., Simoneau, C. R., Kulsuptrakul, J., Bouhaddou, M., Travisano, K. A., Hayashi, J. M., Carlson-Stevermer, J., Zengel, J. R., Richards, C. M., Fozouni, P., et al. (2020) · Cell · doi:10.1016/j.cell.2020.12.004 · Cited by 417
COVID-19 and anosmia: A review based on up-to-date knowledge
Meng, X., Deng, Y., Dai, Z., & Meng, Z. (2020) · American Journal of Otolaryngology · doi:10.1016/j.amjoto.2020.102581 · Cited by 418
Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract
Flerlage, T., Boyd, D. F., Meliopoulos, V., Thomas, P. G., & Schultz‐Cherry, S. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00542-7 · Cited by 419
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7
Meng, B., Kemp, S. A., Papa, G., Datir, R. P., Ferreira, I. A. T. M., Marelli, S., Harvey, W. T., Lytras, S., Mohamed, A., Gallo, G., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109292 · Cited by 407
Fotuhi, M., Mian, A., Meysami, S., & Raji, C. A. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200581 · Cited by 401
Periodontal Disease: The Good, The Bad, and The Unknown
Sedghi, L. M., Bacino, M. S., & Kapila, Y. L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.766944 · Cited by 409
Hoffmann, M., Hofmann-Winkler, H., Smith, J. C., Krüger, N., Arora, P., Sørensen, L. K., Søgaard, O. S., Hasselstrøm, J. B., Winkler, M., Hempel, T., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103255 · Cited by 397
COVID-19 vaccines: The status and perspectives in delivery points of view
Chung, J. Y., Thone, M. N., & Kwon, Y. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.011 · Cited by 375
COVID-19 and Cardiovascular Disease
Chung, M. K., Zidar, D. A., Bristow, M. R., Cameron, S. J., Chan, T. A.-T., Harding, C. V., Kwon, D. H., Singh, T. K., Tilton, J. C., Tsai, E. J., et al. (2021) · Circulation Research · doi:10.1161/circresaha.121.317997 · Cited by 377
Local and systemic responses to SARS-CoV-2 infection in children and adults
Yoshida, M., Worlock, K. B., Huang, N., Lindeboom, R. G. H., Butler, C. R., Kumasaka, N., Dominguez Conde, C., Mamanova, L., Bolt, L., Richardson, L., et al. (2022) · Nature · doi:10.1038/s41586-021-04345-x · Cited by 365
Self-citationKhan, M., Yoo, S., Clijsters, M., Backaert, W., Vanstapel, A., Speleman, K., Lietaer, C., Choi, S., HETHER, T. D., Marcelis, L., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.027 · Cited by 393
A practical solution to pseudoreplication bias in single-cell studies
Zimmerman, K. D., Espeland, M. A., & Langefeld, C. D. (2021) · Nature Communications · doi:10.1038/s41467-021-21038-1 · Cited by 356
SARS-CoV-2, COVID-19 and the aging immune system
Bartleson, J. M., Radenkovic, D., Covarrubias, A. J., Furman, D., Winer, D. A., & Verdin, E. (2021) · Nature Aging · doi:10.1038/s43587-021-00114-7 · Cited by 359
Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro
Kwon, P. S., Oh, H., Kwon, S., Jin, W., Zhang, F., Fraser, K., Hong, J. J., Linhardt, R. J., & Dordick, J. S. (2020) · Cell Discovery · doi:10.1038/s41421-020-00192-8 · Cited by 364
Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells
Zhu, N., Wang, W., Liu, Z., Liang, C., Wang, W., Ye, F., Huang, B., Zhao, L., Wang, H., Zhou, W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17796-z · Cited by 368
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Ziegler, C. G. K., Miao, V. N., Owings, A. H., Navia, A. W., Tang, Y., Bromley, J. D., Lotfy, P., Sloan, M., Laird, H., Williams, H. B., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.023 · Cited by 358
Zhou, L., Xu, Z., Castiglione, G. M., Soiberman, U., Eberhart, C. G., & Duh, E. J. (2020) · The Ocular Surface · doi:10.1016/j.jtos.2020.06.007 · Cited by 352
Olfactory Dysfunction in COVID-19
Whitcroft, K. L., & Hummel, T. R. (2020) · JAMA · doi:10.1001/jama.2020.8391 · Cited by 343
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Muus, C., Luecken, M. D., Eraslan, G., Sikkema, L., Waghray, A., Heimberg, G., Kobayashi, Y., Vaishnav, E. D., Subramanian, A., Smillie, C. S., et al. (2021) · Nature Medicine · doi:10.1038/s41591-020-01227-z · Cited by 347
Self-citationCOVID-19 and the Chemical Senses: Supporting Players Take Center Stage
Cooper, K. W., Brann, D. H., Farruggia, M. C., Bhutani, S., Pellegrino, R., Tsukahara, T., Weinreb, C., Joseph, P. V., Larson, E. D., Parma, V., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.032 · Cited by 341
Huang, J., Hume, A. J., Abo, K. M., Werder, R. B., Villacorta-Martín, C., Alysandratos, K., Beermann, M. L., Simone-Roach, C., Lindstrom-Vautrin, J., Olejnik, J., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.09.013 · Cited by 334
COVID-19 Transmission, Current Treatment, and Future Therapeutic Strategies
Salian, V. S., Wright, J. A., Vedell, P. T., Nair, S. A., Li, C., Kandimalla, M., Tang, X., Carmona, E. M., Kalari, K. R., & Kandimalla, K. K. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00608 · Cited by 343
Lessons for COVID-19 immunity from other coronavirus infections
Sariol, A., & Perlman, S. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.005 · Cited by 317
Tissue-Specific Immunopathology in Fatal COVID-19
Dorward, D. A., Russell, C. D., Um, I. H., Elshani, M., Armstrong, S. D., Penrice-Randal, R., Millar, T., Lerpiniere, C. E. B., Tagliavini, G., Hartley, C. S., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202008-3265oc · Cited by 321
SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions
Uddin, M. J., Mustafa, F., Rizvi, T. A., Loney, T., Suwaidi, H. S. A., Al-Marzouqi, A. H. H., Kamal‐Eldin, A., Alsabeeha, N. H. M., Adrian, T. E., Stefanini, C., et al. (2020) · Viruses · doi:10.3390/v12050526 · Cited by 317
Autoinflammatory and autoimmune conditions at the crossroad of COVID-19
Rodríguez, Y., Novelli, L., Rojas, M., Santis, M. D., Acosta‐Ampudia, Y., Monsalve, D. M., Ramírez-Santana, C., Costanzo, A., Ridgway, W. M., Ansari, A. A., et al. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102506 · Cited by 319
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry
Zhu, Y., Feng, F., Hu, G., Wang, Y., Yin, Y., Zhu, Y., Xü, W., Cai, X., Sun, Z., Han, W., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21213-4 · Cited by 307
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
Brevini, T., Maes, M., Webb, G. J., John, B. V., Fuchs, C. D., Buescher, G., Wang, L., Griffiths, C., Brown, M. L., Scott, W. E., et al. (2022) · Nature · doi:10.1038/s41586-022-05594-0 · Cited by 299
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Vanderheiden, A., Ralfs, P., Chirkova, T., Upadhyay, A. A., Zimmerman, M. G., Bedoya, S., Aoued, H. S., Tharp, G., Pellegrini, K. L., Manfredi, C., et al. (2020) · Journal of Virology · doi:10.1128/jvi.00985-20 · Cited by 304
Brann, D. H., Tsukahara, T., Weinreb, C., Lipovsek, M., den Berge, K. V., Gong, B., Chance, R., Macaulay, I. C., Chou, H.-J., Fletcher, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.25.009084 · Cited by 306
An aberrant STAT pathway is central to COVID-19
Matsuyama, T., Kubli, S. P., Yoshinaga, S. K., Pfeffer, K., & Mak, T. W. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00633-7 · Cited by 295
Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis
Ramasamy, S., & Subbian, S. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00299-20 · Cited by 307
Fodoulian, L., Tuberosa, J., Rossier, D., Boillat, M., Kan, C., Pauli, V., Egervari, K., Lobrinus, J. A., Landis, B. N., Carleton, A., et al. (2020) · doi:10.1101/2020.03.31.013268 · Cited by 286
COVID-19: A review of therapeutic strategies and vaccine candidates
Izda, V., Jeffries, M. A., & Sawalha, A. H. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108634 · Cited by 292
Leung, J. M., Niikura, M., Yang, C. W. T., & Sin, D. D. (2020) · European Respiratory Journal · doi:10.1183/13993003.02108-2020 · Cited by 297
Trougakos, I. P., Stamatelopoulos, K. S., Terpos, E., Tsitsilonis, O., Aivalioti, E., Paraskevis, D. N., Kastritis, E., Pavlakis, G. N., & Dimopoulos, M. A. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-020-00703-5 · Cited by 305
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594495 · Cited by 298
Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?
Piqué-Regi, R., Romero, R. J., Tarca, A. L., Luca, F., Xu, Y., Alazizi, A., Leng, Y., Hsu, C., & Gomez‐Lopez, N. (2020) · eLife · doi:10.7554/elife.58716 · Cited by 282
Yamamoto, M., Kiso, M., Sakai‐Tagawa, Y., Iwatsuki‐Horimoto, K., Imai, M., Takeda, M., Kinoshita, N., Ohmagari, N., Gohda, J., Semba, K., et al. (2020) · Viruses · doi:10.3390/v12060629 · Cited by 283
In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19
Schaefer, I., Padera, R. F., Solomon, I. H., Kanjilal, S., Hammer, M. M., Hornick, J. L., & Sholl, L. M. (2020) · Modern Pathology · doi:10.1038/s41379-020-0595-z · Cited by 281
Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19
Ahn, J. H., Kim, J., Hong, S. P., Choi, S. Y., Yang, M. J., Ju, Y. S., Kim, Y. T., Kim, H. M., Rahman, M. T., Chung, M. K., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148517 · Cited by 295
The total number and mass of SARS-CoV-2 virions
Sender, R., Bar‐On, Y. M., Gleizer, S., Bernshtein, B., Flamholz, A. I., Phillips, R., & Milo, R. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2024815118 · Cited by 292
Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients
Liu, T., Luo, S., Libby, P., & Shi, G. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107587 · Cited by 276
Yeung, M. L., Teng, J. L. L., Jia, L., Zhang, C., Huang, C., Cai, J., Zhou, R., Chan, K., Zhao, H., Zhu, L., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.053 · Cited by 276
Monocytes and Macrophages in COVID-19
Knoll, R., Schultze, J. L., & Schulte-Schrepping, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720109 · Cited by 279
Azuma, K., Yanagi, U., Kagi, N., Kim, H., OGATA, M., & Hayashi, M. (2020) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-020-00904-2 · Cited by 276
Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives
Tandon, R., Sharp, J. S., Zhang, F., Pomin, V. H., Ashpole, N. M., Mitra, D., McCandless, M. G., Jin, W., Liu, H., Sharma, P. C., et al. (2020) · Journal of Virology · doi:10.1128/jvi.01987-20 · Cited by 263
Metadata
- Authors
- HCA Lung Biological Network, Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., Sampaziotis, F., Worlock, K. B., Yoshida, M., & Barnes, J. L.
- Affiliations
- Wellcome Sanger Institute (GB)
- Centre National de la Recherche Scientifique (FR)
- University Medical Center Groningen (NL)
- Max Delbrück Center (DE)
- Harvard University (US)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- University College London (GB)
- Corresponding author
- Sungnak, Waradon
- ORCID
- Venue
- Nature Medicine
- Published
- 2020-04-23
- Volume
- 26
- Issue
- 5
- Pages
- 681-687
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC8637938
- OpenAlex
- W3011483298
- Cited by
- 2,501
- References
- 59
- Citations by year
- 2026: 53 · 2025: 105 · 2024: 140 · 2023: 265 · 2022: 454 · 2021: 814 · 2020: 664
- FWCI
- 71.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature Medicine (publishedVersion, other-oa)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- PubMed Central (acceptedVersion)
- arXiv (Cornell University) (submittedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, public-domain)
- Apollo (University of Cambridge) (submittedVersion)
- HAL (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Site cant be reached (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Apollo
- Funders
- U.S. Department of Defense (W81XWH1910416)
- Howard Hughes Medical Institute
- U.S. Department of Veterans Affairs
- Bill and Melinda Gates Foundation
- Richard and Susan Smith Family Foundation
- Massachusetts General Hospital
- Yale University
- Vanderbilt University
- Massachusetts Institute of Technology
- Memorial Sloan-Kettering Cancer Center
- Northwestern University
- School of Medicine, Boston University
- Arizona State University
- Helsingin Yliopisto
- University of Washington
- Deutsches Zentrum für Infektionsforschung
- Wellcome Trust (211276/Z/18/Z, 211276/D/18/Z, 108082/A/15/Z, #MR/R006237/1, WT206194, 107931/Z/15/Z, GINOP-2.3.2-15-2016-00026, WT211276/Z/18/Z)
- Deutsches Zentrum für Herz-Kreislaufforschung
- European Bioinformatics Institute
- National Jewish Health
- Vanderbilt University Medical Center
- European Molecular Biology Laboratory
- Broad Institute
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Manton Foundation
- University of Alberta
- Cancer Research UK
- National Institute for Health and Care Research (PB-PG-1215-20037, CL-2017-14-001)
- British Heart Foundation (SP/19/1/34461, PG/16/47/32156)
- Cystic Fibrosis Trust (VIA 028)
- Academy of Medical Sciences (SGL019\1071)
- Imperial College London (H2020)
- University College London
- Newcastle University
- European Commission (2018-342, GINOP‐2.3.2‐15‐2016‐00037, 874656, GINOP-2.3.2-15-2016-00006, H2020)
- Rosetrees Trust
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC/T2T0419, NC/N001540/1)
- National Research Foundation
- Deutsche Forschungsgemeinschaft (347286815, DK043351, EXC2151/1, EXC 2151, 329123747, 390873048)
- Agence Nationale de la Recherche (ANR‐10‐INBS‐09‐03, ANR- 10-INBS-09, ANR‐19, ANR-19-CE14, ANR-19-CE14-0027, ANR-10, 10-INBS-09, -15-IDEX-01, ANR‐15‐IDEX‐01)
- Fondation Leducq
- Rijksuniversiteit Groningen
- University of New South Wales
- National Natural Science Foundation of China (31871370)
- Catholic University of Korea
- Cancerfonden (2019-)
- Fondation pour la Recherche Médicale (DEQ20180339158)
- National Research Foundation of Korea
- Karolinska Institutet
- National Science and Technology Development Agency
- Kungliga Tekniska Högskolan
- Vetenskapsrådet (2018-)
- Thailand Research Fund
- Centre National de la Recherche Scientifique
- Universitair Medisch Centrum Groningen
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Medizinischen Hochschule Hannover
- Rheinische Friedrich-Wilhelms-Universität Bonn
- Stockholms Universitet
- Science for Life Laboratory
- Conseil Départemental des Alpes Maritimes (2016-294DGADSH-CV)
- Deutsches Zentrum für Lungenforschung
- National Centre for the Replacement Refinement and Reduction of Animals in Research (NC/N001540/1)
- Ministerie van Economische Zaken en Klimaat
- Berlin Institute of Health
- National Institutes of Health (1r56hl135124-01, H2020, AG‐049665, DK 043351, AI135964)
- Directorate for Biological Sciences
- School of Medicine, Duke University
- School of Medicine, Stanford University
- University of California, San Diego
- Harvard Stem Cell Institute
- Feinberg School of Medicine
- Medical School, University of Michigan
- Horizon 2020 Framework Programme (874656, GINOP-2.3.2)
- Klarman Cell Observatory, Broad Institute
- Medical Research Council (MC_PC_17230, MR/R015635/1, MR/P009581/1, MC_PC_12009, MR/R006237/1, MR/K017047/1, MR/S005579/1)
- Engineering and Physical Sciences Research Council (TS/H001220/1)
- Biotechnology and Biological Sciences Research Council (BB/T004460/1, BB/V01126X/1)
- National Health and Medical Research Council
- Faculty of Medical Sciences, Newcastle University
- European Regional Development Fund (GINOP‐2.3.2‐15‐2016‐00006, H2020, GINOP-2.3.2-15-2016-00037, GINOP-2.3.2-15-2016-00026)
- NIHR Newcastle Biomedical Research Centre
- Helmholtz Zentrum München
- NIHR Cambridge Biomedical Research Centre
- National Institute on Aging (P01AG049665)
- National Heart, Lung, and Blood Institute (HL135124, R01HL146557, U01HL148856, R56 HL135124, K08HL130595, K08HL146943, HL148856, U01HL145567, R01HL145372, R01HL127349)
- National Institute of Allergy and Infectious Diseases (U24AI118672, U19AI135964)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK043351)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24HD000836)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- SARS-CoV-2, viral entry factors, ACE2, TMPRSS2, nasal epithelial cells, innate immunity, respiratory epithelium, corneal epithelium, intestinal epithelium, tissue tropism, COVID-19 pandemic, single-cell transcriptomics, gene co-expression
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